EIF1 and RASA1

Number of citations of the paper that reports this interaction (PMID 21900206)
27

Data Source:
BioGRID (two hybrid)

		EIF1	RASA1
Gene Name		eukaryotic translation initiation factor 1	RAS p21 protein activator (GTPase activating protein) 1
Image
Gene Ontology Annotations	Cellular Component	Cytoplasm	Ruffle Cytoplasm Cytosol Intrinsic Component Of The Cytoplasmic Side Of The Plasma Membrane
	Molecular Function	Translation Initiation Factor Activity Translation Factor Activity, Nucleic Acid Binding Poly(A) RNA Binding	Glycoprotein Binding Ras GTPase Activator Activity Receptor Binding Protein Binding Potassium Channel Inhibitor Activity GTPase Binding
	Biological Process	Translational Initiation Regulation Of Translational Initiation Response To Stress Dosage Compensation By Inactivation Of X Chromosome	Mitotic Cytokinesis Vasculogenesis Negative Regulation Of Cell-matrix Adhesion Negative Regulation Of Cell Adhesion Signal Transduction Axon Guidance Regulation Of Cell Shape Embryo Development Regulation Of Actin Filament Polymerization Positive Regulation Of Ras GTPase Activity Intracellular Signal Transduction Negative Regulation Of Neuron Apoptotic Process Negative Regulation Of Ras Protein Signal Transduction Vascular Endothelial Growth Factor Receptor Signaling Pathway Ephrin Receptor Signaling Pathway Blood Vessel Morphogenesis Regulation Of RNA Metabolic Process
Pathways			Signaling by PDGF EPHB-mediated forward signaling Axon guidance VEGFR2 mediated cell proliferation Signaling by VEGF Downstream signal transduction EPH-Ephrin signaling VEGFA-VEGFR2 Pathway
Drugs
Diseases
GWAS			Major depressive disorder ( 23377640) Personality dimensions ( 21173776)
Protein-Protein Interactions		5 interactors: APP MAPK6 OLFM2 RASA1 UPF2	73 interactors: ABL1 AFAP1L2 ANXA6 APP ARHGAP1 ARHGAP5 AURKB BBS10 BCR BIRC5 CASP3 CASP7 CAV2 CD5 CSF1R CSK DNAJA3 DOK1 DOK2 DOK4 EGFR EIF1 EPHA2 EPHB2 EPHB3 ERBB2 ERBB3 ERBB4 EZH2 FES G3BP1 GNB2L1 GRB2 HCK HRAS HSPD1 HTT IGF1R INSR KDR KHDRBS1 KIT LCK LYN MAGI1 MAP4K4 NCK1 NTRK1 PAG1 PDE6D PDGFRB PIK3R1 PTK2B PTPRC PXN RAB5A RAP1A SERPINA4 SHC1 SLC9A2 SOCS3 SPSB1 SRC STAU1 SYK SYN1 TRMT2A WWP1 WWP2 XRCC6 YES1 ZAP70 ZNF579
Entrez ID		10209	5921
HPRD ID		15449	00745
Ensembl ID			ENSG00000145715
Uniprot IDs		P41567 Q6IAV3	B4DTL2 E9PGC0 P20936 Q59GK3
PDB IDs		2IF1 4KZX 4KZY	1WER 1WQ1 2GQI 2GSB 2J05 2J06 2M51 4FSS
Enriched GO Terms of Interacting Partners?			Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Enzyme Linked Receptor Protein Signaling Pathway Peptidyl-tyrosine Phosphorylation Protein Autophosphorylation Regulation Of Signaling Regulation Of Phosphorylation Regulation Of Signal Transduction Peptidyl-tyrosine Autophosphorylation Regulation Of Phosphorus Metabolic Process Positive Regulation Of Signal Transduction Regulation Of Catalytic Activity Regulation Of Kinase Activity Regulation Of Intracellular Signal Transduction Regulation Of MAPK Cascade Intracellular Signal Transduction Regulation Of Protein Phosphorylation Positive Regulation Of Intracellular Signal Transduction Regulation Of Protein Kinase Activity Epidermal Growth Factor Receptor Signaling Pathway Positive Regulation Of Cellular Protein Metabolic Process ERBB Signaling Pathway Peptidyl-amino Acid Modification Cell Surface Receptor Signaling Pathway Signal Transduction Protein Phosphorylation Immune Response-regulating Cell Surface Receptor Signaling Pathway Signaling Regulation Of Cellular Protein Metabolic Process Positive Regulation Of Protein Metabolic Process Cell Communication Regulation Of Cell Proliferation Immune Response-regulating Signaling Pathway Positive Regulation Of Catalytic Activity Innate Immune Response Positive Regulation Of MAPK Cascade Cellular Response To Stimulus Immune System Process Locomotion Regulation Of Protein Metabolic Process Positive Regulation Of Phosphorylation Regulation Of ERK1 And ERK2 Cascade Regulation Of Immune Response Regulation Of Cell Adhesion Positive Regulation Of Protein Phosphorylation Phosphorylation Response To Stimulus Regulation Of Cellular Component Organization Regulation Of Immune System Process Fc Receptor Signaling Pathway Cellular Response To Organonitrogen Compound
Tagcloud ?		43s 48s 4a 4b 4f assumed cap capped codon coherent description dissociate eif1a eif4a eif4b eif4f exclusively incubated individually initiation mediate messenger preinitiation reach ribosomal ribosomes synergistically unable weakly	adaptors assumptions combinatorial complexity cooperativity dealt demodification descriptions disallow hinders hoc lumped modelling obstacle ode odes ordinary pharmacology phosphatases plcgamma1 reasonably relaxed retaining shc1 shp2 simulate subdomains tyrosines unphosphorylated
Tagcloud (Difference) ?		43s 48s 4a 4b 4f assumed cap capped codon coherent description dissociate eif1a eif4a eif4b eif4f exclusively incubated individually initiation mediate messenger preinitiation reach ribosomal ribosomes synergistically unable weakly	adaptors assumptions combinatorial complexity cooperativity dealt demodification descriptions disallow hinders hoc lumped modelling obstacle ode odes ordinary pharmacology phosphatases plcgamma1 reasonably relaxed retaining shc1 shp2 simulate subdomains tyrosines unphosphorylated
Tagcloud (Intersection) ?