SHMT2 and CMTM5

Number of citations of the paper that reports this interaction (PMID 25416956)
0

Data Source:
BioGRID (two hybrid)

		SHMT2	CMTM5
Gene Name		serine hydroxymethyltransferase 2 (mitochondrial)	CKLF-like MARVEL transmembrane domain containing 5
Image			No pdb structure
Gene Ontology Annotations	Cellular Component	Mitochondrion Mitochondrial Inner Membrane Mitochondrial Intermembrane Space Mitochondrial Matrix Microtubule Cytoskeleton Mitochondrial Nucleoid Extracellular Vesicular Exosome	Extracellular Space Integral Component Of Membrane
	Molecular Function	Chromatin Binding Glycine Hydroxymethyltransferase Activity L-allo-threonine Aldolase Activity Amino Acid Binding Pyridoxal Phosphate Binding Identical Protein Binding	Cytokine Activity
	Biological Process	L-serine Biosynthetic Process One-carbon Metabolic Process Positive Regulation Of Cell Proliferation Glycine Biosynthetic Process From Serine Tetrahydrofolate Interconversion Protein Homotetramerization	Chemotaxis Negative Regulation Of Myoblast Differentiation
Pathways
Drugs		Pyridoxal Phosphate Tetrahydrofolic acid Glycine
Diseases
GWAS
Protein-Protein Interactions		6 interactors: APP ARL6IP1 CMTM5 CSNK2B NDRG1 PPARD	46 interactors: AACS ACSF2 ALDH18A1 APOA1 ARMC9 C12orf10 CPLX1 CYP1A1 DDA1 FAM114A1 FARS2 GAD1 GAD2 GLTP GOLGA2P10 GTF3C1 KIAA0368 LMO2 MCEE MTERF3 NDRG4 PITPNC1 PLIN3 PPIF PPP2R3C PTPN9 RBFA RMDN2 RNF185 RSRC2 SDCBP SH3GLB1 SHMT2 SNX1 SPATA8 SPG21 SSX3 SUCLA2 SYNE4 TIMM44 TPD52L3 TTPA TUBB TUFM VARS2 ZNF391
Entrez ID		6472	116173
HPRD ID		00717	06986
Ensembl ID		ENSG00000182199	ENSG00000166091
Uniprot IDs		B4DJQ3 P34897 Q5BJF5 Q5HYG8	C9JAI6 Q96DZ9
PDB IDs		3OU5
Enriched GO Terms of Interacting Partners?		Locomotion Cellular Response To Hypoxia Cellular Response To Decreased Oxygen Levels Chemotaxis Cellular Response To Oxygen Levels Cholesterol Metabolic Process Sterol Metabolic Process Response To External Stimulus Synaptic Growth At Neuromuscular Junction Hormone-mediated Signaling Pathway Axon Ensheathment Collateral Sprouting In Absence Of Injury Negative Regulation Of Cell Migration Intracellular Receptor Signaling Pathway Nervous System Development Collateral Sprouting Axon Midline Choice Point Recognition Negative Regulation Of Cell Motility Positive Regulation Of Cell Cycle Process Negative Regulation Of Cellular Component Movement Smooth Endoplasmic Reticulum Calcium Ion Homeostasis Negative Regulation Of Locomotion Keratinocyte Migration Positive Regulation Of Spindle Checkpoint Axon Choice Point Recognition Steroid Metabolic Process Regulation Of Binding Response To Abiotic Stimulus Positive Regulation Of Activin Receptor Signaling Pathway Negative Regulation Of Collagen Biosynthetic Process Adiponectin-activated Signaling Pathway Vitamin A Metabolic Process Positive Regulation Of Cell Cycle Response To Hypoxia Neuron Remodeling Negative Regulation Of Multicellular Organismal Metabolic Process Positive Regulation Of Cell Cycle Checkpoint Endothelial Tube Morphogenesis Alcohol Metabolic Process Keratinocyte Proliferation MRNA Transcription Axon Guidance Negative Regulation Of Smooth Muscle Cell Migration Movement Of Cell Or Subcellular Component Cellular Copper Ion Homeostasis Peripheral Nervous System Myelin Maintenance Negative Regulation Of Blood Vessel Endothelial Cell Migration Regulation Of Cell Differentiation Cell Differentiation Regulation Of Activin Receptor Signaling Pathway	Carboxylic Acid Metabolic Process Succinate Metabolic Process Organic Acid Metabolic Process Glutamate Decarboxylation To Succinate Glutamate Metabolic Process Dicarboxylic Acid Metabolic Process Small Molecule Metabolic Process Glutamate Catabolic Process Cellular Amino Acid Metabolic Process Dicarboxylic Acid Catabolic Process Neurotransmitter Biosynthetic Process Response To Nutrient Neurotransmitter Secretion Response To Arsenic-containing Substance Alpha-amino Acid Metabolic Process Neurotransmitter Metabolic Process Cellular Metabolic Process Cellular Amino Acid Biosynthetic Process Response To Drug Regulation Of Neurotransmitter Levels Fatty Acid Metabolic Process Monocarboxylic Acid Metabolic Process Ornithine Biosynthetic Process Regulation Of Proton-transporting ATPase Activity, Rotational Mechanism Succinyl-CoA Pathway Negative Regulation Of Cell Adhesion Molecule Production Negative Regulation Of Establishment Of Blood-brain Barrier L-methylmalonyl-CoA Metabolic Process Dibenzo-p-dioxin Catabolic Process Cofactor Metabolic Process Neurotransmitter Transport Establishment Of Localization In Cell Porphyrin-containing Compound Metabolic Process Valyl-tRNA Aminoacylation Negative Regulation Of Oxidative Phosphorylation Uncoupler Activity Protein-pyridoxal-5-phosphate Linkage Uroporphyrinogen III Biosynthetic Process Negative Regulation Of Interleukin-1 Beta Secretion Regulation Of Establishment Of Blood-brain Barrier
Tagcloud ?		anticancer cancerogenesis capacities carbons controlling depend directs fuels glycine hot hydroxymethyltransferase importantly isoform metabolism novo nucleotides overexpressed player precursors reprogramming serine shift shmt1 starvation thymidilate towards uracil widespread	author bio chance chip chosen cyclin d1 discover egfr epithelium her2 ihc insure makes manners next partner pc3 performance plasmid plays prostate regulated relationship stream traditional transduction transfection whether
Tagcloud (Difference) ?		anticancer cancerogenesis capacities carbons controlling depend directs fuels glycine hot hydroxymethyltransferase importantly isoform metabolism novo nucleotides overexpressed player precursors reprogramming serine shift shmt1 starvation thymidilate towards uracil widespread	author bio chance chip chosen cyclin d1 discover egfr epithelium her2 ihc insure makes manners next partner pc3 performance plasmid plays prostate regulated relationship stream traditional transduction transfection whether
Tagcloud (Intersection) ?