ATRIP and CDK16

Number of citations of the paper that reports this interaction (PubMedID 25416956)
56

Data Source:
BioGRID (two hybrid)

		ATRIP	CDK16
Description		ATR interacting protein	cyclin dependent kinase 16
Image
GO Annotations	Cellular Component	Nucleus Nucleoplasm ATR-ATRIP Complex	Cyclin-dependent Protein Kinase Holoenzyme Complex Nucleus Cytoplasm Cytosol Plasma Membrane Synaptic Vesicle Cytoplasmic Side Of Plasma Membrane Microtubule Cytoskeleton Membrane Transport Vesicle Cytoplasmic Vesicle Neuron Projection Synapse
	Molecular Function	Protein Binding K63-linked Polyubiquitin Modification-dependent Protein Binding	Nucleotide Binding Protein Kinase Activity Protein Serine/threonine Kinase Activity Cyclin-dependent Protein Serine/threonine Kinase Activity Protein Binding ATP Binding Kinase Activity Transferase Activity Protein Serine Kinase Activity
	Biological Process	DNA Damage Checkpoint Signaling Nucleobase-containing Compound Metabolic Process DNA Repair DNA Damage Response Regulation Of Double-strand Break Repair	Protein Phosphorylation Exocytosis Spermatogenesis Positive Regulation Of Autophagy Cell Differentiation Growth Hormone Secretion Neuron Projection Development Regulation Of Insulin Secretion Involved In Cellular Response To Glucose Stimulus Regulation Of Cell Cycle Phase Transition
Pathways		Activation of ATR in response to replication stress HDR through Single Strand Annealing (SSA) Processing of DNA double-strand break ends Presynaptic phase of homologous DNA pairing and strand exchange Fanconi Anemia Pathway Regulation of TP53 Activity through Phosphorylation G2/M DNA damage checkpoint Impaired BRCA2 binding to RAD51
Drugs			(2Z,3E)-2,3'-biindole-2',3(1H,1'H)-dione 3-{O-[(3R)-3,4-dihydroxybutyl]oxime} Fostamatinib
Diseases
GWAS		Brain morphology (min-P) ( 32665545) Brain morphology (MOSTest) ( 32665545) Cortical surface area (MOSTest) ( 32665545) Crohn's disease ( 28067908) Inflammatory bowel disease ( 28067908) Subcortical volume (min-P) ( 32665545) Subcortical volume (MOSTest) ( 32665545) Ulcerative colitis ( 28067908)
Interacting Genes		28 interacting genes: BRCA1 C1orf94 CCDC28B CDC23 CDC6 CDK16 CEP164 CINP ETAA1 FAAP100 FAM156A LNX1 MCM2 MCM3 MCM5 MCM6 METTL21A MID2 MOS MX2 POLR1C PRKDC RPA3 SCG2 SIRT2 SPRY2 TASOR2 ZBTB14	20 interacting genes: APP APPBP2 ATRIP BAG6 CCND3 CDK5 CDK5R1 MAGI3 PJA1 PRKACA S100A10 SEC23A SIRPA SNX27 YWHAE YWHAG YWHAH YWHAQ YWHAZ ZBTB14
Entrez ID		84126	5127
HPRD ID			02409
Ensembl ID		ENSG00000164053	ENSG00000102225
Uniprot IDs		Q8WXE1	A0A140VK97 Q00536 Q9BRL4
PDB IDs		4IGK 4NB3 5YZ0 7XV4	3MTL 5G6V
Enriched GO Terms of Interacting Partners?		DNA Metabolic Process DNA Repair DNA Replication Initiation Double-strand Break Repair Via Homologous Recombination CMG Complex MCM Complex Recombinational Repair DNA Replication Double-strand Break Repair Via Break-induced Replication Regulation Of DNA-templated DNA Replication Initiation DNA Damage Response Double-strand Break Repair DNA Recombination Chromosome, Telomeric Region Regulation Of Cell Cycle Phase Transition Single-stranded DNA Binding Regulation Of DNA Replication DNA Replication Origin Binding Cellular Response To Stress Single-stranded DNA Helicase Activity Regulation Of Cell Cycle Nucleic Acid Metabolic Process Regulation Of DNA Metabolic Process Regulation Of Mitotic Cell Cycle Macromolecule Metabolic Process Regulation Of Mitotic Cell Cycle Phase Transition Mitotic DNA Replication Initiation Regulation Of Cell Cycle Process Response To Stress Negative Regulation Of Cell Cycle Phase Transition Helicase Activity Regulation Of Chromosome Segregation Nucleobase-containing Compound Metabolic Process Negative Regulation Of Cell Cycle Process Mitotic G2/M Transition Checkpoint Nucleoplasm Negative Regulation Of Mitotic Cell Cycle Phase Transition Regulation Of Meiotic Cell Cycle 3'-5' DNA Helicase Activity Negative Regulation Of G2/M Transition Of Mitotic Cell Cycle Mitotic DNA Integrity Checkpoint Signaling Negative Regulation Of Cell Cycle G2/M Phase Transition Negative Regulation Of Cell Cycle Regulation Of Exit From Mitosis Negative Regulation Of Mitotic Cell Cycle Regulation Of Protein Phosphorylation Negative Regulation Of Fatty Acid Biosynthetic Process Regulation Of Phosphorylation Regulation Of DNA Damage Checkpoint Nucleolus	Establishment Of Protein Localization Protein Domain Specific Binding Transmembrane Transporter Binding Acetylcholine Receptor Activator Activity Intracellular Protein Localization Cellular Localization Protein Targeting Protein Kinase 5 Complex Intracellular Signal Transduction Regulation Of Protein Export From Nucleus Regulation Of Synapse Organization Neuron Recognition Cyclin-dependent Protein Kinase Holoenzyme Complex Protein Sequestering Activity Phosphoserine Residue Binding Substantia Nigra Development Localization Within Membrane Establishment Of Localization In Cell Intracellular Protein Transport Positive Regulation Of Establishment Of Protein Localization Intracellular Transport Negative Regulation Of Macromolecule Metabolic Process Extracellular Exosome Regulation Of Protein Localization Protein Catabolic Process TORC1 Signaling Neural Nucleus Development Regulation Of Proteolysis Regulation Of Neuron Differentiation Negative Regulation Of Macromolecule Biosynthetic Process Cytoplasm Negative Regulation Of TORC1 Signaling Positive Regulation Of Neuron Apoptotic Process Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Negative Regulation Of Metabolic Process Hippocampus Development Regulation Of Synaptic Plasticity Negative Regulation Of Biosynthetic Process Cyclin-dependent Protein Serine/threonine Kinase Activator Activity Regulation Of Monoatomic Ion Transport Neuromuscular Junction Macromolecule Catabolic Process TOR Signaling Presynapse Regulation Of Developmental Process Negative Regulation Of TOR Signaling Insulin-like Growth Factor Receptor Binding Signal Transduction Proteasomal Protein Catabolic Process Protein Phosphatase Binding
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