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USP15 and SENP3
Number of citations of the paper that reports this interaction (PubMedID
22626734
)
34
Data Source:
BioGRID
(enzymatic study)
USP15
SENP3
Description
ubiquitin specific peptidase 15
SUMO specific peptidase 3
Image
No pdb structure
GO Annotations
Cellular Component
Nucleus
Nucleoplasm
Cytoplasm
Mitochondrion
Cytosol
Nuclear Body
Nucleus
Nucleoplasm
Nucleolus
Cytoplasm
Nuclear Body
MLL1 Complex
Molecular Function
Catalytic Activity
Cysteine-type Endopeptidase Activity
Cysteine-type Deubiquitinase Activity
Transforming Growth Factor Beta Receptor Binding
Protein Binding
Peptidase Activity
Cysteine-type Peptidase Activity
Hydrolase Activity
Identical Protein Binding
SMAD Binding
Ubiquitin-modified Histone Reader Activity
Deubiquitinase Activity
K48-linked Deubiquitinase Activity
Cysteine-type Deubiquitinase Activity
Protein Binding
Peptidase Activity
Cysteine-type Peptidase Activity
Hydrolase Activity
DeSUMOylase Activity
Biological Process
Proteolysis
Transforming Growth Factor Beta Receptor Signaling Pathway
Protein Deubiquitination
BMP Signaling Pathway
Negative Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway
Monoubiquitinated Protein Deubiquitination
Positive Regulation Of Canonical NF-kappaB Signal Transduction
Regulation Of RNA Metabolic Process
Transcription Elongation-coupled Chromatin Remodeling
Positive Regulation Of RIG-I Signaling Pathway
Regulation Of Intrinsic Apoptotic Signaling Pathway In Response To Osmotic Stress By P53 Class Mediator
Negative Regulation Of Antifungal Innate Immune Response
Protein K27-linked Deubiquitination
Proteolysis
Protein Desumoylation
Negative Regulation Of Double-strand Break Repair Via Homologous Recombination
Pathways
Downregulation of TGF-beta receptor signaling
UCH proteinases
Ub-specific processing proteases
Major pathway of rRNA processing in the nucleolus and cytosol
Drugs
Diseases
GWAS
Alopecia areata (
25608926
)
Metabolite levels (
23823483
)
Platelet distribution width (
32888494
)
Plateletcrit (
27863252
32888494
)
Pulmonary function decline (
22424883
)
Pyoderma gangrenosum in inflammatory bowel disease (
24487271
)
Brain morphology (MOSTest) (
32665545
)
IgM levels (
23118916
)
Refractive error (
32231278
)
Serum metabolite levels (
33031748
)
Interacting Genes
61 interacting genes:
BAP1
BMI1
BMPR1A
BRAP
CARD9
CCDC57
CDC73
CSNK1A1
FHL1
GEMIN4
GLUL
GOLGA2
GOLGA6A
GSPT1
H2BC21
IL1R2
JOSD1
KEAP1
MAD1L1
MDC1
MDM2
OTUB1
PARP1
PHF7
PIBF1
PLA2G2A
PRPF31
RBCK1
RIGI
RNF126
RNF144B
RNF26
SENP3
SENP8
SMURF2
SPDL1
STAM
STK33
SYVN1
TEX11
TRAF6
TRIM17
TRIM21
TRIM25
TRIM46
TRIM5
TRIM54
TRIM63
TRIM74
UBC
UCHL1
UCHL3
USP14
USP2
USP20
USP21
USP28
USP33
USP51
USP8
YOD1
20 interacting genes:
ADRB2
ATF7IP
BECN1
CDCA8
CDK4
CDK6
CEP19
DNM1L
EP300
HIC1
MED25
MTHFD1
NPM1
PARP1
PELP1
SUMO2
TRIM54
TRIM63
USP15
USP21
Entrez ID
9958
26168
HPRD ID
05293
08339
Ensembl ID
ENSG00000135655
ENSG00000161956
Uniprot IDs
Q9Y4E8
Q9H4L4
PDB IDs
1W6V
3LMN
3PPA
3PV1
3T9L
4A3O
4A3P
5JJW
6CPM
6CRN
6DJ9
6GH9
6GHA
6ML1
7R2G
Enriched GO Terms of Interacting Partners
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Post-translational Protein Modification
Protein Modification Process
Cysteine-type Deubiquitinase Activity
Protein Modification By Small Protein Removal
Protein Deubiquitination
Proteolysis
Cysteine-type Peptidase Activity
Protein Metabolic Process
Macromolecule Metabolic Process
Ubiquitin Protein Ligase Activity
Proteolysis Involved In Protein Catabolic Process
Protein Ubiquitination
Peptidase Activity
Protein K48-linked Deubiquitination
Modification-dependent Protein Catabolic Process
Protein Modification By Small Protein Conjugation
Ubiquitin-dependent Protein Catabolic Process
Macromolecule Catabolic Process
Ubiquitin-protein Transferase Activity
DeNEDDylase Activity
Catabolic Process
Zinc Ion Binding
Cytosol
Protein Polyubiquitination
Proteasomal Protein Catabolic Process
Cytoplasm
Deubiquitinase Activity
Protein Catabolic Process
Innate Immune Response
Ubiquitin Binding
Cysteine-type Endopeptidase Activity
Immune Response
Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process
Immune System Process
Transferase Activity
Defense Response To Symbiont
Metal Ion Binding
Defense Response To Other Organism
Response To External Biotic Stimulus
Response To Stress
Response To Other Organism
Hydrolase Activity
Protein K63-linked Deubiquitination
Protein K48-linked Ubiquitination
Regulation Of Signal Transduction
Antiviral Innate Immune Response
Regulation Of Mitotic Cell Cycle
Regulation Of Double-strand Break Repair Via Homologous Recombination
Ubiquitin Protein Ligase Binding
Regulation Of Double-strand Break Repair
Regulation Of Nucleobase-containing Compound Metabolic Process
Regulation Of ATP Metabolic Process
Regulation Of Purine Nucleotide Metabolic Process
Transcription Regulator Complex
Nucleoplasm
Regulation Of Signal Transduction By P53 Class Mediator
Regulation Of RNA Metabolic Process
Protein-DNA Complex
Regulation Of Primary Metabolic Process
Regulation Of Transcription By RNA Polymerase II
Regulation Of Organelle Organization
Positive Regulation Of RNA Biosynthetic Process
Regulation Of DNA-templated Transcription
Regulation Of RNA Biosynthetic Process
Regulation Of Metabolic Process
Positive Regulation Of DNA-templated Transcription
Positive Regulation Of Attachment Of Mitotic Spindle Microtubules To Kinetochore
Regulation Of Attachment Of Mitotic Spindle Microtubules To Kinetochore
Chromatin Remodeling
Regulation Of Cardiac Muscle Hypertrophy
Positive Regulation Of Attachment Of Spindle Microtubules To Kinetochore
Positive Regulation Of RNA Metabolic Process
Nucleus
Regulation Of Metaphase Plate Congression
Cellular Response To UV
Regulation Of Fibroblast Proliferation
Regulation Of Muscle System Process
Protein-containing Complex
Negative Regulation Of Nucleobase-containing Compound Metabolic Process
Positive Regulation Of Intracellular Signal Transduction
Positive Regulation Of Nucleobase-containing Compound Metabolic Process
Positive Regulation Of Protein Localization To Nucleus
Positive Regulation Of Cell Cycle Process
Positive Regulation Of Macromolecule Biosynthetic Process
Cellular Response To Light Stimulus
Chromatin Organization
Regulation Of Cellular Response To Stress
Negative Regulation Of Small Molecule Metabolic Process
Regulation Of Attachment Of Spindle Microtubules To Kinetochore
Positive Regulation Of Biosynthetic Process
Positive Regulation Of Transcription By RNA Polymerase II
Regulation Of Cell Cycle G2/M Phase Transition
Ubiquitin Protein Ligase Binding
Negative Regulation Of ATP Metabolic Process
Regulation Of Phosphorus Metabolic Process
Mononuclear Cell Differentiation
Regulation Of Gene Expression
Cyclin-dependent Protein Serine/threonine Kinase Activity
Regulation Of Macromolecule Metabolic Process
Regulation Of Small Molecule Metabolic Process
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