USP15 and STK33

Number of citations of the paper that reports this interaction (PMID 22451720)
3

Data Source:
BioGRID (pull down)

		USP15	STK33
Gene Name		ubiquitin specific peptidase 15	serine/threonine kinase 33
Image			No pdb structure
Gene Ontology Annotations	Cellular Component	Nucleus Cytoplasm	Perinuclear Region Of Cytoplasm
	Molecular Function	Cysteine-type Endopeptidase Activity Ubiquitin-specific Protease Activity Transforming Growth Factor Beta Receptor Binding Protein Binding Identical Protein Binding SMAD Binding Ubiquitinated Histone Binding	Protein Serine/threonine Kinase Activity ATP Binding
	Biological Process	Transforming Growth Factor Beta Receptor Signaling Pathway Protein Deubiquitination BMP Signaling Pathway Negative Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway Monoubiquitinated Protein Deubiquitination Histone H2B Conserved C-terminal Lysine Deubiquitination Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Pathway-restricted SMAD Protein Phosphorylation Regulation Of Proteasomal Protein Catabolic Process	Protein Autophosphorylation
Pathways		Loss of Function of TGFBR2 in Cancer TGFBR2 MSI Frameshift Mutants in Cancer SMAD2/3 Phosphorylation Motif Mutants in Cancer Loss of Function of SMAD2/3 in Cancer TGFBR2 Kinase Domain Mutants in Cancer Loss of Function of SMAD4 in Cancer Downregulation of TGF-beta receptor signaling SMAD2/3 MH2 Domain Mutants in Cancer TGFBR1 KD Mutants in Cancer TGF-beta receptor signaling activates SMADs TGFBR1 LBD Mutants in Cancer Loss of Function of TGFBR1 in Cancer Signaling by TGF-beta Receptor Complex Signaling by TGF-beta Receptor Complex in Cancer SMAD4 MH2 Domain Mutants in Cancer
Drugs
Diseases
GWAS		Pulmonary function decline ( 22424883)	Body mass index ( 19079261)
Protein-Protein Interactions		45 interactors: BAP1 BMPR1A BRAP CARD9 CCDC57 FHL1 HIST2H2BE JOSD1 MAD1L1 OTUB1 PHF7 PLA2G2A RBCK1 RNF126 RNF144B SART3 SENP3 SENP8 SMAD3 SPDL1 STAM STK33 TRAF6 TRIM17 TRIM21 TRIM25 TRIM46 TRIM5 TRIM54 TRIM63 TRIM74 UBC UBE2S UCHL1 UCHL3 USP14 USP20 USP21 USP28 USP33 USP4 USP51 USP7 USP8 YOD1	4 interactors: APP GLYCTK USP15 USP5
Entrez ID		9958	65975
HPRD ID		05293	09642
Ensembl ID		ENSG00000135655	ENSG00000130413
Uniprot IDs		Q9Y4E8	Q9BYT3
PDB IDs		1W6V 3LMN 3PPA 3PV1 3T9L 4A3O 4A3P
Enriched GO Terms of Interacting Partners?		Protein Modification By Small Protein Removal Protein Deubiquitination Ubiquitin-dependent Protein Catabolic Process Modification-dependent Protein Catabolic Process Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Proteasomal Protein Catabolic Process Proteolysis Involved In Cellular Protein Catabolic Process Cellular Protein Catabolic Process Protein Catabolic Process Proteolysis Cellular Macromolecule Catabolic Process Protein K48-linked Deubiquitination Cellular Protein Modification Process Protein Metabolic Process Cellular Protein Metabolic Process Regulation Of Proteasomal Protein Catabolic Process Regulation Of Protein Catabolic Process Catabolic Process Protein Ubiquitination Protein Modification By Small Protein Conjugation Regulation Of Protein Metabolic Process Regulation Of Cellular Protein Metabolic Process Protein K63-linked Deubiquitination Regulation Of Proteolysis Protein Polyubiquitination Histone Deubiquitination Protein K63-linked Ubiquitination Positive Regulation Of I-kappaB Kinase/NF-kappaB Signaling Regulation Of Sequence-specific DNA Binding Transcription Factor Activity Positive Regulation Of Sequence-specific DNA Binding Transcription Factor Activity Positive Regulation Of NF-kappaB Transcription Factor Activity Negative Regulation Of Viral Release From Host Cell Regulation Of I-kappaB Kinase/NF-kappaB Signaling Cellular Metabolic Process Regulation Of Viral Entry Into Host Cell Regulation Of Viral Release From Host Cell Nucleotide-binding Oligomerization Domain Containing Signaling Pathway Response To Stress Regulation Of Protein Ubiquitination Regulation Of Protein Deubiquitination Nucleotide-binding Domain, Leucine Rich Repeat Containing Receptor Signaling Pathway Negative Regulation Of Cellular Protein Metabolic Process Protein Monoubiquitination Protein Autoubiquitination Cell Cycle Negative Regulation Of Epidermal Growth Factor Receptor Signaling Pathway Regulation Of Metabolic Process Pattern Recognition Receptor Signaling Pathway Negative Regulation Of ERBB Signaling Pathway Innate Immune Response-activating Signal Transduction	Regulation Of Proteolysis Protein Deubiquitination Protein Modification By Small Protein Removal Synaptic Growth At Neuromuscular Junction Histone H2B Conserved C-terminal Lysine Deubiquitination Cellular Protein Modification Process Regulation Of Proteasomal Protein Catabolic Process Collateral Sprouting In Absence Of Injury Protein Phosphorylation Collateral Sprouting Axon Midline Choice Point Recognition Positive Regulation Of Proteolysis Smooth Endoplasmic Reticulum Calcium Ion Homeostasis Axon Choice Point Recognition Cellular Protein Metabolic Process Neuron Remodeling Monoubiquitinated Protein Deubiquitination Regulation Of Protein Catabolic Process Phosphorylation Regulation Of Cellular Protein Metabolic Process Pathway-restricted SMAD Protein Phosphorylation Ubiquitin-dependent Protein Catabolic Process Modification-dependent Protein Catabolic Process Protein K48-linked Deubiquitination Regulation Of Protein Metabolic Process Protein Metabolic Process Cellular Copper Ion Homeostasis Proteolysis Involved In Cellular Protein Catabolic Process Histone Deubiquitination Cellular Protein Catabolic Process Copper Ion Homeostasis Suckling Behavior Protein Catabolic Process Positive Regulation Of G2/M Transition Of Mitotic Cell Cycle Neuron Maturation MRNA Polyadenylation Regulation Of Epidermal Growth Factor-activated Receptor Activity Mating Behavior Endoplasmic Reticulum Calcium Ion Homeostasis RNA Polyadenylation Neuron Recognition Phosphate-containing Compound Metabolic Process Nucleotide-binding Domain, Leucine Rich Repeat Containing Receptor Signaling Pathway Cellular Macromolecule Catabolic Process Ionotropic Glutamate Receptor Signaling Pathway Regulation Of G2/M Transition Of Mitotic Cell Cycle Regulation Of Cell Cycle G2/M Phase Transition Axon Cargo Transport Mating Neuromuscular Junction Development
Tagcloud ?		antitumor bacterial boost challenge characterized class crucial deficiency degradation deubiquitinases dub dubs e3 enhanced induce ligase mdm2 negatively nfatc2 physiological promoted regulated regulator responses stabilized targeting targets turn ubiquitin
Tagcloud (Difference) ?		antitumor bacterial boost challenge characterized class crucial deficiency degradation deubiquitinases dub dubs e3 enhanced induce ligase mdm2 negatively nfatc2 physiological promoted regulated regulator responses stabilized targeting targets turn ubiquitin
Tagcloud (Intersection) ?