ATRIP and METTL21A

Number of citations of the paper that reports this interaction (PubMedID 25416956)
56

Data Source:
BioGRID (two hybrid)

		ATRIP	METTL21A
Description		ATR interacting protein	methyltransferase 21A, HSPA lysine
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GO Annotations	Cellular Component	Nucleus Nucleoplasm ATR-ATRIP Complex	Nucleoplasm Cytoplasm Cytosol Protein-containing Complex
	Molecular Function	Protein Binding K63-linked Polyubiquitin Modification-dependent Protein Binding	Protein Binding Methyltransferase Activity Protein Methyltransferase Activity Protein-lysine N-methyltransferase Activity Transferase Activity Hsp70 Protein Binding Heat Shock Protein Binding ATPase Binding
	Biological Process	DNA Damage Checkpoint Signaling Nucleobase-containing Compound Metabolic Process DNA Repair DNA Damage Response Regulation Of Double-strand Break Repair	Protein Methylation Methylation Negative Regulation Of Protein Folding
Pathways		Activation of ATR in response to replication stress HDR through Single Strand Annealing (SSA) Processing of DNA double-strand break ends Presynaptic phase of homologous DNA pairing and strand exchange Fanconi Anemia Pathway Regulation of TP53 Activity through Phosphorylation G2/M DNA damage checkpoint Impaired BRCA2 binding to RAD51	Protein methylation
Drugs
Diseases
GWAS		Brain morphology (min-P) ( 32665545) Brain morphology (MOSTest) ( 32665545) Cortical surface area (MOSTest) ( 32665545) Crohn's disease ( 28067908) Inflammatory bowel disease ( 28067908) Subcortical volume (min-P) ( 32665545) Subcortical volume (MOSTest) ( 32665545) Ulcerative colitis ( 28067908)	HDL cholesterol levels ( 32203549) Opioid sensitivity ( 23183491) Systolic blood pressure ( 28135244 28739976 30578418)
Interacting Genes		28 interacting genes: BRCA1 C1orf94 CCDC28B CDC23 CDC6 CDK16 CEP164 CINP ETAA1 FAAP100 FAM156A LNX1 MCM2 MCM3 MCM5 MCM6 METTL21A MID2 MOS MX2 POLR1C PRKDC RPA3 SCG2 SIRT2 SPRY2 TASOR2 ZBTB14	14 interacting genes: ARPC4 ATRIP FAM200C HSPA1A HSPA5 LNX1 LZTS1 MEI4 MEOX2 MSRB3 PFDN5 ZNF620 ZNF655 ZRANB1
Entrez ID		84126	151194
HPRD ID			14090
Ensembl ID		ENSG00000164053	ENSG00000144401
Uniprot IDs		Q8WXE1	C9JES0 H7BXH9 Q8WXB1
PDB IDs		4IGK 4NB3 5YZ0 7XV4	4LEC
Enriched GO Terms of Interacting Partners?		DNA Metabolic Process DNA Repair DNA Replication Initiation Double-strand Break Repair Via Homologous Recombination CMG Complex MCM Complex Recombinational Repair DNA Replication Double-strand Break Repair Via Break-induced Replication Regulation Of DNA-templated DNA Replication Initiation DNA Damage Response Double-strand Break Repair DNA Recombination Chromosome, Telomeric Region Regulation Of Cell Cycle Phase Transition Single-stranded DNA Binding Regulation Of DNA Replication DNA Replication Origin Binding Cellular Response To Stress Single-stranded DNA Helicase Activity Regulation Of Cell Cycle Nucleic Acid Metabolic Process Regulation Of DNA Metabolic Process Regulation Of Mitotic Cell Cycle Macromolecule Metabolic Process Regulation Of Mitotic Cell Cycle Phase Transition Mitotic DNA Replication Initiation Regulation Of Cell Cycle Process Response To Stress Negative Regulation Of Cell Cycle Phase Transition Helicase Activity Regulation Of Chromosome Segregation Nucleobase-containing Compound Metabolic Process Negative Regulation Of Cell Cycle Process Mitotic G2/M Transition Checkpoint Nucleoplasm Negative Regulation Of Mitotic Cell Cycle Phase Transition Regulation Of Meiotic Cell Cycle 3'-5' DNA Helicase Activity Negative Regulation Of G2/M Transition Of Mitotic Cell Cycle Mitotic DNA Integrity Checkpoint Signaling Negative Regulation Of Cell Cycle G2/M Phase Transition Negative Regulation Of Cell Cycle Regulation Of Exit From Mitosis Negative Regulation Of Mitotic Cell Cycle Regulation Of Protein Phosphorylation Negative Regulation Of Fatty Acid Biosynthetic Process Regulation Of Phosphorylation Regulation Of DNA Damage Checkpoint Nucleolus
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