PPFIA3 and PTPRU

Number of citations of the paper that reports this interaction (PMID 9624153)
49

Data Source:
HPRD (in vitro)

		PPFIA3	PTPRU
Gene Name		protein tyrosine phosphatase, receptor type, f polypeptide (PTPRF), interacting protein (liprin), alpha 3	protein tyrosine phosphatase, receptor type, U
Image		No pdb structure	No pdb structure
Gene Ontology Annotations	Cellular Component	Cytosol Cell Surface Presynaptic Active Zone	Plasma Membrane Integral Component Of Plasma Membrane Cell-cell Junction
	Molecular Function	Protein Binding	Protein Tyrosine Phosphatase Activity Transmembrane Receptor Protein Tyrosine Phosphatase Activity Protein Binding Beta-catenin Binding
	Biological Process	Synaptic Transmission Neurotransmitter Secretion Glutamate Secretion Regulation Of Short-term Neuronal Synaptic Plasticity	Protein Dephosphorylation Cell Adhesion Transmembrane Receptor Protein Tyrosine Phosphatase Signaling Pathway Negative Regulation Of Cell Proliferation Single Organismal Cell-cell Adhesion Cell Differentiation Negative Regulation Of Cell Migration Organ Regeneration Homotypic Cell-cell Adhesion Protein Localization To Cell Surface Peptidyl-tyrosine Dephosphorylation Response To Glucocorticoid Canonical Wnt Signaling Pathway
Pathways		Dopamine Neurotransmitter Release Cycle Neurotransmitter Release Cycle Acetylcholine Neurotransmitter Release Cycle Norepinephrine Neurotransmitter Release Cycle Serotonin Neurotransmitter Release Cycle Glutamate Neurotransmitter Release Cycle Transmission across Chemical Synapses	Signaling by SCF-KIT
Drugs
Diseases
GWAS			Bipolar disorder and schizophrenia ( 20889312) Non-alcoholic fatty liver disease ( 23535911) Prostate cancer (gene x gene interaction) ( 22219177)
Protein-Protein Interactions		12 interactors: CAST ERC2 GIT1 PPFIA1 PPFIA2 PPFIBP1 PPFIBP2 PTPRD PTPRF PTPRG PTPRS PTPRU	8 interactors: CTNNB1 GNAI1 GNAI2 GNAI3 GNAO1 IRS1 KIT PPFIA3
Entrez ID		8541	10076
HPRD ID		04393	03908
Ensembl ID		ENSG00000177380	ENSG00000060656
Uniprot IDs		O75145	Q92729
PDB IDs
Enriched GO Terms of Interacting Partners?		Transmembrane Receptor Protein Tyrosine Phosphatase Signaling Pathway Peptidyl-tyrosine Dephosphorylation Protein Dephosphorylation Cell Adhesion Enzyme Linked Receptor Protein Signaling Pathway Dephosphorylation Signaling Cell Communication Glutamate Secretion Signal Transduction Acid Secretion Dicarboxylic Acid Transport Cell Surface Receptor Signaling Pathway Cellular Response To Stimulus Neurotransmitter Secretion Regulation Of Neurotransmitter Levels Amino Acid Transport Neurotransmitter Transport Cell-matrix Adhesion Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Negative Regulation Of Type B Pancreatic Cell Apoptotic Process Negative Regulation Of Cell Migration Negative Regulation Of Receptor Binding Cell-substrate Adhesion Presynaptic Membrane Assembly Negative Regulation Of Cell Motility Phosphate-containing Compound Metabolic Process Negative Regulation Of Stress Fiber Assembly Negative Regulation Of Cellular Component Movement Response To Stimulus Presynaptic Membrane Organization Negative Regulation Of Locomotion Negative Regulation Of Actin Filament Bundle Assembly Negative Regulation Of Establishment Of Protein Localization To Plasma Membrane Cellular Protein Modification Process Corpus Callosum Development Carboxylic Acid Transport Organic Acid Transport Protein Localization To Cell Surface Negative Regulation Of Protein Localization To Plasma Membrane Membrane Assembly RRNA Transcription Regulation Of Neuron Projection Development Nervous System Development Termination Of RNA Polymerase I Transcription Transcription Elongation From RNA Polymerase I Promoter Membrane Biogenesis	Adenylate Cyclase-modulating G-protein Coupled Receptor Signaling Pathway G-protein Coupled Receptor Signaling Pathway, Coupled To Cyclic Nucleotide Second Messenger Synaptic Transmission Adenylate Cyclase-inhibiting G-protein Coupled Receptor Signaling Pathway Cell Activation Cell-cell Signaling Cell Surface Receptor Signaling Pathway Cell Division Response To Stress Signaling Cell Communication Negative Regulation Of Adenylate Cyclase Activity Negative Regulation Of Lyase Activity Regulation Of Calcium Ion Transport Platelet Activation Positive Regulation Of Phosphatidylinositol 3-kinase Activity Negative Regulation Of CAMP Biosynthetic Process Regulation Of Phosphorus Metabolic Process Negative Regulation Of CAMP Metabolic Process Positive Regulation Of Mesenchymal Cell Proliferation Negative Regulation Of Nucleotide Metabolic Process Positive Regulation Of Cell Proliferation Response To Organonitrogen Compound Regulation Of Mesenchymal Cell Proliferation Positive Regulation Of Phosphorylation Regulation Of Synaptic Transmission Regulation Of Phosphatidylinositol 3-kinase Activity Vesicle Fusion Response To Hormone Regulation Of Adenylate Cyclase Activity Regulation Of Neuronal Synaptic Plasticity Signal Transduction Regulation Of Lipid Kinase Activity Regulation Of Cyclase Activity Positive Regulation Of Stem Cell Proliferation Organelle Fusion Blood Coagulation Hemostasis G-protein Coupled Receptor Signaling Pathway Positive Regulation Of MAPK Cascade Mast Cell Cytokine Production Melanocyte Adhesion Dendritic Cell Cytokine Production Mast Cell Proliferation Response To Peptide Hormone Regulation Of CAMP Biosynthetic Process Response To Peptide Regulation Of Catalytic Activity Positive Regulation Of Kinase Activity Positive Regulation Of Signal Transduction
Tagcloud ?			adhesion adjacent attenuation catenin colon delivered dephosphorylating find focal fragment full gastric isoform kda knockdown lentivirus localized lowly lysine phosphatase reducing relatively respective serve shrna suppressor tissues tyrosine
Tagcloud (Difference) ?			adhesion adjacent attenuation catenin colon delivered dephosphorylating find focal fragment full gastric isoform kda knockdown lentivirus localized lowly lysine phosphatase reducing relatively respective serve shrna suppressor tissues tyrosine
Tagcloud (Intersection) ?