CDKN2B and CDK8

Number of citations of the paper that reports this interaction (PMID 12007796)
0

Data Source:
HPRD (in vitro)

		CDKN2B	CDK8
Gene Name		cyclin-dependent kinase inhibitor 2B (p15, inhibits CDK4)	cyclin-dependent kinase 8
Image		No pdb structure
Gene Ontology Annotations	Cellular Component	Nucleus Nucleoplasm Cytoplasm Cytosol	Nucleus Nucleoplasm Mediator Complex
	Molecular Function	Cyclin-dependent Protein Serine/threonine Kinase Inhibitor Activity Protein Binding Protein Kinase Binding	Protein Kinase Activity Cyclin-dependent Protein Serine/threonine Kinase Activity Protein Binding ATP Binding RNA Polymerase II Carboxy-terminal Domain Kinase Activity
	Biological Process	Regulation Of Cyclin-dependent Protein Serine/threonine Kinase Activity G2/M Transition Of Mitotic Cell Cycle Mitotic Cell Cycle Liver Development Transcription, DNA-templated Transcription Initiation From RNA Polymerase II Promoter Cell Cycle Arrest Mitotic Cell Cycle Checkpoint Transforming Growth Factor Beta Receptor Signaling Pathway Aging Negative Regulation Of Cell Proliferation Gene Expression Response To Organic Cyclic Compound Megakaryocyte Differentiation Positive Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway Positive Regulation Of Epithelial Cell Differentiation Cellular Response To Extracellular Stimulus Cellular Response To Nutrient Response To Cytokine Negative Regulation Of Phosphorylation Positive Regulation Of Transcription From RNA Polymerase II Promoter Spleen Development Negative Regulation Of Epithelial Cell Proliferation Negative Regulation Of Protein Serine/threonine Kinase Activity Negative Regulation Of G1/S Transition Of Mitotic Cell Cycle	Transcription, DNA-templated Transcription Initiation From RNA Polymerase II Promoter Protein Phosphorylation Transforming Growth Factor Beta Receptor Signaling Pathway Notch Signaling Pathway Gene Expression Positive Regulation Of Transcription From RNA Polymerase II Promoter Regulation Of Cell Cycle
Pathways		Loss of Function of TGFBR2 in Cancer SMAD2/3 MH2 Domain Mutants in Cancer Cellular Senescence Oncogene Induced Senescence TGFBR1 LBD Mutants in Cancer SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription Transcriptional activity of SMAD2/SMAD3:SMAD4 heterotrimer Generic Transcription Pathway Mitotic G1-G1/S phases TGFBR2 MSI Frameshift Mutants in Cancer SMAD2/3 Phosphorylation Motif Mutants in Cancer Loss of Function of SMAD2/3 in Cancer TGFBR2 Kinase Domain Mutants in Cancer Loss of Function of SMAD4 in Cancer G1 Phase Senescence-Associated Secretory Phenotype (SASP) TGFBR1 KD Mutants in Cancer Cell Cycle, Mitotic Loss of Function of TGFBR1 in Cancer Cyclin D associated events in G1 Signaling by TGF-beta Receptor Complex in Cancer Signaling by TGF-beta Receptor Complex Oxidative Stress Induced Senescence SMAD4 MH2 Domain Mutants in Cancer	Loss of Function of TGFBR2 in Cancer PPARA activates gene expression Signaling by NOTCH1 HD Domain Mutants in Cancer Metabolism of lipids and lipoproteins Signaling by NOTCH1 HD+PEST Domain Mutants in Cancer SMAD2/3 MH2 Domain Mutants in Cancer TGFBR1 LBD Mutants in Cancer SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription Transcriptional activity of SMAD2/SMAD3:SMAD4 heterotrimer Signaling by NOTCH1 t(7;9)(NOTCH1:M1580_K2555) Translocation Mutant Generic Transcription Pathway Signaling by NOTCH1 Transcriptional regulation of white adipocyte differentiation Signaling by NOTCH1 in Cancer Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants FBXW7 Mutants and NOTCH1 in Cancer TGFBR2 MSI Frameshift Mutants in Cancer Fatty acid, triacylglycerol, and ketone body metabolism SMAD2/3 Phosphorylation Motif Mutants in Cancer Loss of Function of SMAD2/3 in Cancer Signaling by NOTCH TGFBR2 Kinase Domain Mutants in Cancer Loss of Function of SMAD4 in Cancer TGFBR1 KD Mutants in Cancer Loss of Function of TGFBR1 in Cancer NOTCH1 Intracellular Domain Regulates Transcription Signaling by TGF-beta Receptor Complex in Cancer Signaling by TGF-beta Receptor Complex Signaling by NOTCH1 PEST Domain Mutants in Cancer Regulation of lipid metabolism by Peroxisome proliferator-activated receptor alpha (PPARalpha) Constitutive Signaling by NOTCH1 PEST Domain Mutants SMAD4 MH2 Domain Mutants in Cancer
Drugs
Diseases
GWAS		Ankle-brachial index ( 22199011) Breast cancer ( 23535729 20453838) Coronary artery calcification ( 22144573 23561647) Coronary heart disease ( 21626137 21971053 17554300 21378990) Endometriosis ( 23104006) Fasting glucose-related traits (interaction with BMI) ( 22581228) Glaucoma ( 22792221) Glaucoma (primary open-angle) ( 22419738) Glioma ( 21531791 19578367) Intracranial aneurysm ( 18997786 20364137) Myocardial infarction ( 17478679) Myocardial infarction (early onset) ( 19198609) Nasopharyngeal carcinoma ( 20512145) Type 2 diabetes ( 21573907 18372903 22293688 22961080 20581827 19401414 17463246 17463248 17463249 19056611) Vertical cup-disc ratio ( 20548946)
Protein-Protein Interactions		15 interactors: APP ARPC3 CCDC33 CCDC90B CDK4 CDK6 CDK8 IKBKAP ISL1 KIAA1377 MAGEA11 NIF3L1 TGFB1I1 TRAF1 ZBTB17	29 interactors: BCL6 CCNC CCNH CDKN2B CTD CTDP1 ERCC3 ESR1 ESR2 HIST2H3C MAML1 MBP MED12 MED21 MED25 MED26 MED8 MED9 MYC NRIP1 POLR2A SGCG SMAD2 SMAD3 SMARCA4 SREBF1 SUZ12 TOP1 TP53
Entrez ID		1030	1024
HPRD ID		02696	04422
Ensembl ID		ENSG00000147883	ENSG00000132964
Uniprot IDs		K7PPU3 P42772	P49336
PDB IDs			3RGF 4F6S 4F6U 4F6W 4F70 4F7J 4F7L 4F7N 4F7S 4G6L
Enriched GO Terms of Interacting Partners?		Positive Regulation Of Gene Expression Positive Regulation Of Macromolecule Biosynthetic Process Positive Regulation Of Cellular Biosynthetic Process Regulation Of Gene Expression Positive Regulation Of Transcription, DNA-templated Notch Signaling Pathway Positive Regulation Of Metabolic Process Regulation Of Cell Cycle Positive Regulation Of G2/M Transition Of Mitotic Cell Cycle Positive Regulation Of Cellular Metabolic Process Cellular Response To Stimulus Regulation Of Protein Phosphorylation Signal Transduction Regulation Of G2/M Transition Of Mitotic Cell Cycle Signaling Regulation Of Cell Cycle G2/M Phase Transition Regulation Of Transcription, DNA-templated Regulation Of Phosphorylation Protein Phosphorylation Cell Communication Regulation Of Nucleic Acid-templated Transcription Regulation Of RNA Biosynthetic Process Regulation Of Metabolic Process Positive Regulation Of Mitotic Cell Cycle Phase Transition Negative Regulation Of Cell Differentiation Regulation Of RNA Metabolic Process Regulation Of Protein Kinase Activity Positive Regulation Of Cell Cycle Phase Transition Regulation Of Kinase Activity Positive Regulation Of Fibroblast Proliferation Regulation Of Phosphorus Metabolic Process Cell Dedifferentiation Anatomical Structure Morphogenesis Cell Projection Morphogenesis Cell Part Morphogenesis Transcription From RNA Polymerase II Promoter Anatomical Structure Development Response To Stimulus Regulation Of Nitrogen Compound Metabolic Process Axon Guidance Positive Regulation Of Macrophage Colony-stimulating Factor Production Synaptic Growth At Neuromuscular Junction Positive Regulation Of Granulocyte Colony-stimulating Factor Production 7,8-dihydroneopterin 3'-triphosphate Biosynthetic Process Pancreas Development Regulation Of Fibroblast Proliferation Forebrain Development Negative Regulation Of Cell Cycle Phosphorylation Cell Morphogenesis	Transcription Initiation From RNA Polymerase II Promoter DNA-templated Transcription, Initiation Transcription From RNA Polymerase II Promoter Transcription, DNA-templated RNA Biosynthetic Process Regulation Of Transcription From RNA Polymerase II Promoter Gene Expression Cellular Macromolecule Biosynthetic Process Macromolecule Biosynthetic Process RNA Metabolic Process Nucleobase-containing Compound Metabolic Process Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process Regulation Of Gene Expression Regulation Of RNA Biosynthetic Process Cellular Nitrogen Compound Metabolic Process Regulation Of RNA Metabolic Process Positive Regulation Of Macromolecule Biosynthetic Process Positive Regulation Of Transcription From RNA Polymerase II Promoter Positive Regulation Of Gene Expression Positive Regulation Of Cellular Biosynthetic Process Nitrogen Compound Metabolic Process Biosynthetic Process Regulation Of Transcription, DNA-templated Regulation Of Nitrogen Compound Metabolic Process Regulation Of Nucleic Acid-templated Transcription Positive Regulation Of Transcription, DNA-templated Positive Regulation Of Cellular Metabolic Process Negative Regulation Of Gene Expression Regulation Of Metabolic Process Positive Regulation Of Metabolic Process Negative Regulation Of Cell Differentiation Negative Regulation Of Transcription From RNA Polymerase II Promoter Negative Regulation Of Transcription, DNA-templated Negative Regulation Of Nucleic Acid-templated Transcription Negative Regulation Of RNA Biosynthetic Process Positive Regulation Of Viral Transcription Regulation Of Gene Expression, Epigenetic Regulation Of Cell Differentiation Transforming Growth Factor Beta Receptor Signaling Pathway Negative Regulation Of Biosynthetic Process Regulation Of Viral Transcription Positive Regulation Of Viral Process Negative Regulation Of Gene Expression, Epigenetic Cellular Metabolic Process Cellular Response To Transforming Growth Factor Beta Stimulus Response To Transforming Growth Factor Beta Anatomical Structure Development Negative Regulation Of Cellular Metabolic Process Organ Development
Tagcloud ?		a134c abp allelic ankyrin balb cdk6 cdnas chr congenic d2 dba g232a ifna inbred inefficient ink4c le multigenic mus p15 p16 p18 pctr1 plasmacytoma pristane spretus typed	absent acetyltransferase acetyltransferases cbp chromatography competent complex contains conventional directed elongation form histone homolog ii importantly interacts nonphosphorylated notably pcaf polymerase purified remodeling rna snf srb srb10 swi yeast
Tagcloud (Difference) ?		a134c abp allelic ankyrin balb cdk6 cdnas chr congenic d2 dba g232a ifna inbred inefficient ink4c le multigenic mus p15 p16 p18 pctr1 plasmacytoma pristane spretus typed	absent acetyltransferase acetyltransferases cbp chromatography competent complex contains conventional directed elongation form histone homolog ii importantly interacts nonphosphorylated notably pcaf polymerase purified remodeling rna snf srb srb10 swi yeast
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