GPNMB and ITSN2

Number of citations of the paper that reports this interaction (PubMedID 22558309)
58

Data Source:
BioGRID (two hybrid)

		GPNMB	ITSN2
Description		glycoprotein nmb	intersectin 2
Image		No pdb structure
GO Annotations	Cellular Component	Endosome Plasma Membrane Membrane Cytoplasmic Vesicle Early Endosome Membrane Melanosome Membrane	Cytoplasm Centrosome Cytosol Plasma Membrane Presynaptic Membrane Extracellular Exosome Intracellular Vesicle
	Molecular Function	Integrin Binding Protein Binding Heparin Binding Chemoattractant Activity Syndecan Binding Receptor Ligand Activity	Guanyl-nucleotide Exchange Factor Activity Calcium Ion Binding Protein Binding Protein-macromolecule Adaptor Activity Metal Ion Binding
	Biological Process	Negative Regulation Of Cytokine Production Cell Adhesion Signal Transduction Cell-cell Signaling Negative Regulation Of Cell Population Proliferation Positive Regulation Of Cell Migration Negative Regulation Of Tumor Necrosis Factor Production Regulation Of Tissue Remodeling Negative Regulation Of T Cell Proliferation Regulation Of Angiogenesis Negative Regulation Of T Cell Activation Positive Chemotaxis Positive Regulation Of ERK1 And ERK2 Cascade Negative Regulation Of G1/S Transition Of Mitotic Cell Cycle	Endocytosis Endosomal Transport Cell Differentiation Clathrin-dependent Synaptic Vesicle Endocytosis Positive Regulation Of Dendrite Extension
Pathways		PTK6 promotes HIF1A stabilization	Cargo recognition for clathrin-mediated endocytosis Clathrin-mediated endocytosis RHOU GTPase cycle
Drugs		Glembatumumab vedotin
Diseases
GWAS		Blood protein levels ( 30072576) Electrocardiogram morphology (amplitude at temporal datapoints) ( 32916098) Parkinson's disease ( 25064009 28892059) Parkinson's disease or first degree relation to individual with Parkinson's disease ( 31701892)	Appendicular lean mass ( 33097823) Asthma ( 29273806) Chromium levels ( 26025379) Diffuse large B cell lymphoma ( 25261932) Feeling fed-up ( 29500382) Low density lipoprotein cholesterol levels ( 32154731 33339817) Lung cancer ( 28604730) Lung cancer in ever smokers ( 28604730) Response to antipsychotic treatment in schizophrenia (working memory) ( 21107309) Sjögren's syndrome ( 24097067) Total cholesterol levels ( 33339817)
Interacting Genes		4 interacting genes: EGFR ITSN2 LINC01139 SMAD4	74 interacting genes: AGT AHDC1 AMPH ANKRD17 BCCIP CBL CCDC88C CHIC2 CPSF6 DLGAP1 DST EGFR EPS8 ERC1 FASLG FCHSD1 FCHSD2 FNBP4 GAREM2 GOLGA2 GOLGA8A GOLGB1 GPNMB HNRNPK HOOK2 ITPKA ITSN1 KCTD10 KDM1A KHDRBS1 KIAA1549 KXD1 LSM8 LTBP4 LUC7L3 MAP4K3 MBNL1 MEGF10 NBR1 NR2C2 PDCD6IP PDE4DIP PIK3AP1 PIK3C2B PSEN1 PTN RAD9A RBMX REPS1 RNF20 ROCK1 RUFY1 SEMA6A SH3GL1 SH3KBP1 SNAP29 SNCA SOS1 SOS2 STX4 SYN1 SYNJ2 TACC1 TBL3 TMF1 TRIO UBC WAS WASF2 WASL WIPF1 WIPF2 YLPM1 YTHDF1
Entrez ID		10457	50618
HPRD ID		05081	09193
Ensembl ID		ENSG00000136235	ENSG00000198399
Uniprot IDs		Q14956 Q96F58	A6H8W8 Q9NZM3
PDB IDs			1J3T 1UDL 1UE9 1UFF 1UHF 3GF9 3JZY 4IIO
Enriched GO Terms of Interacting Partners?		Negative Regulation Of Cardiocyte Differentiation Intracellular Vesicle Regulation Of Cell Growth Regulation Of MiRNA Transcription Regulation Of MiRNA Metabolic Process Positive Regulation Of MiRNA Metabolic Process Positive Regulation Of MiRNA Transcription Multivesicular Body, Internal Vesicle Lumen Negative Regulation Of Cardiac Myofibril Assembly Positive Regulation Of Cell Proliferation Involved In Heart Valve Morphogenesis Female Gonad Morphogenesis Regulation Of MAPK Cascade Regulation Of Growth Negative Regulation Of Protein Catabolic Process Shc-EGFR Complex Gonad Morphogenesis Nephrogenic Mesenchyme Morphogenesis Clathrin-dependent Synaptic Vesicle Endocytosis Positive Regulation Of Cell Growth Positive Regulation Of Protein Kinase C Signaling Epidermal Growth Factor Receptor Activity Activin Responsive Factor Complex Left Ventricular Cardiac Muscle Tissue Morphogenesis Metanephric Mesenchyme Morphogenesis Epidermal Growth Factor Binding Positive Regulation Of Luteinizing Hormone Secretion Regulation Of Protein Kinase C Signaling Sulfate Binding Endocardial Cell Differentiation Wide Pore Channel Activity Cell Differentiation Regulation Of Canonical Wnt Signaling Pathway Positive Regulation Of Growth ERBB2-EGFR Signaling Pathway MAPK Cascade SMAD Protein Complex Regulation Of Follicle-stimulating Hormone Secretion Positive Regulation Of Follicle-stimulating Hormone Secretion Atrioventricular Valve Formation Sebaceous Gland Development Heteromeric SMAD Protein Complex Formation Of Anatomical Boundary Brainstem Development Mesendoderm Development Positive Regulation Of Cell Proliferation Involved In Heart Morphogenesis Regulation Of Transforming Growth Factor Beta2 Production Positive Regulation Of Intracellular Signal Transduction Cellular Response To Growth Factor Stimulus Tube Morphogenesis Regulation Of ERK1 And ERK2 Cascade	SH3 Domain Binding Endocytosis Cell Projection Vesicle-mediated Transport Actin Filament-based Movement Import Into Cell Regulation Of Epidermal Growth Factor Receptor Signaling Pathway Regulation Of ERBB Signaling Pathway Establishment Of Localization In Cell Cytoskeleton Positive Regulation Of Cellular Component Organization Regulation Of Supramolecular Fiber Organization Positive Regulation Of Epidermal Growth Factor Receptor Signaling Pathway Positive Regulation Of ERBB Signaling Pathway Cytoplasmic Vesicle Cytoskeleton Organization Small GTPase-mediated Signal Transduction Cytoplasm Synaptic Vesicle Endocytosis Organelle Localization Glutamatergic Synapse Presynaptic Endocytosis Actin Binding Vesicle-mediated Transport In Synapse Organelle Organization Supramolecular Fiber Organization Cadherin Binding Actin Filament-based Process Positive Regulation Of Cellular Component Biogenesis Regulation Of Cell Communication Regulation Of Signaling Cellular Localization Regulation Of Cellular Component Organization Regulation Of Cytoskeleton Organization Membrane Organization MRNA Binding Protein Complex Oligomerization Regulation Of Vesicle-mediated Transport Regulation Of Angiotensin-activated Signaling Pathway Intracellular Transport Apical Constriction Positive Regulation Of RNA Export From Nucleus Cellular Component Assembly Cytosol Actin Cytoskeleton Negative Regulation Of Epidermal Growth Factor Receptor Signaling Pathway Regulation Of Synaptic Plasticity Cell-cell Signaling Regulation Of Intracellular Signal Transduction Modulation Of Chemical Synaptic Transmission
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