FXR2 and PHLDB1

Number of citations of the paper that reports this interaction (PubMedID 21653829)
54

Data Source:
BioGRID (proximity labelling technology, two hybrid)

		FXR2	PHLDB1
Description		FMR1 autosomal homolog 2	pleckstrin homology like domain family B member 1
Image			No pdb structure
GO Annotations	Cellular Component	Nucleus Cytoplasm Cytosol Cytoplasmic Stress Granule Membrane Cytoplasmic Ribonucleoprotein Granule Neuron Projection Synapse Presynapse Postsynapse	Basal Cortex
	Molecular Function	Nucleic Acid Binding RNA Binding MRNA Binding MRNA 3'-UTR Binding Protein Binding Identical Protein Binding Protein Homodimerization Activity Translation Regulator Activity Protein Heterodimerization Activity	Protein Binding
	Biological Process	Regulation Of Translation Dentate Gyrus Development Regulation Of MRNA Stability Positive Regulation Of Translation Positive Regulation Of Long-term Neuronal Synaptic Plasticity Animal Organ Development MRNA Transport MRNA Destabilization Regulation Of Translation At Presynapse, Modulating Synaptic Transmission	Basement Membrane Organization
Pathways
Drugs
Diseases
GWAS		Atrial fibrillation ( 30061737) Brain morphology (MOSTest) ( 32665545) IgM levels ( 23118916) Monocyte count ( 32888494) Refractive error ( 32231278) Sex hormone-binding globulin levels ( 22675492)	Adult diffuse glioma (IDH mutation) ( 32386320) Adult diffuse glioma (IDH mutation, 1p/19q non-codeleted) ( 32386320) Age-related hearing impairment ( 34108613) Celiac disease ( 25920553) Cholesterol, total ( 24097068) Glioma ( 29743610 30714141 19578367 28346443 21531791) Heel bone mineral density ( 28869591 30598549) Multiple sclerosis ( 31604244) Non-glioblastoma glioma ( 28346443 29743610) Refractive error ( 32231278) Serum alkaline phosphatase levels ( 29403010 33339817) Thiazide-induced adverse metabolic effects in hypertensive patients ( 23400010) Total cholesterol levels ( 30275531 28334899) Vitiligo ( 22951725)
Interacting Genes		191 interacting genes: AKAP9 AMOTL2 AP1M1 AP2M1 ARHGEF7 ARL6IP1 ATN1 AXIN1 AXIN2 BAZ2B BCKDK BCL11A BLK BRCA1 BYSL C10orf62 C1orf35 CALCOCO2 CAMK2B CAMK2G CAPRIN1 CBS CCAR2 CCDC33 CCDC85B CCDC92 CCN3 CCR4 CDKL3 CEP44 CEP55 CHRD COIL COMT CSNK2B CWF19L2 CYFIP1 CYFIP2 DCTN2 DCTPP1 DDX17 DEAF1 DGKD DMRTB1 DNM2 DPPA2 DYNLT1 ECH1 ECHS1 EDC4 EGFL7 EIF4G1 EVL EWSR1 FAM90A1 FBP1 FMR1 FTH1 FXR1 GFAP GKAP1 GOLGA2 GPSM1 GPSM2 GRIP1 GTSE1 HIVEP1 HMBOX1 HNRNPC HNRNPM HNRNPR HOMER3 HSPB1 IGFN1 IMPDH2 INPP5J KCNRG KCTD4 KHDRBS1 KIAA1217 KIF1A KIF2A KIF7 KRT18 KRT20 KXD1 L3MBTL1 L3MBTL3 LASP1 LCMT1 LCP2 LDOC1 MAGED1 MAPKBP1 MAPRE3 MBIP MCRS1 MEAF6 MFAP1 MIA3 MORF4L1 MPP1 MRPL43 MSANTD3 MVP MYH10 NASP NCK2 NDEL1 NDN NECAB2 NEXN NIF3L1 NKD2 NME1 NME3 NONO NT5C2 PAF1 PAICS PCBD1 PCM1 PDE9A PHC1P1 PHC2 PHLDB1 PICK1 PIM1 PKM PNMA1 POM121 PPP1R12C PRAM1 PRC1 PRPF6 PSME1 PSME3 PTS PYCR2 PYCR3 RABAC1 RAD54L2 RAI2 RALYL RBBP8 RBM14 RBM45 RBMX RBPMS RPIA RPS2 RTN3 RTN4 SCEL SCMH1 SF3B2 SFPQ SNAP23 SPRY1 SPRY2 SRPK2 SYT6 SYTL4 TBC1D22B TFCP2 THAP1 TLE5 TNFAIP1 TNIP2 TNNT1 TRAF2 TRIM23 TRIM29 TRIM3 TRIM37 TRIOBP TSC22D4 TUT4 USP39 VIM WDR59 WEE2-AS1 YES1 ZBTB22 ZBTB8A ZMAT2 ZMYND8 ZNF232 ZNF451 ZNRD2 ZSCAN1	6 interacting genes: FXR1 FXR2 SHANK3 SRPK2 TSC1 TSC2
Entrez ID		9513	23187
HPRD ID		05629	15128
Ensembl ID		ENSG00000129245	ENSG00000019144
Uniprot IDs		P51116	Q6ZUD6 Q86UU1 Q8NC75
PDB IDs		3H8Z
Enriched GO Terms of Interacting Partners?		Identical Protein Binding Protein Binding Cytoplasm Cytosol Cytoskeleton Negative Regulation Of RNA Metabolic Process Neuron Projection MRNA Metabolic Process MRNA Processing MRNA Splicing, Via Spliceosome RNA Splicing RNA Splicing, Via Transesterification Reactions Negative Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of Primary Metabolic Process Establishment Of Mitotic Spindle Orientation Paraspeckles Nucleoplasm Regulation Of RNA Metabolic Process Centrosome Regulation Of Neurotrophin TRK Receptor Signaling Pathway MRNA Binding Negative Regulation Of DNA-templated Transcription Establishment Of Mitotic Spindle Localization Negative Regulation Of RNA Biosynthetic Process Regulation Of Cellular Component Organization Negative Regulation Of Macromolecule Metabolic Process Establishment Of Spindle Orientation Microtubule-based Process Microtubule Cytoskeleton Organization Involved In Mitosis Regulation Of Nucleobase-containing Compound Metabolic Process Nucleolus Regulation Of MRNA Metabolic Process Endoplasmic Reticulum Tubular Network Formation Regulation Of Dendritic Spine Development RNA Binding Signaling Adaptor Activity Negative Regulation Of Metabolic Process Establishment Of Spindle Localization Negative Regulation Of Centriole Replication Intracellular Membraneless Organelle Establishment Of Organelle Localization Protein Domain Specific Binding Spindle Localization Regulation Of DNA-templated Transcription Regulation Of Cell Projection Organization Negative Regulation Of Macromolecule Biosynthetic Process Regulation Of RNA Biosynthetic Process Positive Regulation Of Dendritic Spine Development Endoplasmic Reticulum Tubular Network Membrane Organization System Development	Positive Regulation Of Long-term Neuronal Synaptic Plasticity Regulation Of Long-term Neuronal Synaptic Plasticity TSC1-TSC2 Complex Regulation Of Translation At Presynapse, Modulating Synaptic Transmission Regulation Of Neuronal Synaptic Plasticity Positive Regulation Of Translation Translation Regulator Activity Regulation Of Synaptic Plasticity Dentate Gyrus Development Positive Regulation Of Neurogenesis Presynapse Postsynaptic Density Negative Regulation Of Macroautophagy Hsp90 Protein Binding Presynaptic Modulation Of Chemical Synaptic Transmission Positive Regulation Of Nervous System Development Regulation Of Long-term Synaptic Potentiation Synapse Regulation Of MRNA Metabolic Process Neuron Projection Regulation Of Neurogenesis Negative Regulation Of TORC1 Signaling Positive Regulation Of TORC1 Signaling Negative Regulation Of Catabolic Process TORC1 Signaling Regulation Of Translation Regulation Of Synaptic Transmission, Glutamatergic Positive Regulation Of Gene Expression Memory T Cell Differentiation Regulation Of Cell Size TOR Signaling Neural Tube Closure Positive Regulation Of Cell Development Cytoplasmic Ribonucleoprotein Granule Regulation Of Nervous System Development Nucleus Organization Positive Regulation Of TOR Signaling Tube Closure Negative Regulation Of TOR Signaling Cytoplasmic Stress Granule Modulation Of Chemical Synaptic Transmission Regulation Of TORC1 Signaling Associative Learning MRNA Destabilization RNA Destabilization Negative Regulation Of Autophagy Animal Organ Development Positive Regulation Of Catabolic Process Positive Regulation Of MRNA Catabolic Process Developmental Process
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