NME1 and TNPO3

Number of citations of the paper that reports this interaction (PubMedID 32296183)
50

Data Source:
BioGRID (two hybrid)

		NME1	TNPO3
Description		NME/NM23 nucleoside diphosphate kinase 1	transportin 3
Image
GO Annotations	Cellular Component	Nucleus Cytoplasm Early Endosome Cytosol Membrane Ruffle Membrane Extracellular Exosome	Nucleus Nuclear Envelope Annulate Lamellae Nucleoplasm Cytoplasm Cytosol
	Molecular Function	Nucleotide Binding Magnesium Ion Binding DNA Binding RNA Binding DNA Endonuclease Activity DNA Nuclease Activity Nucleoside Diphosphate Kinase Activity Protein Histidine Kinase Activity Protein Binding ATP Binding 3'-5'-DNA Exonuclease Activity Kinase Activity Transferase Activity Phosphotransferase Activity, Phosphate Group As Acceptor GDP Binding Identical Protein Binding Ribosomal Small Subunit Binding ADP Binding Metal Ion Binding Farnesyl Diphosphate Kinase Activity Coenzyme A Binding Succinyl-CoA Binding Acetyl-CoA Binding	Protein Binding Small GTPase Binding Identical Protein Binding Nuclear Import Signal Receptor Activity
	Biological Process	GTP Biosynthetic Process UTP Biosynthetic Process CTP Biosynthetic Process DNA Catabolic Process Apoptotic DNA Fragmentation Isoprenoid Metabolic Process Endocytosis Nervous System Development Lactation Negative Regulation Of Cell Population Proliferation Nucleotide Metabolic Process Nucleoside Diphosphate Metabolic Process Nucleoside Triphosphate Biosynthetic Process Cell Differentiation Mammary Gland Development Protein Hexamerization Regulation Of Fatty Acid Biosynthetic Process Regulation Of Apoptotic Process ITP Biosynthetic Process Acetyl-CoA Catabolic Process Positive Regulation Of Epithelial Cell Proliferation	Protein Import Into Nucleus Protein Transport
Pathways		Interconversion of nucleotide di- and triphosphates Azathioprine ADME Ribavirin ADME
Drugs		Zinc 2'-Deoxyguanosine-5'-Triphosphate Selenocysteine 2',3'-Dehydro-2',3'-Deoxy-Thymidine 5'-Diphosphate Adenosine Phosphonoacetic Acid Stavudine triphosphate Thymidine-5'- Diphosphate 2'-Deoxyguanosine-5'-Diphosphate 2',3'-dideoxy-3'-fluoro-urididine-5'-diphosphate Guanosine-5'-Diphosphate 3'-Deoxy 3'-Amino Adenosine-5'-Diphosphate Zidovudine diphosphate Copper Zinc acetate Zinc chloride Zinc sulfate, unspecified form
Diseases
GWAS		Bipolar disorder ( 31043756) Conjunctival UV autofluorescence (CUVAF) ( 25590795) Metabolite levels ( 23823483)	Diffuse cutaneous systemic sclerosis ( 29293537) Limited cutaneous systemic scleroderma ( 29293537) Platelet count ( 32888494) Plateletcrit ( 32888494) Primary biliary cholangitis ( 20639880) Primary biliary cirrhosis ( 22961000) Sjögren's syndrome ( 24097067) Systemic lupus erythematosus ( 18204446 32771030 28714469 26606652 26502338 24871463 23053960 18204098) Systemic lupus erythematosus and Systemic sclerosis ( 23740937) Systemic lupus erythematosus or rheumatoid arthritis ( 27193031) Systemic sclerosis ( 29293537 30247649 31672989 21750679) Systemic sclerosis (anti-centromere-positive) ( 29293537) Systemic sclerosis (anti-topoisomerase-positive) ( 29293537) Systemic seropositive rheumatic diseases (Systemic sclerosis or systemic lupus erythematosus or rheumatoid arthritis or idiopathic inflammatory myopathies) ( 30573655) Ulcerative colitis ( 23128233 21297633)
Interacting Genes		35 interacting genes: APEX1 AURKA CCND3 DDX19A FBXO24 FXR1 FXR2 GORASP2 ITGB1 KSR1 LNX1 MIF NIF3L1 NME3 NME4 NTAQ1 NUTF2 NXF1 PID1 POLR1C PRPF6 PRUNE1 RAC1 RORA RORB RRAD SET SMARCD1 SNCA SOX30 SREK1IP1 TERF1 TIAM1 TNPO2 TNPO3	23 interacting genes: BLMH CAMK2B CAMK2D CAMK2G CEBPA CHMP3 CLPP ECI2 GCH1 ICA1L KRT75 KRTAP10-8 MEOX2 NME1 PPP1R1C PTEN RNF10 SMURF2 SRSF1 SSX2 SSX2B TRA2B USP7
Entrez ID		4830	23534
HPRD ID		01131	18209
Ensembl ID		ENSG00000239672	ENSG00000064419
Uniprot IDs		A0A384MTW7 P15531	B3KMX1 C9J7E5 E9PFH4 Q9Y5L0
PDB IDs		1JXV 1UCN 2HVD 2HVE 3L7U 4ENO 5UI4 8OOV	4C0O 4C0P 4C0Q 4OL0 6GX9 8CMK
Enriched GO Terms of Interacting Partners?		Mitochondrion-mitochondrion Outer Membrane Tether Activity Regulation Of Neuronal Synaptic Plasticity Regulation Of Translation At Presynapse, Modulating Synaptic Transmission MRNA Transport RNA Transport Nuclear Import Signal Receptor Activity Regulation Of Long-term Neuronal Synaptic Plasticity Cytoplasmic Stress Granule Cytoplasm Nucleobase-containing Compound Transport Negative Regulation Of Biosynthetic Process Postsynapse Double-stranded Telomeric DNA Binding Cellular Component Assembly UTP Biosynthetic Process GTP Biosynthetic Process UTP Metabolic Process Positive Regulation Of Long-term Neuronal Synaptic Plasticity Nuclear Transport Nucleocytoplasmic Transport Regulation Of Cell Differentiation Central Nervous System Neuron Differentiation Protein Hexamerization Protein Binding Regulation Of Cell Development Regulation Of Macrophage Activation Negative Regulation Of Macromolecule Biosynthetic Process Positive Regulation Of Cell Development CTP Biosynthetic Process CTP Metabolic Process Regulation Of Microtubule Polymerization Protein-containing Complex Organization Nucleoside Diphosphate Kinase Activity Regulation Of Hydrogen Peroxide Metabolic Process Nucleus Translation Regulator Activity Positive Regulation Of Macromolecule Metabolic Process Negative Regulation Of Metabolic Process Cytoplasmic Ribonucleoprotein Granule Negative Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of Neurotransmitter Uptake Neuron Differentiation Protein-containing Complex Assembly Regulation Of Synaptic Plasticity Nucleosome Disassembly Regulation Of Rho Protein Signal Transduction Regulation Of Neurogenesis GTP Metabolic Process Regulation Of Cell Maturation Protein-DNA Complex Disassembly	Calcium- And Calmodulin-dependent Protein Kinase Complex Identical Protein Binding Calcium/calmodulin-dependent Protein Kinase Activity Sarcoplasmic Reticulum Membrane Long-term Synaptic Potentiation Regulation Of Neuronal Synaptic Plasticity Regulation Of System Process Sarcoplasmic Reticulum Regulation Of Skeletal Muscle Adaptation Endocytic Vesicle Membrane Ubiquitin-specific Protease Binding Postsynaptic Density Regulation Of Protein Localization To Plasma Membrane Regulation Of Cellular Localization
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