EIF1 and UPF2

Number of citations of the paper that reports this interaction (PubMedID 11073994)
78

Data Source:
HPRD (two hybrid, in vitro)

		EIF1	UPF2
Description		eukaryotic translation initiation factor 1	UPF2 regulator of nonsense mediated mRNA decay
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GO Annotations	Cellular Component	Nucleus Cytoplasm Eukaryotic 43S Preinitiation Complex Eukaryotic 48S Preinitiation Complex Multi-eIF Complex	Nucleus Cytoplasm Cytosol Exon-exon Junction Complex Cytoplasmic Ribonucleoprotein Granule Perinuclear Region Of Cytoplasm
	Molecular Function	RNA Binding Translation Initiation Factor Activity Protein Binding Translation Factor Activity, RNA Binding Ribosomal Small Subunit Binding	RNA Binding Protein Binding Telomeric DNA Binding
	Biological Process	Translation Translational Initiation Regulation Of Translational Initiation Regulation Of Gene Expression Regulation Of Primary Metabolic Process	Nuclear-transcribed MRNA Catabolic Process, Nonsense-mediated Decay Liver Development MRNA Export From Nucleus Animal Organ Regeneration
Pathways			Regulation of expression of SLITs and ROBOs Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)
Drugs
Diseases
GWAS			Diverticular disease ( 30177863)
Interacting Genes		9 interacting genes: APP CEBPA EIF4G1 HMGB1 HMGB2 MAPK6 OLFM2 RASA1 UPF2	76 interacting genes: ABCF2 AGPAT1 AKTIP ART4 ATP1B3 BLM CALR CENPU CIZ1 COMTD1 CYBA DCP1B DCP2 DPF2 E4F1 EIF1 EIF4A1 EIF4G1 ENO1 EXOSC1 EXOSC10 EXOSC4 EXOSC6 EXOSC8 GADD45GIP1 HBZ HMGA1 HS3ST3A1 HSF2BP ITGB1 KRT18 LDHA LSM1 MAP1A MAP1LC3B MIF MRPL40 MTERF3 MTREX MYB NDUFA7 NOB1 NOMO1 NOP53 PHB2 PITX1 PUF60 RNPS1 RPL13 RPL5 RPL8 RPS15 RPS25 RPS6 RPS7 RRP7A RSRC2 SERBP1 SERF2 SMG1 SUMO3 TK1 TNNI2 TOP3B TUBB2A TYMS UPF1 UPF3B WNK1 XRN1 XRN2 ZBTB48 ZFP36 ZGPAT ZNF408 ZNF44
Entrez ID		10209	26019
HPRD ID		15449	10405
Ensembl ID		ENSG00000173812	ENSG00000151461
Uniprot IDs		P41567 Q6IAV3	Q9HAU5
PDB IDs		2IF1 4KZX 4KZY 6YBW 6ZMW 6ZP4 6ZVJ 7A09 7QP6 8PJ1 8PPK 8PPL 8XXN 9BLN	1UW4 2WJV 4CEK 4CEM 7NWU 7QG6
Enriched GO Terms of Interacting Partners?		RAGE Receptor Binding Chemoattractant Activity Positive Regulation Of Developmental Process Regulation Of Developmental Process Positive Chemotaxis Positive Regulation Of Cell Differentiation Supercoiled DNA Binding DNA Geometric Change DNA Topological Change Regulation Of Cell Differentiation DNA Binding, Bending DNA Conformation Change Four-way Junction DNA Binding V(D)J Recombination Positive Regulation Of Defense Response Positive Regulation Of Monocyte Chemotaxis Regulation Of Presynapse Organization Regulation Of Presynapse Assembly DNA-binding Transcription Factor Binding Negative Regulation Of Gene Expression Regulation Of Monocyte Chemotaxis Inflammatory Response To Antigenic Stimulus Condensed Chromosome Response To Steroid Hormone Positive Regulation Of Gene Expression Positive Regulation Of Interferon-beta Production Somatic Cell DNA Recombination Negative Regulation Of Macromolecule Biosynthetic Process Transcription Cis-regulatory Region Binding Defense Response Negative Regulation Of Biosynthetic Process Amyloid-beta Complex Growth Cone Lamellipodium Regulation Of Response To Calcium Ion Regulation Of Carbohydrate Catabolic Process Macrophage Activation Amylin Binding Positive Regulation Of Toll Signaling Pathway Positive Regulation Of Interleukin-1 Beta Production Protein-containing Complex Positive Regulation Of Non-canonical NF-kappaB Signal Transduction Animal Organ Regeneration RNA Polymerase I Transcription Regulatory Region Sequence-specific DNA Binding Positive Regulation Of Eukaryotic Translation Initiation Factor 4F Complex Assembly Calcium-dependent Protein Kinase Regulator Activity Regulation Of Restriction Endodeoxyribonuclease Activity Damaged DNA Binding Positive Regulation Of Myeloid Progenitor Cell Differentiation Double-strand Break Repair Via Nonhomologous End Joining Regulation Of Interferon-beta Production	RNA Binding Nuclear-transcribed MRNA Catabolic Process RNA Catabolic Process MRNA Catabolic Process Nucleobase-containing Compound Catabolic Process RRNA Metabolic Process RRNA Processing Nucleic Acid Metabolic Process Exosome (RNase Complex) Nucleus Nucleobase-containing Compound Metabolic Process Negative Regulation Of Macromolecule Metabolic Process RNA Metabolic Process Histone MRNA Catabolic Process Nuclear Exosome (RNase Complex) Negative Regulation Of Metabolic Process Nuclear-transcribed MRNA Catabolic Process, Nonsense-mediated Decay Nucleolar Exosome (RNase Complex) Negative Regulation Of Macromolecule Biosynthetic Process Nuclear MRNA Surveillance Ribosome Histone MRNA Metabolic Process Negative Regulation Of Biosynthetic Process Cytoplasmic Exosome (RNase Complex) RNA Exonuclease Activity Regulation Of Gene Expression Ribonucleoprotein Complex Biogenesis Regulation Of Macromolecule Biosynthetic Process MRNA Metabolic Process Macromolecule Metabolic Process Negative Regulation Of Gene Expression RNA Processing Ribosomal Small Subunit Biogenesis Translation Regulation Of Macromolecule Metabolic Process Ribonucleoprotein Complex Nucleolus Nucleic Acid Binding Cytosolic Ribosome Positive Regulation Of MRNA Cis Splicing, Via Spliceosome 5'-3' RNA Exonuclease Activity Regulation Of Metabolic Process Nuclear RNA Surveillance RRNA Catabolic Process RNA Surveillance DNA Metabolic Process Cytosol Cytoplasmic Translation Negative Regulation Of Protein Metabolic Process Macromolecule Catabolic Process
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