FXR2 and CCR4

Number of citations: 90 (PubMedID 28298427)
Data Source: BioGRID (two hybrid)

		FXR2	CCR4
Name		FMR1 autosomal homolog 2	C-C motif chemokine receptor 4
Structure			No pdb structure
GO Annotations	Cellular Component	Nucleus Cytoplasm Cytosol Cytoplasmic Stress Granule Membrane Cytoplasmic Ribonucleoprotein Granule Neuron Projection Synapse Presynapse Postsynapse	Plasma Membrane External Side Of Plasma Membrane Membrane
	Molecular Function	Nucleic Acid Binding RNA Binding MRNA Binding MRNA 3'-UTR Binding Protein Binding Identical Protein Binding Protein Homodimerization Activity Translation Regulator Activity Protein Heterodimerization Activity	G Protein-coupled Receptor Activity Chemokine Receptor Activity Protein Binding C-C Chemokine Receptor Activity C-C Chemokine Binding
	Biological Process	Regulation Of Translation Dentate Gyrus Development Regulation Of MRNA Stability Positive Regulation Of Translation Positive Regulation Of Long-term Neuronal Synaptic Plasticity Animal Organ Development MRNA Transport MRNA Destabilization Regulation Of Translation At Presynapse, Modulating Synaptic Transmission	Neuron Migration Tolerance Induction Chemotaxis Inflammatory Response Immune Response Signal Transduction Cell Surface Receptor Signaling Pathway G Protein-coupled Receptor Signaling Pathway Positive Regulation Of Cytosolic Calcium Ion Concentration Calcium-mediated Signaling Homeostasis Of Number Of Cells Cell Chemotaxis Chemokine-mediated Signaling Pathway Cellular Response To Cytokine Stimulus Interneuron Migration
Pathways		None	Chemokine receptors bind chemokines G alpha (i) signalling events
Drugs		None	Mogamulizumab FLX475
GWAS		Atrial fibrillation ( 30061737 ) Brain morphology (MOSTest) ( 32665545 ) IgM levels ( 23118916 ) Monocyte count ( 32888494 ) Refractive error ( 32231278 ) Sex hormone-binding globulin levels ( 22675492 )	Asthma ( 31959851 ) Celiac disease ( 20190752 22057235 ) Multiple sclerosis ( 24076602 ) Psychosis proneness (hypomanic personality scale and revised social anhedonia scale) ( 28525603 ) Psychosis proneness (perceptual aberration scale and revised social anhedonia scale) ( 28525603 ) Psychosis proneness (revised physical anhedonia scale and revised social anhedonia scale) ( 28525603 ) Psychosis proneness (revised social anhedonia scale) ( 28525603 )
Interacting Genes		191 interacting genes: AKAP9 AMOTL2 AP1M1 AP2M1 ARHGEF7 ARL6IP1 ATN1 AXIN1 AXIN2 BAZ2B BCKDK BCL11A BLK BRCA1 BYSL C10orf62 C1orf35 CALCOCO2 CAMK2B CAMK2G CAPRIN1 CBS CCAR2 CCDC33 CCDC85B CCDC92 CCN3 CCR4 CDKL3 CEP44 CEP55 CHRD COIL COMT CSNK2B CWF19L2 CYFIP1 CYFIP2 DCTN2 DCTPP1 DDX17 DEAF1 DGKD DMRTB1 DNM2 DPPA2 DYNLT1 ECH1 ECHS1 EDC4 EGFL7 EIF4G1 EVL EWSR1 FAM90A1 FBP1 FMR1 FTH1 FXR1 GFAP GKAP1 GOLGA2 GPSM1 GPSM2 GRIP1 GTSE1 HIVEP1 HMBOX1 HNRNPC HNRNPM HNRNPR HOMER3 HSPB1 IGFN1 IMPDH2 INPP5J KCNRG KCTD4 KHDRBS1 KIAA1217 KIF1A KIF2A KIF7 KRT18 KRT20 KXD1 L3MBTL1 L3MBTL3 LASP1 LCMT1 LCP2 LDOC1 MAGED1 MAPKBP1 MAPRE3 MBIP MCRS1 MEAF6 MFAP1 MIA3 MORF4L1 MPP1 MRPL43 MSANTD3 MVP MYH10 NASP NCK2 NDEL1 NDN NECAB2 NEXN NIF3L1 NKD2 NME1 NME3 NONO NT5C2 PAF1 PAICS PCBD1 PCM1 PDE9A PHC1P1 PHC2 PHLDB1 PICK1 PIM1 PKM PNMA1 POM121 PPP1R12C PRAM1 PRC1 PRPF6 PSME1 PSME3 PTS PYCR2 PYCR3 RABAC1 RAD54L2 RAI2 RALYL RBBP8 RBM14 RBM45 RBMX RBPMS RPIA RPS2 RTN3 RTN4 SCEL SCMH1 SF3B2 SFPQ SNAP23 SPRY1 SPRY2 SRPK2 SYT6 SYTL4 TBC1D22B TFCP2 THAP1 TLE5 TNFAIP1 TNIP2 TNNT1 TRAF2 TRIM23 TRIM29 TRIM3 TRIM37 TRIOBP TSC22D4 TUT4 USP39 VIM WDR59 WEE2-AS1 YES1 ZBTB22 ZBTB8A ZMAT2 ZMYND8 ZNF232 ZNF451 ZNRD2 ZSCAN1	37 interacting genes: ATP2A2 B3GAT3 BSG CACNA1H CCKBR CCL17 CCL22 CCL3 CCL5 CDK10 CH25H CLASP2 CLPTM1 CNTNAP1 DHCR24 ERGIC3 FAM234A FXR2 GHITM GRK2 GRK3 NAT14 NDRG2 NSUN2 PKM PRDX1 PTOV1 RTN1 RTN4 SLC12A5 SLC3A2 SLCO4A1 STIMATE SYNGR2 TMEM101 TMEM11 TRARG1
Entrez ID		9513	1233
HPRD ID		05629	05324
Ensembl ID		ENSG00000129245	ENSG00000183813
Uniprot IDs		P51116	A0N0Q1 P51679
PDB IDs		3H8Z	Not available
GO Terms Enriched among Interactors		Identical Protein Binding Protein Binding Cytoplasm Cytosol Cytoskeleton Negative Regulation Of RNA Metabolic Process Neuron Projection MRNA Metabolic Process MRNA Processing MRNA Splicing, Via Spliceosome RNA Splicing RNA Splicing, Via Transesterification Reactions Negative Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of Primary Metabolic Process Establishment Of Mitotic Spindle Orientation Paraspeckles Nucleoplasm Regulation Of RNA Metabolic Process Centrosome Regulation Of Neurotrophin TRK Receptor Signaling Pathway MRNA Binding Negative Regulation Of DNA-templated Transcription Establishment Of Mitotic Spindle Localization Negative Regulation Of RNA Biosynthetic Process Regulation Of Cellular Component Organization Negative Regulation Of Macromolecule Metabolic Process Establishment Of Spindle Orientation Microtubule-based Process Microtubule Cytoskeleton Organization Involved In Mitosis Regulation Of Nucleobase-containing Compound Metabolic Process Nucleolus Regulation Of MRNA Metabolic Process Endoplasmic Reticulum Tubular Network Formation Regulation Of Dendritic Spine Development RNA Binding Signaling Adaptor Activity Negative Regulation Of Metabolic Process Establishment Of Spindle Localization Negative Regulation Of Centriole Replication Intracellular Membraneless Organelle Establishment Of Organelle Localization Protein Domain Specific Binding Spindle Localization Regulation Of DNA-templated Transcription Regulation Of Cell Projection Organization Negative Regulation Of Macromolecule Biosynthetic Process Regulation Of RNA Biosynthetic Process Positive Regulation Of Dendritic Spine Development Endoplasmic Reticulum Tubular Network Membrane Organization System Development	Calcium Ion Transport Cell Chemotaxis Chemokine Activity Leukocyte Chemotaxis Leukocyte Migration Eosinophil Migration Eosinophil Chemotaxis Beta-adrenergic Receptor Kinase Activity Granulocyte Chemotaxis Positive Regulation Of Macrophage Migration CCR Chemokine Receptor Binding Metal Ion Transport Membrane Granulocyte Migration Positive Regulation Of Natural Killer Cell Chemotaxis Desensitization Of G Protein-coupled Receptor Signaling Pathway Membrane Organization Chemotaxis Endoplasmic Reticulum Tubular Network Formation CCR1 Chemokine Receptor Binding G Protein-coupled Receptor Kinase Activity Negative Adaptation Of Signaling Pathway Monoatomic Ion Transport Locomotion Endoplasmic Reticulum Tubular Network Membrane Organization Antimicrobial Humoral Immune Response Mediated By Antimicrobial Peptide CCR5 Chemokine Receptor Binding Regulation Of Macrophage Migration Monoatomic Cation Transport Myeloid Leukocyte Migration Negative Regulation Of G Protein-coupled Receptor Signaling Pathway Phospholipase Activator Activity Thyroid Hormone Transport Endoplasmic Reticulum Membrane Positive Regulation Of Transport Host-mediated Suppression Of Viral Transcription Antimicrobial Humoral Response Sarcoplasmic Reticulum Calcium Ion Transport Endoplasmic Reticulum Membrane Organization Host-mediated Suppression Of Viral Proces Cadherin Binding Macrophage Chemotaxis Chemokine-mediated Signaling Pathway Positive Regulation Of Lymphocyte Chemotaxis Calcium Ion Transmembrane Transport Steroid Biosynthetic Process Endoplasmic Reticulum Tubular Network Organization Negative Regulation Of Heart Contraction Regulation Of Viral Entry Into Host Cell Positive Regulation Of Neuroinflammatory Response