CDKN2B and TRAF1

Number of citations of the paper that reports this interaction (PMID 25416956)
0

Data Source:
BioGRID (two hybrid)

		CDKN2B	TRAF1
Gene Name		cyclin-dependent kinase inhibitor 2B (p15, inhibits CDK4)	TNF receptor-associated factor 1
Image		No pdb structure
Gene Ontology Annotations	Cellular Component	Nucleus Nucleoplasm Cytoplasm Cytosol	Cytoplasm
	Molecular Function	Cyclin-dependent Protein Serine/threonine Kinase Inhibitor Activity Protein Binding Protein Kinase Binding	Tumor Necrosis Factor Receptor Binding Protein Binding Zinc Ion Binding Ubiquitin Protein Ligase Binding Thioesterase Binding
	Biological Process	Regulation Of Cyclin-dependent Protein Serine/threonine Kinase Activity G2/M Transition Of Mitotic Cell Cycle Mitotic Cell Cycle Liver Development Transcription, DNA-templated Transcription Initiation From RNA Polymerase II Promoter Cell Cycle Arrest Mitotic Cell Cycle Checkpoint Transforming Growth Factor Beta Receptor Signaling Pathway Aging Negative Regulation Of Cell Proliferation Gene Expression Response To Organic Cyclic Compound Megakaryocyte Differentiation Positive Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway Positive Regulation Of Epithelial Cell Differentiation Cellular Response To Extracellular Stimulus Cellular Response To Nutrient Response To Cytokine Negative Regulation Of Phosphorylation Positive Regulation Of Transcription From RNA Polymerase II Promoter Spleen Development Negative Regulation Of Epithelial Cell Proliferation Negative Regulation Of Protein Serine/threonine Kinase Activity Negative Regulation Of G1/S Transition Of Mitotic Cell Cycle	Protein Complex Assembly Apoptotic Process Signal Transduction Positive Regulation Of NF-kappaB Transcription Factor Activity Regulation Of Extrinsic Apoptotic Signaling Pathway
Pathways		Loss of Function of TGFBR2 in Cancer SMAD2/3 MH2 Domain Mutants in Cancer Cellular Senescence Oncogene Induced Senescence TGFBR1 LBD Mutants in Cancer SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription Transcriptional activity of SMAD2/SMAD3:SMAD4 heterotrimer Generic Transcription Pathway Mitotic G1-G1/S phases TGFBR2 MSI Frameshift Mutants in Cancer SMAD2/3 Phosphorylation Motif Mutants in Cancer Loss of Function of SMAD2/3 in Cancer TGFBR2 Kinase Domain Mutants in Cancer Loss of Function of SMAD4 in Cancer G1 Phase Senescence-Associated Secretory Phenotype (SASP) TGFBR1 KD Mutants in Cancer Cell Cycle, Mitotic Loss of Function of TGFBR1 in Cancer Cyclin D associated events in G1 Signaling by TGF-beta Receptor Complex in Cancer Signaling by TGF-beta Receptor Complex Oxidative Stress Induced Senescence SMAD4 MH2 Domain Mutants in Cancer
Drugs
Diseases
GWAS		Ankle-brachial index ( 22199011) Breast cancer ( 23535729 20453838) Coronary artery calcification ( 22144573 23561647) Coronary heart disease ( 21626137 21971053 17554300 21378990) Endometriosis ( 23104006) Fasting glucose-related traits (interaction with BMI) ( 22581228) Glaucoma ( 22792221) Glaucoma (primary open-angle) ( 22419738) Glioma ( 21531791 19578367) Intracranial aneurysm ( 18997786 20364137) Myocardial infarction ( 17478679) Myocardial infarction (early onset) ( 19198609) Nasopharyngeal carcinoma ( 20512145) Type 2 diabetes ( 21573907 18372903 22293688 22961080 20581827 19401414 17463246 17463248 17463249 19056611) Vertical cup-disc ratio ( 20548946)	Celiac disease and Rheumatoid arthritis ( 21383967) Rheumatoid arthritis ( 20453842 19503088)
Protein-Protein Interactions		15 interactors: APP ARPC3 CCDC33 CCDC90B CDK4 CDK6 CDK8 IKBKAP ISL1 KIAA1377 MAGEA11 NIF3L1 TGFB1I1 TRAF1 ZBTB17	164 interactors: A1CF ACTN3 AES AKAP17A ALS2CR11 AQP1 ARNT2 ARSJ BARD1 BCL6 BEX2 BIRC2 BIRC3 C14orf105 C19orf66 C1orf109 C1orf216 C5orf30 CARHSP1 CASP10 CASP3 CASP6 CASP8 CCDC116 CCDC120 CCDC146 CCHCR1 CD40 CDCA3 CDKN1A CDKN2B CFLAR CHCHD3 COX5B CRYGA CYB5R2 DEPTOR DGCR6 DMRT3 DOK3 ECH1 EDAR EHHADH EWSR1 FAM161A FAM86C1 FBF1 FBXL18 FOSL2 GATA2 GATAD2B GEM GFI1B GIT2 GLRX3 GMCL1P1 GNG5 GORASP2 HAUS1 HEY2 HIVEP3 HOXA1 HOXD12 IKBKB JOSD1 KIAA1217 KIF1A KLHL38 KPNA2 LATS1 LCOR LOC149950 LTBR MAP3K14 MAP6 MAPRE2 METTL17 MORN3 MOS MYEF2 NEBL NGFRAP1 NUFIP2 NUPL1 OLIG3 PBX3 PDE4D PHF21A PIN1 PKN1 PLEKHN1 POM121L4P POP5 PPP1R13B PRDM7 PSMA1 PSMB1 QRICH1 RASAL2 RASSF5 RBCK1 RBM41 RBM45 RIPK1 RIPK2 RNF31 RTP5 SCNM1 SIK3 SLC25A48 SLC25A6 SNW1 SPG21 SPOP SRC SSC5D STK3 SYCE1 TANK TBC1D16 TCL1A TEAD4 TFAP4 THAP7 TICAM1 TNFAIP3 TNFRSF11A TNFRSF12A TNFRSF14 TNFRSF17 TNFRSF18 TNFRSF19 TNFRSF1A TNFRSF1B TNFRSF4 TNFRSF8 TNFRSF9 TNFSF9 TRADD TRAF2 TRAF3IP2 TRAF6 TRAIP TRIM23 TRIM37 TRIM42 TRPV6 TSSC4 USP7 WAC ZC2HC1C ZFYVE21 ZFYVE26 ZNF124 ZNF20 ZNF417 ZNF440 ZNF502 ZNF512B ZNF564 ZNF572 ZNF581 ZNF587 ZNF662
Entrez ID		1030	7185
HPRD ID		02696	03418
Ensembl ID		ENSG00000147883	ENSG00000056558
Uniprot IDs		K7PPU3 P42772	Q13077
PDB IDs			3M0D
Enriched GO Terms of Interacting Partners?		Positive Regulation Of Gene Expression Positive Regulation Of Macromolecule Biosynthetic Process Positive Regulation Of Cellular Biosynthetic Process Regulation Of Gene Expression Positive Regulation Of Transcription, DNA-templated Notch Signaling Pathway Positive Regulation Of Metabolic Process Regulation Of Cell Cycle Positive Regulation Of G2/M Transition Of Mitotic Cell Cycle Positive Regulation Of Cellular Metabolic Process Cellular Response To Stimulus Regulation Of Protein Phosphorylation Signal Transduction Regulation Of G2/M Transition Of Mitotic Cell Cycle Signaling Regulation Of Cell Cycle G2/M Phase Transition Regulation Of Transcription, DNA-templated Regulation Of Phosphorylation Protein Phosphorylation Cell Communication Regulation Of Nucleic Acid-templated Transcription Regulation Of RNA Biosynthetic Process Regulation Of Metabolic Process Positive Regulation Of Mitotic Cell Cycle Phase Transition Negative Regulation Of Cell Differentiation Regulation Of RNA Metabolic Process Regulation Of Protein Kinase Activity Positive Regulation Of Cell Cycle Phase Transition Regulation Of Kinase Activity Positive Regulation Of Fibroblast Proliferation Regulation Of Phosphorus Metabolic Process Cell Dedifferentiation Anatomical Structure Morphogenesis Cell Projection Morphogenesis Cell Part Morphogenesis Transcription From RNA Polymerase II Promoter Anatomical Structure Development Response To Stimulus Regulation Of Nitrogen Compound Metabolic Process Axon Guidance Positive Regulation Of Macrophage Colony-stimulating Factor Production Synaptic Growth At Neuromuscular Junction Positive Regulation Of Granulocyte Colony-stimulating Factor Production 7,8-dihydroneopterin 3'-triphosphate Biosynthetic Process Pancreas Development Regulation Of Fibroblast Proliferation Forebrain Development Negative Regulation Of Cell Cycle Phosphorylation Cell Morphogenesis	Cell Death Death Programmed Cell Death Apoptotic Process Positive Regulation Of I-kappaB Kinase/NF-kappaB Signaling Regulation Of I-kappaB Kinase/NF-kappaB Signaling Regulation Of Apoptotic Process Tumor Necrosis Factor-mediated Signaling Pathway Regulation Of Cell Death Positive Regulation Of Protein Metabolic Process Positive Regulation Of Cellular Protein Metabolic Process Positive Regulation Of Intracellular Signal Transduction Positive Regulation Of Signal Transduction Regulation Of Nitrogen Compound Metabolic Process Regulation Of Cellular Protein Metabolic Process Positive Regulation Of NF-kappaB Transcription Factor Activity Response To Tumor Necrosis Factor Regulation Of Protein Metabolic Process Positive Regulation Of Programmed Cell Death Intracellular Signal Transduction Positive Regulation Of Cell Death Regulation Of Metabolic Process Positive Regulation Of Apoptotic Process Regulation Of Cellular Process TRIF-dependent Toll-like Receptor Signaling Pathway Regulation Of Sequence-specific DNA Binding Transcription Factor Activity MyD88-independent Toll-like Receptor Signaling Pathway Toll-like Receptor 3 Signaling Pathway Cellular Response To Tumor Necrosis Factor Regulation Of Necroptotic Process Regulation Of Transcription, DNA-templated Immune System Process Positive Regulation Of Sequence-specific DNA Binding Transcription Factor Activity Regulation Of RNA Metabolic Process Regulation Of Nucleic Acid-templated Transcription Signal Transduction Regulation Of RNA Biosynthetic Process Toll-like Receptor 4 Signaling Pathway Regulation Of Gene Expression Regulation Of Intracellular Signal Transduction Regulation Of Signal Transduction Positive Regulation Of Cellular Metabolic Process Signaling Immune Response-regulating Signaling Pathway Regulation Of Cytokine Production Cell Communication Pattern Recognition Receptor Signaling Pathway Positive Regulation Of Immune System Process Innate Immune Response-activating Signal Transduction Positive Regulation Of Protein Modification Process
Tagcloud ?		a134c abp allelic ankyrin balb cdk6 cdnas chr congenic d2 dba g232a ifna inbred inefficient ink4c le multigenic mus p15 p16 p18 pctr1 plasmacytoma pristane spretus typed	adaptor appear characterization convey daxx death domains effector fadd far growing homologies insights isolation jun mammalian members mort necrosis represents rip seem share signals superfamily tnfr tradd transmit
Tagcloud (Difference) ?		a134c abp allelic ankyrin balb cdk6 cdnas chr congenic d2 dba g232a ifna inbred inefficient ink4c le multigenic mus p15 p16 p18 pctr1 plasmacytoma pristane spretus typed	adaptor appear characterization convey daxx death domains effector fadd far growing homologies insights isolation jun mammalian members mort necrosis represents rip seem share signals superfamily tnfr tradd transmit
Tagcloud (Intersection) ?