EIF1 and HMGB2

Number of citations of the paper that reports this interaction (PubMedID 29721183)
101

Data Source:
BioGRID (two hybrid)

		EIF1	HMGB2
Description		eukaryotic translation initiation factor 1	high mobility group box 2
Image			No pdb structure
GO Annotations	Cellular Component	Nucleus Cytoplasm Eukaryotic 43S Preinitiation Complex Eukaryotic 48S Preinitiation Complex Multi-eIF Complex	Chromatin Condensed Chromosome Extracellular Region Extracellular Space Nucleus Nucleoplasm Chromosome Nucleolus Cytoplasm Protein-containing Complex Perinuclear Region Of Cytoplasm
	Molecular Function	RNA Binding Translation Initiation Factor Activity Protein Binding Translation Factor Activity, RNA Binding Ribosomal Small Subunit Binding	Four-way Junction DNA Binding Transcription Cis-regulatory Region Binding Cis-regulatory Region Sequence-specific DNA Binding DNA Binding Damaged DNA Binding Double-stranded DNA Binding Single-stranded DNA Binding Transcription Coactivator Activity RNA Binding Protein Binding Transcription Factor Binding DNA Binding, Bending Protein Domain Specific Binding Chemoattractant Activity Non-sequence-specific DNA Binding, Bending RAGE Receptor Binding Supercoiled DNA Binding DNA-binding Transcription Factor Binding
	Biological Process	Translation Translational Initiation Regulation Of Translational Initiation Regulation Of Gene Expression Regulation Of Primary Metabolic Process	Negative Regulation Of Transcription By RNA Polymerase II Positive Regulation Of Endothelial Cell Proliferation Immune System Process Inflammatory Response To Antigenic Stimulus DNA Topological Change Double-strand Break Repair Via Nonhomologous End Joining DNA Recombination Chromatin Organization Nucleosome Assembly Chromatin Remodeling Regulation Of Transcription By RNA Polymerase II Chemotaxis Inflammatory Response Spermatogenesis Spermatid Nucleus Differentiation Male Gonad Development Extrinsic Apoptotic Signaling Pathway Via Death Domain Receptors Positive Regulation Of Gene Expression Negative Regulation Of Gene Expression DNA Geometric Change Response To Lipopolysaccharide Positive Regulation Of Interferon-beta Production V(D)J Recombination Innate Immune Response Positive Regulation Of Innate Immune Response Positive Regulation Of Erythrocyte Differentiation Positive Regulation Of Megakaryocyte Differentiation Negative Regulation Of DNA-templated Transcription Positive Regulation Of DNA-templated Transcription Positive Regulation Of Transcription By RNA Polymerase II Response To Steroid Hormone Regulation Of Neurogenesis Defense Response To Gram-negative Bacterium Defense Response To Gram-positive Bacterium Positive Chemotaxis Cell Chemotaxis Cellular Response To Lipopolysaccharide Regulation Of Stem Cell Proliferation Negative Regulation Of Extrinsic Apoptotic Signaling Pathway Via Death Domain Receptors Regulation Of Hemopoiesis
Pathways			Apoptosis induced DNA fragmentation
Drugs
Diseases
GWAS
Interacting Genes		9 interacting genes: APP CEBPA EIF4G1 HMGB1 HMGB2 MAPK6 OLFM2 RASA1 UPF2	54 interacting genes: - APEX1 APP AR ARCN1 BCCIP C1QBP CACTIN CEBPA CHAF1A COMMD1 CRBN CREBBP CSNK1A1 EIF1 FBXO7 FLNA GZMA GZMK H3-3A HACD3 HDLBP HMGA1 LZTS1 MIEN1 MYL6 NAP1L1 NCBP3 NEXN NOP53 NR3C1 PCBP1 PGR PKNOX1 POU2F1 POU2F2 POU3F1 POU5F1 PRKDC RAG1 ROCK1 RPS28 SAMM50 SET SNAPIN TBC1D25 TP53 TSNAX U2AF1 UHRF2 ZFR ZNF428 ZNF622 ZNF668
Entrez ID		10209	3148
HPRD ID		15449	01229
Ensembl ID		ENSG00000173812	ENSG00000164104
Uniprot IDs		P41567 Q6IAV3	P26583
PDB IDs		2IF1 4KZX 4KZY 6YBW 6ZMW 6ZP4 6ZVJ 7A09 7QP6 8PJ1 8PPK 8PPL 8XXN 9BLN
Enriched GO Terms of Interacting Partners?		RAGE Receptor Binding Chemoattractant Activity Positive Regulation Of Developmental Process Regulation Of Developmental Process Positive Chemotaxis Positive Regulation Of Cell Differentiation Supercoiled DNA Binding DNA Geometric Change DNA Topological Change Regulation Of Cell Differentiation DNA Binding, Bending DNA Conformation Change Four-way Junction DNA Binding V(D)J Recombination Positive Regulation Of Defense Response Positive Regulation Of Monocyte Chemotaxis Regulation Of Presynapse Organization Regulation Of Presynapse Assembly DNA-binding Transcription Factor Binding Negative Regulation Of Gene Expression Regulation Of Monocyte Chemotaxis Inflammatory Response To Antigenic Stimulus Condensed Chromosome Response To Steroid Hormone Positive Regulation Of Gene Expression Positive Regulation Of Interferon-beta Production Somatic Cell DNA Recombination Negative Regulation Of Macromolecule Biosynthetic Process Transcription Cis-regulatory Region Binding Defense Response Negative Regulation Of Biosynthetic Process Amyloid-beta Complex Growth Cone Lamellipodium Regulation Of Response To Calcium Ion Regulation Of Carbohydrate Catabolic Process Macrophage Activation Amylin Binding Positive Regulation Of Toll Signaling Pathway Positive Regulation Of Interleukin-1 Beta Production Protein-containing Complex Positive Regulation Of Non-canonical NF-kappaB Signal Transduction Animal Organ Regeneration RNA Polymerase I Transcription Regulatory Region Sequence-specific DNA Binding Positive Regulation Of Eukaryotic Translation Initiation Factor 4F Complex Assembly Calcium-dependent Protein Kinase Regulator Activity Regulation Of Restriction Endodeoxyribonuclease Activity Damaged DNA Binding Positive Regulation Of Myeloid Progenitor Cell Differentiation Double-strand Break Repair Via Nonhomologous End Joining Regulation Of Interferon-beta Production	Nucleus RNA Binding Nucleic Acid Metabolic Process Regulation Of MiRNA Transcription DNA Metabolic Process Regulation Of MiRNA Metabolic Process DNA Binding Macromolecule Metabolic Process Negative Regulation Of Metabolic Process Chromatin Sequence-specific DNA Binding Regulation Of Metabolic Process Nucleobase-containing Compound Metabolic Process Negative Regulation Of Macromolecule Metabolic Process Negative Regulation Of Macromolecule Biosynthetic Process DNA Repair Transcription Coactivator Binding Negative Regulation Of Biosynthetic Process Positive Regulation Of MiRNA Transcription Transcription Regulator Complex Regulation Of Apoptotic Process Chromatin Organization Positive Regulation Of MiRNA Metabolic Process Regulation Of Programmed Cell Death Chromatin Binding RNA Polymerase II-specific DNA-binding Transcription Factor Binding Regulation Of DNA-templated Transcription Regulation Of RNA Biosynthetic Process Negative Regulation Of Transcription By RNA Polymerase I Regulation Of Macromolecule Metabolic Process Regulation Of RNA Metabolic Process Estrogen Response Element Binding Regulation Of Gene Expression Nucleoplasm Cytoplasm Chromatin Remodeling Positive Regulation Of Transcription By RNA Polymerase II Regulation Of Nucleobase-containing Compound Metabolic Process Positive Regulation Of RNA Metabolic Process Nuclear Speck Negative Regulation Of DNA-templated Transcription Regulation Of Macromolecule Biosynthetic Process Negative Regulation Of RNA Biosynthetic Process RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding Positive Regulation Of RNA Biosynthetic Process Positive Regulation Of DNA-templated Transcription Negative Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of Neuron Apoptotic Process Regulation Of Protein Stability Negative Regulation Of RNA Metabolic Process
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