PIAS1 and GLUL

Number of citations of the paper that reports this interaction (PMID 20936779)
48

Data Source:
BioGRID (two hybrid)

		PIAS1	GLUL
Gene Name		protein inhibitor of activated STAT, 1	glutamate-ammonia ligase
Image
Gene Ontology Annotations	Cellular Component	Nucleus Nucleoplasm PML Body Nuclear Speck	Nucleus Cytoplasm Mitochondrion Rough Endoplasmic Reticulum Cytosol Perikaryon Protein Complex Axon Terminus Extracellular Vesicular Exosome Glial Cell Projection
	Molecular Function	DNA Binding Transcription Coactivator Activity Transcription Corepressor Activity Protein Binding Zinc Ion Binding Ligase Activity Enzyme Binding Protein Domain Specific Binding Ubiquitin Protein Ligase Binding Androgen Receptor Binding SUMO Ligase Activity	Magnesium Ion Binding Glutamate Decarboxylase Activity Glutamate-ammonia Ligase Activity ATP Binding Glutamate Binding Manganese Ion Binding Identical Protein Binding Dynein Light Chain Binding
	Biological Process	Negative Regulation Of Transcription From RNA Polymerase II Promoter Transcription, DNA-templated JAK-STAT Cascade Spermatogenesis Protein Sumoylation Cytokine-mediated Signaling Pathway Androgen Receptor Signaling Pathway Positive Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Positive Regulation Of Protein Sumoylation Regulation Of Cell Proliferation Positive Regulation Of Transcription, DNA-templated Positive Regulation Of Smooth Muscle Cell Differentiation Interferon-gamma-mediated Signaling Pathway Regulation Of Interferon-gamma-mediated Signaling Pathway Protein-DNA Complex Assembly	Neurotransmitter Uptake Glutamate Catabolic Process Glutamine Biosynthetic Process Synaptic Transmission Cell Proliferation Cellular Amino Acid Biosynthetic Process Cellular Response To Starvation Response To Glucose Positive Regulation Of Insulin Secretion Cellular Nitrogen Compound Metabolic Process Small Molecule Metabolic Process Positive Regulation Of Epithelial Cell Proliferation Protein Homooligomerization Positive Regulation Of Synaptic Transmission, Glutamatergic
Pathways		Interferon gamma signaling Interferon Signaling Cytokine Signaling in Immune system Regulation of IFNG signaling	Astrocytic Glutamate-Glutamine Uptake And Metabolism Neurotransmitter uptake and Metabolism In Glial Cells Amino acid synthesis and interconversion (transamination) Metabolism of amino acids and derivatives Transmission across Chemical Synapses
Drugs			L-Glutamine L-Glutamic Acid
Diseases
GWAS		Major depressive disorder ( 23377640)
Protein-Protein Interactions		92 interactors: AKT1 AR ATXN1 AXIN1 BARD1 BRCA1 CARM1 CASP8 CBS CEBPA CEBPE CHUK CREB1 CREBBP CSNK2A1 CSRP2 DCLRE1A DDX21 DDX5 DNM1 DNMT3A ELK3 ESR1 ESR2 FLI1 GATA4 GLUL GRM8 HIC1 HTT JUN L3MBTL2 MAML1 MBD1 MDC1 MDM2 MITF MSX1 MX1 MYB NCOR1 NFATC1 NIN NR2F2 NR3C2 NR5A1 PAXIP1 PGR PIAS2 PIAS4 PLAG1 PML PPP1CA PPP1CC PRDM1 PRMT1 PRMT6 PRPF40A PTK2 PTPN1 RAD54L2 RBBP6 RELA SATB1 SATB2 SERBP1 SGTA SIAH1 SIAH2 SKIL SMAD1 SMAD4 SMAD7 SNIP1 SP3 SPOP SREBF2 STAT1 SUFU SUMO1 SUMO2 SUMO3 TBP TP53 TP73 TRIM27 TRIM55 TRIM63 UBE2I YWHAZ ZNF451 ZNF76	18 interactors: CASP8AP2 CYP39A1 DYNLL1 HIPK1 HIPK3 HTR2A ND5 NFKB1 NUDT18 PIAS1 PIAS2 PIAS3 PLEKHF2 PPARD RABEPK RBBP6 SKIL UBE2I
Entrez ID		8554	2752
HPRD ID		16029	00701
Ensembl ID		ENSG00000033800	ENSG00000135821
Uniprot IDs		O75925 Q1XBU8	A8YXX4 P15104
PDB IDs		1V66	2OJW 2QC8
Enriched GO Terms of Interacting Partners?		Negative Regulation Of Gene Expression Regulation Of Transcription From RNA Polymerase II Promoter Regulation Of Gene Expression Negative Regulation Of Nucleic Acid-templated Transcription Negative Regulation Of RNA Biosynthetic Process Negative Regulation Of Biosynthetic Process Negative Regulation Of Transcription, DNA-templated Transcription, DNA-templated Transcription From RNA Polymerase II Promoter Regulation Of RNA Metabolic Process Regulation Of Nucleic Acid-templated Transcription RNA Biosynthetic Process Regulation Of RNA Biosynthetic Process Regulation Of Nitrogen Compound Metabolic Process Regulation Of Transcription, DNA-templated Regulation Of Metabolic Process Positive Regulation Of Gene Expression Negative Regulation Of Cellular Metabolic Process Gene Expression Cellular Nitrogen Compound Metabolic Process RNA Metabolic Process Positive Regulation Of Transcription, DNA-templated Negative Regulation Of Transcription From RNA Polymerase II Promoter Positive Regulation Of Transcription From RNA Polymerase II Promoter Nucleobase-containing Compound Metabolic Process Heterocycle Metabolic Process Positive Regulation Of Macromolecule Biosynthetic Process Positive Regulation Of Cellular Metabolic Process Nitrogen Compound Metabolic Process Cellular Aromatic Compound Metabolic Process Cellular Metabolic Process Positive Regulation Of Cellular Biosynthetic Process Positive Regulation Of Metabolic Process Cellular Macromolecule Biosynthetic Process Cellular Response To Organic Substance Macromolecule Biosynthetic Process Response To Organic Substance Cellular Response To Stimulus Regulation Of Cellular Process Multicellular Organismal Development Biosynthetic Process Response To Stimulus Regulation Of Signaling Cell Differentiation Organ Development Signaling Signal Transduction Anatomical Structure Development Developmental Process Regulation Of Signal Transduction	Protein Sumoylation Transcription, DNA-templated RNA Biosynthetic Process Cell Death Death Regulation Of Signal Transduction Nucleobase-containing Compound Metabolic Process Regulation Of Signaling Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process RNA Metabolic Process Regulation Of Nitrogen Compound Metabolic Process Peptidyl-lysine Modification Cellular Nitrogen Compound Metabolic Process Positive Regulation Of Protein Sumoylation Apoptotic Process Regulation Of Transcription, DNA-templated Gene Expression MRNA Transcription Regulation Of Nucleic Acid-templated Transcription Regulation Of RNA Biosynthetic Process Negative Regulation Of Cellular Metabolic Process Programmed Cell Death Protein Modification By Small Protein Conjugation Regulation Of RNA Metabolic Process Cellular Macromolecule Biosynthetic Process Macromolecule Biosynthetic Process Nitrogen Compound Metabolic Process Regulation Of Protein Sumoylation Apoptotic Signaling Pathway Negative Regulation Of Nucleic Acid-templated Transcription Negative Regulation Of RNA Biosynthetic Process Biosynthetic Process Regulation Of Gene Expression Negative Regulation Of Transcription From RNA Polymerase II Promoter Positive Regulation Of Signal Transduction Negative Regulation Of Biosynthetic Process Positive Regulation Of Cell Differentiation Intracellular Receptor Signaling Pathway Androgen Receptor Signaling Pathway Regulation Of Apoptotic Process Cellular Metabolic Process Peptidyl-amino Acid Modification Response To Mechanical Stimulus Regulation Of Cell Death Regulation Of Cell Differentiation Positive Regulation Of Fat Cell Differentiation DGDP Catabolic Process DADP Catabolic Process Negative Regulation Of Interleukin-12 Biosynthetic Process
Tagcloud ?		akap6 atf7 atxn1 bmpr2 categorize deltan eef1a1 grip2 gtf2f1 interactors jbd jbds jnk1alpha1 jnk3 jnk3alpha1 jnks kcne4 myo9b nnat ptgds ptpn2 rabgap1 rusc2 shank1 sumo1 sypl1 tkt topbp1 znf668	bell bgh bio blots bromo cnp deoxyuridine dlgap2 dor fibrillary gfap gh glutamine grin2a gs haemoglobin hbb igf1 igf1r inactivity ionotropic modestly phosphodiesterase postsynaptic robustly sapap2 synapse synthetase tg
Tagcloud (Difference) ?		akap6 atf7 atxn1 bmpr2 categorize deltan eef1a1 grip2 gtf2f1 interactors jbd jbds jnk1alpha1 jnk3 jnk3alpha1 jnks kcne4 myo9b nnat ptgds ptpn2 rabgap1 rusc2 shank1 sumo1 sypl1 tkt topbp1 znf668	bell bgh bio blots bromo cnp deoxyuridine dlgap2 dor fibrillary gfap gh glutamine grin2a gs haemoglobin hbb igf1 igf1r inactivity ionotropic modestly phosphodiesterase postsynaptic robustly sapap2 synapse synthetase tg
Tagcloud (Intersection) ?