ATRIP and ETAA1

Number of citations of the paper that reports this interaction (PubMedID 27723720)
44

Data Source:
BioGRID (affinity chromatography technology, affinity chromatography technology, pull down)

		ATRIP	ETAA1
Description		ATR interacting protein	ETAA1 activator of ATR kinase
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GO Annotations	Cellular Component	Nucleus Nucleoplasm ATR-ATRIP Complex	Nucleus Nucleoplasm Cytosol Plasma Membrane Nuclear Speck Nuclear Replication Fork
	Molecular Function	Protein Binding K63-linked Polyubiquitin Modification-dependent Protein Binding	Protein Binding Protein Serine/threonine Kinase Activator Activity
	Biological Process	DNA Damage Checkpoint Signaling Nucleobase-containing Compound Metabolic Process DNA Repair DNA Damage Response Regulation Of Double-strand Break Repair	G2/M Transition Of Mitotic Cell Cycle DNA Repair DNA Damage Response Replication Fork Processing Mitotic G2/M Transition Checkpoint Positive Regulation Of Protein Serine/threonine Kinase Activity Regulation Of DNA Damage Checkpoint
Pathways		Activation of ATR in response to replication stress HDR through Single Strand Annealing (SSA) Processing of DNA double-strand break ends Presynaptic phase of homologous DNA pairing and strand exchange Fanconi Anemia Pathway Regulation of TP53 Activity through Phosphorylation G2/M DNA damage checkpoint Impaired BRCA2 binding to RAD51
Drugs
Diseases
GWAS		Brain morphology (min-P) ( 32665545) Brain morphology (MOSTest) ( 32665545) Cortical surface area (MOSTest) ( 32665545) Crohn's disease ( 28067908) Inflammatory bowel disease ( 28067908) Subcortical volume (min-P) ( 32665545) Subcortical volume (MOSTest) ( 32665545) Ulcerative colitis ( 28067908)	Adult body size ( 32376654) Body size at age 10 ( 32376654) Endometriosis ( 28537267) Hip circumference adjusted for BMI ( 34021172) Lung adenocarcinoma ( 28604730) Lung cancer ( 28604730) Lung cancer in ever smokers ( 28604730) Male-pattern baldness ( 27182965) Milk allergy ( 25710614) Pancreatic cancer ( 26098869) Periodontitis (CDC/AAP) ( 24024966) Photic sneeze reflex ( 27182965) Systolic blood pressure response to hydrochlorothiazide in hypertension ( 27802415) Vincristine-induced peripheral neuropathy in acute lymphoblastic leukemia ( 25710658) Waist-hip ratio ( 23966867) Waist-to-hip ratio adjusted for BMI (joint analysis for main effect and physical activity interaction) ( 28448500) Waist-to-hip ratio adjusted for BMI in active individuals ( 28448500) Waist-to-hip ratio adjusted for body mass index ( 28448500 28430825)
Interacting Genes		28 interacting genes: BRCA1 C1orf94 CCDC28B CDC23 CDC6 CDK16 CEP164 CINP ETAA1 FAAP100 FAM156A LNX1 MCM2 MCM3 MCM5 MCM6 METTL21A MID2 MOS MX2 POLR1C PRKDC RPA3 SCG2 SIRT2 SPRY2 TASOR2 ZBTB14	2 interacting genes: ATR ATRIP
Entrez ID		84126	54465
HPRD ID			13282
Ensembl ID		ENSG00000164053	ENSG00000143971
Uniprot IDs		Q8WXE1	Q9NY74
PDB IDs		4IGK 4NB3 5YZ0 7XV4	8JZV
Enriched GO Terms of Interacting Partners?		DNA Metabolic Process DNA Repair DNA Replication Initiation Double-strand Break Repair Via Homologous Recombination CMG Complex MCM Complex Recombinational Repair DNA Replication Double-strand Break Repair Via Break-induced Replication Regulation Of DNA-templated DNA Replication Initiation DNA Damage Response Double-strand Break Repair DNA Recombination Chromosome, Telomeric Region Regulation Of Cell Cycle Phase Transition Single-stranded DNA Binding Regulation Of DNA Replication DNA Replication Origin Binding Cellular Response To Stress Single-stranded DNA Helicase Activity Regulation Of Cell Cycle Nucleic Acid Metabolic Process Regulation Of DNA Metabolic Process Regulation Of Mitotic Cell Cycle Macromolecule Metabolic Process Regulation Of Mitotic Cell Cycle Phase Transition Mitotic DNA Replication Initiation Regulation Of Cell Cycle Process Response To Stress Negative Regulation Of Cell Cycle Phase Transition Helicase Activity Regulation Of Chromosome Segregation Nucleobase-containing Compound Metabolic Process Negative Regulation Of Cell Cycle Process Mitotic G2/M Transition Checkpoint Nucleoplasm Negative Regulation Of Mitotic Cell Cycle Phase Transition Regulation Of Meiotic Cell Cycle 3'-5' DNA Helicase Activity Negative Regulation Of G2/M Transition Of Mitotic Cell Cycle Mitotic DNA Integrity Checkpoint Signaling Negative Regulation Of Cell Cycle G2/M Phase Transition Negative Regulation Of Cell Cycle Regulation Of Exit From Mitosis Negative Regulation Of Mitotic Cell Cycle Regulation Of Protein Phosphorylation Negative Regulation Of Fatty Acid Biosynthetic Process Regulation Of Phosphorylation Regulation Of DNA Damage Checkpoint Nucleolus	ATR-ATRIP Complex Establishment Of Protein-containing Complex Localization To Telomere Regulation Of Double-strand Break Repair Establishment Of RNA Localization To Telomere Signal Transduction In Response To DNA Damage DNA Damage Checkpoint Signaling Positive Regulation Of Telomerase Catalytic Core Complex Assembly Glucosidase Activity Glc3Man9GlcNAc2 Oligosaccharide Glucosidase Activity Histone H2AXS139 Kinase Activity Negative Regulation Of Cell Cycle Phase Transition Regulation Of DNA Repair Negative Regulation Of Cell Cycle Process MutSalpha Complex Binding Negative Regulation Of Cell Cycle MutLalpha Complex Binding Protein Localization To Chromosome, Telomeric Region Regulation Of Cell Cycle Phase Transition Regulation Of DNA Metabolic Process Membrane Disassembly Regulation Of Cellular Response To Stress Regulation Of Cellular Response To Heat Nuclear Membrane Disassembly DNA Repair Positive Regulation Of DNA Damage Response, Signal Transduction By P53 Class Mediator DNA Strand Resection Involved In Replication Fork Processing Replicative Senescence Positive Regulation Of Telomere Maintenance Via Telomerase Nuclear Envelope Organization Negative Regulation Of DNA Replication Positive Regulation Of Telomere Maintenance Via Telomere Lengthening Protein Localization To Site Of Double-strand Break K63-linked Polyubiquitin Modification-dependent Protein Binding Cellular Response To Gamma Radiation Viral Protein Processing Response To Arsenic-containing Substance DNA Metabolic Process Regulation Of Cell Cycle Process Positive Regulation Of Signal Transduction By P53 Class Mediator DNA Damage Response Regulation Of DNA Damage Response, Signal Transduction By P53 Class Mediator Replication Fork Processing Interstrand Cross-link Repair Site Of DNA Damage Regulation Of Telomere Maintenance Via Telomerase Positive Regulation Of DNA Biosynthetic Process Nuclear Membrane Organization Regulation Of Telomere Maintenance Via Telomere Lengthening Response To Gamma Radiation Mitotic G2/M Transition Checkpoint
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