USP15 and FHL1

Number of citations of the paper that reports this interaction (PubMedID 21219870)
0

Data Source:
BioGRID (affinity chromatography technology, pull down)

		USP15	FHL1
Description		ubiquitin specific peptidase 15	four and a half LIM domains 1
Image
GO Annotations	Cellular Component	Nucleus Nucleoplasm Cytoplasm Mitochondrion Cytosol Nuclear Body	Nucleus Cytoplasm Cytosol Plasma Membrane Focal Adhesion
	Molecular Function	Catalytic Activity Cysteine-type Endopeptidase Activity Cysteine-type Deubiquitinase Activity Transforming Growth Factor Beta Receptor Binding Protein Binding Peptidase Activity Cysteine-type Peptidase Activity Hydrolase Activity Identical Protein Binding SMAD Binding Ubiquitin-modified Histone Reader Activity Deubiquitinase Activity K48-linked Deubiquitinase Activity	Protein Binding Zinc Ion Binding Transmembrane Transporter Binding Metal Ion Binding Channel Activator Activity Potassium Channel Activator Activity
	Biological Process	Proteolysis Transforming Growth Factor Beta Receptor Signaling Pathway Protein Deubiquitination BMP Signaling Pathway Negative Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway Monoubiquitinated Protein Deubiquitination Positive Regulation Of Canonical NF-kappaB Signal Transduction Regulation Of RNA Metabolic Process Transcription Elongation-coupled Chromatin Remodeling Positive Regulation Of RIG-I Signaling Pathway Regulation Of Intrinsic Apoptotic Signaling Pathway In Response To Osmotic Stress By P53 Class Mediator Negative Regulation Of Antifungal Innate Immune Response Protein K27-linked Deubiquitination	Muscle Organ Development Animal Organ Morphogenesis Negative Regulation Of G2/M Transition Of Mitotic Cell Cycle Cell Differentiation Negative Regulation Of Cell Growth Regulation Of Atrial Cardiac Muscle Cell Membrane Depolarization Positive Regulation Of Potassium Ion Transmembrane Transport Negative Regulation Of G1/S Transition Of Mitotic Cell Cycle
Pathways		Downregulation of TGF-beta receptor signaling UCH proteinases Ub-specific processing proteases
Drugs
Diseases			X-linked myopathy with postural muscle atrophy (XMPMA) Scapuloperoneal myopathy (SPM) Reducing body myopathy (RBM) Emery-Dreifuss muscular dystrophy
GWAS		Alopecia areata ( 25608926) Metabolite levels ( 23823483) Platelet distribution width ( 32888494) Plateletcrit ( 27863252 32888494) Pulmonary function decline ( 22424883) Pyoderma gangrenosum in inflammatory bowel disease ( 24487271)
Interacting Genes		61 interacting genes: BAP1 BMI1 BMPR1A BRAP CARD9 CCDC57 CDC73 CSNK1A1 FHL1 GEMIN4 GLUL GOLGA2 GOLGA6A GSPT1 H2BC21 IL1R2 JOSD1 KEAP1 MAD1L1 MDC1 MDM2 OTUB1 PARP1 PHF7 PIBF1 PLA2G2A PRPF31 RBCK1 RIGI RNF126 RNF144B RNF26 SENP3 SENP8 SMURF2 SPDL1 STAM STK33 SYVN1 TEX11 TRAF6 TRIM17 TRIM21 TRIM25 TRIM46 TRIM5 TRIM54 TRIM63 TRIM74 UBC UCHL1 UCHL3 USP14 USP2 USP20 USP21 USP28 USP33 USP51 USP8 YOD1	30 interacting genes: APP CBX4 CHEK2 CLMN CSRP3 DBN1 DEAF1 DOCK9 EED ENO1 FHL2 HES1 HIVEP3 IGFBP5 LAMA4 MACF1 MYBPC1 NFIL3 PAX7 PDE4DIP PDLIM3 RBPJ RING1 SRF SRPK1 TTN TXNIP USP15 YWHAE ZBTB40
Entrez ID		9958	2273
HPRD ID		05293	02157
Ensembl ID		ENSG00000135655	ENSG00000022267
Uniprot IDs		Q9Y4E8	B7Z9A1 Q13642 Q5JXI2
PDB IDs		1W6V 3LMN 3PPA 3PV1 3T9L 4A3O 4A3P 5JJW 6CPM 6CRN 6DJ9 6GH9 6GHA 6ML1 7R2G	1X63 2CUP 2CUR 2EGQ
Enriched GO Terms of Interacting Partners?		Post-translational Protein Modification Protein Modification Process Cysteine-type Deubiquitinase Activity Protein Modification By Small Protein Removal Protein Deubiquitination Proteolysis Cysteine-type Peptidase Activity Protein Metabolic Process Macromolecule Metabolic Process Ubiquitin Protein Ligase Activity Proteolysis Involved In Protein Catabolic Process Protein Ubiquitination Peptidase Activity Protein K48-linked Deubiquitination Modification-dependent Protein Catabolic Process Protein Modification By Small Protein Conjugation Ubiquitin-dependent Protein Catabolic Process Macromolecule Catabolic Process Ubiquitin-protein Transferase Activity DeNEDDylase Activity Catabolic Process Zinc Ion Binding Cytosol Protein Polyubiquitination Proteasomal Protein Catabolic Process Cytoplasm Deubiquitinase Activity Protein Catabolic Process Innate Immune Response Ubiquitin Binding Cysteine-type Endopeptidase Activity Immune Response Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Immune System Process Transferase Activity Defense Response To Symbiont Metal Ion Binding Defense Response To Other Organism Response To External Biotic Stimulus Response To Stress Response To Other Organism Hydrolase Activity Protein K63-linked Deubiquitination Protein K48-linked Ubiquitination Regulation Of Signal Transduction Antiviral Innate Immune Response Regulation Of Mitotic Cell Cycle Regulation Of Double-strand Break Repair Via Homologous Recombination Ubiquitin Protein Ligase Binding Regulation Of Double-strand Break Repair	Regulation Of RNA Metabolic Process Negative Regulation Of RNA Biosynthetic Process Regulation Of Nucleobase-containing Compound Metabolic Process Negative Regulation Of DNA-templated Transcription Sarcomere Organization Structural Constituent Of Muscle Negative Regulation Of RNA Metabolic Process Cardiac Myofibril Assembly Regulation Of DNA-templated Transcription Regulation Of RNA Biosynthetic Process Negative Regulation Of Transcription By RNA Polymerase II Regulation Of Transcription By RNA Polymerase II Negative Regulation Of Nucleobase-containing Compound Metabolic Process Cellular Developmental Process Regulation Of Gene Expression Regulation Of Macromolecule Biosynthetic Process Nucleus M Band Aorta Morphogenesis Chromatin Binding Regulation Of Primary Metabolic Process Regulation Of Macromolecule Metabolic Process Regulation Of Metabolic Process Supramolecular Fiber Organization Myofibril Assembly Developmental Process Negative Regulation Of Macromolecule Biosynthetic Process Actin Binding Actomyosin Structure Organization Negative Regulation Of Biosynthetic Process Sex Chromatin Detection Of Muscle Stretch Telethonin Binding Cell Differentiation Negative Regulation Of Metabolic Process Transcription Corepressor Binding Z Disc Dorsal Aorta Morphogenesis Cardiac Muscle Cell Myoblast Differentiation Negative Regulation Of Macromolecule Metabolic Process Artery Morphogenesis Cadherin Binding Regulation Of Timing Of Cell Differentiation Cardioblast Differentiation Cytoskeleton Organization Heart Trabecula Formation Regulation Of Development, Heterochronic Actinin Binding Muscle Tissue Morphogenesis Muscle Alpha-actinin Binding
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