PIAS1 and SATB1

Number of citations: 68 (PubMedID 18408014)
Data Source: BioGRID (enzymatic study)

		PIAS1	SATB1
Name		protein inhibitor of activated STAT 1	SATB homeobox 1
Structure
GO Annotations	Cellular Component	Chromatin Nucleus Nucleoplasm Cytoplasm Cytoskeleton PML Body Nuclear Speck Nuclear Periphery Glutamatergic Synapse Presynaptic Cytosol Postsynaptic Cytosol	Chromatin Nucleus Nucleoplasm Nuclear Matrix Nuclear Body PML Body Nuclear Lumen
	Molecular Function	Transcription Cis-regulatory Region Binding DNA Binding Transcription Coregulator Activity Transcription Corepressor Activity Protein Binding Zinc Ion Binding Transferase Activity SUMO Transferase Activity Enzyme Binding Protein Domain Specific Binding Ubiquitin Protein Ligase Binding Metal Ion Binding SUMO Ligase Activity DNA-binding Transcription Factor Binding	RNA Polymerase II Transcription Regulatory Region Sequence-specific DNA Binding RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific DNA-binding Transcription Repressor Activity, RNA Polymerase II-specific DNA Binding Double-stranded DNA Binding DNA-binding Transcription Factor Activity Protein Binding Sequence-specific DNA Binding
	Biological Process	G1/S Transition Of Mitotic Cell Cycle Negative Regulation Of Transcription By RNA Polymerase II Double-strand Break Repair Via Homologous Recombination DNA Double-strand Break Processing Regulation Of Transcription By RNA Polymerase II DNA Damage Response Cell Surface Receptor Signaling Pathway Via JAK-STAT Spermatogenesis Visual Learning Protein Sumoylation Positive Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Positive Regulation Of Protein Sumoylation Regulation Of Cell Population Proliferation Negative Regulation Of Apoptotic Process Fat Cell Differentiation Positive Regulation Of DNA-templated Transcription Positive Regulation Of Smooth Muscle Cell Differentiation Regulation Of Macromolecule Metabolic Process Protein-DNA Complex Assembly Positive Regulation Of Protein Localization To Cell Periphery	Negative Regulation Of Transcription By RNA Polymerase II Chromatin Organization Chromatin Remodeling Regulation Of Transcription By RNA Polymerase II
Pathways		SUMOylation of DNA damage response and repair proteins SUMOylation of transcription factors SUMOylation of ubiquitinylation proteins SUMOylation of transcription cofactors SUMOylation of intracellular receptors SUMOylation of intracellular receptors SUMOylation of chromatin organization proteins Formation of Incision Complex in GG-NER Regulation of IFNG signaling	Apoptotic cleavage of cellular proteins SUMOylation of chromatin organization proteins
GWAS		Diastolic blood pressure ( 30224653 ) Diverticular disease ( 30177863 ) Gut microbiota (bacterial taxa, hurdle binary method) ( 32572223 ) Haemorrhoidal disease ( 33888516 ) Major depressive disorder ( 23377640 ) Number of twin births ( 30760885 )	Adventurousness ( 30643258 ) Aspartate aminotransferase levels ( 33547301 ) Chronic mucus hypersecretion ( 24714607 ) Familial lung adenocarcinoma ( 29924316 ) General risk tolerance (MTAG) ( 30643258 ) Itch intensity from mosquito bite ( 28199695 ) Left-handedness ( 32989287 ) Parkinson's disease ( 28892059 ) Parkinson's disease or first degree relation to individual with Parkinson's disease ( 31701892 ) Platelet count ( 22139419 ) Response to fenofibrate (HDL cholesterol levels) ( 27002377 ) Sjögren's syndrome ( 24097067 )
Interacting Genes		118 interacting genes: AKT1 AR ATXN1 AXIN1 BARD1 BRCA1 CASP8 CBS CDK4 CEBPA CEBPE CHD3 CHUK CNOT7 CREB1 CREBBP CSNK2A1 CSRP2 DCLRE1A DDX21 DDX5 DNM1 DNMT3A ELK3 EP300 ERG ESR1 ESR2 FANCI FHL3 FLI1 GATA4 GLUL GRM8 GSK3B GTF2IRD1 H2AZ1 H2BC3 H3C1 HECTD2 HIC1 HTT IKZF5 JUN L3MBTL2 LSM3 MAML1 MBD1 MDC1 MDM2 MITF MORC3 MSX1 MX1 MYB NCOR1 NFATC1 NIN NR2F2 NR3C2 NR5A1 NRIP1 PAXIP1 PGR PIAS2 PIAS4 PLAG1 PML PPP1CA PPP1CC PRDM1 PRPF40A PTK2 PTPN1 QKI RAD51 RAD54L2 RBBP6 RELA RHOB RPA2 SATB1 SATB2 SERBP1 SETX SGTA SKIL SMAD1 SMAD4 SMAD7 SNAI2 SNIP1 SP3 SPOP SREBF2 STAT1 SUFU SUMO1 SUMO1P1 SUMO2 SUMO3 TBP TERF2 TERF2IP TEX11 TP53 TP73 TRIM27 TRIM5 TRIM55 TRIM63 TSG101 UBE2I UBE2L3 YWHAZ ZBED1 ZNF451 ZNF76	28 interacting genes: BAZ1A CASP6 CBS CBX4 CHD3 CUX1 EP300 FOXP1 FOXP2 FOXP4 GATA3 HDAC1 KAT2B MEOX2 MTA2 PIAS1 PIAS3 PIAS4 POLR2J SIRT1 SMARCA5 SPG21 SUMO1 SUMO1P1 TOPORS UBE2I UBR5 USP16
Entrez ID		8554	6304
HPRD ID		16029	03647
Ensembl ID		ENSG00000033800	ENSG00000182568
Uniprot IDs		O75925	Q01826
PDB IDs		1V66	1YSE 2L1P 2MW8 2O49 2O4A 3NZL 3TUO 6LFF
GO Terms Enriched among Interactors		Nucleus Regulation Of Nucleobase-containing Compound Metabolic Process Nucleoplasm Regulation Of Transcription By RNA Polymerase II Regulation Of DNA-templated Transcription Regulation Of RNA Biosynthetic Process Regulation Of RNA Metabolic Process Negative Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of Primary Metabolic Process Negative Regulation Of RNA Metabolic Process Regulation Of Macromolecule Metabolic Process Negative Regulation Of DNA-templated Transcription Negative Regulation Of RNA Biosynthetic Process Regulation Of Metabolic Process Negative Regulation Of Macromolecule Biosynthetic Process Negative Regulation Of Macromolecule Metabolic Process Regulation Of Macromolecule Biosynthetic Process Regulation Of Gene Expression DNA Binding Negative Regulation Of Biosynthetic Process Negative Regulation Of Transcription By RNA Polymerase II Negative Regulation Of Metabolic Process Positive Regulation Of Transcription By RNA Polymerase II Positive Regulation Of DNA-templated Transcription Positive Regulation Of RNA Biosynthetic Process Positive Regulation Of Nucleobase-containing Compound Metabolic Process Positive Regulation Of RNA Metabolic Process Chromatin PML Body Positive Regulation Of Macromolecule Metabolic Process Positive Regulation Of Metabolic Process RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity Sequence-specific DNA Binding Positive Regulation Of Macromolecule Biosynthetic Process Positive Regulation Of Biosynthetic Process Enzyme Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific Protein Sumoylation Macromolecule Metabolic Process Ubiquitin Protein Ligase Binding DNA-binding Transcription Activator Activity, RNA Polymerase II-specific Response To Stress Cellular Response To Stress RNA Polymerase II-specific DNA-binding Transcription Factor Binding Regulation Of Cellular Response To Stress Nucleic Acid Metabolic Process Chromatin Binding Intracellular Signal Transduction SUMO Transferase Activity	Negative Regulation Of Transcription By RNA Polymerase II Protein Sumoylation Negative Regulation Of DNA-templated Transcription Chromatin Negative Regulation Of RNA Biosynthetic Process Negative Regulation Of RNA Metabolic Process SUMO Transferase Activity Negative Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of Transcription By RNA Polymerase II PML Body Regulation Of DNA-templated Transcription Regulation Of RNA Biosynthetic Process Regulation Of RNA Metabolic Process Nucleus Negative Regulation Of Macromolecule Biosynthetic Process Regulation Of Nucleobase-containing Compound Metabolic Process Negative Regulation Of Biosynthetic Process Nucleoplasm Chromatin Organization Post-translational Protein Modification Chromatin Remodeling SUMO Ligase Activity Negative Regulation Of Macromolecule Metabolic Process Regulation Of Gene Expression Protein Modification Process Regulation Of Macromolecule Biosynthetic Process Macromolecule Metabolic Process Negative Regulation Of Metabolic Process DNA Binding Transcription Coregulator Activity Protein Modification By Small Protein Conjugation Presynaptic Cytosol Postsynaptic Cytosol Regulation Of Primary Metabolic Process Regulation Of Macromolecule Metabolic Process Positive Regulation Of Macromolecule Metabolic Process Regulation Of Androgen Receptor Signaling Pathway DNA Damage Response DNA-binding Transcription Factor Binding Cellular Response To Stress Zinc Ion Binding Positive Regulation Of Metabolic Process Regulation Of Cell Fate Commitment Positive Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of Metabolic Process Transcription Corepressor Activity Peptidyl-lysine Acetylation Positive Regulation Of Protein Sumoylation Metal Ion Binding NuRD Complex