SHMT2 and ACVR1B

		SHMT2	ACVR1B
Description		serine hydroxymethyltransferase 2	activin A receptor type 1B
Image
GO Annotations	Cellular Component	Nucleus Cytoplasm Mitochondrion Mitochondrial Inner Membrane Mitochondrial Matrix Microtubule Cytoskeleton Membrane Mitochondrial Nucleoid Intracellular Organelle Lumen Extracellular Exosome BRISC Complex	Plasma Membrane Cell Surface Membrane Receptor Complex Activin Receptor Complex Serine/threonine Protein Kinase Complex
	Molecular Function	Chromatin Binding Glycine Hydroxymethyltransferase Activity Protein Binding L-allo-threonine Aldolase Activity Amino Acid Binding Transferase Activity Pyridoxal Phosphate Binding Identical Protein Binding	Nucleotide Binding Protein Kinase Activity Protein Serine/threonine Kinase Activity Transmembrane Receptor Protein Serine/threonine Kinase Activity Protein Binding ATP Binding Kinase Activity Activin Receptor Activity, Type I Transferase Activity Activin Receptor Activity Growth Factor Binding Ubiquitin Protein Ligase Binding Inhibin Binding SMAD Binding Metal Ion Binding Activin Binding I-SMAD Binding
	Biological Process	Regulation Of Oxidative Phosphorylation Regulation Of Translation Glycine Metabolic Process Glycine Biosynthetic Process L-serine Metabolic Process L-serine Biosynthetic Process One-carbon Metabolic Process Positive Regulation Of Cell Population Proliferation Formate Biosynthetic Process Glycine Biosynthetic Process From Serine Response To Type I Interferon Tetrahydrofolate Interconversion Tetrahydrofolate Metabolic Process Protein Tetramerization Protein Homotetramerization Regulation Of Mitochondrial Translation Protein K63-linked Deubiquitination Regulation Of Aerobic Respiration	G1/S Transition Of Mitotic Cell Cycle In Utero Embryonic Development Hair Follicle Development Regulation Of DNA-templated Transcription Signal Transduction Cell Surface Receptor Protein Serine/threonine Kinase Signaling Pathway Nervous System Development Regulation Of Signal Transduction Regulation Of Gene Expression Positive Regulation Of Gene Expression Negative Regulation Of Gene Expression Peptidyl-threonine Phosphorylation Negative Regulation Of Ossification Negative Regulation Of Cell Growth Regulation Of Cell Migration Activin Receptor Signaling Pathway Positive Regulation Of Activin Receptor Signaling Pathway Nodal Signaling Pathway Negative Regulation Of Cell Differentiation Positive Regulation Of Erythrocyte Differentiation Protein Autophosphorylation Regulation Of Multicellular Organismal Process Cellular Response To Growth Factor Stimulus Extrinsic Apoptotic Signaling Pathway Positive Regulation Of Trophoblast Cell Migration
Pathways		Metabolism of folate and pterines RHOG GTPase cycle Mitochondrial protein degradation	Signaling by NODAL Regulation of signaling by NODAL Signaling by Activin
Drugs		Pyridoxal phosphate Tetrahydrofolic acid Glycine Artenimol	ATP Fostamatinib
Diseases
GWAS		Anorexia nervosa, attention-deficit/hyperactivity disorder, autism spectrum disorder, bipolar disorder, major depression, obsessive-compulsive disorder, schizophrenia, or Tourette syndrome (pleiotropy) ( 31835028) Asthma ( 31619474) Autism spectrum disorder or schizophrenia ( 28540026) Cognitive ability, years of educational attainment or schizophrenia (pleiotropy) ( 31374203) Schizophrenia ( 25056061 29483656)	Adenocarcinoma ( 26732429) Age-related hearing impairment ( 24939585) Granulocyte count ( 27863252) Hematocrit ( 29403010) Hemoglobin ( 29403010) Lung cancer ( 26732429) Neutrophil count ( 27863252) Post bronchodilator FEV1/FVC ratio ( 26634245) Serum CC16 levels ( 32839289) Sum basophil neutrophil counts ( 27863252) Sum neutrophil eosinophil counts ( 27863252) Urate levels ( 23263486)
Interacting Genes		15 interacting genes: APP ARL6IP1 BRCC3 CAB39 CLEC2D CMTM5 CREB3 CSNK2B DUX4 ESR1 KASH5 MAL2 NDRG1 OGT PPARD	22 interacting genes: ACVR2B BAG6 BAMBI BMPR2 CRIPTO FKBP1A IGSF1 INHBA INHBB INHBC NEDD4L NODAL OS9 OTUB1 PRKACB RXRA SMAD2 SMAD4 SMAD7 SNX1 SNX2 TGFBRAP1
Entrez ID		6472	91
HPRD ID		00717	03193
Ensembl ID		ENSG00000182199	ENSG00000135503
Uniprot IDs		B4DJQ3 B4DLV4 P34897 Q5BJF5 V9HW06	P36896
PDB IDs		4PVF 5V7I 5X3V 6DK3 6H3C 6M5O 6QVG 6QVL 6R8F 7BYI 8AQL 8FJT 8FJU 8GKS 8GKT 8GKU 8GKW 8GKY 8GKZ 8QI7 8SSJ 8T4O 8T4P 8TLC 9BOX	7MRZ 7OLY
Enriched GO Terms of Interacting Partners?		Negative Regulation Of MiRNA Transcription Signal Transduction Release From Viral Latency Positive Regulation Of Activin Receptor Signaling Pathway Regulation Of Glycolytic Process Regulation Of Carbohydrate Catabolic Process Regulation Of ATP Metabolic Process Regulation Of MiRNA Transcription Neuron Remodeling Regulation Of Purine Nucleotide Metabolic Process Protein Kinase Regulator Activity Regulation Of MiRNA Metabolic Process Peptidyl-threonine Phosphorylation Serine/threonine Protein Kinase Complex Intracellular Signal Transduction Protein Serine/threonine Kinase Binding Positive Regulation Of Monocyte Chemotaxis Nuclear Steroid Receptor Activity Protein-containing Complex Regulation Of Activin Receptor Signaling Pathway Amyloid-beta Complex Regulation Of Endoplasmic Reticulum Stress-induced Intrinsic Apoptotic Signaling Pathway Growth Cone Lamellipodium Positive Regulation Of Nitric Oxide Biosynthetic Process Regulation Of Toll-like Receptor Signaling Pathway Regulation Of Response To Calcium Ion Regulation Of Cell Population Proliferation Amylin Binding Neuron Maturation Cell Maturation Positive Regulation Of Toll Signaling Pathway Regulation Of Small Molecule Metabolic Process Positive Regulation Of Small Molecule Metabolic Process Protein-containing Complex Assembly Regulation Of Generation Of Precursor Metabolites And Energy Regulation Of Monocyte Chemotaxis Positive Regulation Of Transcription By RNA Polymerase II Positive Regulation Of Insulin Secretion Involved In Cellular Response To Glucose Stimulus 14-3-3 Protein Binding Developmental Process Involved In Reproduction Cellular Response To Stress Intracellularly ATP-gated Chloride Channel Activity Positive Regulation Of Voltage-gated Chloride Channel Activity Sec61 Translocon Complex Binding Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Hormone-mediated Signaling Pathway Negative Regulation Of Myoblast Differentiation NF-kappaB Binding Linoleic Acid Binding Beta-catenin-TCF Complex Assembly	Cell Surface Receptor Protein Serine/threonine Kinase Signaling Pathway Activin Receptor Signaling Pathway Transforming Growth Factor Beta Receptor Superfamily Signaling Pathway Regulation Of Transmembrane Receptor Protein Serine/threonine Kinase Signaling Pathway Enzyme-linked Receptor Protein Signaling Pathway I-SMAD Binding Transforming Growth Factor Beta Receptor Binding Transforming Growth Factor Beta Receptor Signaling Pathway Positive Regulation Of Transmembrane Receptor Protein Serine/threonine Kinase Signaling Pathway Signal Transduction Regulation Of Activin Receptor Signaling Pathway Regulation Of SMAD Protein Signal Transduction Activin Receptor Binding SMAD Protein Signal Transduction Regulation Of Follicle-stimulating Hormone Secretion Positive Regulation Of Follicle-stimulating Hormone Secretion Cell Surface Receptor Signaling Pathway Anterior/posterior Pattern Specification Regulation Of Primary Metabolic Process Heteromeric SMAD Protein Complex Anatomical Structure Morphogenesis Lung Development Positive Regulation Of SMAD Protein Signal Transduction Type I Transforming Growth Factor Beta Receptor Binding Mesoderm Formation Nodal Signaling Pathway Gastrulation Positive Regulation Of Signal Transduction Regulation Of Ossification Regulation Of Macromolecule Metabolic Process Negative Regulation Of Activin Receptor Signaling Pathway Embryonic Pattern Specification Formation Of Primary Germ Layer Gastrulation With Mouth Forming Second Regionalization Positive Regulation Of Ovulation Positive Regulation Of Cell Communication Positive Regulation Of Signaling Growth Factor Activity Regulation Of Signal Transduction Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway Regulation Of Protein Metabolic Process Axis Specification Roof Of Mouth Development Regulation Of Metabolic Process Response To Growth Factor Activin Receptor Activity, Type II Negative Regulation Of Follicle-stimulating Hormone Secretion Activin Responsive Factor Complex Cell Differentiation
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