ATRIP and TASOR2

Number of citations of the paper that reports this interaction (PubMedID 25416956)
56

Data Source:
BioGRID (two hybrid)

		ATRIP	TASOR2
Description		ATR interacting protein	transcription activation suppressor family member 2
Image			No pdb structure
GO Annotations	Cellular Component	Nucleus Nucleoplasm ATR-ATRIP Complex	Nucleoplasm Cytosol
	Molecular Function	Protein Binding K63-linked Polyubiquitin Modification-dependent Protein Binding	Protein Binding
	Biological Process	DNA Damage Checkpoint Signaling Nucleobase-containing Compound Metabolic Process DNA Repair DNA Damage Response Regulation Of Double-strand Break Repair	Negative Regulation Of Gene Expression, Epigenetic
Pathways		Activation of ATR in response to replication stress HDR through Single Strand Annealing (SSA) Processing of DNA double-strand break ends Presynaptic phase of homologous DNA pairing and strand exchange Fanconi Anemia Pathway Regulation of TP53 Activity through Phosphorylation G2/M DNA damage checkpoint Impaired BRCA2 binding to RAD51
Drugs
Diseases
GWAS		Brain morphology (min-P) ( 32665545) Brain morphology (MOSTest) ( 32665545) Cortical surface area (MOSTest) ( 32665545) Crohn's disease ( 28067908) Inflammatory bowel disease ( 28067908) Subcortical volume (min-P) ( 32665545) Subcortical volume (MOSTest) ( 32665545) Ulcerative colitis ( 28067908)
Interacting Genes		28 interacting genes: BRCA1 C1orf94 CCDC28B CDC23 CDC6 CDK16 CEP164 CINP ETAA1 FAAP100 FAM156A LNX1 MCM2 MCM3 MCM5 MCM6 METTL21A MID2 MOS MX2 POLR1C PRKDC RPA3 SCG2 SIRT2 SPRY2 TASOR2 ZBTB14	51 interacting genes: AIRIM ARMC7 ATRIP CARD9 CCDC33 CCDC85B CCNG2 CFAP206 COX5B CRK CTNNA3 ERH FBF1 FXR1 GPRASP3 GPSM1 HGS HSF2BP KCTD9 KIFC3 KLHL40 LDOC1 LMO1 LONRF1 MDFI MEOX2 MID2 MKRN3 MLH1 MORN3 NEK6 PACRGL PIH1D2 PIK3R3 PNMA1 POLR1C PPP1R16B PRKAB2 PRKAR1B RFC5 SCAMP1 SERTAD3 SMARCB1 STAT3 TRIM23 TRIM42 TRIM73 TSEN15 USHBP1 YPEL3 ZNF76
Entrez ID		84126	54906
HPRD ID			10695
Ensembl ID		ENSG00000164053	ENSG00000108021
Uniprot IDs		Q8WXE1	A0A2R8YH03 A0A8Q3SI84 Q5VWN6
PDB IDs		4IGK 4NB3 5YZ0 7XV4
Enriched GO Terms of Interacting Partners?		DNA Metabolic Process DNA Repair DNA Replication Initiation Double-strand Break Repair Via Homologous Recombination CMG Complex MCM Complex Recombinational Repair DNA Replication Double-strand Break Repair Via Break-induced Replication Regulation Of DNA-templated DNA Replication Initiation DNA Damage Response Double-strand Break Repair DNA Recombination Chromosome, Telomeric Region Regulation Of Cell Cycle Phase Transition Single-stranded DNA Binding Regulation Of DNA Replication DNA Replication Origin Binding Cellular Response To Stress Single-stranded DNA Helicase Activity Regulation Of Cell Cycle Nucleic Acid Metabolic Process Regulation Of DNA Metabolic Process Regulation Of Mitotic Cell Cycle Macromolecule Metabolic Process Regulation Of Mitotic Cell Cycle Phase Transition Mitotic DNA Replication Initiation Regulation Of Cell Cycle Process Response To Stress Negative Regulation Of Cell Cycle Phase Transition Helicase Activity Regulation Of Chromosome Segregation Nucleobase-containing Compound Metabolic Process Negative Regulation Of Cell Cycle Process Mitotic G2/M Transition Checkpoint Nucleoplasm Negative Regulation Of Mitotic Cell Cycle Phase Transition Regulation Of Meiotic Cell Cycle 3'-5' DNA Helicase Activity Negative Regulation Of G2/M Transition Of Mitotic Cell Cycle Mitotic DNA Integrity Checkpoint Signaling Negative Regulation Of Cell Cycle G2/M Phase Transition Negative Regulation Of Cell Cycle Regulation Of Exit From Mitosis Negative Regulation Of Mitotic Cell Cycle Regulation Of Protein Phosphorylation Negative Regulation Of Fatty Acid Biosynthetic Process Regulation Of Phosphorylation Regulation Of DNA Damage Checkpoint Nucleolus
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