TOMM20 and TOMM22

Number of citations of the paper that reports this interaction (PubMedID 10982837)
40

Data Source:
HPRD (in vitro, in vivo)

		TOMM20	TOMM22
Description		translocase of outer mitochondrial membrane 20	translocase of outer mitochondrial membrane 22
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GO Annotations	Cellular Component	Mitochondrion Mitochondrial Envelope Mitochondrial Outer Membrane Mitochondrial Outer Membrane Translocase Complex Membrane Mitochondria-associated Endoplasmic Reticulum Membrane Contact Site Cell Periphery Sperm Midpiece Migrasome TOM Complex	Mitochondrion Mitochondrial Outer Membrane Mitochondrial Outer Membrane Translocase Complex Membrane TOM Complex
	Molecular Function	Protein Binding Protein Transmembrane Transporter Activity Protein-transporting ATPase Activity Mitochondrion Targeting Sequence Binding Unfolded Protein Binding	Protein Binding Protein Transmembrane Transporter Activity Mitochondrion Targeting Sequence Binding
	Biological Process	Protein Targeting Protein Targeting To Mitochondrion Intracellular Protein Transport Protein Transport TRNA Import Into Mitochondrion Protein Import Into Mitochondrial Matrix Protein Insertion Into Mitochondrial Outer Membrane	Protein Targeting To Mitochondrion Intracellular Protein Transport Protein Transport Protein Import Into Mitochondrial Matrix Protein Insertion Into Mitochondrial Outer Membrane
Pathways		Mitochondrial protein import PINK1-PRKN Mediated Mitophagy Ub-specific processing proteases	Mitochondrial protein import PINK1-PRKN Mediated Mitophagy
Drugs
Diseases
GWAS		Apolipoprotein A1 levels ( 32203549) Cholesterol, total ( 20686565) Cobalt levels ( 26025379) Immune reponse to smallpox (secreted IL-2) ( 22610502) LDL cholesterol ( 20686565) LDL cholesterol levels ( 32203549) Night sleep phenotypes ( 27126917) Obesity-related traits ( 23251661) Serum alkaline phosphatase levels ( 33547301)	C-reactive protein levels ( 30388399) Resting heart rate ( 27798624) Sleep duration ( 30846698)
Interacting Genes		22 interacting genes: AIP APOA1 ATXN1 BAG6 BCL2 CDC73 CEP126 DHFR FBXO7 FEZ1 HAP1 HSD17B10 OTC PINK1 PPHLN1 PTN RECQL4 SNCA TOMM22 UCP1 USP40 VDAC1	5 interacting genes: AQP6 HSD17B10 KRTAP5-9 TOMM20 TOMM7
Entrez ID		9804	56993
HPRD ID		03507	06130
Ensembl ID		ENSG00000173726	ENSG00000100216
Uniprot IDs		Q15388	Q549C5 Q9NS69
PDB IDs		4APO 7VBY 7VC9 8XVA 9EIH 9EII 9EIJ	7CK6 7CP9 7VBY 7VC4 7VD2 7VDD 8XVA 9EIH 9EII 9EIJ
Enriched GO Terms of Interacting Partners?		Regulation Of Protein Stability Mitochondrion Organization Regulation Of Reactive Oxygen Species Metabolic Process Mitochondrion Establishment Of Protein Localization To Mitochondrion Mitochondrial Outer Membrane Neuron Projection Regeneration Regulation Of Autophagy Positive Regulation Of Mitophagy Positive Regulation Of Autophagy Of Mitochondrion Protein Targeting Protein Targeting To Mitochondrion Negative Regulation Of Autophagy Mitochondrial Transport Growth Cone Regulation Of Mitophagy Regulation Of Calcium Ion Transmembrane Transport Negative Regulation Of Metabolic Process Regulation Of Autophagy Of Mitochondrion Negative Regulation Of Neuron Apoptotic Process Establishment Of Protein Localization To Organelle Regulation Of Organelle Transport Along Microtubule Negative Regulation Of Apoptotic Process Negative Regulation Of G1/S Transition Of Mitotic Cell Cycle Negative Regulation Of Cell Cycle G1/S Phase Transition Negative Regulation Of Programmed Cell Death Positive Regulation Of Type 2 Mitophagy Negative Regulation Of Catabolic Process Regulation Of Macroautophagy Negative Regulation Of Autophagosome Assembly Pore Complex Regulation Of Biological Quality Negative Regulation Of Oxidative Stress-induced Neuron Intrinsic Apoptotic Signaling Pathway Regulation Of Calcium Ion Transport Regulation Of Hydrogen Peroxide Metabolic Process Inclusion Body Positive Regulation Of Macroautophagy Regulation Of Neuron Apoptotic Process Axon Regeneration Regulation Of Monoatomic Cation Transmembrane Transport Regulation Of Cellular Response To Oxidative Stress Dopamine Transport Regulation Of Oxidative Phosphorylation Mitochondrial Transmembrane Transport Regulation Of Oxidative Stress-induced Neuron Intrinsic Apoptotic Signaling Pathway Negative Regulation Of Intrinsic Apoptotic Signaling Pathway Mitochondrial Membrane Organization Cellular Localization Regulation Of Dopamine Secretion Establishment Of Localization In Cell	Mitochondrial Outer Membrane Translocase Complex TOM Complex Protein Insertion Into Mitochondrial Outer Membrane Protein Import Into Mitochondrial Matrix Protein Transmembrane Transporter Activity Mitochondrion Organization Establishment Of Protein Localization To Mitochondrial Membrane Protein Insertion Into Mitochondrial Membrane Protein Localization To Mitochondrion Protein Insertion Into Membrane Nitrate Transmembrane Transporter Activity Isoursodeoxycholate 7-beta-dehydrogenase (NAD+) Activity Chenodeoxycholate 7-alpha-dehydrogenase (NAD+) Activity 3-hydroxy-2-methylbutyryl-CoA Dehydrogenase Activity Cholate 7-alpha-dehydrogenase (NAD+) Activity Ursodeoxycholate 7-beta-dehydrogenase (NAD+) Activity Protein Transmembrane Transport Establishment Of Protein Localization To Mitochondrion Protein-transporting ATPase Activity Mitochondrial Membrane Organization PH-gated Chloride Channel Activity Nitrate Transmembrane Transport 17-beta-hydroxysteroid Dehydrogenase (NAD+) Activity Brexanolone Metabolic Process TRNA Import Into Mitochondrion Mitochondrial Ribonuclease P Complex Mitochondrial TRNA 5'-end Processing Mitochondrial TRNA 3'-end Processing Mitochondrial TRNA Methylation Mitochondrial RNA 5'-end Processing Migrasome Carbon Dioxide Transmembrane Transporter Activity Carbon Dioxide Transmembrane Transport Isoleucine Metabolic Process L-isoleucine Catabolic Process RNA Import Into Mitochondrion Establishment Of Protein Localization To Membrane Mitochondrion Targeting Sequence Binding Mitochondrial Outer Membrane TRNA Methyltransferase Complex Mitochondrial RNA 3'-end Processing Testosterone Dehydrogenase (NAD+) Activity (3S)-3-hydroxyacyl-CoA Dehydrogenase (NAD+) Activity TRNA Transport Androstan-3-alpha,17-beta-diol Dehydrogenase (NAD+) Activity Monoatomic Anion Channel Activity Renal Water Transport TRNA 3'-end Processing Transmembrane Transport Ammonium Channel Activity
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