NME1 and RAC1

Number of citations of the paper that reports this interaction (PMID 11274357)
34

Data Source:
BioGRID (enzymatic study)

		NME1	RAC1
Gene Name		NME/NM23 nucleoside diphosphate kinase 1	ras-related C3 botulinum toxin substrate 1 (rho family, small GTP binding protein Rac1)
Image
Gene Ontology Annotations	Cellular Component	Nucleus Cytoplasm Mitochondrion Cytosol Membrane Ruffle Membrane Extracellular Vesicular Exosome	Golgi Membrane Phagocytic Cup Cytoplasm Trans-Golgi Network Cytosol Actin Filament Plasma Membrane Focal Adhesion Membrane Extrinsic Component Of Plasma Membrane Lamellipodium Ruffle Membrane Cytoplasmic Ribonucleoprotein Granule Melanosome Extracellular Vesicular Exosome
	Molecular Function	Magnesium Ion Binding Deoxyribonuclease Activity Nucleoside Diphosphate Kinase Activity Protein Binding ATP Binding GTP Binding Identical Protein Binding Ribosomal Small Subunit Binding Poly(A) RNA Binding	GTPase Activity Protein Binding GTP Binding Rab GTPase Binding Enzyme Binding Protein Kinase Binding GTP-dependent Protein Binding Thioesterase Binding Rho GDP-dissociation Inhibitor Binding
	Biological Process	Purine Nucleotide Metabolic Process Nucleoside Diphosphate Phosphorylation GTP Biosynthetic Process Pyrimidine Nucleotide Metabolic Process UTP Biosynthetic Process CTP Biosynthetic Process DNA Catabolic Process Endocytosis Nervous System Development Negative Regulation Of Cell Proliferation Nucleoside Triphosphate Biosynthetic Process Nucleobase-containing Small Molecule Interconversion Cell Differentiation Regulation Of Apoptotic Process Positive Regulation Of DNA Binding Small Molecule Metabolic Process Positive Regulation Of Epithelial Cell Proliferation Nucleobase-containing Small Molecule Metabolic Process	Positive Regulation Of Protein Phosphorylation Auditory Receptor Cell Morphogenesis Mast Cell Chemotaxis Epithelial Cell Morphogenesis Movement Of Cell Or Subcellular Component Inflammatory Response Hyperosmotic Response Cell Adhesion Cell-matrix Adhesion G-protein Coupled Receptor Signaling Pathway Small GTPase Mediated Signal Transduction Axon Guidance Blood Coagulation Metabolic Process Cell Proliferation Response To Wounding Anatomical Structure Morphogenesis Regulation Of Hydrogen Peroxide Metabolic Process Positive Regulation Of Lamellipodium Assembly Positive Regulation Of Cell-substrate Adhesion Viral Process Cerebral Cortex Radially Oriented Cell Migration Embryonic Olfactory Bulb Interneuron Precursor Migration Lamellipodium Assembly Actin Cytoskeleton Organization Actin Filament Polymerization Platelet Activation Regulation Of Cell Migration Positive Regulation Of Actin Filament Polymerization T Cell Costimulation Ruffle Organization Negative Regulation Of Interleukin-23 Production Substrate Adhesion-dependent Cell Spreading Positive Regulation Of Rho Protein Signal Transduction Intracellular Signal Transduction Fc-epsilon Receptor Signaling Pathway Fc-gamma Receptor Signaling Pathway Involved In Phagocytosis Positive Regulation Of Apoptotic Process Positive Regulation Of Phosphatidylinositol 3-kinase Activity Engulfment Of Apoptotic Cell Innate Immune Response Cell-cell Junction Organization Bone Resorption Positive Regulation Of DNA Replication Vascular Endothelial Growth Factor Receptor Signaling Pathway Neurotrophin TRK Receptor Signaling Pathway Ephrin Receptor Signaling Pathway Negative Regulation Of Receptor-mediated Endocytosis Anatomical Structure Arrangement Dendrite Morphogenesis Cell Motility Regulation Of Defense Response To Virus By Virus Positive Regulation Of Stress Fiber Assembly Localization Within Membrane Positive Regulation Of Focal Adhesion Assembly Wnt Signaling Pathway, Planar Cell Polarity Pathway Regulation Of Respiratory Burst Semaphorin-plexin Signaling Pathway Dopaminergic Neuron Differentiation Protein Localization To Plasma Membrane Positive Regulation Of Neutrophil Chemotaxis Cochlea Morphogenesis Ruffle Assembly Apoptotic Signaling Pathway Positive Regulation Of Substrate Adhesion-dependent Cell Spreading
Pathways		Metabolism of nucleotides Synthesis and interconversion of nucleotide di- and triphosphates	Signaling by GPCR DCC mediated attractive signaling FCERI mediated MAPK activation Signaling by Wnt Nef and signal transduction Signaling by SCF-KIT DAP12 signaling EPH-Ephrin signaling Fcgamma receptor (FCGR) dependent phagocytosis Regulation of actin dynamics for phagocytic cup formation Sema4D induced cell migration and growth-cone collapse DAP12 interactions Host Interactions of HIV factors CD28 co-stimulation The role of Nef in HIV-1 replication and disease pathogenesis Factors involved in megakaryocyte development and platelet production GPCR downstream signaling Signaling by VEGF Fc epsilon receptor (FCERI) signaling Sema3A PAK dependent Axon repulsion SEMA3A-Plexin repulsion signaling by inhibiting Integrin adhesion Platelet activation, signaling and aggregation PCP/CE pathway Adaptive Immune System Axon guidance Costimulation by the CD28 family HIV Infection Translocation of GLUT4 to the plasma membrane L1CAM interactions VEGFA-VEGFR2 Pathway EPHB-mediated forward signaling Inactivation of Cdc42 and Rac Ephrin signaling EPH-ephrin mediated repulsion of cells Activation of Rac VEGFR2 mediated vascular permeability Sema4D mediated inhibition of cell attachment and migration G alpha (12/13) signalling events Sema4D in semaphorin signaling Netrin-1 signaling Innate Immune System Signalling by NGF Signal transduction by L1 Cell death signalling via NRAGE, NRIF and NADE Semaphorin interactions p75 NTR receptor-mediated signalling beta-catenin independent WNT signaling CD28 dependent Vav1 pathway DSCAM interactions NRAGE signals death through JNK GPVI-mediated activation cascade Signaling by Robo receptor
Drugs			Guanosine-5\'-Diphosphate
Diseases
GWAS
Protein-Protein Interactions		27 interactors: APEX1 AURKA CCND3 FXR2 GORASP2 ITGB1 KSR1 MIF NIF3L1 NME2 NME3 NME4 PID1 POLR1C PRUNE RAC1 RORA RORB RRAD SET SMARCD1 SOX30 SREK1IP1 TERF1 TIAM1 TNPO2 WDYHV1	144 interactors: ACTA1 ACTB AKT1 ARFIP2 ARHGAP1 ARHGAP15 ARHGAP17 ARHGAP27 ARHGAP31 ARHGAP32 ARHGAP33 ARHGAP44 ARHGDIA ARHGDIB ARHGDIG ARHGEF2 ARHGEF25 ARHGEF4 ARHGEF7 ARL2BP BAG6 BAIAP2 BCR BIRC2 BRINP1 CASP3 CASP7 CAV1 CDC23 CDC42 CDC42BPG CDC42SE1 CDC42SE2 CFAP36 CHN1 CHN2 CIT CNTNAP1 COG5 COX3 CSN2 CYBA CYBB CYFIP1 DEF6 DIAPH1 DIAPH3 DMPK DOCK1 DOCK2 DOCK8 DVL1 DVL2 EIF2AK2 FHOD1 FLNA FMNL1 GRN HACD3 HPS4 ICMT IFNGR1 IL1RAP IQGAP1 IQGAP2 KALRN KPNA4 KPNA6 KRT40 KTN1 LATS1 LTBP3 LTBP4 LZTS2 MAGI1 MAP3K10 MAP3K11 MAP3K4 MCF2L MCM3AP METAP2 MTNR1A MYD88 MYH9 NCF2 NCK1 NCKAP1 NEDD4 NME1 NOS2 NOXA1 OCRL OPHN1 PAK1 PAK2 PAK3 PAK7 PARD6A PARD6B PARD6G PARK2 PIAS3 PIK3R1 PIP4K2A PLD1 PLEKHG2 PLXNB1 PPP2R2B PRKCA PRKCD PRKCI PRMT6 PTK2 RALBP1 RAP1GDS1 RASGRF1 RCC2 RGL2 RPS6KB1 SET SFPQ SH3BP1 SH3RF1 SH3RF3 STAT1 STAT3 STAU1 SUMO2 SYNJ2 TBC1D3F TIAM1 TLR2 TNFRSF12A TRIO TUBA4A UNKL USH1C USP6 VAV1 VAV2 VAV3 VWF WAS WASF1
Entrez ID		4830	5879
HPRD ID		01131	03627
Ensembl ID		ENSG00000239672	ENSG00000136238
Uniprot IDs		P15531	A4D2P0 A4D2P1 P63000
PDB IDs		1JXV 1UCN 2HVD 2HVE 3L7U 4ENO	1E96 1FOE 1G4U 1HE1 1HH4 1I4D 1I4L 1I4T 1MH1 1RYF 1RYH 2FJU 2H7V 2NZ8 2P2L 2RMK 2VRW 2WKP 2WKQ 2WKR 2YIN 3B13 3BJI 3RYT 3SBD 3SBE 3SU8 3SUA 3TH5 4GZL 4GZM
Enriched GO Terms of Interacting Partners?		Positive Regulation Of Cellular Metabolic Process Regulation Of Apoptotic Process GTP Biosynthetic Process UTP Biosynthetic Process GTP Metabolic Process UTP Metabolic Process Regulation Of Cell Death CTP Biosynthetic Process Positive Regulation Of Metabolic Process Nucleoside Diphosphate Phosphorylation Pyrimidine Ribonucleotide Biosynthetic Process Pyrimidine Nucleoside Biosynthetic Process Pyrimidine Nucleotide Biosynthetic Process Nucleotide Phosphorylation Nucleoside Diphosphate Metabolic Process Regulation Of Metabolic Process Response To Organic Cyclic Compound Pyrimidine Nucleoside Metabolic Process Regulation Of Cell Cycle Response To Hormone Pyrimidine Nucleotide Metabolic Process Cellular Response To Lipid Nucleoside Triphosphate Biosynthetic Process Nucleosome Disassembly Mitotic Cell Cycle Nucleobase-containing Small Molecule Interconversion Regulation Of Cell Cycle Process Regulation Of Cellular Protein Metabolic Process Positive Regulation Of Cell Development Response To Drug Positive Regulation Of Cell Projection Organization Response To Organic Substance Positive Regulation Of Cell Cycle Response To Lipid Ribonucleotide Metabolic Process Positive Regulation Of Mitotic Cell Cycle Purine Nucleotide Metabolic Process Ribose Phosphate Metabolic Process Regulation Of DNA Replication Regulation Of Macrophage Activation Regulation Of Protein Metabolic Process Cell Cycle Telomere Maintenance Via Telomere Lengthening Cellular Response To Organic Substance Purine Nucleotide Biosynthetic Process Cell-matrix Adhesion Ribose Phosphate Biosynthetic Process Cellular Response To Organic Cyclic Compound Regulation Of Cellular Component Organization Cellular Response To Acid Chemical	Regulation Of Catalytic Activity Intracellular Signal Transduction Regulation Of Signal Transduction Signal Transduction Regulation Of Signaling Regulation Of Intracellular Signal Transduction Positive Regulation Of Catalytic Activity Signaling Cell Communication Cellular Response To Stimulus Small GTPase Mediated Signal Transduction Regulation Of GTPase Activity Positive Regulation Of Metabolic Process Positive Regulation Of GTPase Activity Positive Regulation Of Hydrolase Activity Response To Stimulus Regulation Of Small GTPase Mediated Signal Transduction Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Enzyme Linked Receptor Protein Signaling Pathway Vascular Endothelial Growth Factor Receptor Signaling Pathway Regulation Of Rho GTPase Activity Regulation Of Cellular Process Positive Regulation Of Rho GTPase Activity Positive Regulation Of Ras GTPase Activity Regulation Of Ras GTPase Activity Regulation Of Rho Protein Signal Transduction Regulation Of Metabolic Process Positive Regulation Of Rac GTPase Activity Regulation Of Ras Protein Signal Transduction Cell Surface Receptor Signaling Pathway Regulation Of Cellular Component Organization Cell Death Death Regulation Of Apoptotic Process Regulation Of Cell Death Neurotrophin TRK Receptor Signaling Pathway Neurotrophin Signaling Pathway Apoptotic Process Programmed Cell Death Positive Regulation Of Apoptotic Process Positive Regulation Of Programmed Cell Death Response To External Stimulus Positive Regulation Of Cell Death Innate Immune Response Cellular Response To Growth Factor Stimulus Movement Of Cell Or Subcellular Component Response To Growth Factor Cell Projection Organization Cellular Response To Organic Substance Generation Of Neurons
Tagcloud ?		17q12 anonymous brca1 cloning colia1 d17s183 dinucleotide edh17b exclude excludes families heterozygosity hox2 inherited locale ngfr nme2 ovarian phb pinpoint polymorphisms positional q21 rara recombination resolving scg43 thra1 wnt3	3t3 activate bind chimeric cytoskeletal dispensable effector effectors interrelationship jnk jun lamellipodia lamellipodium mediate nh2 nih p65 pak ras rho rhoa ruffling srf stimulate surprisingly threonine transformation transforming tumorigenic
Tagcloud (Difference) ?		17q12 anonymous brca1 cloning colia1 d17s183 dinucleotide edh17b exclude excludes families heterozygosity hox2 inherited locale ngfr nme2 ovarian phb pinpoint polymorphisms positional q21 rara recombination resolving scg43 thra1 wnt3	3t3 activate bind chimeric cytoskeletal dispensable effector effectors interrelationship jnk jun lamellipodia lamellipodium mediate nh2 nih p65 pak ras rho rhoa ruffling srf stimulate surprisingly threonine transformation transforming tumorigenic
Tagcloud (Intersection) ?