EIF1 and MAPK6

Number of citations of the paper that reports this interaction (PubMedID 21900206)
0

Data Source:
BioGRID (two hybrid)

		EIF1	MAPK6
Description		eukaryotic translation initiation factor 1	mitogen-activated protein kinase 6
Image
GO Annotations	Cellular Component	Nucleus Cytoplasm Eukaryotic 43S Preinitiation Complex Eukaryotic 48S Preinitiation Complex Multi-eIF Complex	Nucleus Nucleoplasm Cytoplasm Cytosol Septin Cytoskeleton Protein-containing Complex
	Molecular Function	RNA Binding Translation Initiation Factor Activity Protein Binding Translation Factor Activity, RNA Binding Ribosomal Small Subunit Binding	Nucleotide Binding Protein Kinase Activity Protein Serine/threonine Kinase Activity MAP Kinase Activity Protein Binding ATP Binding Kinase Activity Transferase Activity Protein Kinase Binding Protein Heterodimerization Activity Protein Serine Kinase Activity
	Biological Process	Translation Translational Initiation Regulation Of Translational Initiation Regulation Of Gene Expression Regulation Of Primary Metabolic Process	MAPK Cascade Protein Phosphorylation Signal Transduction Intracellular Signal Transduction Positive Regulation Of Dendritic Spine Development
Pathways			MAPK6/MAPK4 signaling
Drugs			Acetylsalicylic acid Minocycline Colforsin
Diseases
GWAS			Frailty index ( 34431594) Serum uric acid levels in response to allopurinol in gout ( 25676789)
Interacting Genes		9 interacting genes: APP CEBPA EIF4G1 HMGB1 HMGB2 MAPK6 OLFM2 RASA1 UPF2	167 interacting genes: ACTG1 ACTR1B AMPH ANAPC5 ANK3 ANKRD2 APBA2 ARHGDIA ARPC3 ATG9A ATP5PF BAG6 BARX1 BBS10 BTRC CA1 CA12 CALR CASP6 CCND3 CCT3 CDH13 CERS1 CFAP298 CFL1 CNTN1 CNTRL COPS6 CSE1L CYRIB CYTH2 DBN1 DCTN2 DDOST DDR1 DGKZ DKC1 DNAJC28 DPPA4 DST DYNC2I2 EDF1 EEF1A2 EIF1 EIF3C EIF4A1 ELOF1 EMD FBXL16 FOXO3 FXYD3 GALNT7 GATA1 GLRX3 GORASP1 GPX1 HACL1 HAUS2 HDAC11 HIP1 HNRNPA0 HNRNPD HNRNPH3 HSP90AB1 HSP90B1 HSPD1 IDH3B INS ITGB3BP ITSN1 JUNB KDSR KLC1 KNSTRN LPXN MAP3K12 MAP3K7 MAPKAPK5 MASP1 MBIP MBOAT7 MCM3 MDK METTL17 METTL2A MGAT1 MIPEP MOK MON1A MTG2 MYBL2 MYOZ3 MZB1 NAT9 NAXE NDUFS6 NECTIN2 NELFB NOL4 NRXN2 NUDT5 OSTF1 PDCD6IP PDLIM1 PHACTR3 PHC2 PHGDH PIH1D1 PLEKHM1 PLSCR1 PPBP PPP1R7 PPP2R1A PRKAB1 PRKAR1A PRKCB PRPF38A PSAT1 PSIP1 PTPMT1 RAB2A RAB31 RACK1 RANBP9 RAP1GAP RARA RBL1 RGS19 RPL10 RRP7A SEPTIN3 SEPTIN5 SERPINA4 SHC1 SLC20A1 SLC41A3 SMAD6 SMS SNAPC4 SNW1 SOCS3 SPG7 SPRR2D SPTAN1 SRSF5 STX7 TDP2 THAP4 TPI1 TTK TUBA1A UBA52 UBE2L3 URB1 USP20 VPS26C WDR26 WFS1 WWC1 XPO1 ZNF133 ZNF205 ZNF331 ZNF579 ZNF600 ZNF671 ZNF775
Entrez ID		10209	5597
HPRD ID		15449	04213
Ensembl ID		ENSG00000173812	ENSG00000069956
Uniprot IDs		P41567 Q6IAV3	Q16659
PDB IDs		2IF1 4KZX 4KZY 6YBW 6ZMW 6ZP4 6ZVJ 7A09 7QP6 8PJ1 8PPK 8PPL 8XXN 9BLN	6YKY 6YLC 6YLL 7AQB
Enriched GO Terms of Interacting Partners?		RAGE Receptor Binding Chemoattractant Activity Positive Regulation Of Developmental Process Regulation Of Developmental Process Positive Chemotaxis Positive Regulation Of Cell Differentiation Supercoiled DNA Binding DNA Geometric Change DNA Topological Change Regulation Of Cell Differentiation DNA Binding, Bending DNA Conformation Change Four-way Junction DNA Binding V(D)J Recombination Positive Regulation Of Defense Response Positive Regulation Of Monocyte Chemotaxis Regulation Of Presynapse Organization Regulation Of Presynapse Assembly DNA-binding Transcription Factor Binding Negative Regulation Of Gene Expression Regulation Of Monocyte Chemotaxis Inflammatory Response To Antigenic Stimulus Condensed Chromosome Response To Steroid Hormone Positive Regulation Of Gene Expression Positive Regulation Of Interferon-beta Production Somatic Cell DNA Recombination Negative Regulation Of Macromolecule Biosynthetic Process Transcription Cis-regulatory Region Binding Defense Response Negative Regulation Of Biosynthetic Process Amyloid-beta Complex Growth Cone Lamellipodium Regulation Of Response To Calcium Ion Regulation Of Carbohydrate Catabolic Process Macrophage Activation Amylin Binding Positive Regulation Of Toll Signaling Pathway Positive Regulation Of Interleukin-1 Beta Production Protein-containing Complex Positive Regulation Of Non-canonical NF-kappaB Signal Transduction Animal Organ Regeneration RNA Polymerase I Transcription Regulatory Region Sequence-specific DNA Binding Positive Regulation Of Eukaryotic Translation Initiation Factor 4F Complex Assembly Calcium-dependent Protein Kinase Regulator Activity Regulation Of Restriction Endodeoxyribonuclease Activity Damaged DNA Binding Positive Regulation Of Myeloid Progenitor Cell Differentiation Double-strand Break Repair Via Nonhomologous End Joining Regulation Of Interferon-beta Production	Cytosol Cytoplasm Nucleus Protein Binding Extracellular Exosome Ubiquitin Protein Ligase Binding
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