SHMT2 and PRKAG1

		SHMT2	PRKAG1
Description		serine hydroxymethyltransferase 2	protein kinase AMP-activated non-catalytic subunit gamma 1
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GO Annotations	Cellular Component	Nucleus Cytoplasm Mitochondrion Mitochondrial Inner Membrane Mitochondrial Matrix Microtubule Cytoskeleton Membrane Mitochondrial Nucleoid Intracellular Organelle Lumen Extracellular Exosome BRISC Complex	Nucleus Nucleoplasm Cytoplasm Cytosol Membrane Nucleotide-activated Protein Kinase Complex Protein-containing Complex
	Molecular Function	Chromatin Binding Glycine Hydroxymethyltransferase Activity Protein Binding L-allo-threonine Aldolase Activity Amino Acid Binding Transferase Activity Pyridoxal Phosphate Binding Identical Protein Binding	Nucleotide Binding AMP-activated Protein Kinase Activity CAMP-dependent Protein Kinase Activity Protein Binding ATP Binding CAMP-dependent Protein Kinase Regulator Activity AMP Binding Protein Kinase Regulator Activity Protein Kinase Binding ADP Binding Protein-containing Complex Binding
	Biological Process	Regulation Of Oxidative Phosphorylation Regulation Of Translation Glycine Metabolic Process Glycine Biosynthetic Process L-serine Metabolic Process L-serine Biosynthetic Process One-carbon Metabolic Process Positive Regulation Of Cell Population Proliferation Formate Biosynthetic Process Glycine Biosynthetic Process From Serine Response To Type I Interferon Tetrahydrofolate Interconversion Tetrahydrofolate Metabolic Process Protein Tetramerization Protein Homotetramerization Regulation Of Mitochondrial Translation Protein K63-linked Deubiquitination Regulation Of Aerobic Respiration	Regulation Of Glycolytic Process Protein Phosphorylation Lipid Metabolic Process Fatty Acid Metabolic Process Fatty Acid Biosynthetic Process Signal Transduction Spermatogenesis Cellular Response To Nutrient Levels Cellular Response To Glucose Starvation Regulation Of Carbon Utilization Positive Regulation Of Gluconeogenesis Import Into Nucleus Regulation Of Cell Cycle
Pathways		Metabolism of folate and pterines RHOG GTPase cycle Mitochondrial protein degradation	Translocation of SLC2A4 (GLUT4) to the plasma membrane Macroautophagy Activation of PPARGC1A (PGC-1alpha) by phosphorylation Energy dependent regulation of mTOR by LKB1-AMPK TP53 Regulates Metabolic Genes Regulation of TP53 Activity through Phosphorylation Lipophagy Activation of AMPK downstream of NMDARs AMPK-induced ERAD and lysosome mediated degradation of PD-L1(CD274)
Drugs		Pyridoxal phosphate Tetrahydrofolic acid Glycine Artenimol	Adenosine phosphate Acetylsalicylic acid Fostamatinib
Diseases
GWAS		Anorexia nervosa, attention-deficit/hyperactivity disorder, autism spectrum disorder, bipolar disorder, major depression, obsessive-compulsive disorder, schizophrenia, or Tourette syndrome (pleiotropy) ( 31835028) Asthma ( 31619474) Autism spectrum disorder or schizophrenia ( 28540026) Cognitive ability, years of educational attainment or schizophrenia (pleiotropy) ( 31374203) Schizophrenia ( 25056061 29483656)	Adult body size ( 32376654) Bipolar disorder ( 31043756) Body mass index ( 29273807) HDL cholesterol ( 30275531) Pulse pressure ( 27618447) Red cell distribution width ( 32888494) Systolic blood pressure ( 27618447 30578418)
Interacting Genes		15 interacting genes: APP ARL6IP1 BRCC3 CAB39 CLEC2D CMTM5 CREB3 CSNK2B DUX4 ESR1 KASH5 MAL2 NDRG1 OGT PPARD	31 interacting genes: ACACA AP1S3 C1orf94 CBS CRBN EIF3G KCNN4 KEAP1 KLHL20 KRTAP1-1 KRTAP10-1 KRTAP10-11 KRTAP10-3 KRTAP10-5 KRTAP4-12 KRTAP4-2 KRTAP9-2 KRTAP9-8 MEOX1 MEOX2 PAICS PAX6 PLEKHF2 PRKAA1 PRKAA2 PRKAB1 PRKAB2 PRKAG2 PRKDC TEKT1 TNFAIP1
Entrez ID		6472	5571
HPRD ID		00717	04118
Ensembl ID		ENSG00000182199	ENSG00000181929
Uniprot IDs		B4DJQ3 B4DLV4 P34897 Q5BJF5 V9HW06	F8VYY9 P54619
PDB IDs		4PVF 5V7I 5X3V 6DK3 6H3C 6M5O 6QVG 6QVL 6R8F 7BYI 8AQL 8FJT 8FJU 8GKS 8GKT 8GKU 8GKW 8GKY 8GKZ 8QI7 8SSJ 8T4O 8T4P 8TLC 9BOX	2UV4 2UV5 2UV6 2UV7 4CFE 4CFF 4RER 4REW 4ZHX 5EZV 5ISO 6B1U 6B2E 6C9F 6C9G 6C9H 6C9J 7JHG 7JHH 7JIJ 7M74 7MYJ 8BIK
Enriched GO Terms of Interacting Partners?		Negative Regulation Of MiRNA Transcription Signal Transduction Release From Viral Latency Positive Regulation Of Activin Receptor Signaling Pathway Regulation Of Glycolytic Process Regulation Of Carbohydrate Catabolic Process Regulation Of ATP Metabolic Process Regulation Of MiRNA Transcription Neuron Remodeling Regulation Of Purine Nucleotide Metabolic Process Protein Kinase Regulator Activity Regulation Of MiRNA Metabolic Process Peptidyl-threonine Phosphorylation Serine/threonine Protein Kinase Complex Intracellular Signal Transduction Protein Serine/threonine Kinase Binding Positive Regulation Of Monocyte Chemotaxis Nuclear Steroid Receptor Activity Protein-containing Complex Regulation Of Activin Receptor Signaling Pathway Amyloid-beta Complex Regulation Of Endoplasmic Reticulum Stress-induced Intrinsic Apoptotic Signaling Pathway Growth Cone Lamellipodium Positive Regulation Of Nitric Oxide Biosynthetic Process Regulation Of Toll-like Receptor Signaling Pathway Regulation Of Response To Calcium Ion Regulation Of Cell Population Proliferation Amylin Binding Neuron Maturation Cell Maturation Positive Regulation Of Toll Signaling Pathway Regulation Of Small Molecule Metabolic Process Positive Regulation Of Small Molecule Metabolic Process Protein-containing Complex Assembly Regulation Of Generation Of Precursor Metabolites And Energy Regulation Of Monocyte Chemotaxis Positive Regulation Of Transcription By RNA Polymerase II Positive Regulation Of Insulin Secretion Involved In Cellular Response To Glucose Stimulus 14-3-3 Protein Binding Developmental Process Involved In Reproduction Cellular Response To Stress Intracellularly ATP-gated Chloride Channel Activity Positive Regulation Of Voltage-gated Chloride Channel Activity Sec61 Translocon Complex Binding Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Hormone-mediated Signaling Pathway Negative Regulation Of Myoblast Differentiation NF-kappaB Binding Linoleic Acid Binding Beta-catenin-TCF Complex Assembly	Keratin Filament Nucleotide-activated Protein Kinase Complex Intermediate Filament AMP-activated Protein Kinase Activity Carboxylic Acid Biosynthetic Process Cytosol Fatty Acid Biosynthetic Process Small Molecule Biosynthetic Process Histone H2BS36 Kinase Activity [hydroxymethylglutaryl-CoA Reductase (NADPH)] Kinase Activity Cellular Response To Prostaglandin E Stimulus Cellular Response To Prostaglandin Stimulus Fatty Acid Metabolic Process Response To Prostaglandin E Protein Localization To Lipid Droplet Monocarboxylic Acid Metabolic Process Somite Specification Carboxylic Acid Metabolic Process Negative Regulation Of Tubulin Deacetylation Negative Regulation Of Hepatocyte Apoptotic Process Organic Acid Metabolic Process Regulation Of Tubulin Deacetylation Lipid Droplet Disassembly Sterol Biosynthetic Process Cellular Response To Glucose Starvation Regulation Of Generation Of Precursor Metabolites And Energy Cellular Response To Nutrient Levels Regulation Of Glycolytic Process Phosphatidylethanolamine Biosynthetic Process Cul3-RING Ubiquitin Ligase Complex Regulation Of Protein Deacetylation Regulation Of Stress Granule Assembly Protein Homotetramerization HMG Box Domain Binding Regulation Of Carbohydrate Catabolic Process Response To Nutrient Levels L-serine Metabolic Process Hair Cycle Segment Specification Somite Development Regulation Of ATP Metabolic Process Lipid Biosynthetic Process Fatty Acid Homeostasis Hepatocyte Apoptotic Process Protein Homooligomerization Regulation Of Purine Nucleotide Metabolic Process Steroid Biosynthetic Process Protein Tetramerization Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Phosphatidylcholine Biosynthetic Process
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