TOMM20 and UCP1

Number of citations: 0 (PubMedID 9119086)
Data Source: HPRD (in vitro)

		TOMM20	UCP1
Name		translocase of outer mitochondrial membrane 20	uncoupling protein 1
Structure
GO Annotations	Cellular Component	Mitochondrion Mitochondrial Envelope Mitochondrial Outer Membrane Mitochondrial Outer Membrane Translocase Complex Membrane Mitochondria-associated Endoplasmic Reticulum Membrane Contact Site Cell Periphery Sperm Midpiece Migrasome TOM Complex	Mitochondrion Mitochondrial Envelope Mitochondrial Inner Membrane Membrane
	Molecular Function	Protein Binding Protein Transmembrane Transporter Activity Protein-transporting ATPase Activity Mitochondrion Targeting Sequence Binding Unfolded Protein Binding	Protein Binding GTP Binding Proton Transmembrane Transporter Activity Oxidative Phosphorylation Uncoupler Activity GDP Binding Transmembrane Transporter Activity Purine Ribonucleotide Binding Long-chain Fatty Acid Binding Anion Binding Cardiolipin Binding
	Biological Process	Protein Targeting Protein Targeting To Mitochondrion Intracellular Protein Transport Protein Transport TRNA Import Into Mitochondrion Protein Import Into Mitochondrial Matrix Protein Insertion Into Mitochondrial Outer Membrane	Diet Induced Thermogenesis Regulation Of Transcription By RNA Polymerase II Monoatomic Ion Transport Mitochondrial Transport Response To Temperature Stimulus Response To Cold Response To Nutrient Levels Cellular Response To Hormone Stimulus Monoatomic Ion Transmembrane Transport Cellular Response To Reactive Oxygen Species Brown Fat Cell Differentiation Transmembrane Transport Cellular Response To Cold Cellular Response To Fatty Acid Positive Regulation Of Cold-induced Thermogenesis Proton Transmembrane Transport Regulation Of Reactive Oxygen Species Biosynthetic Process Cellular Response To Dehydroepiandrosterone Mitochondrial Transmembrane Transport Adaptive Thermogenesis
Pathways		Mitochondrial protein import PINK1-PRKN Mediated Mitophagy Ub-specific processing proteases	Mitochondrial Uncoupling The fatty acid cycling model Transcriptional regulation of brown and beige adipocyte differentiation by EBF2
GWAS		Apolipoprotein A1 levels ( 32203549 ) Cholesterol, total ( 20686565 ) Cobalt levels ( 26025379 ) Immune reponse to smallpox (secreted IL-2) ( 22610502 ) LDL cholesterol ( 20686565 ) LDL cholesterol levels ( 32203549 ) Night sleep phenotypes ( 27126917 ) Obesity-related traits ( 23251661 ) Serum alkaline phosphatase levels ( 33547301 )	Malaria ( 31844061 )
Interacting Genes		22 interacting genes: AIP APOA1 ATXN1 BAG6 BCL2 CDC73 CEP126 DHFR FBXO7 FEZ1 HAP1 HSD17B10 OTC PINK1 PPHLN1 PTN RECQL4 SNCA TOMM22 UCP1 USP40 VDAC1	2 interacting genes: CIDEA TOMM20
Entrez ID		9804	7350
HPRD ID		03507	00221
Ensembl ID		ENSG00000173726	ENSG00000109424
Uniprot IDs		Q15388	P25874 Q4KMT7
PDB IDs		4APO 7VBY 7VC9 8XVA 9EIH 9EII 9EIJ	8G8W 8HBV 8HBW 8J1N
GO Terms Enriched among Interactors		Regulation Of Protein Stability Mitochondrion Organization Regulation Of Reactive Oxygen Species Metabolic Process Mitochondrion Establishment Of Protein Localization To Mitochondrion Mitochondrial Outer Membrane Neuron Projection Regeneration Regulation Of Autophagy Positive Regulation Of Mitophagy Positive Regulation Of Autophagy Of Mitochondrion Protein Targeting Protein Targeting To Mitochondrion Negative Regulation Of Autophagy Mitochondrial Transport Growth Cone Regulation Of Mitophagy Regulation Of Calcium Ion Transmembrane Transport Negative Regulation Of Metabolic Process Regulation Of Autophagy Of Mitochondrion Negative Regulation Of Neuron Apoptotic Process Establishment Of Protein Localization To Organelle Regulation Of Organelle Transport Along Microtubule Negative Regulation Of Apoptotic Process Negative Regulation Of G1/S Transition Of Mitotic Cell Cycle Negative Regulation Of Cell Cycle G1/S Phase Transition Negative Regulation Of Programmed Cell Death Positive Regulation Of Type 2 Mitophagy Negative Regulation Of Catabolic Process Regulation Of Macroautophagy Negative Regulation Of Autophagosome Assembly Pore Complex Regulation Of Biological Quality Negative Regulation Of Oxidative Stress-induced Neuron Intrinsic Apoptotic Signaling Pathway Regulation Of Calcium Ion Transport Regulation Of Hydrogen Peroxide Metabolic Process Inclusion Body Positive Regulation Of Macroautophagy Regulation Of Neuron Apoptotic Process Axon Regeneration Regulation Of Monoatomic Cation Transmembrane Transport Regulation Of Cellular Response To Oxidative Stress Dopamine Transport Regulation Of Oxidative Phosphorylation Mitochondrial Transmembrane Transport Regulation Of Oxidative Stress-induced Neuron Intrinsic Apoptotic Signaling Pathway Negative Regulation Of Intrinsic Apoptotic Signaling Pathway Mitochondrial Membrane Organization Cellular Localization Regulation Of Dopamine Secretion Establishment Of Localization In Cell	Mitochondrial Envelope Protein-transporting ATPase Activity TRNA Import Into Mitochondrion Regulation Of Apoptotic DNA Fragmentation Response To Stilbenoid Lipid Droplet Fusion Negative Regulation Of Execution Phase Of Apoptosis TRNA Transport Mitochondrial Outer Membrane Translocase Complex RNA Import Into Mitochondrion TOM Complex Mitochondrion Targeting Sequence Binding Migrasome Membrane Organization Lipid Transfer Activity Protein Insertion Into Mitochondrial Outer Membrane Cellular Response To Cold Phosphatidic Acid Binding Negative Regulation Of Lipid Catabolic Process Mitochondria-associated Endoplasmic Reticulum Membrane Contact Site Protein Import Into Mitochondrial Matrix Protein Targeting To Mitochondrion Protein Transmembrane Transporter Activity Intermembrane Lipid Transfer Temperature Homeostasis Lipid Storage Establishment Of Protein Localization To Mitochondrial Membrane Protein Insertion Into Mitochondrial Membrane Lipid Droplet Organization Response To Cold Protein Localization To Mitochondrion Negative Regulation Of Cold-induced Thermogenesis Sperm Midpiece Regulation Of Lipid Catabolic Process Negative Regulation Of Tumor Necrosis Factor Production Negative Regulation Of Tumor Necrosis Factor Superfamily Cytokine Production Protein Insertion Into Membrane Mitochondrion Protein Transmembrane Transport Establishment Of Protein Localization To Mitochondrion Lipid Droplet Cell Periphery Negative Regulation Of Lipid Metabolic Process Negative Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway Unfolded Protein Binding Mitochondrial Membrane Organization Fat Cell Differentiation Organelle Fusion Regulation Of Cold-induced Thermogenesis Response To Temperature Stimulus