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TOMM20 and BCL2
Number of citations of the paper that reports this interaction (PMID
9119086
)
5
Data Source:
HPRD
(in vitro)
TOMM20
BCL2
Gene Name
translocase of outer mitochondrial membrane 20 homolog (yeast)
B-cell CLL/lymphoma 2
Image
Gene Ontology Annotations
Cellular Component
Mitochondrion
Mitochondrial Outer Membrane Translocase Complex
Integral Component Of Membrane
ER-mitochondrion Membrane Contact Site
Nucleus
Cytoplasm
Mitochondrion
Mitochondrial Outer Membrane
Endoplasmic Reticulum
Endoplasmic Reticulum Membrane
Cytosol
Membrane
Nuclear Membrane
Myelin Sheath
Pore Complex
Molecular Function
Protein Binding
P-P-bond-hydrolysis-driven Protein Transmembrane Transporter Activity
Unfolded Protein Binding
Protease Binding
Protein Binding
Transcription Factor Binding
Channel Activity
Channel Inhibitor Activity
Ubiquitin Protein Ligase Binding
Identical Protein Binding
Protein Homodimerization Activity
Sequence-specific DNA Binding
Protein Heterodimerization Activity
BH3 Domain Binding
Protein Phosphatase 2A Binding
Biological Process
Protein Targeting To Mitochondrion
Cellular Protein Metabolic Process
Protein Transmembrane Transport
Protein Polyubiquitination
Ossification
Ovarian Follicle Development
Metanephros Development
Branching Involved In Ureteric Bud Morphogenesis
Behavioral Fear Response
B Cell Homeostasis
Release Of Cytochrome C From Mitochondria
Regulation Of Cell-matrix Adhesion
Lymphoid Progenitor Cell Differentiation
B Cell Lineage Commitment
Response To Ischemia
Renal System Process
Protein Dephosphorylation
Melanin Metabolic Process
Regulation Of Nitrogen Utilization
Apoptotic Process
Humoral Immune Response
Cellular Response To DNA Damage Stimulus
Actin Filament Organization
Axonogenesis
Female Pregnancy
Cell Aging
Male Gonad Development
Extrinsic Apoptotic Signaling Pathway Via Death Domain Receptors
Intrinsic Apoptotic Signaling Pathway In Response To DNA Damage
Intrinsic Apoptotic Signaling Pathway In Response To Oxidative Stress
Response To Radiation
Response To Toxic Substance
Post-embryonic Development
Response To Iron Ion
Response To UV-B
Response To Gamma Radiation
Negative Regulation Of Autophagy
Negative Regulation Of Calcium Ion Transport Into Cytosol
Regulation Of Glycoprotein Biosynthetic Process
Mesenchymal Cell Development
Positive Regulation Of Neuron Maturation
Positive Regulation Of Smooth Muscle Cell Migration
Cell Growth
Peptidyl-serine Phosphorylation
Peptidyl-threonine Phosphorylation
Cochlear Nucleus Development
Gland Morphogenesis
Regulation Of Transmembrane Transporter Activity
Negative Regulation Of Ossification
Positive Regulation Of Cell Growth
Negative Regulation Of Cell Growth
Melanocyte Differentiation
Negative Regulation Of Cell Migration
Positive Regulation Of B Cell Proliferation
Hair Follicle Morphogenesis
Axon Regeneration
Regulation Of Protein Stability
Endoplasmic Reticulum Calcium Ion Homeostasis
Glomerulus Development
Negative Regulation Of Cellular PH Reduction
Negative Regulation Of Myeloid Cell Apoptotic Process
T Cell Differentiation In Thymus
Positive Regulation Of Peptidyl-serine Phosphorylation
Negative Regulation Of Osteoblast Proliferation
Response To Cytokine
Response To Nicotine
Organ Growth
Nucleotide-binding Domain, Leucine Rich Repeat Containing Receptor Signaling Pathway
Positive Regulation Of Multicellular Organism Growth
B Cell Proliferation
Cellular Response To Glucose Starvation
Response To Drug
Response To Hydrogen Peroxide
T Cell Homeostasis
Negative Regulation Of Apoptotic Process
Positive Regulation Of Catalytic Activity
CD8-positive, Alpha-beta T Cell Lineage Commitment
Regulation Of Protein Homodimerization Activity
Regulation Of Protein Heterodimerization Activity
Negative Regulation Of Neuron Apoptotic Process
Ear Development
Regulation Of Viral Genome Replication
Innate Immune Response
Positive Regulation Of Melanocyte Differentiation
Negative Regulation Of Retinal Cell Programmed Cell Death
Regulation Of Mitochondrial Membrane Permeability
Focal Adhesion Assembly
Spleen Development
Thymus Development
Digestive Tract Morphogenesis
Developmental Growth
Oocyte Development
Positive Regulation Of Skeletal Muscle Fiber Development
Pigment Granule Organization
Homeostasis Of Number Of Cells Within A Tissue
B Cell Receptor Signaling Pathway
Response To Glucocorticoid
Neuron Apoptotic Process
Defense Response To Virus
Regulation Of Mitochondrial Membrane Potential
Negative Regulation Of Mitochondrial Depolarization
Regulation Of Calcium Ion Transport
Transmembrane Transport
Intrinsic Apoptotic Signaling Pathway In Response To Endoplasmic Reticulum Stress
Cellular Response To Organic Substance
Cellular Response To Hypoxia
Reactive Oxygen Species Metabolic Process
Extrinsic Apoptotic Signaling Pathway In Absence Of Ligand
Intrinsic Apoptotic Signaling Pathway
Positive Regulation Of Protein Insertion Into Mitochondrial Membrane Involved In Apoptotic Signaling Pathway
Negative Regulation Of G1/S Transition Of Mitotic Cell Cycle
Negative Regulation Of Anoikis
Negative Regulation Of Apoptotic Signaling Pathway
Negative Regulation Of Extrinsic Apoptotic Signaling Pathway In Absence Of Ligand
Negative Regulation Of Intrinsic Apoptotic Signaling Pathway
Positive Regulation Of Intrinsic Apoptotic Signaling Pathway
Pathways
Mitochondrial protein import
Activation of BAD and translocation to mitochondria
Inflammasomes
The NLRP1 inflammasome
Nucleotide-binding domain, leucine rich repeat containing receptor (NLR) signaling pathways
Programmed Cell Death
Activation of BH3-only proteins
BH3-only proteins associate with and inactivate anti-apoptotic BCL-2 members
Innate Immune System
Intrinsic Pathway for Apoptosis
Drugs
Ibuprofen
Paclitaxel
Docetaxel
Rasagiline
Diseases
GWAS
Cholesterol, total (
20686565
)
Immune reponse to smallpox (secreted IL-2) (
22610502
)
LDL cholesterol (
20686565
)
Obesity-related traits (
23251661
)
Cardiac Troponin-T levels (
23247143
)
Protein-Protein Interactions
17 interactors:
AIP
APOA1
ATXN1
BAG6
BCL2
CDC73
DHFR
FEZ1
HAP1
KIAA1377
OTC
PPHLN1
PTN
TOMM22
TOMM40
UCP1
VDAC1
83 interactors:
ATP2A2
BAD
BAG1
BAG3
BAG4
BAK1
BAX
BBC3
BCAP31
BCL2L1
BCL2L10
BCL2L11
BCL2L14
BCLAF1
BECN1
BFAR
BID
BIK
BLK
BMF
BNIP1
BNIP2
BNIP3
BNIP3L
BNIPL
CAPN2
CASP3
CASP8
CDK1
CDK2
CPT1A
CYCS
EPHB2
FKBP8
HNRNPD
HRAS
HRK
HSPA1A
ITM2B
ITPR1
KRAS
MAPK1
MAPK11
MAPK14
MAPK3
MAPK8
MEX3D
MOAP1
MYC
NLRP1
NMT2
NR4A1
NRAS
PARP1
PIN1
PKMYT1
PMAIP1
PML
PPID
PPP1CA
PPP2CA
PPP2R4
PPP2R5A
PPP3CA
PPP3CC
PRKACA
PRKCA
PSEN1
PXN
RAD9A
RAF1
RRAS
RTN4
SF1
SMN1
SOD1
SPNS1
SQSTM1
TMBIM6
TOMM20
TP53
TP53AIP1
TP53BP2
Entrez ID
9804
596
HPRD ID
03507
01045
Ensembl ID
ENSG00000173726
ENSG00000171791
Uniprot IDs
Q15388
C9JHD5
P10415
PDB IDs
4APO
1G5M
1GJH
1YSW
2O21
2O22
2O2F
2W3L
2XA0
4AQ3
4IEH
4LVT
4LXD
4LXE
Enriched GO Terms of Interacting Partners
?
Mitochondrial Transport
Cellular Localization
Regulation Of Protein Stability
Establishment Of Localization In Cell
Developmental Process
Anatomical Structure Development
Posttranscriptional Regulation Of Gene Expression
Protein Targeting To Mitochondrion
Protein Localization To Mitochondrion
Intracellular Transport
Transport
Regulation Of G1/S Transition Of Mitotic Cell Cycle
Regulation Of Cell Cycle G1/S Phase Transition
Learning
Mitochondrion Organization
Regulation Of Mitotic Cell Cycle
Cell Differentiation
Cell Cycle
Single-organism Behavior
Negative Regulation Of Autophagy
Response To Organic Cyclic Compound
Intrinsic Apoptotic Signaling Pathway In Response To Endoplasmic Reticulum Stress
Behavioral Fear Response
Regulation Of Cell Cycle Process
Positive Regulation Of Cell Development
Fear Response
Protein Localization To Organelle
Response To Drug
Axon Regeneration
Regulation Of Smooth Muscle Cell Migration
Multicellular Organismal Development
Regulation Of Mitotic Cell Cycle Phase Transition
Negative Regulation Of Mitotic Cell Cycle
Anion Homeostasis
Organ Development
Regulation Of Cell Cycle Phase Transition
Neuron Projection Regeneration
Behavior
Organelle Organization
Ornithine Catabolic Process
Negative Regulation Of Cellular PH Reduction
Positive Regulation Of Neurotrophin Production
Positive Regulation Of Nonmotile Primary Cilium Assembly
CD8-positive, Alpha-beta T Cell Lineage Commitment
Negative Regulation Of Retinal Cell Programmed Cell Death
Negative Regulation Of Cell Adhesion Molecule Production
Learning Or Memory
Protein Transmembrane Transport
System Development
Mitochondrial Membrane Organization
Apoptotic Process
Programmed Cell Death
Cell Death
Death
Regulation Of Apoptotic Process
Regulation Of Cell Death
Positive Regulation Of Apoptotic Process
Positive Regulation Of Programmed Cell Death
Positive Regulation Of Cell Death
Apoptotic Signaling Pathway
Intrinsic Apoptotic Signaling Pathway
Positive Regulation Of Signal Transduction
Positive Regulation Of Apoptotic Signaling Pathway
Intracellular Signal Transduction
Regulation Of Signaling
Positive Regulation Of Mitochondrion Organization
Regulation Of Signal Transduction
Positive Regulation Of Cellular Protein Metabolic Process
Regulation Of Mitochondrion Organization
Positive Regulation Of Release Of Cytochrome C From Mitochondria
Positive Regulation Of Protein Metabolic Process
Cellular Response To Stimulus
Positive Regulation Of Cellular Metabolic Process
Negative Regulation Of Programmed Cell Death
Regulation Of Cellular Protein Metabolic Process
Cellular Response To Growth Factor Stimulus
Negative Regulation Of Cell Death
Negative Regulation Of Apoptotic Process
Regulation Of Protein Metabolic Process
Response To Growth Factor
Signal Transduction
Cell Communication
Response To Abiotic Stimulus
Positive Regulation Of Mitochondrial Outer Membrane Permeabilization Involved In Apoptotic Signaling Pathway
Signaling
Positive Regulation Of Metabolic Process
Positive Regulation Of Intracellular Signal Transduction
Apoptotic Mitochondrial Changes
Response To Organic Substance
Neurotrophin TRK Receptor Signaling Pathway
Regulation Of Mitochondrial Outer Membrane Permeabilization Involved In Apoptotic Signaling Pathway
Neurotrophin Signaling Pathway
Regulation Of Cellular Component Organization
Response To Stress
Regulation Of Catalytic Activity
Cellular Response To Organic Substance
Regulation Of Intracellular Signal Transduction
Positive Regulation Of Catalytic Activity
Positive Regulation Of Intrinsic Apoptotic Signaling Pathway
Regulation Of Mitochondrial Membrane Permeability
Tagcloud
?
adenocarcinomas
anthracene
carcinogenic
chorionic
dawley
dimethylbenz
dmba
elevation
exists
glands
gonadotropin
hcg
ice
iu
makes
mammary
modulated
myc
ovaries
phenomenon
probed
programmed
rnas
sprague
trpm2
virgin
xl
xs
Tagcloud (Difference)
?
adenocarcinomas
anthracene
carcinogenic
chorionic
dawley
dimethylbenz
dmba
elevation
exists
glands
gonadotropin
hcg
ice
iu
makes
mammary
modulated
myc
ovaries
phenomenon
probed
programmed
rnas
sprague
trpm2
virgin
xl
xs
Tagcloud (Intersection)
?