ATRIP and CEP164

Number of citations of the paper that reports this interaction (PMID 18283122)
18

Data Source:
BioGRID (affinity chromatography technology, pull down)

		ATRIP	CEP164
Gene Name		ATR interacting protein	centrosomal protein 164kDa
Image		No pdb structure	No pdb structure
Gene Ontology Annotations	Cellular Component	Nucleus Nucleoplasm	Extracellular Space Nucleoplasm Centrosome Centriole Cytosol Ciliary Transition Fiber
	Molecular Function	Protein Binding K63-linked Polyubiquitin Binding	Protein Binding
	Biological Process	DNA Damage Checkpoint DNA Replication DNA Repair	G2/M Transition Of Mitotic Cell Cycle Mitotic Cell Cycle DNA Repair Organelle Organization Mitotic Nuclear Division Cilium Assembly Cell Division
Pathways		G2/M DNA damage checkpoint G2/M Checkpoints Activation of ATR in response to replication stress Cell Cycle Checkpoints	Organelle biogenesis and maintenance Loss of proteins required for interphase microtubule organizationÂ from the centrosome Loss of Nlp from mitotic centrosomes G2/M Transition Assembly of the primary cilium Centrosome maturation Regulation of PLK1 Activity at G2/M Transition Mitotic G2-G2/M phases Anchoring of the basal body to the plasma membrane Recruitment of mitotic centrosome proteins and complexes Cell Cycle, Mitotic
Drugs
Diseases
GWAS
Protein-Protein Interactions		21 interactors: ATR BRCA1 C1orf94 CCDC28B CDC23 CDC6 CDK16 CEP164 CINP FAM156A FAM208B LNX1 METTL21A MID2 MOS MX2 POLR1C PRKDC RPA1 SCG2 SPRY2	4 interactors: ATR ATRIP MAPK14 UBC
Entrez ID		84126	22897
HPRD ID			10854
Ensembl ID		ENSG00000164053	ENSG00000110274
Uniprot IDs		Q8WXE1	Q9UPV0
PDB IDs
Enriched GO Terms of Interacting Partners?		Cell Cycle Cell Cycle Process DNA Repair Regulation Of Cell Cycle Double-strand Break Repair Via Homologous Recombination Recombinational Repair DNA Metabolic Process Cell Cycle Checkpoint Cellular Response To DNA Damage Stimulus DNA Replication Organelle Organization Response To Ionizing Radiation Double-strand Break Repair Negative Regulation Of DNA Replication Mitotic Cell Cycle Process Response To Gamma Radiation Mitotic Cell Cycle Negative Regulation Of Cell Cycle Negative Regulation Of Cellular Protein Metabolic Process Regulation Of Cell Cycle Phase Transition Regulation Of Cell Cycle Process DNA Recombination Cellular Protein Modification Process Negative Regulation Of Protein Metabolic Process Regulation Of Cell Division Mitotic Cell Cycle Phase Transition Cell Cycle Phase Transition Regulation Of Cellular Protein Metabolic Process Response To Stress Negative Regulation Of DNA Metabolic Process Cellular Response To Stress Negative Regulation Of Cellular Metabolic Process Regulation Of Protein Metabolic Process Regulation Of DNA Replication DNA Damage Checkpoint Regulation Of Cellular Response To Heat Cell Division Response To Radiation Positive Regulation Of Histone Methylation Cellular Protein Metabolic Process Positive Regulation Of Protein Modification Process Regulation Of Organelle Organization Regulation Of Chromosome Organization Cellular Metabolic Process Establishment Of Spindle Orientation Regulation Of Mitotic Cell Cycle Phase Transition Regulation Of Mitotic Metaphase/anaphase Transition Regulation Of Histone Methylation Protein Ubiquitination Chromosome Organization	DNA Damage Checkpoint Cell Cycle Checkpoint Cellular Response To DNA Damage Stimulus Cell Cycle Process Cell Cycle Cellular Response To Stress Toll-like Receptor 5 Signaling Pathway Toll-like Receptor 10 Signaling Pathway Toll-like Receptor TLR6:TLR2 Signaling Pathway Toll-like Receptor TLR1:TLR2 Signaling Pathway Cellular Response To Ionizing Radiation Toll-like Receptor 2 Signaling Pathway Toll-like Receptor 9 Signaling Pathway TRIF-dependent Toll-like Receptor Signaling Pathway MyD88-independent Toll-like Receptor Signaling Pathway Toll-like Receptor 3 Signaling Pathway MyD88-dependent Toll-like Receptor Signaling Pathway Cell Aging DNA Repair Toll-like Receptor 4 Signaling Pathway Signal Transduction In Response To DNA Damage Toll-like Receptor Signaling Pathway Stress-activated MAPK Cascade Peptidyl-serine Phosphorylation Stress-activated Protein Kinase Signaling Cascade Positive Regulation Of Intracellular Signal Transduction P38MAPK Cascade Pattern Recognition Receptor Signaling Pathway Innate Immune Response-activating Signal Transduction Cellular Response To Radiation Activation Of MAPK Activity Activation Of Innate Immune Response Glucose Metabolic Process Response To Ionizing Radiation Negative Regulation Of Canonical Wnt Signaling Pathway DNA Metabolic Process Positive Regulation Of Innate Immune Response Response To Abiotic Stimulus Negative Regulation Of Wnt Signaling Pathway Pathogenesis Hexose Metabolic Process Response To Stress Neurotrophin TRK Receptor Signaling Pathway Positive Regulation Of MAP Kinase Activity Neurotrophin Signaling Pathway Regulation Of Canonical Wnt Signaling Pathway MAPK Cascade Cellular Macromolecule Biosynthetic Process Positive Regulation Of Signal Transduction Macromolecule Biosynthetic Process
Tagcloud ?		biochemically canonical checkpoint checkpoints concert constitute damage damaged enlargement ercc1 excision exo1 exonuclease gap integrity mimetic minimum nucleotide repair rpa steps stranded tfiih topbp1 xpa xpc xpf xpg	accessory align appendage appendages cby cenexin centriogenesis centriolar centriole centrioles centrosome chibby cilia cilium cnx coincident collaboration daughter dispensable distal dot foxj1 mother motile organelles precisely quiescent subdistal tracheal
Tagcloud (Difference) ?		biochemically canonical checkpoint checkpoints concert constitute damage damaged enlargement ercc1 excision exo1 exonuclease gap integrity mimetic minimum nucleotide repair rpa steps stranded tfiih topbp1 xpa xpc xpf xpg	accessory align appendage appendages cby cenexin centriogenesis centriolar centriole centrioles centrosome chibby cilia cilium cnx coincident collaboration daughter dispensable distal dot foxj1 mother motile organelles precisely quiescent subdistal tracheal
Tagcloud (Intersection) ?