PIAS1 and DCLRE1A

Number of citations of the paper that reports this interaction (PubMedID 15572677)
44

Data Source:
BioGRID (affinity chromatography technology, affinity chromatography technology)
HPRD (two hybrid, in vitro)

		PIAS1	DCLRE1A
Description		protein inhibitor of activated STAT 1	DNA cross-link repair 1A
Image
GO Annotations	Cellular Component	Chromatin Nucleus Nucleoplasm Cytoplasm Cytoskeleton PML Body Nuclear Speck Nuclear Periphery Glutamatergic Synapse Presynaptic Cytosol Postsynaptic Cytosol	Fibrillar Center Nucleus Nucleoplasm
	Molecular Function	Transcription Cis-regulatory Region Binding DNA Binding Transcription Coregulator Activity Transcription Corepressor Activity Protein Binding Zinc Ion Binding Transferase Activity SUMO Transferase Activity Enzyme Binding Protein Domain Specific Binding Ubiquitin Protein Ligase Binding Metal Ion Binding SUMO Ligase Activity DNA-binding Transcription Factor Binding	DNA Binding Damaged DNA Binding Zinc Ion Binding Beta-lactamase Activity Hydrolase Activity 5'-3' DNA Exonuclease Activity Metal Ion Binding
	Biological Process	G1/S Transition Of Mitotic Cell Cycle Negative Regulation Of Transcription By RNA Polymerase II Double-strand Break Repair Via Homologous Recombination DNA Double-strand Break Processing Regulation Of Transcription By RNA Polymerase II DNA Damage Response Cell Surface Receptor Signaling Pathway Via JAK-STAT Spermatogenesis Visual Learning Protein Sumoylation Positive Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Positive Regulation Of Protein Sumoylation Regulation Of Cell Population Proliferation Negative Regulation Of Apoptotic Process Fat Cell Differentiation Positive Regulation Of DNA-templated Transcription Positive Regulation Of Smooth Muscle Cell Differentiation Regulation Of Macromolecule Metabolic Process Protein-DNA Complex Assembly Positive Regulation Of Protein Localization To Cell Periphery	DNA Repair Double-strand Break Repair Via Nonhomologous End Joining DNA Damage Response Interstrand Cross-link Repair Cell Division
Pathways		SUMOylation of DNA damage response and repair proteins SUMOylation of transcription factors SUMOylation of ubiquitinylation proteins SUMOylation of transcription cofactors SUMOylation of intracellular receptors SUMOylation of intracellular receptors SUMOylation of chromatin organization proteins Formation of Incision Complex in GG-NER Regulation of IFNG signaling	Fanconi Anemia Pathway
Drugs
Diseases
GWAS		Diastolic blood pressure ( 30224653) Diverticular disease ( 30177863) Gut microbiota (bacterial taxa, hurdle binary method) ( 32572223) Haemorrhoidal disease ( 33888516) Major depressive disorder ( 23377640) Number of twin births ( 30760885)
Interacting Genes		118 interacting genes: AKT1 AR ATXN1 AXIN1 BARD1 BRCA1 CASP8 CBS CDK4 CEBPA CEBPE CHD3 CHUK CNOT7 CREB1 CREBBP CSNK2A1 CSRP2 DCLRE1A DDX21 DDX5 DNM1 DNMT3A ELK3 EP300 ERG ESR1 ESR2 FANCI FHL3 FLI1 GATA4 GLUL GRM8 GSK3B GTF2IRD1 H2AZ1 H2BC3 H3C1 HECTD2 HIC1 HTT IKZF5 JUN L3MBTL2 LSM3 MAML1 MBD1 MDC1 MDM2 MITF MORC3 MSX1 MX1 MYB NCOR1 NFATC1 NIN NR2F2 NR3C2 NR5A1 NRIP1 PAXIP1 PGR PIAS2 PIAS4 PLAG1 PML PPP1CA PPP1CC PRDM1 PRPF40A PTK2 PTPN1 QKI RAD51 RAD54L2 RBBP6 RELA RHOB RPA2 SATB1 SATB2 SERBP1 SETX SGTA SKIL SMAD1 SMAD4 SMAD7 SNAI2 SNIP1 SP3 SPOP SREBF2 STAT1 SUFU SUMO1 SUMO1P1 SUMO2 SUMO3 TBP TERF2 TERF2IP TEX11 TP53 TP73 TRIM27 TRIM5 TRIM55 TRIM63 TSG101 UBE2I UBE2L3 YWHAZ ZBED1 ZNF451 ZNF76	4 interacting genes: ADRB2 ERCC6 PIAS1 TP53BP1
Entrez ID		8554	9937
HPRD ID		16029	08519
Ensembl ID		ENSG00000033800	ENSG00000198924
Uniprot IDs		O75925	Q6PJP8
PDB IDs		1V66	4B87 5AHR 5NZW 5NZX 5NZY 5Q1J 5Q1K 5Q1L 5Q1M 5Q1N 5Q1O 5Q1P 5Q1Q 5Q1R 5Q1S 5Q1T 5Q1U 5Q1V 5Q1W 5Q1X 5Q1Y 5Q1Z 5Q20 5Q22 5Q23 5Q24 5Q25 5Q26 5Q27 5Q28 5Q29 5Q2A 5Q2B 5Q2C 5Q2D 5Q2E 5Q2F 5Q2G 5Q2H 5Q2I 5Q2J 5Q2K 5Q2L 5Q2M 5Q2N 5Q2O 5Q2P 5Q2Q 5Q2R 5Q2S 5Q2T 5Q2U 5Q2V 5Q2W 5Q2X 5Q2Y 5Q2Z 5Q30 5Q31 5Q32 5Q33 5Q34 5Q35 5Q36 5Q37 5Q38 5Q39 5Q3A 5Q3B 5Q3C 5Q3D 5Q3E 5Q3F 5Q3G 5Q3H 5Q3I 5Q3J 5Q3K 5Q3L 5Q3M 5Q3N 5Q3O 5Q3P 5Q3Q 5Q3R 5Q3S 5Q3T 5Q3U 5Q3V 5Q3W 5Q3X 5Q3Y 5Q3Z 5Q40 5Q41 5Q42 5Q43 5Q44 5Q45 5Q46 5Q47 5Q48 5Q49 5Q4A 5Q4B 5Q4C 5Q4D 5Q4E 5Q4F 5Q4G 5Q4H 5Q4I 5Q4J 5Q4K 5Q4L 5Q4M 5Q4N 5Q4O 5Q4P 5Q4Q 5Q4R 5Q4S 5Q4T 5Q4U 5Q4V 5Q4W 5Q4X 5Q4Y 5Q4Z 5Q50 5Q51 5Q52 5Q53 5Q54 5Q55 5Q56 5Q57 5Q58 5Q59 5Q5A 5Q5B 5Q5C 5Q5D 5Q5E 5Q5F 5Q5G 5Q5H 5Q5I 5Q5J 5Q5K 5Q5L 5Q5M 5Q5N 5Q5O 5Q5P 5Q5Q 5Q5R 5Q5S 5Q5T 5Q5U 5Q5V 5Q5W 5Q5X 5Q5Y 5Q5Z 5Q60 5Q61 5Q62 5Q63 5Q64 5Q65 5Q66 5Q67 5Q68 5Q69 5Q6A 5Q6B 5Q6C 5Q6D 5Q6E 5Q6F 5Q6G 5Q6H 5Q6I 5Q6J 5Q6K 5Q6L 5Q6M 5Q6N 5Q6O 5Q6P 5Q6Q 5Q6R 5Q6S 5Q6T 5Q6U 5Q6V 5Q6W 5Q6X 5Q6Y 5Q6Z 5Q70 5Q71 5Q72 5Q73 5Q74 5Q75 5Q76 5Q77 5Q78 5Q79 5Q7A 5Q7B 5Q7C 5Q7D 5Q7E 5Q7F 5Q7G 5Q7H 5Q7I 5Q7J 5Q7K 5Q7L 5Q7M 5Q7N 5Q7O 5Q7P 5Q7Q 5Q7R 5Q7S 5Q7T 5Q7U 5Q7V 5Q7W 5Q7X 5Q7Y 5Q7Z 5Q80 5Q81 5Q82 5Q83 5Q84 5Q85 5Q86 5Q87 5Q88 5Q89 5Q8A 5Q8B 5Q8C 5Q8D 5Q8E 5Q8F 5Q8G 5Q8H 5Q8I 5Q8J 5Q8K 5Q8L 5Q8M 5Q8N 5Q8O 5Q8P 5Q8Q 5Q8R 5Q8S 5Q8T 5Q8U 5Q8V 5Q8W 5Q8X 5Q8Y 5Q8Z 5Q90 5Q91 5Q92 5Q93 5Q94 5Q95 5Q96 5Q97 5Q98 5Q99 5Q9A 5Q9B 5Q9C 5Q9D 5Q9E 5Q9F 5Q9G 5Q9H 5Q9I 5Q9J 5Q9K 5Q9L 5Q9M 5Q9N 5Q9O 5Q9P 5Q9Q 5Q9R 5Q9S 5Q9T 5Q9U 5Q9V 5Q9W 5Q9X 5Q9Y 5Q9Z 5QA0 5QA1 5QA2 8C8B 8C8D 8C8S 8CEW 8CF0 8CG9
Enriched GO Terms of Interacting Partners?		Nucleus Regulation Of Nucleobase-containing Compound Metabolic Process Nucleoplasm Regulation Of Transcription By RNA Polymerase II Regulation Of DNA-templated Transcription Regulation Of RNA Biosynthetic Process Regulation Of RNA Metabolic Process Negative Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of Primary Metabolic Process Negative Regulation Of RNA Metabolic Process Regulation Of Macromolecule Metabolic Process Negative Regulation Of DNA-templated Transcription Negative Regulation Of RNA Biosynthetic Process Regulation Of Metabolic Process Negative Regulation Of Macromolecule Biosynthetic Process Negative Regulation Of Macromolecule Metabolic Process Regulation Of Macromolecule Biosynthetic Process Regulation Of Gene Expression DNA Binding Negative Regulation Of Biosynthetic Process Negative Regulation Of Transcription By RNA Polymerase II Negative Regulation Of Metabolic Process Positive Regulation Of Transcription By RNA Polymerase II Positive Regulation Of DNA-templated Transcription Positive Regulation Of RNA Biosynthetic Process Positive Regulation Of Nucleobase-containing Compound Metabolic Process Positive Regulation Of RNA Metabolic Process Chromatin PML Body Positive Regulation Of Macromolecule Metabolic Process Positive Regulation Of Metabolic Process RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity Sequence-specific DNA Binding Positive Regulation Of Macromolecule Biosynthetic Process Positive Regulation Of Biosynthetic Process Enzyme Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific Protein Sumoylation Macromolecule Metabolic Process Ubiquitin Protein Ligase Binding DNA-binding Transcription Activator Activity, RNA Polymerase II-specific Response To Stress Cellular Response To Stress RNA Polymerase II-specific DNA-binding Transcription Factor Binding Regulation Of Cellular Response To Stress Nucleic Acid Metabolic Process Chromatin Binding Intracellular Signal Transduction SUMO Transferase Activity	Double-strand Break Repair Via Classical Nonhomologous End Joining Double-strand Break Repair Response To X-ray Negative Regulation Of DNA Repair Negative Regulation Of Double-strand Break Repair Double-strand Break Repair Via Nonhomologous End Joining Response To Radiation Positive Regulation Of RNA Biosynthetic Process Positive Regulation Of DNA-templated Transcription Positive Regulation Of RNA Metabolic Process Positive Regulation Of DNA Recombination DNA Repair Regulation Of Double-strand Break Repair Via Homologous Recombination Regulation Of Systemic Arterial Blood Pressure By Norepinephrine-epinephrine Positive Regulation Of Nucleobase-containing Compound Metabolic Process Positive Regulation Of Mini Excitatory Postsynaptic Potential Nucleic Acid Metabolic Process Protein Localization To Chromosome DNA Damage Checkpoint Signaling Nucleobase-containing Compound Metabolic Process Fat Cell Differentiation Regulation Of Transcription By RNA Polymerase II Positive Regulation Of Macromolecule Biosynthetic Process Beta2-adrenergic Receptor Activity Regulation Of DNA Recombination Negative Regulation Of DNA Metabolic Process Regulation Of Double-strand Break Repair DNA Metabolic Process DNA Damage Response Response To Ionizing Radiation Signal Transduction In Response To DNA Damage Positive Regulation Of Peptidyl-serine Phosphorylation Of STAT Protein Negative Regulation Of DNA Strand Resection Involved In Replication Fork Processing Transcription Coregulator Activity Positive Regulation Of Biosynthetic Process Norepinephrine-epinephrine-mediated Vasodilation Involved In Regulation Of Systemic Arterial Blood Pressure Beta-adrenergic Receptor Activity Regulation Of DNA Strand Resection Involved In Replication Fork Processing Norepinephrine Binding Histone H4K20me Methyltransferase Activity Response To Psychosocial Stress Positive Regulation Of Macromolecule Metabolic Process Regulation Of DNA-templated Transcription Response To Stress Positive Regulation Of Lipophagy Regulation Of RNA Biosynthetic Process AMPA Selective Glutamate Receptor Signaling Pathway Negative Regulation Of Cell Cycle Phase Transition Regulation Of DNA Repair Positive Regulation Of Metabolic Process
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