TOMM20 and CDC73

Number of citations of the paper that reports this interaction (PubMedID 16169070)
0

Data Source:
HPRD (two hybrid)

		TOMM20	CDC73
Description		translocase of outer mitochondrial membrane 20	cell division cycle 73
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GO Annotations	Cellular Component	Mitochondrion Mitochondrial Envelope Mitochondrial Outer Membrane Mitochondrial Outer Membrane Translocase Complex Membrane Mitochondria-associated Endoplasmic Reticulum Membrane Contact Site Cell Periphery Sperm Midpiece Migrasome TOM Complex	Chromosome, Telomeric Region Nucleus Nucleoplasm Cytosol Cdc73/Paf1 Complex
	Molecular Function	Protein Binding Protein Transmembrane Transporter Activity Protein-transporting ATPase Activity Mitochondrion Targeting Sequence Binding Unfolded Protein Binding	RNA Polymerase II Complex Binding Protein Binding
	Biological Process	Protein Targeting Protein Targeting To Mitochondrion Intracellular Protein Transport Protein Transport TRNA Import Into Mitochondrion Protein Import Into Mitochondrial Matrix Protein Insertion Into Mitochondrial Outer Membrane	Negative Regulation Of Transcription By RNA Polymerase II Regulation Of Cell Growth Endodermal Cell Fate Commitment Regulation Of Transcription By RNA Polymerase II Transcription Elongation By RNA Polymerase II Negative Regulation Of Cell Population Proliferation Wnt Signaling Pathway Stem Cell Population Maintenance Positive Regulation Of Wnt Signaling Pathway MRNA 3'-end Processing Positive Regulation Of MRNA 3'-end Processing Protein Destabilization Positive Regulation Of Transcription Elongation By RNA Polymerase II Negative Regulation Of Apoptotic Process Negative Regulation Of Myeloid Cell Differentiation Positive Regulation Of Transcription By RNA Polymerase II Negative Regulation Of Fibroblast Proliferation Negative Regulation Of Epithelial Cell Proliferation Cellular Response To Lipopolysaccharide Positive Regulation Of Cell Cycle G1/S Phase Transition Negative Regulation Of G1/S Transition Of Mitotic Cell Cycle
Pathways		Mitochondrial protein import PINK1-PRKN Mediated Mitophagy Ub-specific processing proteases	Formation of RNA Pol II elongation complex Formation of the beta-catenin:TCF transactivating complex Hedgehog 'on' state RNA Polymerase II Pre-transcription Events RNA Polymerase II Transcription Elongation E3 ubiquitin ligases ubiquitinate target proteins
Drugs
Diseases			Primary hyperparathyroidism; Familial hyperparathyroidism (HRPT)
GWAS		Apolipoprotein A1 levels ( 32203549) Cholesterol, total ( 20686565) Cobalt levels ( 26025379) Immune reponse to smallpox (secreted IL-2) ( 22610502) LDL cholesterol ( 20686565) LDL cholesterol levels ( 32203549) Night sleep phenotypes ( 27126917) Obesity-related traits ( 23251661) Serum alkaline phosphatase levels ( 33547301)	Chronotype ( 30696823) High density lipoprotein cholesterol levels ( 34074324) Ovarian disease with few adhesions ( 28333195) Photic sneeze reflex ( 27182965) Subcutaneous adipose tissue ( 22589738) Takayasu arteritis ( 25604533) White matter hyperintensity burden ( 25663218)
Interacting Genes		22 interacting genes: AIP APOA1 ATXN1 BAG6 BCL2 CDC73 CEP126 DHFR FBXO7 FEZ1 HAP1 HSD17B10 OTC PINK1 PPHLN1 PTN RECQL4 SNCA TOMM22 UCP1 USP40 VDAC1	45 interacting genes: ALAS1 ANXA6 CEP70 CLTCL1 CTNNB1 DDAH2 DES DMPK EEA1 FAF1 FHL2 FSD2 GC GOLGA2 GOLGA6L9 H1-2 HAP1 HSF2BP HSPA4 ITFG1 KASH5 KCNH2 KIAA1549 KIDINS220 MCM3AP MTUS2 MYC PICK1 PITHD1 PTPN11 RABEP1 RNF20 RNF40 TCEA1 TCF4 TFCP2 TOMM20 TRIM23 TSGA10 USP12 USP15 USP25 USP28 VPS37B WWC1
Entrez ID		9804	79577
HPRD ID		03507	09581
Ensembl ID		ENSG00000173726	ENSG00000134371
Uniprot IDs		Q15388	Q6P1J9
PDB IDs		4APO 7VBY 7VC9 8XVA 9EIH 9EII 9EIJ	5YDE 5YDF 6TED 7OOP 7OPC 7OPD 7UNC 7UND 8A3Y 9EGX 9EGY 9EGZ 9EH0 9EH2
Enriched GO Terms of Interacting Partners?		Regulation Of Protein Stability Mitochondrion Organization Regulation Of Reactive Oxygen Species Metabolic Process Mitochondrion Establishment Of Protein Localization To Mitochondrion Mitochondrial Outer Membrane Neuron Projection Regeneration Regulation Of Autophagy Positive Regulation Of Mitophagy Positive Regulation Of Autophagy Of Mitochondrion Protein Targeting Protein Targeting To Mitochondrion Negative Regulation Of Autophagy Mitochondrial Transport Growth Cone Regulation Of Mitophagy Regulation Of Calcium Ion Transmembrane Transport Negative Regulation Of Metabolic Process Regulation Of Autophagy Of Mitochondrion Negative Regulation Of Neuron Apoptotic Process Establishment Of Protein Localization To Organelle Regulation Of Organelle Transport Along Microtubule Negative Regulation Of Apoptotic Process Negative Regulation Of G1/S Transition Of Mitotic Cell Cycle Negative Regulation Of Cell Cycle G1/S Phase Transition Negative Regulation Of Programmed Cell Death Positive Regulation Of Type 2 Mitophagy Negative Regulation Of Catabolic Process Regulation Of Macroautophagy Negative Regulation Of Autophagosome Assembly Pore Complex Regulation Of Biological Quality Negative Regulation Of Oxidative Stress-induced Neuron Intrinsic Apoptotic Signaling Pathway Regulation Of Calcium Ion Transport Regulation Of Hydrogen Peroxide Metabolic Process Inclusion Body Positive Regulation Of Macroautophagy Regulation Of Neuron Apoptotic Process Axon Regeneration Regulation Of Monoatomic Cation Transmembrane Transport Regulation Of Cellular Response To Oxidative Stress Dopamine Transport Regulation Of Oxidative Phosphorylation Mitochondrial Transmembrane Transport Regulation Of Oxidative Stress-induced Neuron Intrinsic Apoptotic Signaling Pathway Negative Regulation Of Intrinsic Apoptotic Signaling Pathway Mitochondrial Membrane Organization Cellular Localization Regulation Of Dopamine Secretion Establishment Of Localization In Cell	Deubiquitinase Activity Ubiquitin Protein Ligase Binding Beta-catenin-TCF7L2 Complex Neurotrophin Signaling Pathway HULC Complex Cysteine-type Deubiquitinase Activity Identical Protein Binding Protein Deubiquitination Fascia Adherens Protein Modification By Small Protein Removal
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