NME1 and FBXO24

Number of citations of the paper that reports this interaction (PubMedID 25582197)
46

Data Source:
BioGRID (pull down)

		NME1	FBXO24
Description		NME/NM23 nucleoside diphosphate kinase 1	F-box protein 24
Image			No pdb structure
GO Annotations	Cellular Component	Nucleus Cytoplasm Early Endosome Cytosol Membrane Ruffle Membrane Extracellular Exosome	Ubiquitin Ligase Complex SCF Ubiquitin Ligase Complex
	Molecular Function	Nucleotide Binding Magnesium Ion Binding DNA Binding RNA Binding DNA Endonuclease Activity DNA Nuclease Activity Nucleoside Diphosphate Kinase Activity Protein Histidine Kinase Activity Protein Binding ATP Binding 3'-5'-DNA Exonuclease Activity Kinase Activity Transferase Activity Phosphotransferase Activity, Phosphate Group As Acceptor GDP Binding Identical Protein Binding Ribosomal Small Subunit Binding ADP Binding Metal Ion Binding Farnesyl Diphosphate Kinase Activity Coenzyme A Binding Succinyl-CoA Binding Acetyl-CoA Binding	Ubiquitin-protein Transferase Activity Protein Binding
	Biological Process	GTP Biosynthetic Process UTP Biosynthetic Process CTP Biosynthetic Process DNA Catabolic Process Apoptotic DNA Fragmentation Isoprenoid Metabolic Process Endocytosis Nervous System Development Lactation Negative Regulation Of Cell Population Proliferation Nucleotide Metabolic Process Nucleoside Diphosphate Metabolic Process Nucleoside Triphosphate Biosynthetic Process Cell Differentiation Mammary Gland Development Protein Hexamerization Regulation Of Fatty Acid Biosynthetic Process Regulation Of Apoptotic Process ITP Biosynthetic Process Acetyl-CoA Catabolic Process Positive Regulation Of Epithelial Cell Proliferation	MRNA Splicing, Via Spliceosome Chromatin Organization Mitochondrion Organization Spermatogenesis Single Fertilization Protein Ubiquitination Protein Catabolic Process PiRNA Processing Axoneme Assembly Cilium Organization
Pathways		Interconversion of nucleotide di- and triphosphates Azathioprine ADME Ribavirin ADME
Drugs		Zinc 2'-Deoxyguanosine-5'-Triphosphate Selenocysteine 2',3'-Dehydro-2',3'-Deoxy-Thymidine 5'-Diphosphate Adenosine Phosphonoacetic Acid Stavudine triphosphate Thymidine-5'- Diphosphate 2'-Deoxyguanosine-5'-Diphosphate 2',3'-dideoxy-3'-fluoro-urididine-5'-diphosphate Guanosine-5'-Diphosphate 3'-Deoxy 3'-Amino Adenosine-5'-Diphosphate Zidovudine diphosphate Copper Zinc acetate Zinc chloride Zinc sulfate, unspecified form
Diseases
GWAS		Bipolar disorder ( 31043756) Conjunctival UV autofluorescence (CUVAF) ( 25590795) Metabolite levels ( 23823483)	Brain morphology (MOSTest) ( 32665545) Mean spheric corpuscular volume ( 32888494) Subcortical volume (MOSTest) ( 32665545)
Interacting Genes		35 interacting genes: APEX1 AURKA CCND3 DDX19A FBXO24 FXR1 FXR2 GORASP2 ITGB1 KSR1 LNX1 MIF NIF3L1 NME3 NME4 NTAQ1 NUTF2 NXF1 PID1 POLR1C PRPF6 PRUNE1 RAC1 RORA RORB RRAD SET SMARCD1 SNCA SOX30 SREK1IP1 TERF1 TIAM1 TNPO2 TNPO3	3 interacting genes: KDM1A NME1 SRPK2
Entrez ID		4830	26261
HPRD ID		01131	16438
Ensembl ID		ENSG00000239672	ENSG00000106336
Uniprot IDs		A0A384MTW7 P15531	A4D2D3 O75426
PDB IDs		1JXV 1UCN 2HVD 2HVE 3L7U 4ENO 5UI4 8OOV
Enriched GO Terms of Interacting Partners?		Mitochondrion-mitochondrion Outer Membrane Tether Activity Regulation Of Neuronal Synaptic Plasticity Regulation Of Translation At Presynapse, Modulating Synaptic Transmission MRNA Transport RNA Transport Nuclear Import Signal Receptor Activity Regulation Of Long-term Neuronal Synaptic Plasticity Cytoplasmic Stress Granule Cytoplasm Nucleobase-containing Compound Transport Negative Regulation Of Biosynthetic Process Postsynapse Double-stranded Telomeric DNA Binding Cellular Component Assembly UTP Biosynthetic Process GTP Biosynthetic Process UTP Metabolic Process Positive Regulation Of Long-term Neuronal Synaptic Plasticity Nuclear Transport Nucleocytoplasmic Transport Regulation Of Cell Differentiation Central Nervous System Neuron Differentiation Protein Hexamerization Protein Binding Regulation Of Cell Development Regulation Of Macrophage Activation Negative Regulation Of Macromolecule Biosynthetic Process Positive Regulation Of Cell Development CTP Biosynthetic Process CTP Metabolic Process Regulation Of Microtubule Polymerization Protein-containing Complex Organization Nucleoside Diphosphate Kinase Activity Regulation Of Hydrogen Peroxide Metabolic Process Nucleus Translation Regulator Activity Positive Regulation Of Macromolecule Metabolic Process Negative Regulation Of Metabolic Process Cytoplasmic Ribonucleoprotein Granule Negative Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of Neurotransmitter Uptake Neuron Differentiation Protein-containing Complex Assembly Regulation Of Synaptic Plasticity Nucleosome Disassembly Regulation Of Rho Protein Signal Transduction Regulation Of Neurogenesis GTP Metabolic Process Regulation Of Cell Maturation Protein-DNA Complex Disassembly	Acetyl-CoA Catabolic Process Regulation Of Programmed Cell Death Regulation Of Apoptotic Process Positive Regulation Of Cell Population Proliferation Acetyl-CoA Binding Coenzyme A Binding Magnesium Ion Binding ITP Biosynthetic Process Farnesyl Diphosphate Kinase Activity Protein Histidine Kinase Activity ITP Metabolic Process RNA Binding Succinyl-CoA Binding Nuclear Speck Organization Protein Demethylase Activity Telomeric Repeat-containing RNA Binding FAD-dependent H3K4me/H3K4me3 Demethylase Activity Negative Regulation Of Transcription Initiation-coupled Chromatin Remodeling Regulation Of Cell Population Proliferation MRF Binding Response To Fungicide Guanine Metabolic Process Phosphotransferase Activity, Phosphate Group As Acceptor UTP Biosynthetic Process DNA Nuclease Activity Histone H3K4 Demethylase Activity GTP Biosynthetic Process UTP Metabolic Process R-loop Processing 3'-5'-DNA Exonuclease Activity Protein Hexamerization Histone H3K9 Demethylase Activity CTP Metabolic Process CTP Biosynthetic Process Purine-containing Compound Metabolic Process Apoptotic DNA Fragmentation Positive Regulation Of Cell Size Nucleoside Diphosphate Kinase Activity Cell Differentiation Negative Regulation Of DNA Damage Response, Signal Transduction By P53 Class Mediator DNA Repair Complex Negative Regulation Of Intrinsic Apoptotic Signaling Pathway In Response To DNA Damage By P53 Class Mediator Nucleobase-containing Small Molecule Metabolic Process Nucleobase-containing Compound Metabolic Process Ribosomal Small Subunit Binding Nuclear Body Organization Purine Nucleobase Metabolic Process Histone Demethylase Activity Regulation Of Intrinsic Apoptotic Signaling Pathway In Response To DNA Damage By P53 Class Mediator GTP Metabolic Process
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