SHMT2 and ARL6IP1

Number of citations of the paper that reports this interaction (PMID 25416956)
0

Data Source:
BioGRID (two hybrid)

		SHMT2	ARL6IP1
Gene Name		serine hydroxymethyltransferase 2 (mitochondrial)	ADP-ribosylation factor-like 6 interacting protein 1
Image			No pdb structure
Gene Ontology Annotations	Cellular Component	Mitochondrion Mitochondrial Inner Membrane Mitochondrial Intermembrane Space Mitochondrial Matrix Microtubule Cytoskeleton Mitochondrial Nucleoid Extracellular Vesicular Exosome	Sec61 Translocon Complex Cytosol Membrane Integral Component Of Membrane
	Molecular Function	Chromatin Binding Glycine Hydroxymethyltransferase Activity L-allo-threonine Aldolase Activity Amino Acid Binding Pyridoxal Phosphate Binding Identical Protein Binding	Protein Binding
	Biological Process	L-serine Biosynthetic Process One-carbon Metabolic Process Positive Regulation Of Cell Proliferation Glycine Biosynthetic Process From Serine Tetrahydrofolate Interconversion Protein Homotetramerization	Cotranslational Protein Targeting To Membrane
Pathways
Drugs		Pyridoxal Phosphate Tetrahydrofolic acid Glycine
Diseases
GWAS
Protein-Protein Interactions		6 interactors: APP ARL6IP1 CMTM5 CSNK2B NDRG1 PPARD	40 interactors: ACSF2 ARL4D ARL6 C12orf10 COL4A3BP DIABLO FAM134C FBXW7 FDFT1 FXR2 GAD2 GOLPH3 GORASP2 HGS HMGCL INPP5K MTERF3 NAPB NDRG4 NUDT3 PAM16 PBX3 RAB33A RTN4 SENP2 SHMT2 SNX1 SNX10 SNX11 SNX12 SNX15 SNX3 SNX4 SPG21 SUCLA2 TFAM TUFM WIPI2 ZFYVE21 ZNF391
Entrez ID		6472	23204
HPRD ID		00717	09641
Ensembl ID		ENSG00000182199	ENSG00000170540
Uniprot IDs		B4DJQ3 P34897 Q5BJF5 Q5HYG8	B7Z6S5 F5GXP4 Q15041
PDB IDs		3OU5
Enriched GO Terms of Interacting Partners?		Locomotion Cellular Response To Hypoxia Cellular Response To Decreased Oxygen Levels Chemotaxis Cellular Response To Oxygen Levels Cholesterol Metabolic Process Sterol Metabolic Process Response To External Stimulus Synaptic Growth At Neuromuscular Junction Hormone-mediated Signaling Pathway Axon Ensheathment Collateral Sprouting In Absence Of Injury Negative Regulation Of Cell Migration Intracellular Receptor Signaling Pathway Nervous System Development Collateral Sprouting Axon Midline Choice Point Recognition Negative Regulation Of Cell Motility Positive Regulation Of Cell Cycle Process Negative Regulation Of Cellular Component Movement Smooth Endoplasmic Reticulum Calcium Ion Homeostasis Negative Regulation Of Locomotion Keratinocyte Migration Positive Regulation Of Spindle Checkpoint Axon Choice Point Recognition Steroid Metabolic Process Regulation Of Binding Response To Abiotic Stimulus Positive Regulation Of Activin Receptor Signaling Pathway Negative Regulation Of Collagen Biosynthetic Process Adiponectin-activated Signaling Pathway Vitamin A Metabolic Process Positive Regulation Of Cell Cycle Response To Hypoxia Neuron Remodeling Negative Regulation Of Multicellular Organismal Metabolic Process Positive Regulation Of Cell Cycle Checkpoint Endothelial Tube Morphogenesis Alcohol Metabolic Process Keratinocyte Proliferation MRNA Transcription Axon Guidance Negative Regulation Of Smooth Muscle Cell Migration Movement Of Cell Or Subcellular Component Cellular Copper Ion Homeostasis Peripheral Nervous System Myelin Maintenance Negative Regulation Of Blood Vessel Endothelial Cell Migration Regulation Of Cell Differentiation Cell Differentiation Regulation Of Activin Receptor Signaling Pathway	Protein Transport Establishment Of Protein Localization Protein Localization Cellular Localization Vesicle Organization Establishment Of Localization In Cell Intracellular Transport Organelle Organization Cellular Protein Localization Intracellular Protein Transport Negative Regulation Of Early Endosome To Late Endosome Transport Mitochondrion Organization Regulation Of DNA Endoreduplication Succinate Metabolic Process Regulation Of Early Endosome To Late Endosome Transport Transport Protein Localization To Cilium Regulation Of Protein Catabolic Process Membrane Invagination Endomembrane System Organization Negative Regulation Of Intracellular Transport Cell Projection Assembly Protein Localization To Organelle Vesicle-mediated Transport Negative Regulation Of SREBP Signaling Pathway Succinyl-CoA Pathway Diphosphoinositol Polyphosphate Catabolic Process Posterior Compartment Specification Anterior Compartment Pattern Formation Positive Regulation Of Renal Water Transport Diadenosine Polyphosphate Catabolic Process Intralumenal Vesicle Formation Membrane Organization Localization Within Membrane Protein Localization To Membrane Endoplasmic Reticulum Organization Regulation Of Vesicle-mediated Transport Inositol Phosphate Metabolic Process Negative Regulation Of Protein Transport Lamellipodium Organization Alcohol Catabolic Process Glutamate Decarboxylation To Succinate Negative Regulation Of Triglyceride Biosynthetic Process ER To Golgi Ceramide Transport Uroporphyrinogen III Biosynthetic Process Cell Adhesion Molecule Production Intermembrane Transport Endosomal Transport Protein Targeting Biosynthetic Process
Tagcloud ?		anticancer cancerogenesis capacities carbons controlling depend directs fuels glycine hot hydroxymethyltransferase importantly isoform metabolism novo nucleotides overexpressed player precursors reprogramming serine shift shmt1 starvation thymidilate towards uracil widespread	1a 2b 3c 4c cisternae elaborate elucidated envelope er exogenously harboring homology interconnected localizes organelle potency reticulon reticulons shaped shaping sheet sheets suppress suppresses tmem33 transmembrane tubular tubulation tubules
Tagcloud (Difference) ?		anticancer cancerogenesis capacities carbons controlling depend directs fuels glycine hot hydroxymethyltransferase importantly isoform metabolism novo nucleotides overexpressed player precursors reprogramming serine shift shmt1 starvation thymidilate towards uracil widespread	1a 2b 3c 4c cisternae elaborate elucidated envelope er exogenously harboring homology interconnected localizes organelle potency reticulon reticulons shaped shaping sheet sheets suppress suppresses tmem33 transmembrane tubular tubulation tubules
Tagcloud (Intersection) ?