SEPT7 and CDC42EP3

Number of citations of the paper that reports this interaction (PMID 11584266)
38

Data Source:
BioGRID (pull down)

		SEPT7	CDC42EP3
Gene Name		septin 7	CDC42 effector protein (Rho GTPase binding) 3
Image			No pdb structure
Gene Ontology Annotations	Cellular Component	Condensed Chromosome Kinetochore Stress Fiber Nucleus Nucleolus Cytoplasm Spindle Plasma Membrane Axoneme Cell Cortex Actin Cytoskeleton Microtubule Cytoskeleton Apical Plasma Membrane Midbody Cleavage Furrow Axon Terminus Synapse Extracellular Vesicular Exosome	Cytoplasm Plasma Membrane Endomembrane System Actin Cytoskeleton
	Molecular Function	Structural Molecule Activity Protein Binding GTP Binding Identical Protein Binding	Rho GTPase Activator Activity Cytoskeletal Regulatory Protein Binding GTP-Rho Binding
	Biological Process	Cytokinesis Mitotic Nuclear Division Regulation Of Embryonic Cell Shape Protein Heterooligomerization Cilium Morphogenesis	Signal Transduction Rho Protein Signal Transduction Regulation Of Cell Shape Positive Regulation Of Actin Filament Polymerization Positive Regulation Of Pseudopodium Assembly Positive Regulation Of Rho GTPase Activity
Pathways
Drugs
Diseases
GWAS			Height ( 20881960 23563607) Total ventricular volume ( 21116278)
Protein-Protein Interactions		11 interactors: ANLN CDC42EP2 CDC42EP3 CDC42EP5 CENPE REL S100A4 SEPT10 SEPT11 SEPT5 SEPT9	7 interactors: CDC42 RHOQ SEPT6 SEPT7 SNCA SRPK1 UMPS
Entrez ID		989	10602
HPRD ID		04398	09364
Ensembl ID			ENSG00000163171
Uniprot IDs		A8K3D0 B4DNE4 Q16181	Q9UKI2
PDB IDs		2QAG 3T5D 3TW4
Enriched GO Terms of Interacting Partners?		Cell Division Positive Regulation Of Pseudopodium Assembly Cell Cycle Positive Regulation Of Actin Filament Polymerization Regulation Of Cell Projection Assembly Positive Regulation Of Protein Polymerization Regulation Of Organelle Organization Regulation Of Cell Shape Positive Regulation Of Protein Complex Assembly Regulation Of Actin Filament Polymerization Positive Regulation Of Cytoskeleton Organization Regulation Of Actin Polymerization Or Depolymerization Regulation Of Actin Filament Length Positive Regulation Of Rho GTPase Activity Regulation Of Rho GTPase Activity Positive Regulation Of Cell Projection Organization Rho Protein Signal Transduction Positive Regulation Of Cellular Component Biogenesis Regulation Of Cellular Component Size Regulation Of Protein Complex Assembly Regulation Of Rho Protein Signal Transduction Septin Ring Assembly Regulation Of Actin Cytoskeleton Organization Regulation Of Intracellular Signal Transduction Positive Regulation Of Organelle Organization Regulation Of Actin Filament-based Process Positive Regulation Of Ras GTPase Activity Protein Complex Assembly Septin Cytoskeleton Organization Regulation Of Cellular Component Organization Cytokinesis Regulation Of Cell Morphogenesis Regulation Of Signaling Regulation Of Cell Projection Organization Regulation Of Cytoskeleton Organization Mitotic Chromosome Movement Towards Spindle Pole Glomerular Visceral Epithelial Cell Migration Regulation Of Mitotic Nuclear Division Regulation Of Ras GTPase Activity Protein Heterooligomerization Attachment Of Mitotic Spindle Microtubules To Kinetochore Regulation Of Ras Protein Signal Transduction Positive Regulation Of I-kappaB Kinase/NF-kappaB Signaling Synaptic Vesicle Targeting Positive Regulation Of GTPase Activity Positive Regulation Of Catalytic Activity Regulation Of Small GTPase Mediated Signal Transduction Ras Protein Signal Transduction Regulation Of GTPase Activity Regulation Of I-kappaB Kinase/NF-kappaB Signaling	Regulation Of Filopodium Assembly Positive Regulation Of Peptidyl-serine Phosphorylation Regulation Of Cell Morphogenesis Negative Regulation Of Thrombin Receptor Signaling Pathway Positive Regulation Of Hydrogen Peroxide Catabolic Process Positive Regulation Of Glutathione Peroxidase Activity Negative Regulation Of Dopamine Uptake Involved In Synaptic Transmission Negative Regulation Of Norepinephrine Uptake Regulation Of Cytoskeleton Organization Regulation Of Peptidyl-serine Phosphorylation Cytokinesis Regulation Of Cell Projection Assembly Negative Regulation Of Mitochondrial Electron Transport, NADH To Ubiquinone Regulation Of Embryonic Cell Shape Positive Regulation Of Hair Follicle Cell Proliferation Negative Regulation Of Protein Complex Assembly Regulation Of Protein Stability Organelle Organization Regulation Of Microtubule Cytoskeleton Organization Negative Regulation Of Dopamine Metabolic Process Submandibular Salivary Gland Formation Dopamine Uptake Involved In Synaptic Transmission Negative Regulation Of Serotonin Uptake Actin Filament Branching Negative Regulation Of Cellular Respiration 'de Novo' UMP Biosynthetic Process Positive Regulation Of Transport Regulation Of Cell Shape Regulation Of Microtubule-based Process Negative Regulation Of Synaptic Transmission, Dopaminergic Negative Regulation Of Oxidative Phosphorylation Regulation Of Hair Follicle Cell Proliferation Positive Regulation Of Synapse Structural Plasticity Innate Immune Response Regulation Of Cellular Component Organization Establishment Of Golgi Localization Response To Iron(II) Ion Cellular Response To Copper Ion Regulation Of Organelle Organization Positive Regulation Of Metalloenzyme Activity Positive Regulation Of Intracellular Transport Regulation Of Neuron Apoptotic Process Regulation Of Synaptic Vesicle Recycling 'de Novo' Pyrimidine Nucleobase Biosynthetic Process Epithelial-mesenchymal Cell Signaling Neuron Fate Determination Regulation Of Cellular Localization Sperm Chromatin Condensation Regulation Of Protein Heterodimerization Activity Regulation Of Dopamine Uptake Involved In Synaptic Transmission
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