NXF1 and DVL3

Number of citations of the paper that reports this interaction (PMID 25416956)
0

Data Source:
BioGRID (two hybrid)

		NXF1	DVL3
Gene Name		nuclear RNA export factor 1	dishevelled segment polarity protein 3
Image			No pdb structure
Gene Ontology Annotations	Cellular Component	Transcription Export Complex Nuclear Pore Nucleoplasm Cytosol Nuclear Speck Nuclear Inclusion Body	Cytosol
	Molecular Function	Nucleotide Binding MRNA Binding Nucleocytoplasmic Transporter Activity Protein Binding Poly(A) RNA Binding	Protease Binding Receptor Binding Frizzled Binding Protein Binding Beta-catenin Binding Protein Heterodimerization Activity
	Biological Process	MRNA Export From Nucleus Gene Expression Viral Process Poly(A)+ MRNA Export From Nucleus	Positive Regulation Of Protein Phosphorylation Outflow Tract Septum Morphogenesis Wnt Signaling Pathway Intracellular Signal Transduction Non-canonical Wnt Signaling Pathway Non-canonical Wnt Signaling Pathway Via JNK Cascade Response To Drug Positive Regulation Of JUN Kinase Activity Positive Regulation Of Transcription, DNA-templated Canonical Wnt Signaling Pathway Wnt Signaling Pathway, Planar Cell Polarity Pathway Negative Regulation Of Canonical Wnt Signaling Pathway Cochlea Morphogenesis Planar Cell Polarity Pathway Involved In Neural Tube Closure Positive Regulation Of Canonical Wnt Signaling Pathway
Pathways		Transport of Mature mRNA Derived from an Intronless Transcript Processing of Capped Intron-Containing Pre-mRNA Transport of the SLBP Dependant Mature mRNA Transport of Mature mRNA derived from an Intron-Containing Transcript Transport of Mature mRNAs Derived from Intronless Transcripts Transport of the SLBP independent Mature mRNA Transport of Mature Transcript to Cytoplasm	disassembly of the destruction complex and recruitment of AXIN to the membrane WNT mediated activation of DVL misspliced LRP5 mutants have enhanced beta-catenin-dependent signaling TCF dependent signaling in response to WNT RNF mutants show enhanced WNT signaling and proliferation XAV939 inhibits tankyrase, stabilizing AXIN degradation of DVL negative regulation of TCF-dependent signaling by DVL-interacting proteins Signaling by Wnt Signaling by WNT in cancer PCP/CE pathway beta-catenin independent WNT signaling
Drugs
Diseases
GWAS			Major depressive disorder ( 22472876)
Protein-Protein Interactions		51 interactors: ALYREF CSNK2A1 DHX9 DVL3 EIF4A3 ELAVL4 ESRRA GFAP HNRNPUL1 IMPA1 IPO11 IPO4 KCTD5 KRT40 LDOC1 MAGOH MAP1A MAP1B MID2 NUP153 NUP214 NUP62 NUP98 NXF2 NXF3 NXF5 NXT1 NXT2 RAD51 RAE1 RAN RANBP2 RBM15B RBM8A SGTA SH2D3A SRSF1 SRSF3 SRSF7 STRAP THOC5 TIFA TNPO1 TNPO2 TRA2A TRA2B U2AF1 UBQLN4 UPF3A XIST ZBED2	48 interactors: ADAP1 AXIN1 BAHD1 C8orf33 CCNK CSNK1D CSNK1E CSNK2A1 CTNNB1 DAB2 DIDO1 DPPA2 DVL1 ENKD1 FAM13C KAT7 KLF3 KLHL12 LNX1 LRRK2 LY6H MARK2 MATN2 NKD1 NOL12 NXF1 PIK3CB PITX1 PLN PPM1A PPP2CA PRPF3 PSMF1 RPS10 RWDD2B SNX22 STOM SYT6 TNFAIP8L1 UTP3 VANGL1 WT1 YTHDC1 ZBTB48 ZNF264 ZNF408 ZNF512B ZNF697
Entrez ID		10482	1857
HPRD ID		04035	03222
Ensembl ID		ENSG00000162231	ENSG00000161202
Uniprot IDs		Q59E96 Q9UBU9	Q92997
PDB IDs		1FO1 1FT8 1GO5 1JKG 1JN5 1KOH 1KOO 1OAI 2Z5K 2Z5M 3RW6 3RW7
Enriched GO Terms of Interacting Partners?		RNA Transport RNA Localization MRNA Transport Nucleocytoplasmic Transport Nuclear Transport RNA Export From Nucleus Nuclear Export MRNA Export From Nucleus Cytoplasmic Transport Intracellular Transport MRNA Processing RNA Splicing MRNA Metabolic Process MRNA Splicing, Via Spliceosome RNA Splicing, Via Transesterification Reactions Establishment Of Localization In Cell RNA Processing Gene Expression Cellular Localization Termination Of RNA Polymerase II Transcription MRNA 3'-end Processing Viral Process RNA 3'-end Processing Mitotic Nuclear Envelope Disassembly DNA-templated Transcription, Termination Viral Life Cycle RNA Metabolic Process Nuclear Envelope Disassembly Regulation Of MRNA Splicing, Via Spliceosome Nuclear Import Nuclear Envelope Organization Glucose Transport Nucleobase-containing Compound Metabolic Process Hexose Transport Regulation Of MRNA Processing Viral Transcription Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process Regulation Of Glucose Transport Regulation Of RNA Splicing Transport Cellular Nitrogen Compound Metabolic Process Protein Import Into Nucleus Nucleus Organization Carbohydrate Transport Intracellular Transport Of Virus Regulation Of Alternative MRNA Splicing, Via Spliceosome Protein Import Nitrogen Compound Metabolic Process Protein Localization To Nucleus	Positive Regulation Of Wnt Signaling Pathway Regulation Of Wnt Signaling Pathway Wnt Signaling Pathway Positive Regulation Of Protein Catabolic Process Regulation Of Canonical Wnt Signaling Pathway Regulation Of Protein Catabolic Process Regulation Of Proteasomal Protein Catabolic Process Positive Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Positive Regulation Of Proteasomal Protein Catabolic Process Gene Expression RNA Metabolic Process Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Positive Regulation Of Proteolysis Involved In Cellular Protein Catabolic Process Positive Regulation Of Cellular Protein Catabolic Process Nucleobase-containing Compound Metabolic Process Cellular Nitrogen Compound Metabolic Process Negative Regulation Of Wnt Signaling Pathway RNA Biosynthetic Process Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process Positive Regulation Of Canonical Wnt Signaling Pathway Positive Regulation Of Protein Metabolic Process Transcription, DNA-templated Nitrogen Compound Metabolic Process Negative Regulation Of Canonical Wnt Signaling Pathway Negative Regulation Of Signal Transduction Regulation Of Protein Metabolic Process Negative Regulation Of Signaling Regulation Of Cellular Protein Metabolic Process Positive Regulation Of Proteolysis Positive Regulation Of Signal Transduction Positive Regulation Of Cellular Protein Metabolic Process Regulation Of Metabolic Process Regulation Of Signal Transduction Regulation Of Cell Morphogenesis Regulation Of Proteolysis Regulation Of Cellular Component Organization Cellular Macromolecule Biosynthetic Process Positive Regulation Of Protein Modification Process Macromolecule Biosynthetic Process Negative Regulation Of Binding Regulation Of Gene Expression Cellular Metabolic Process Regulation Of Protein Kinase Activity Positive Regulation Of Metabolic Process Regulation Of Signaling Positive Regulation Of Transferase Activity Regulation Of Transcription, DNA-templated Regulation Of Kinase Activity Protein Complex Assembly
Tagcloud ?		betaretrovirus cte gag gammaretroviral gammaretrovirus gammaretroviruses isogenic lentiviruses license mason mlv mpmv nxt pfizer pol polyprotein polyribosomes polysome polysomes pr65gag quantitated retrovirus retroviruses shuttling srp20 synergized synthesize unspliced xmrv	achieves adaptor analogous blockade dab2 encouraging erks grb2 igfi igfir influencing insufficient links mek nonredundant pharmacologic postreceptor relied responded sensitization sensitizing sevenless shc son sos synergized tracked unselected
Tagcloud (Difference) ?		betaretrovirus cte gag gammaretroviral gammaretrovirus gammaretroviruses isogenic lentiviruses license mason mlv mpmv nxt pfizer pol polyprotein polyribosomes polysome polysomes pr65gag quantitated retrovirus retroviruses shuttling srp20 synthesize unspliced xmrv	achieves adaptor analogous blockade dab2 encouraging erks grb2 igfi igfir influencing insufficient links mek nonredundant pharmacologic postreceptor relied responded sensitization sensitizing sevenless shc son sos tracked unselected
Tagcloud (Intersection) ?		synergized