USP15 and OTUB1

Number of citations of the paper that reports this interaction (PMID 22626734)
2

Data Source:
BioGRID (enzymatic study)

		USP15	OTUB1
Gene Name		ubiquitin specific peptidase 15	OTU deubiquitinase, ubiquitin aldehyde binding 1
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Gene Ontology Annotations	Cellular Component	Nucleus Cytoplasm	Cytoplasm Extracellular Vesicular Exosome
	Molecular Function	Cysteine-type Endopeptidase Activity Ubiquitin-specific Protease Activity Transforming Growth Factor Beta Receptor Binding Protein Binding Identical Protein Binding SMAD Binding Ubiquitinated Histone Binding	Ubiquitin-specific Protease Activity Protein Binding NEDD8-specific Protease Activity Ubiquitin Protein Ligase Binding Ubiquitin Binding
	Biological Process	Transforming Growth Factor Beta Receptor Signaling Pathway Protein Deubiquitination BMP Signaling Pathway Negative Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway Monoubiquitinated Protein Deubiquitination Histone H2B Conserved C-terminal Lysine Deubiquitination Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Pathway-restricted SMAD Protein Phosphorylation Regulation Of Proteasomal Protein Catabolic Process	Immune System Process DNA Repair Proteolysis Cellular Response To DNA Damage Stimulus Protein K48-linked Deubiquitination Negative Regulation Of Histone H2A K63-linked Ubiquitination Negative Regulation Of Double-strand Break Repair
Pathways		Loss of Function of TGFBR2 in Cancer TGFBR2 MSI Frameshift Mutants in Cancer SMAD2/3 Phosphorylation Motif Mutants in Cancer Loss of Function of SMAD2/3 in Cancer TGFBR2 Kinase Domain Mutants in Cancer Loss of Function of SMAD4 in Cancer Downregulation of TGF-beta receptor signaling SMAD2/3 MH2 Domain Mutants in Cancer TGFBR1 KD Mutants in Cancer TGF-beta receptor signaling activates SMADs TGFBR1 LBD Mutants in Cancer Loss of Function of TGFBR1 in Cancer Signaling by TGF-beta Receptor Complex Signaling by TGF-beta Receptor Complex in Cancer SMAD4 MH2 Domain Mutants in Cancer
Drugs
Diseases
GWAS		Pulmonary function decline ( 22424883)
Protein-Protein Interactions		45 interactors: BAP1 BMPR1A BRAP CARD9 CCDC57 FHL1 HIST2H2BE JOSD1 MAD1L1 OTUB1 PHF7 PLA2G2A RBCK1 RNF126 RNF144B SART3 SENP3 SENP8 SMAD3 SPDL1 STAM STK33 TRAF6 TRIM17 TRIM21 TRIM25 TRIM46 TRIM5 TRIM54 TRIM63 TRIM74 UBC UBE2S UCHL1 UCHL3 USP14 USP20 USP21 USP28 USP33 USP4 USP51 USP7 USP8 YOD1	32 interactors: ANXA1 ANXA7 BIRC2 CDKN1A ECT2 ESR1 H2AFX KDM1A PJA1 RFFL RHOA RNF126 RNF128 SMAD2 SMAD3 SMAD4 SMAD9 TRAF6 TRIM54 TRIM55 TRIM63 TSC22D1 TTR UBE2D1 UBE2D2 UBE2D3 UBE2D4 UBE2S UBE2V2 USP15 USP21 USP28
Entrez ID		9958	55611
HPRD ID		05293	08493
Ensembl ID		ENSG00000135655
Uniprot IDs		Q9Y4E8	B3KUV5 Q96FW1
PDB IDs		1W6V 3LMN 3PPA 3PV1 3T9L 4A3O 4A3P	2ZFY 3VON 4DDG 4DDI 4DHZ 4I6L 4LDT
Enriched GO Terms of Interacting Partners?		Protein Modification By Small Protein Removal Protein Deubiquitination Ubiquitin-dependent Protein Catabolic Process Modification-dependent Protein Catabolic Process Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Proteasomal Protein Catabolic Process Proteolysis Involved In Cellular Protein Catabolic Process Cellular Protein Catabolic Process Protein Catabolic Process Proteolysis Cellular Macromolecule Catabolic Process Protein K48-linked Deubiquitination Cellular Protein Modification Process Protein Metabolic Process Cellular Protein Metabolic Process Regulation Of Proteasomal Protein Catabolic Process Regulation Of Protein Catabolic Process Catabolic Process Protein Ubiquitination Protein Modification By Small Protein Conjugation Regulation Of Protein Metabolic Process Regulation Of Cellular Protein Metabolic Process Protein K63-linked Deubiquitination Regulation Of Proteolysis Protein Polyubiquitination Histone Deubiquitination Protein K63-linked Ubiquitination Positive Regulation Of I-kappaB Kinase/NF-kappaB Signaling Regulation Of Sequence-specific DNA Binding Transcription Factor Activity Positive Regulation Of Sequence-specific DNA Binding Transcription Factor Activity Positive Regulation Of NF-kappaB Transcription Factor Activity Negative Regulation Of Viral Release From Host Cell Regulation Of I-kappaB Kinase/NF-kappaB Signaling Cellular Metabolic Process Regulation Of Viral Entry Into Host Cell Regulation Of Viral Release From Host Cell Nucleotide-binding Oligomerization Domain Containing Signaling Pathway Response To Stress Regulation Of Protein Ubiquitination Regulation Of Protein Deubiquitination Nucleotide-binding Domain, Leucine Rich Repeat Containing Receptor Signaling Pathway Negative Regulation Of Cellular Protein Metabolic Process Protein Monoubiquitination Protein Autoubiquitination Cell Cycle Negative Regulation Of Epidermal Growth Factor Receptor Signaling Pathway Regulation Of Metabolic Process Pattern Recognition Receptor Signaling Pathway Negative Regulation Of ERBB Signaling Pathway Innate Immune Response-activating Signal Transduction	Protein Polyubiquitination Protein Ubiquitination Protein Modification By Small Protein Conjugation Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Proteasomal Protein Catabolic Process Response To Abiotic Stimulus Transforming Growth Factor Beta Receptor Signaling Pathway Protein Catabolic Process Protein K48-linked Ubiquitination Cellular Protein Modification Process Ubiquitin-dependent Protein Catabolic Process Modification-dependent Protein Catabolic Process Cellular Response To Transforming Growth Factor Beta Stimulus Proteolysis Involved In Cellular Protein Catabolic Process Response To Transforming Growth Factor Beta Cellular Protein Catabolic Process Cellular Response To Growth Factor Stimulus Response To Growth Factor Cellular Macromolecule Catabolic Process Transmembrane Receptor Protein Serine/threonine Kinase Signaling Pathway Protein K63-linked Ubiquitination Response To Organic Substance Cellular Response To Organic Substance Cellular Protein Metabolic Process Enzyme Linked Receptor Protein Signaling Pathway Catabolic Process TRIF-dependent Toll-like Receptor Signaling Pathway MyD88-independent Toll-like Receptor Signaling Pathway Regulation Of Protein Metabolic Process Toll-like Receptor 3 Signaling Pathway Positive Regulation Of Cellular Metabolic Process Response To Stress Protein Metabolic Process BMP Signaling Pathway Regulation Of Metabolic Process Regulation Of Cellular Protein Metabolic Process Toll-like Receptor 4 Signaling Pathway Transcription Initiation From RNA Polymerase II Promoter Response To Hypoxia SMAD Protein Complex Assembly Regulation Of Cellular Process Cellular Metabolic Process Regulation Of Cell Proliferation Cellular Response To Stimulus Proteolysis Regulation Of Cell Death Negative Regulation Of Cell Death Toll-like Receptor Signaling Pathway Regulation Of Cellular Component Organization Response To Stimulus
Tagcloud ?		antitumor bacterial boost challenge characterized class crucial deficiency degradation deubiquitinases dub dubs e3 enhanced induce ligase mdm2 negatively nfatc2 physiological promoted regulated regulator responses stabilized targeting targets turn ubiquitin	2beta accord accordance adenosyl aggressiveness alls calponine classify collections cube daemon dataanalysis deubiquitinating drawing equipped favored i4 lc1200 lists lymphoblastes lymphoblastic lymphoblasts mascot msf myeloblastic ribonucleo septin spots tryptic
Tagcloud (Difference) ?		antitumor bacterial boost challenge characterized class crucial deficiency degradation deubiquitinases dub dubs e3 enhanced induce ligase mdm2 negatively nfatc2 physiological promoted regulated regulator responses stabilized targeting targets turn ubiquitin	2beta accord accordance adenosyl aggressiveness alls calponine classify collections cube daemon dataanalysis deubiquitinating drawing equipped favored i4 lc1200 lists lymphoblastes lymphoblastic lymphoblasts mascot msf myeloblastic ribonucleo septin spots tryptic
Tagcloud (Intersection) ?