FXR2 and SYTL4

Number of citations of the paper that reports this interaction (PubMedID 32296183)
50

Data Source:
BioGRID (two hybrid)

		FXR2	SYTL4
Description		FMR1 autosomal homolog 2	synaptotagmin like 4
Image
GO Annotations	Cellular Component	Nucleus Cytoplasm Cytosol Cytoplasmic Stress Granule Membrane Cytoplasmic Ribonucleoprotein Granule Neuron Projection Synapse Presynapse Postsynapse	Endosome Plasma Membrane Membrane Secretory Granule Transport Vesicle Membrane Platelet Alpha Granule Membrane Cytoplasmic Vesicle Exocytic Vesicle
	Molecular Function	Nucleic Acid Binding RNA Binding MRNA Binding MRNA 3'-UTR Binding Protein Binding Identical Protein Binding Protein Homodimerization Activity Translation Regulator Activity Protein Heterodimerization Activity	Protein Binding Phospholipid Binding Zinc Ion Binding Small GTPase Binding Neurexin Family Protein Binding Metal Ion Binding
	Biological Process	Regulation Of Translation Dentate Gyrus Development Regulation Of MRNA Stability Positive Regulation Of Translation Positive Regulation Of Long-term Neuronal Synaptic Plasticity Animal Organ Development MRNA Transport MRNA Destabilization Regulation Of Translation At Presynapse, Modulating Synaptic Transmission	Plasma Membrane Repair Intracellular Protein Transport Exocytosis Insulin Secretion Lysosome Localization Positive Regulation Of Exocytosis Negative Regulation Of Insulin Secretion Positive Regulation Of Protein Secretion Multivesicular Body Sorting Pathway Regulation Of Plasma Membrane Repair
Pathways			Platelet degranulation
Drugs
Diseases
GWAS		Atrial fibrillation ( 30061737) Brain morphology (MOSTest) ( 32665545) IgM levels ( 23118916) Monocyte count ( 32888494) Refractive error ( 32231278) Sex hormone-binding globulin levels ( 22675492)	Lean body mass ( 28552196) Mean platelet volume ( 32888494) Platelet distribution width ( 32888494)
Interacting Genes		191 interacting genes: AKAP9 AMOTL2 AP1M1 AP2M1 ARHGEF7 ARL6IP1 ATN1 AXIN1 AXIN2 BAZ2B BCKDK BCL11A BLK BRCA1 BYSL C10orf62 C1orf35 CALCOCO2 CAMK2B CAMK2G CAPRIN1 CBS CCAR2 CCDC33 CCDC85B CCDC92 CCN3 CCR4 CDKL3 CEP44 CEP55 CHRD COIL COMT CSNK2B CWF19L2 CYFIP1 CYFIP2 DCTN2 DCTPP1 DDX17 DEAF1 DGKD DMRTB1 DNM2 DPPA2 DYNLT1 ECH1 ECHS1 EDC4 EGFL7 EIF4G1 EVL EWSR1 FAM90A1 FBP1 FMR1 FTH1 FXR1 GFAP GKAP1 GOLGA2 GPSM1 GPSM2 GRIP1 GTSE1 HIVEP1 HMBOX1 HNRNPC HNRNPM HNRNPR HOMER3 HSPB1 IGFN1 IMPDH2 INPP5J KCNRG KCTD4 KHDRBS1 KIAA1217 KIF1A KIF2A KIF7 KRT18 KRT20 KXD1 L3MBTL1 L3MBTL3 LASP1 LCMT1 LCP2 LDOC1 MAGED1 MAPKBP1 MAPRE3 MBIP MCRS1 MEAF6 MFAP1 MIA3 MORF4L1 MPP1 MRPL43 MSANTD3 MVP MYH10 NASP NCK2 NDEL1 NDN NECAB2 NEXN NIF3L1 NKD2 NME1 NME3 NONO NT5C2 PAF1 PAICS PCBD1 PCM1 PDE9A PHC1P1 PHC2 PHLDB1 PICK1 PIM1 PKM PNMA1 POM121 PPP1R12C PRAM1 PRC1 PRPF6 PSME1 PSME3 PTS PYCR2 PYCR3 RABAC1 RAD54L2 RAI2 RALYL RBBP8 RBM14 RBM45 RBMX RBPMS RPIA RPS2 RTN3 RTN4 SCEL SCMH1 SF3B2 SFPQ SNAP23 SPRY1 SPRY2 SRPK2 SYT6 SYTL4 TBC1D22B TFCP2 THAP1 TLE5 TNFAIP1 TNIP2 TNNT1 TRAF2 TRIM23 TRIM29 TRIM3 TRIM37 TRIOBP TSC22D4 TUT4 USP39 VIM WDR59 WEE2-AS1 YES1 ZBTB22 ZBTB8A ZMAT2 ZMYND8 ZNF232 ZNF451 ZNRD2 ZSCAN1	29 interacting genes: CCDC85B CEP70 DVL3 FCHO1 FXR2 HMG20A INS KIFC3 LMO1 LZTS1 OSBPL3 PRKAR1B RAB27A RAB27B RAB3A RAB3D RAB8A ROPN1 SNCA SPANXN2 STX1A STXBP1 TBC1D1 TRIM37 TRIM41 TUBA1A ZBTB7B ZBTB9 ZRANB1
Entrez ID		9513	94121
HPRD ID		05629	06735
Ensembl ID		ENSG00000129245	ENSG00000102362
Uniprot IDs		P51116	A8K973 B2R7R4 Q71SF7 Q96C24
PDB IDs		3H8Z	2CSZ 3FDW 5X6T
Enriched GO Terms of Interacting Partners?		Identical Protein Binding Protein Binding Cytoplasm Cytosol Cytoskeleton Negative Regulation Of RNA Metabolic Process Neuron Projection MRNA Metabolic Process MRNA Processing MRNA Splicing, Via Spliceosome RNA Splicing RNA Splicing, Via Transesterification Reactions Negative Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of Primary Metabolic Process Establishment Of Mitotic Spindle Orientation Paraspeckles Nucleoplasm Regulation Of RNA Metabolic Process Centrosome Regulation Of Neurotrophin TRK Receptor Signaling Pathway MRNA Binding Negative Regulation Of DNA-templated Transcription Establishment Of Mitotic Spindle Localization Negative Regulation Of RNA Biosynthetic Process Regulation Of Cellular Component Organization Negative Regulation Of Macromolecule Metabolic Process Establishment Of Spindle Orientation Microtubule-based Process Microtubule Cytoskeleton Organization Involved In Mitosis Regulation Of Nucleobase-containing Compound Metabolic Process Nucleolus Regulation Of MRNA Metabolic Process Endoplasmic Reticulum Tubular Network Formation Regulation Of Dendritic Spine Development RNA Binding Signaling Adaptor Activity Negative Regulation Of Metabolic Process Establishment Of Spindle Localization Negative Regulation Of Centriole Replication Intracellular Membraneless Organelle Establishment Of Organelle Localization Protein Domain Specific Binding Spindle Localization Regulation Of DNA-templated Transcription Regulation Of Cell Projection Organization Negative Regulation Of Macromolecule Biosynthetic Process Regulation Of RNA Biosynthetic Process Positive Regulation Of Dendritic Spine Development Endoplasmic Reticulum Tubular Network Membrane Organization System Development	Myosin V Binding Positive Regulation Of Exocytosis Regulation Of Synaptic Plasticity Exocytosis Vesicle-mediated Transport In Synapse Positive Regulation Of Regulated Secretory Pathway Positive Regulation Of Secretion By Cell Regulation Of Exocytosis Positive Regulation Of Secretion Modulation Of Chemical Synaptic Transmission Secretion Secretion By Cell Synaptic Vesicle Exocytosis Secretory Granule Regulated Exocytosis SNARE Complex Assembly Identical Protein Binding Regulation Of Regulated Secretory Pathway Regulation Of Vesicle-mediated Transport Regulation Of Neuronal Synaptic Plasticity Synaptic Vesicle Regulation Of Secretion By Cell Positive Regulation Of Synaptic Transmission Positive Regulation Of Neurotransmitter Secretion Regulation Of Secretion Organelle Localization Regulation Of Long-term Neuronal Synaptic Plasticity Regulation Of Neurotransmitter Secretion Neurotransmitter Transport Calcium-ion Regulated Exocytosis GTP Binding Regulation Of Vesicle Fusion Establishment Of Vesicle Localization Synaptic Vesicle Transport Vesicle Docking Involved In Exocytosis Postsynapse Regulation Of Calcium Ion-dependent Exocytosis Neurotransmitter Secretion Synaptic Vesicle Endocytosis Regulation Of Reactive Oxygen Species Biosynthetic Process Protein Transport Positive Regulation Of Transport Vesicle Localization Presynaptic Endocytosis Synaptic Vesicle Membrane Synaptic Vesicle Maturation Establishment Of Organelle Localization Regulation Of Cellular Component Organization Vesicle-mediated Transport Synapse
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