SEPTIN7 and PCNT

Number of citations: 83 (PubMedID 35914814)
Data Source: BioGRID (two hybrid)

		SEPTIN7	PCNT
Name		septin 7	pericentrin
Structure			No pdb structure
GO Annotations	Cellular Component	Chromosome, Centromeric Region Kinetochore Stress Fiber Nucleus Chromosome Cytoplasm Spindle Cytosol Cytoskeleton Cilium Axoneme Septin Ring Microtubule Cytoskeleton Apical Plasma Membrane Midbody Septin Complex Motile Cilium Cell Division Site Cleavage Furrow Cell Projection Extracellular Exosome Sperm Annulus Non-motile Cilium	Cytoplasm Centrosome Centriole Microtubule Organizing Center Cytosol Cytoskeleton Microtubule Membrane Centriolar Satellite
	Molecular Function	Nucleotide Binding GTPase Activity Structural Molecule Activity Protein Binding GTP Binding Identical Protein Binding Cadherin Binding Molecular Adaptor Activity	Protein Binding Calmodulin Binding Molecular Adaptor Activity
	Biological Process	Spermatogenesis Intracellular Protein Localization Regulation Of Embryonic Cell Shape Cell Differentiation Cell Division Cilium Assembly Cytoskeleton-dependent Cytokinesis Positive Regulation Of Non-motile Cilium Assembly	Microtubule Cytoskeleton Organization Microtubule Nucleation Mitotic Spindle Organization Signal Transduction Cilium Assembly Positive Regulation Of Intracellular Protein Transport
Pathways		MAPK6/MAPK4 signaling	Regulation of PLK1 Activity at G2/M Transition Loss of Nlp from mitotic centrosomes Recruitment of mitotic centrosome proteins and complexes Loss of proteins required for interphase microtubule organization from the centrosome Recruitment of NuMA to mitotic centrosomes Anchoring of the basal body to the plasma membrane AURKA Activation by TPX2 Chaperone Mediated Autophagy Late endosomal microautophagy Aggrephagy Aggrephagy
Diseases		None	Microcephalic osteodysplastic primordial dwarfism, type II (MOPD II) Seckel syndrome
GWAS		No GWAS studies recorded	Heel bone mineral density ( 30598549 ) Pre-treatment viral load in HIV-1 infection ( 31219150 ) S100 calcium-binding protein levels ( 33227023 ) Treatment resistant depression ( 30468137 )
Interacting Genes		15 interacting genes: ANLN CDC42EP2 CDC42EP3 CDC42EP5 CENPE GRIK1 HDAC6 LINC01554 OGT PCNT REL S100A4 SEPTIN11 SEPTIN5 SEPTIN9	55 interacting genes: AKAP6 AKAP9 ANKRD24 ARHGAP21 CALM1 CALM2 CCP110 CEP55 CEP85L CYTH1 DISC1 DMXL2 DNM1 DNM2 DNM3 DST EIF4G3 FEZ1 HMOX2 HUWE1 KALRN KIF1A KIF5C MACF1 MADD MAP1LC3A MAP1LC3B MRFAP1 MYT1L NECAB1 NIPBL ODF2L PARVB PCM1 PNISR RPRD1A RRBP1 RTRAF SEPTIN7 SHTN1 SPTAN1 SPTBN1 SPTBN2 SRGAP2 ST18 SYNE1 TP53BP1 TRAF3IP1 TUBG1 TUBGCP2 TUBGCP3 UTRN YWHAH YWHAZ YY1AP1
Entrez ID		989	5116
HPRD ID		04398	05804
Ensembl ID		ENSG00000122545	ENSG00000160299
Uniprot IDs		A0A023T695 A0A024RA87 A8K3D0 B4DNE4 G3V1Q4 Q16181	O95613
PDB IDs		2QAG 3T5D 3TW4 6N0B 6N12 6UQQ 7M6J 8SJJ	Not available
GO Terms Enriched among Interactors		Microtubule Cytoskeleton Cytoskeleton Positive Regulation Of Plasma Membrane Bounded Cell Projection Assembly Septin Ring Septin Complex Positive Regulation Of Pseudopodium Assembly Cell Division Site Positive Regulation Of Cell Projection Organization Cytoskeleton-dependent Cytokinesis Regulation Of Cell Projection Assembly Positive Regulation Of Cellular Component Biogenesis Septin Cytoskeleton Organization Positive Regulation Of Actin Filament Polymerization Regulation Of Plasma Membrane Bounded Cell Projection Organization Regulation Of Cell Projection Organization Molecular Adaptor Activity Regulation Of Protein-containing Complex Assembly Positive Regulation Of Protein-containing Complex Assembly Rho Protein Signal Transduction Cell Division Regulation Of Cell Morphogenesis Positive Regulation Of Protein Polymerization Membraneless Organelle Assembly Regulation Of Actin Filament Polymerization Microtubule Regulation Of Cell Shape Positive Regulation Of Cellular Component Organization Regulation Of Actin Polymerization Or Depolymerization Regulation Of Actin Filament Length Organelle Assembly Regulation Of Supramolecular Fiber Organization Regulation Of Organelle Organization Cytoplasm Positive Regulation Of Supramolecular Fiber Organization Regulation Of Cellular Component Organization Positive Regulation Of Cytoskeleton Organization Intracellular Signaling Cassette Microtubule Plus-end Directed Mitotic Chromosome Migration Lateral Attachment Of Mitotic Spindle Microtubules To Kinetochore Protein N-acetylglucosaminyltransferase Complex Negative Regulation Of Non-canonical Inflammasome Complex Assembly Polyubiquitinated Misfolded Protein Transport Positive Regulation Of Cholangiocyte Proliferation Positive Regulation Of Organelle Organization Cytoskeletal Regulatory Protein Binding Septin Ring Assembly Regulation Of Cytoskeleton Organization Mitophagy Cytoskeleton Organization Regulation Of Cellular Component Size	Cytoskeleton Microtubule Cell Projection Organelle Organization Cytoplasm Centrosome Microtubule Binding Cell Projection Organization Synaptic Vesicle Budding From Presynaptic Endocytic Zone Membrane Microtubule-based Process Actin Binding Centriole Cytoskeleton Organization Plasma Membrane Bounded Cell Projection Organization Spectrin Identical Protein Binding Microtubule Nucleation Gamma-tubulin Complex Cell Projection Assembly Cellular Component Assembly Transmembrane Transporter Binding Negative Regulation Of Ryanodine-sensitive Calcium-release Channel Activity Vesicle Scission Microtubule Minus-end Binding Ciliary Basal Body Microtubule Organizing Center Structural Constituent Of Cytoskeleton Transport Along Microtubule Microtubule Cytoskeleton Cytosol Plasma Membrane Bounded Cell Projection Assembly Organelle Localization Sarcomere Establishment Of Organelle Localization Cell Leading Edge Pericentriolar Material Cytoskeleton-dependent Intracellular Transport Cytoplasmic Microtubule Organization Actin Filament Binding Regulation Of Ryanodine-sensitive Calcium-release Channel Activity Negative Regulation Of Calcium Ion Export Across Plasma Membrane Adenylate Cyclase Activator Activity Calcium Channel Complex Polar Microtubule Actin Filament-based Process Microtubule-based Transport Cadherin Binding Regulation Of Cellular Component Organization Negative Regulation Of Release Of Sequestered Calcium Ion Into Cytosol Transporter Inhibitor Activity