FXR2 and L3MBTL1

Number of citations of the paper that reports this interaction (PubMedID 21653829)
54

Data Source:
BioGRID (two hybrid)

		FXR2	L3MBTL1
Description		FMR1 autosomal homolog 2	L3MBTL histone methyl-lysine binding protein 1
Image
GO Annotations	Cellular Component	Nucleus Cytoplasm Cytosol Cytoplasmic Stress Granule Membrane Cytoplasmic Ribonucleoprotein Granule Neuron Projection Synapse Presynapse Postsynapse	Chromatin Condensed Chromosome Nucleus Nucleoplasm Nucleolus Chromatin Lock Complex
	Molecular Function	Nucleic Acid Binding RNA Binding MRNA Binding MRNA 3'-UTR Binding Protein Binding Identical Protein Binding Protein Homodimerization Activity Translation Regulator Activity Protein Heterodimerization Activity	Chromatin Binding Protein Binding Zinc Ion Binding Nucleosome Binding SAM Domain Binding Histone Binding Identical Protein Binding Metal Ion Binding Histone H4K20me2 Reader Activity Histone H1 Reader Activity
	Biological Process	Regulation Of Translation Dentate Gyrus Development Regulation Of MRNA Stability Positive Regulation Of Translation Positive Regulation Of Long-term Neuronal Synaptic Plasticity Animal Organ Development MRNA Transport MRNA Destabilization Regulation Of Translation At Presynapse, Modulating Synaptic Transmission	Chromatin Organization Regulation Of DNA-templated Transcription Regulation Of Mitotic Nuclear Division Hemopoiesis Heterochromatin Formation Regulation Of Megakaryocyte Differentiation Negative Regulation Of DNA-templated Transcription Regulation Of Cell Cycle Regulation Of Macromolecule Metabolic Process Regulation Of Primary Metabolic Process Constitutive Heterochromatin Formation
Pathways			Regulation of TP53 Activity through Methylation
Drugs			2-(N-morpholino)ethanesulfonic acid
Diseases
GWAS		Atrial fibrillation ( 30061737) Brain morphology (MOSTest) ( 32665545) IgM levels ( 23118916) Monocyte count ( 32888494) Refractive error ( 32231278) Sex hormone-binding globulin levels ( 22675492)	Antibody level in response to infection ( 25758998) Daytime sleep phenotypes ( 27126917)
Interacting Genes		191 interacting genes: AKAP9 AMOTL2 AP1M1 AP2M1 ARHGEF7 ARL6IP1 ATN1 AXIN1 AXIN2 BAZ2B BCKDK BCL11A BLK BRCA1 BYSL C10orf62 C1orf35 CALCOCO2 CAMK2B CAMK2G CAPRIN1 CBS CCAR2 CCDC33 CCDC85B CCDC92 CCN3 CCR4 CDKL3 CEP44 CEP55 CHRD COIL COMT CSNK2B CWF19L2 CYFIP1 CYFIP2 DCTN2 DCTPP1 DDX17 DEAF1 DGKD DMRTB1 DNM2 DPPA2 DYNLT1 ECH1 ECHS1 EDC4 EGFL7 EIF4G1 EVL EWSR1 FAM90A1 FBP1 FMR1 FTH1 FXR1 GFAP GKAP1 GOLGA2 GPSM1 GPSM2 GRIP1 GTSE1 HIVEP1 HMBOX1 HNRNPC HNRNPM HNRNPR HOMER3 HSPB1 IGFN1 IMPDH2 INPP5J KCNRG KCTD4 KHDRBS1 KIAA1217 KIF1A KIF2A KIF7 KRT18 KRT20 KXD1 L3MBTL1 L3MBTL3 LASP1 LCMT1 LCP2 LDOC1 MAGED1 MAPKBP1 MAPRE3 MBIP MCRS1 MEAF6 MFAP1 MIA3 MORF4L1 MPP1 MRPL43 MSANTD3 MVP MYH10 NASP NCK2 NDEL1 NDN NECAB2 NEXN NIF3L1 NKD2 NME1 NME3 NONO NT5C2 PAF1 PAICS PCBD1 PCM1 PDE9A PHC1P1 PHC2 PHLDB1 PICK1 PIM1 PKM PNMA1 POM121 PPP1R12C PRAM1 PRC1 PRPF6 PSME1 PSME3 PTS PYCR2 PYCR3 RABAC1 RAD54L2 RAI2 RALYL RBBP8 RBM14 RBM45 RBMX RBPMS RPIA RPS2 RTN3 RTN4 SCEL SCMH1 SF3B2 SFPQ SNAP23 SPRY1 SPRY2 SRPK2 SYT6 SYTL4 TBC1D22B TFCP2 THAP1 TLE5 TNFAIP1 TNIP2 TNNT1 TRAF2 TRIM23 TRIM29 TRIM3 TRIM37 TRIOBP TSC22D4 TUT4 USP39 VIM WDR59 WEE2-AS1 YES1 ZBTB22 ZBTB8A ZMAT2 ZMYND8 ZNF232 ZNF451 ZNRD2 ZSCAN1	8 interacting genes: CBX3 ETV6 ETV7 FXR2 H1-5 H4C16 RB1 SETD7
Entrez ID		9513	26013
HPRD ID		05629	16387
Ensembl ID		ENSG00000129245	ENSG00000185513
Uniprot IDs		P51116	A0A0A0MRR4 A0A3B3ISS0 A0A3F2YNZ1 B0QYN5 Q9Y468
PDB IDs		3H8Z	1OYX 1OZ2 1OZ3 2PQW 2RHI 2RHU 2RHX 2RHY 2RHZ 2RI2 2RI3 2RI5 2RJC 2RJD 2RJE 2RJF 3OQ5 3P8H 3UWN 6BYB
Enriched GO Terms of Interacting Partners?		Identical Protein Binding Protein Binding Cytoplasm Cytosol Cytoskeleton Negative Regulation Of RNA Metabolic Process Neuron Projection MRNA Metabolic Process MRNA Processing MRNA Splicing, Via Spliceosome RNA Splicing RNA Splicing, Via Transesterification Reactions Negative Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of Primary Metabolic Process Establishment Of Mitotic Spindle Orientation Paraspeckles Nucleoplasm Regulation Of RNA Metabolic Process Centrosome Regulation Of Neurotrophin TRK Receptor Signaling Pathway MRNA Binding Negative Regulation Of DNA-templated Transcription Establishment Of Mitotic Spindle Localization Negative Regulation Of RNA Biosynthetic Process Regulation Of Cellular Component Organization Negative Regulation Of Macromolecule Metabolic Process Establishment Of Spindle Orientation Microtubule-based Process Microtubule Cytoskeleton Organization Involved In Mitosis Regulation Of Nucleobase-containing Compound Metabolic Process Nucleolus Regulation Of MRNA Metabolic Process Endoplasmic Reticulum Tubular Network Formation Regulation Of Dendritic Spine Development RNA Binding Signaling Adaptor Activity Negative Regulation Of Metabolic Process Establishment Of Spindle Localization Negative Regulation Of Centriole Replication Intracellular Membraneless Organelle Establishment Of Organelle Localization Protein Domain Specific Binding Spindle Localization Regulation Of DNA-templated Transcription Regulation Of Cell Projection Organization Negative Regulation Of Macromolecule Biosynthetic Process Regulation Of RNA Biosynthetic Process Positive Regulation Of Dendritic Spine Development Endoplasmic Reticulum Tubular Network Membrane Organization System Development	Chromatin Lock Complex Chromatin Remodeling Chromatin Organization Chromatin Negative Regulation Of DNA-templated Transcription Negative Regulation Of Macromolecule Biosynthetic Process Negative Regulation Of RNA Biosynthetic Process Negative Regulation Of Biosynthetic Process Regulation Of RNA Metabolic Process Heterochromatin Protein Localization To Chromosome, Centromeric Region Negative Regulation Of RNA Metabolic Process Euchromatin Negative Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of Nucleobase-containing Compound Metabolic Process Thermosensory Behavior Negative Regulation Of Macromolecule Metabolic Process Chromosome Organization RNA Polymerase II Transcription Regulatory Region Sequence-specific DNA Binding Structural Constituent Of Chromatin Negative Regulation Of Metabolic Process Negative Regulation Of Transcription By RNA Polymerase II Regulation Of DNA-templated Transcription Vitellogenesis Regulation Of RNA Biosynthetic Process Nucleosome Nucleosome Assembly Nucleosome Organization Protein Localization To Chromosome Sister Chromatid Biorientation Maintenance Of Mitotic Sister Chromatid Cohesion Regulation Of Lipid Kinase Activity Positive Regulation Of Collagen Fibril Organization Regulation Of Translation At Presynapse, Modulating Synaptic Transmission Senescence-associated Heterochromatin Focus DNA Binding Nucleus Heterochromatin Formation Regulation Of Gene Expression Glial Cell Apoptotic Process Rb-E2F Complex Peptidyl-lysine Dimethylation Regulation Of Macromolecule Biosynthetic Process Regulation Of Primary Metabolic Process Negative Regulation Of Myofibroblast Differentiation Negative Regulation Of Hepatocyte Apoptotic Process Regulation Of Centromere Complex Assembly Potassium:chloride Symporter Activity Enucleate Erythrocyte Differentiation Negative Regulation Of Gene Expression, Epigenetic
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