PIAS1 and CSRP2

Number of citations of the paper that reports this interaction (PMID 11672422)
6

Data Source:
HPRD (two hybrid, in vivo, in vitro)

		PIAS1	CSRP2
Gene Name		protein inhibitor of activated STAT, 1	cysteine and glycine-rich protein 2
Image			No pdb structure
Gene Ontology Annotations	Cellular Component	Nucleus Nucleoplasm PML Body Nuclear Speck	Nucleus Focal Adhesion
	Molecular Function	DNA Binding Transcription Coactivator Activity Transcription Corepressor Activity Protein Binding Zinc Ion Binding Ligase Activity Enzyme Binding Protein Domain Specific Binding Ubiquitin Protein Ligase Binding Androgen Receptor Binding SUMO Ligase Activity	Molecular_function Zinc Ion Binding
	Biological Process	Negative Regulation Of Transcription From RNA Polymerase II Promoter Transcription, DNA-templated JAK-STAT Cascade Spermatogenesis Protein Sumoylation Cytokine-mediated Signaling Pathway Androgen Receptor Signaling Pathway Positive Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Positive Regulation Of Protein Sumoylation Regulation Of Cell Proliferation Positive Regulation Of Transcription, DNA-templated Positive Regulation Of Smooth Muscle Cell Differentiation Interferon-gamma-mediated Signaling Pathway Regulation Of Interferon-gamma-mediated Signaling Pathway Protein-DNA Complex Assembly	Multicellular Organismal Development Cell Differentiation
Pathways		Interferon gamma signaling Interferon Signaling Cytokine Signaling in Immune system Regulation of IFNG signaling
Drugs
Diseases
GWAS		Major depressive disorder ( 23377640)
Protein-Protein Interactions		92 interactors: AKT1 AR ATXN1 AXIN1 BARD1 BRCA1 CARM1 CASP8 CBS CEBPA CEBPE CHUK CREB1 CREBBP CSNK2A1 CSRP2 DCLRE1A DDX21 DDX5 DNM1 DNMT3A ELK3 ESR1 ESR2 FLI1 GATA4 GLUL GRM8 HIC1 HTT JUN L3MBTL2 MAML1 MBD1 MDC1 MDM2 MITF MSX1 MX1 MYB NCOR1 NFATC1 NIN NR2F2 NR3C2 NR5A1 PAXIP1 PGR PIAS2 PIAS4 PLAG1 PML PPP1CA PPP1CC PRDM1 PRMT1 PRMT6 PRPF40A PTK2 PTPN1 RAD54L2 RBBP6 RELA SATB1 SATB2 SERBP1 SGTA SIAH1 SIAH2 SKIL SMAD1 SMAD4 SMAD7 SNIP1 SP3 SPOP SREBF2 STAT1 SUFU SUMO1 SUMO2 SUMO3 TBP TP53 TP73 TRIM27 TRIM55 TRIM63 UBE2I YWHAZ ZNF451 ZNF76	4 interactors: CSRP2BP EEF1A1 PIAS1 TRIM27
Entrez ID		8554	1466
HPRD ID		16029	03523
Ensembl ID		ENSG00000033800	ENSG00000175183
Uniprot IDs		O75925 Q1XBU8	Q16527
PDB IDs		1V66
Enriched GO Terms of Interacting Partners?		Negative Regulation Of Gene Expression Regulation Of Transcription From RNA Polymerase II Promoter Regulation Of Gene Expression Negative Regulation Of Nucleic Acid-templated Transcription Negative Regulation Of RNA Biosynthetic Process Negative Regulation Of Biosynthetic Process Negative Regulation Of Transcription, DNA-templated Transcription, DNA-templated Transcription From RNA Polymerase II Promoter Regulation Of RNA Metabolic Process Regulation Of Nucleic Acid-templated Transcription RNA Biosynthetic Process Regulation Of RNA Biosynthetic Process Regulation Of Nitrogen Compound Metabolic Process Regulation Of Transcription, DNA-templated Regulation Of Metabolic Process Positive Regulation Of Gene Expression Negative Regulation Of Cellular Metabolic Process Gene Expression Cellular Nitrogen Compound Metabolic Process RNA Metabolic Process Positive Regulation Of Transcription, DNA-templated Negative Regulation Of Transcription From RNA Polymerase II Promoter Positive Regulation Of Transcription From RNA Polymerase II Promoter Nucleobase-containing Compound Metabolic Process Heterocycle Metabolic Process Positive Regulation Of Macromolecule Biosynthetic Process Positive Regulation Of Cellular Metabolic Process Nitrogen Compound Metabolic Process Cellular Aromatic Compound Metabolic Process Cellular Metabolic Process Positive Regulation Of Cellular Biosynthetic Process Positive Regulation Of Metabolic Process Cellular Macromolecule Biosynthetic Process Cellular Response To Organic Substance Macromolecule Biosynthetic Process Response To Organic Substance Cellular Response To Stimulus Regulation Of Cellular Process Multicellular Organismal Development Biosynthetic Process Response To Stimulus Regulation Of Signaling Cell Differentiation Organ Development Signaling Signal Transduction Anatomical Structure Development Developmental Process Regulation Of Signal Transduction	Peptidyl-amino Acid Modification Negative Regulation Of Interleukin-2 Secretion Peptidyl-lysine Modification Positive Regulation Of Smooth Muscle Cell Differentiation Negative Regulation Of Calcium Ion Import Cellular Protein Metabolic Process Interferon-gamma Secretion Positive Regulation Of Protein Sumoylation Negative Regulation Of Viral Release From Host Cell Spermatogenesis Male Gamete Generation Regulation Of Smooth Muscle Cell Differentiation Protein Metabolic Process Interferon-gamma Production Negative Regulation Of Interleukin-2 Production Regulation Of Protein Sumoylation Transcription, DNA-templated Regulation Of Interferon-gamma-mediated Signaling Pathway Negative Regulation Of Viral Transcription Regulation Of Response To Interferon-gamma Regulation Of Viral Release From Host Cell RNA Biosynthetic Process Protein Modification By Small Protein Conjugation Regulation Of Calcium Ion Import Gamete Generation Protein Sumoylation Cellular Response To Epidermal Growth Factor Stimulus Response To Epidermal Growth Factor Protein K63-linked Ubiquitination Cytokine Secretion Protein Trimerization Negative Regulation Of Cytokine Secretion Negative Regulation Of Transcription From RNA Polymerase II Promoter Negative Regulation Of Adaptive Immune Response Sexual Reproduction Innate Immune Response Multicellular Organismal Reproductive Process Androgen Receptor Signaling Pathway Negative Regulation Of Tumor Necrosis Factor Production Negative Regulation Of Tumor Necrosis Factor Superfamily Cytokine Production Negative Regulation Of Calcium Ion Transport Multicellular Organism Reproduction Arp2/3 Complex-mediated Actin Nucleation Regulation Of Immune Response Histone H3 Acetylation Negative Regulation Of Ion Transmembrane Transport RNA Metabolic Process JAK-STAT Cascade Cellular Protein Modification Process Negative Regulation Of Transmembrane Transport
Tagcloud ?		akap6 atf7 atxn1 bmpr2 categorize deltan eef1a1 grip2 gtf2f1 interactors jbd jbds jnk1alpha1 jnk3 jnk3alpha1 jnks kcne4 myo9b nnat ptgds ptpn2 rabgap1 rusc2 shank1 sumo1 sypl1 tkt topbp1 znf668	acvrl1 adora2a adora2b agtrap angpt2 angptl4 apln cbf ednra egfl7 ero1l flowmetry flt1 hi id1 immunolabeled iodoantipyrine kdr microvasculature mins nitroarginine normoxia nos3 nudt6 perimed pf5001 prrx1 serpine1 stereological
Tagcloud (Difference) ?		akap6 atf7 atxn1 bmpr2 categorize deltan eef1a1 grip2 gtf2f1 interactors jbd jbds jnk1alpha1 jnk3 jnk3alpha1 jnks kcne4 myo9b nnat ptgds ptpn2 rabgap1 rusc2 shank1 sumo1 sypl1 tkt topbp1 znf668	acvrl1 adora2a adora2b agtrap angpt2 angptl4 apln cbf ednra egfl7 ero1l flowmetry flt1 hi id1 immunolabeled iodoantipyrine kdr microvasculature mins nitroarginine normoxia nos3 nudt6 perimed pf5001 prrx1 serpine1 stereological
Tagcloud (Intersection) ?