PIAS1 and SATB1

Number of citations of the paper that reports this interaction (PMID 18408014)
14

Data Source:
BioGRID (enzymatic study)

		PIAS1	SATB1
Gene Name		protein inhibitor of activated STAT, 1	SATB homeobox 1
Image
Gene Ontology Annotations	Cellular Component	Nucleus Nucleoplasm PML Body Nuclear Speck	Nucleus Nucleoplasm Nuclear Heterochromatin Nuclear Matrix PML Body
	Molecular Function	DNA Binding Transcription Coactivator Activity Transcription Corepressor Activity Protein Binding Zinc Ion Binding Ligase Activity Enzyme Binding Protein Domain Specific Binding Ubiquitin Protein Ligase Binding Androgen Receptor Binding SUMO Ligase Activity	RNA Polymerase II Regulatory Region Sequence-specific DNA Binding RNA Polymerase II Transcription Regulatory Region Sequence-specific DNA Binding Transcription Factor Activity Involved In Negative Regulation Of Transcription Chromatin Binding Double-stranded DNA Binding Protein Binding
	Biological Process	Negative Regulation Of Transcription From RNA Polymerase II Promoter Transcription, DNA-templated JAK-STAT Cascade Spermatogenesis Protein Sumoylation Cytokine-mediated Signaling Pathway Androgen Receptor Signaling Pathway Positive Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Positive Regulation Of Protein Sumoylation Regulation Of Cell Proliferation Positive Regulation Of Transcription, DNA-templated Positive Regulation Of Smooth Muscle Cell Differentiation Interferon-gamma-mediated Signaling Pathway Regulation Of Interferon-gamma-mediated Signaling Pathway Protein-DNA Complex Assembly	Negative Regulation Of Transcription From RNA Polymerase II Promoter Chromatin Organization Chromatin Remodeling Transcription, DNA-templated Apoptotic Process Cellular Component Disassembly Involved In Execution Phase Of Apoptosis Epidermis Development Viral Process Histone Methylation CD4-positive, Alpha-beta T Cell Differentiation CD8-positive, Alpha-beta T Cell Differentiation Activated T Cell Proliferation Reflex
Pathways		Interferon gamma signaling Interferon Signaling Cytokine Signaling in Immune system Regulation of IFNG signaling	Apoptotic cleavage of cellular proteins Programmed Cell Death Apoptotic execution phase
Drugs
Diseases
GWAS		Major depressive disorder ( 23377640)	Platelet counts ( 22139419)
Protein-Protein Interactions		92 interactors: AKT1 AR ATXN1 AXIN1 BARD1 BRCA1 CARM1 CASP8 CBS CEBPA CEBPE CHUK CREB1 CREBBP CSNK2A1 CSRP2 DCLRE1A DDX21 DDX5 DNM1 DNMT3A ELK3 ESR1 ESR2 FLI1 GATA4 GLUL GRM8 HIC1 HTT JUN L3MBTL2 MAML1 MBD1 MDC1 MDM2 MITF MSX1 MX1 MYB NCOR1 NFATC1 NIN NR2F2 NR3C2 NR5A1 PAXIP1 PGR PIAS2 PIAS4 PLAG1 PML PPP1CA PPP1CC PRDM1 PRMT1 PRMT6 PRPF40A PTK2 PTPN1 RAD54L2 RBBP6 RELA SATB1 SATB2 SERBP1 SGTA SIAH1 SIAH2 SKIL SMAD1 SMAD4 SMAD7 SNIP1 SP3 SPOP SREBF2 STAT1 SUFU SUMO1 SUMO2 SUMO3 TBP TP53 TP73 TRIM27 TRIM55 TRIM63 UBE2I YWHAZ ZNF451 ZNF76	23 interactors: BAZ1A CASP6 CBX4 CHD3 CUX1 DYT10 EP300 GATA3 HDAC1 KAT2B MTA2 PIAS1 PIAS3 PIAS4 POLR2J SIRT1 SMARCA5 SUMO1 SUMO1P1 SUMO3 TOPORS UBE2I UBR5
Entrez ID		8554	6304
HPRD ID		16029	03647
Ensembl ID		ENSG00000033800	ENSG00000182568
Uniprot IDs		O75925 Q1XBU8	Q01826
PDB IDs		1V66	1YSE 2L1P 2O49 2O4A 3NZL 3TUO
Enriched GO Terms of Interacting Partners?		Negative Regulation Of Gene Expression Regulation Of Transcription From RNA Polymerase II Promoter Regulation Of Gene Expression Negative Regulation Of Nucleic Acid-templated Transcription Negative Regulation Of RNA Biosynthetic Process Negative Regulation Of Biosynthetic Process Negative Regulation Of Transcription, DNA-templated Transcription, DNA-templated Transcription From RNA Polymerase II Promoter Regulation Of RNA Metabolic Process Regulation Of Nucleic Acid-templated Transcription RNA Biosynthetic Process Regulation Of RNA Biosynthetic Process Regulation Of Nitrogen Compound Metabolic Process Regulation Of Transcription, DNA-templated Regulation Of Metabolic Process Positive Regulation Of Gene Expression Negative Regulation Of Cellular Metabolic Process Gene Expression Cellular Nitrogen Compound Metabolic Process RNA Metabolic Process Positive Regulation Of Transcription, DNA-templated Negative Regulation Of Transcription From RNA Polymerase II Promoter Positive Regulation Of Transcription From RNA Polymerase II Promoter Nucleobase-containing Compound Metabolic Process Heterocycle Metabolic Process Positive Regulation Of Macromolecule Biosynthetic Process Positive Regulation Of Cellular Metabolic Process Nitrogen Compound Metabolic Process Cellular Aromatic Compound Metabolic Process Cellular Metabolic Process Positive Regulation Of Cellular Biosynthetic Process Positive Regulation Of Metabolic Process Cellular Macromolecule Biosynthetic Process Cellular Response To Organic Substance Macromolecule Biosynthetic Process Response To Organic Substance Cellular Response To Stimulus Regulation Of Cellular Process Multicellular Organismal Development Biosynthetic Process Response To Stimulus Regulation Of Signaling Cell Differentiation Organ Development Signaling Signal Transduction Anatomical Structure Development Developmental Process Regulation Of Signal Transduction	Protein Sumoylation Peptidyl-lysine Modification Regulation Of Nitrogen Compound Metabolic Process Negative Regulation Of Transcription, DNA-templated Transcription, DNA-templated Negative Regulation Of Nucleic Acid-templated Transcription Negative Regulation Of RNA Biosynthetic Process Protein Modification By Small Protein Conjugation RNA Biosynthetic Process Regulation Of RNA Biosynthetic Process Regulation Of RNA Metabolic Process Peptidyl-amino Acid Modification Nucleobase-containing Compound Metabolic Process Negative Regulation Of Cellular Metabolic Process Negative Regulation Of Gene Expression Negative Regulation Of Biosynthetic Process Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process Regulation Of Gene Expression Negative Regulation Of Transcription From RNA Polymerase II Promoter Regulation Of Transcription From RNA Polymerase II Promoter Cellular Nitrogen Compound Metabolic Process Regulation Of Transcription, DNA-templated Regulation Of Nucleic Acid-templated Transcription Chromatin Modification Regulation Of Metabolic Process Positive Regulation Of Cellular Metabolic Process RNA Metabolic Process Nitrogen Compound Metabolic Process Chromatin Organization Positive Regulation Of Metabolic Process Gene Expression Chromatin Remodeling Cellular Macromolecule Biosynthetic Process Macromolecule Biosynthetic Process Positive Regulation Of Gene Expression Cellular Protein Modification Process Chromosome Organization Regulation Of Intracellular Steroid Hormone Receptor Signaling Pathway Positive Regulation Of Macromolecule Biosynthetic Process Regulation Of Cellular Protein Metabolic Process Positive Regulation Of Protein Sumoylation Positive Regulation Of Cellular Biosynthetic Process Cellular Metabolic Process Regulation Of Protein Metabolic Process Biosynthetic Process Regulation Of Protein Sumoylation Positive Regulation Of Transcription, DNA-templated Regulation Of Androgen Receptor Signaling Pathway Cellular Protein Metabolic Process
Tagcloud ?		akap6 atf7 atxn1 bmpr2 categorize deltan eef1a1 grip2 gtf2f1 interactors jbd jbds jnk1alpha1 jnk3 jnk3alpha1 jnks kcne4 myo9b nnat ptgds ptpn2 rabgap1 rusc2 shank1 sumo1 sypl1 tkt topbp1 znf668	biomarker clinicopathologic confidence depth endometrial federation gynecology hazards histological international interval invasion lymphatic metastasis myometrial node obstetrics organizer overexpressed parameter predicting prognostic rich serve serves special treating untreated worse
Tagcloud (Difference) ?		akap6 atf7 atxn1 bmpr2 categorize deltan eef1a1 grip2 gtf2f1 interactors jbd jbds jnk1alpha1 jnk3 jnk3alpha1 jnks kcne4 myo9b nnat ptgds ptpn2 rabgap1 rusc2 shank1 sumo1 sypl1 tkt topbp1 znf668	biomarker clinicopathologic confidence depth endometrial federation gynecology hazards histological international interval invasion lymphatic metastasis myometrial node obstetrics organizer overexpressed parameter predicting prognostic rich serve serves special treating untreated worse
Tagcloud (Intersection) ?