USP15 and CDC73

Number of citations of the paper that reports this interaction (PubMedID 35742816)
38

Data Source:
BioGRID (two hybrid, pull down)

		USP15	CDC73
Description		ubiquitin specific peptidase 15	cell division cycle 73
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GO Annotations	Cellular Component	Nucleus Nucleoplasm Cytoplasm Mitochondrion Cytosol Nuclear Body	Chromosome, Telomeric Region Nucleus Nucleoplasm Cytosol Cdc73/Paf1 Complex
	Molecular Function	Catalytic Activity Cysteine-type Endopeptidase Activity Cysteine-type Deubiquitinase Activity Transforming Growth Factor Beta Receptor Binding Protein Binding Peptidase Activity Cysteine-type Peptidase Activity Hydrolase Activity Identical Protein Binding SMAD Binding Ubiquitin-modified Histone Reader Activity Deubiquitinase Activity K48-linked Deubiquitinase Activity	RNA Polymerase II Complex Binding Protein Binding
	Biological Process	Proteolysis Transforming Growth Factor Beta Receptor Signaling Pathway Protein Deubiquitination BMP Signaling Pathway Negative Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway Monoubiquitinated Protein Deubiquitination Positive Regulation Of Canonical NF-kappaB Signal Transduction Regulation Of RNA Metabolic Process Transcription Elongation-coupled Chromatin Remodeling Positive Regulation Of RIG-I Signaling Pathway Regulation Of Intrinsic Apoptotic Signaling Pathway In Response To Osmotic Stress By P53 Class Mediator Negative Regulation Of Antifungal Innate Immune Response Protein K27-linked Deubiquitination	Negative Regulation Of Transcription By RNA Polymerase II Regulation Of Cell Growth Endodermal Cell Fate Commitment Regulation Of Transcription By RNA Polymerase II Transcription Elongation By RNA Polymerase II Negative Regulation Of Cell Population Proliferation Wnt Signaling Pathway Stem Cell Population Maintenance Positive Regulation Of Wnt Signaling Pathway MRNA 3'-end Processing Positive Regulation Of MRNA 3'-end Processing Protein Destabilization Positive Regulation Of Transcription Elongation By RNA Polymerase II Negative Regulation Of Apoptotic Process Negative Regulation Of Myeloid Cell Differentiation Positive Regulation Of Transcription By RNA Polymerase II Negative Regulation Of Fibroblast Proliferation Negative Regulation Of Epithelial Cell Proliferation Cellular Response To Lipopolysaccharide Positive Regulation Of Cell Cycle G1/S Phase Transition Negative Regulation Of G1/S Transition Of Mitotic Cell Cycle
Pathways		Downregulation of TGF-beta receptor signaling UCH proteinases Ub-specific processing proteases	Formation of RNA Pol II elongation complex Formation of the beta-catenin:TCF transactivating complex Hedgehog 'on' state RNA Polymerase II Pre-transcription Events RNA Polymerase II Transcription Elongation E3 ubiquitin ligases ubiquitinate target proteins
Drugs
Diseases			Primary hyperparathyroidism; Familial hyperparathyroidism (HRPT)
GWAS		Alopecia areata ( 25608926) Metabolite levels ( 23823483) Platelet distribution width ( 32888494) Plateletcrit ( 27863252 32888494) Pulmonary function decline ( 22424883) Pyoderma gangrenosum in inflammatory bowel disease ( 24487271)	Chronotype ( 30696823) High density lipoprotein cholesterol levels ( 34074324) Ovarian disease with few adhesions ( 28333195) Photic sneeze reflex ( 27182965) Subcutaneous adipose tissue ( 22589738) Takayasu arteritis ( 25604533) White matter hyperintensity burden ( 25663218)
Interacting Genes		61 interacting genes: BAP1 BMI1 BMPR1A BRAP CARD9 CCDC57 CDC73 CSNK1A1 FHL1 GEMIN4 GLUL GOLGA2 GOLGA6A GSPT1 H2BC21 IL1R2 JOSD1 KEAP1 MAD1L1 MDC1 MDM2 OTUB1 PARP1 PHF7 PIBF1 PLA2G2A PRPF31 RBCK1 RIGI RNF126 RNF144B RNF26 SENP3 SENP8 SMURF2 SPDL1 STAM STK33 SYVN1 TEX11 TRAF6 TRIM17 TRIM21 TRIM25 TRIM46 TRIM5 TRIM54 TRIM63 TRIM74 UBC UCHL1 UCHL3 USP14 USP2 USP20 USP21 USP28 USP33 USP51 USP8 YOD1	45 interacting genes: ALAS1 ANXA6 CEP70 CLTCL1 CTNNB1 DDAH2 DES DMPK EEA1 FAF1 FHL2 FSD2 GC GOLGA2 GOLGA6L9 H1-2 HAP1 HSF2BP HSPA4 ITFG1 KASH5 KCNH2 KIAA1549 KIDINS220 MCM3AP MTUS2 MYC PICK1 PITHD1 PTPN11 RABEP1 RNF20 RNF40 TCEA1 TCF4 TFCP2 TOMM20 TRIM23 TSGA10 USP12 USP15 USP25 USP28 VPS37B WWC1
Entrez ID		9958	79577
HPRD ID		05293	09581
Ensembl ID		ENSG00000135655	ENSG00000134371
Uniprot IDs		Q9Y4E8	Q6P1J9
PDB IDs		1W6V 3LMN 3PPA 3PV1 3T9L 4A3O 4A3P 5JJW 6CPM 6CRN 6DJ9 6GH9 6GHA 6ML1 7R2G	5YDE 5YDF 6TED 7OOP 7OPC 7OPD 7UNC 7UND 8A3Y 9EGX 9EGY 9EGZ 9EH0 9EH2
Enriched GO Terms of Interacting Partners?		Post-translational Protein Modification Protein Modification Process Cysteine-type Deubiquitinase Activity Protein Modification By Small Protein Removal Protein Deubiquitination Proteolysis Cysteine-type Peptidase Activity Protein Metabolic Process Macromolecule Metabolic Process Ubiquitin Protein Ligase Activity Proteolysis Involved In Protein Catabolic Process Protein Ubiquitination Peptidase Activity Protein K48-linked Deubiquitination Modification-dependent Protein Catabolic Process Protein Modification By Small Protein Conjugation Ubiquitin-dependent Protein Catabolic Process Macromolecule Catabolic Process Ubiquitin-protein Transferase Activity DeNEDDylase Activity Catabolic Process Zinc Ion Binding Cytosol Protein Polyubiquitination Proteasomal Protein Catabolic Process Cytoplasm Deubiquitinase Activity Protein Catabolic Process Innate Immune Response Ubiquitin Binding Cysteine-type Endopeptidase Activity Immune Response Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Immune System Process Transferase Activity Defense Response To Symbiont Metal Ion Binding Defense Response To Other Organism Response To External Biotic Stimulus Response To Stress Response To Other Organism Hydrolase Activity Protein K63-linked Deubiquitination Protein K48-linked Ubiquitination Regulation Of Signal Transduction Antiviral Innate Immune Response Regulation Of Mitotic Cell Cycle Regulation Of Double-strand Break Repair Via Homologous Recombination Ubiquitin Protein Ligase Binding Regulation Of Double-strand Break Repair	Deubiquitinase Activity Ubiquitin Protein Ligase Binding Beta-catenin-TCF7L2 Complex Neurotrophin Signaling Pathway HULC Complex Cysteine-type Deubiquitinase Activity Identical Protein Binding Protein Deubiquitination Fascia Adherens Protein Modification By Small Protein Removal
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