CDKN2B and FZR1

Number of citations of the paper that reports this interaction (PubMedID 28205554)
55

Data Source:
BioGRID (fluorescent resonance energy transfer)

		CDKN2B	FZR1
Description		cyclin dependent kinase inhibitor 2B	fizzy and cell division cycle 20 related 1
Image		No pdb structure
GO Annotations	Cellular Component	Nucleus Cytoplasm Cytosol	Nucleus Nucleoplasm Anaphase-promoting Complex Cytoplasm Cytosol Nuclear Membrane
	Molecular Function	Cyclin-dependent Protein Serine/threonine Kinase Inhibitor Activity Protein Binding Protein Kinase Binding	Protein Binding Anaphase-promoting Complex Binding Ubiquitin-protein Transferase Activator Activity Ubiquitin-like Ligase-substrate Adaptor Activity Ubiquitin Ligase Activator Activity
	Biological Process	Transforming Growth Factor Beta Receptor Signaling Pathway Negative Regulation Of Cell Population Proliferation Megakaryocyte Differentiation Positive Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway Cellular Response To Nutrient Spleen Development Negative Regulation Of Epithelial Cell Proliferation Regulation Of G0 To G1 Transition Cellular Response To Cell-matrix Adhesion Cellular Senescence Regulation Of G1/S Transition Of Mitotic Cell Cycle Negative Regulation Of G1/S Transition Of Mitotic Cell Cycle	DNA Repair DNA Damage Response Mitotic G2 DNA Damage Checkpoint Signaling Regulation Of Mitotic Cell Cycle Positive Regulation Of Cell Population Proliferation Protein Ubiquitination Anaphase-promoting Complex-dependent Catabolic Process Regulation Of Meiotic Nuclear Division Thymidine Biosynthetic Process Cell Division Regulation Of Meiotic Cell Cycle Proteolysis Involved In Protein Catabolic Process Lens Fiber Cell Differentiation Protein K11-linked Ubiquitination Positive Regulation Of Ubiquitin Protein Ligase Activity DNA Synthesis Involved In Mitotic DNA Replication Positive Regulation Of Anaphase-promoting Complex-dependent Catabolic Process Negative Regulation Of Cellular Senescence
Pathways		SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription Oxidative Stress Induced Senescence Senescence-Associated Secretory Phenotype (SASP) Oncogene Induced Senescence Cyclin D associated events in G1	Autodegradation of Cdh1 by Cdh1:APC/C SCF-beta-TrCP mediated degradation of Emi1 APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1 Conversion from APC/C:Cdc20 to APC/C:Cdh1 in late anaphase Regulation of APC/C activators between G1/S and early anaphase Phosphorylation of Emi1 Senescence-Associated Secretory Phenotype (SASP) Assembly of the pre-replicative complex CDK-mediated phosphorylation and removal of Cdc6 Cyclin A/B1/B2 associated events during G2/M transition Cyclin A:Cdk2-associated events at S phase entry Transcriptional Regulation by VENTX Aberrant regulation of mitotic exit in cancer due to RB1 defects Antigen processing: Ubiquitination & Proteasome degradation
Drugs
Diseases		Type II diabetes mellitus Osteosarcoma Malignant pleural mesothelioma
GWAS		Ankle-brachial index ( 22199011) Basal cell carcinoma ( 27539887 25855136 24403052) Breast cancer ( 29059683 23535729 20453838) Cancer ( 27197191) Cancer (pleiotropy) ( 27197191) Carotid plaque burden ( 28282560) Cataracts ( 34127677) Chronic lymphocytic leukemia ( 23770605) Coronary artery calcification ( 23561647 22144573) Coronary artery disease ( 26708285 21239051 29212778 29263402) Coronary heart disease ( 21378990 29615537 21971053 17554300) Coronary heart disease (SNP X SNP interaction) ( 21626137) Coronary heart disease x type 2 diabetes interaction ( 32541925) Cutaneous malignant melanoma ( 32341527) Endometrial cancer ( 30093612) Endometrial cancer (endometrioid histology) ( 30093612) Endometriosis ( 23104006) Esophageal squamous cell carcinoma ( 25129146) Facial pigmentation measurement (polar light) ( 32835660) Facial pigmentation measurement (UV light) ( 32835660) Fasting blood glucose ( 33842983 22581228 25631608) Fasting blood glucose (BMI interaction) ( 22581228) Fasting plasma glucose ( 25187374) Glaucoma ( 22792221) Glaucoma (primary open-angle) ( 22419738) Glioblastoma ( 28346443) Glioblastoma (age-stratified) ( 30152087) Glioma ( 28346443 21531791 19578367) Haemorrhoidal disease ( 33888516) Inflammatory bowel disease ( 27569725) Intracranial aneurysm ( 18997786 20364137) Intracranial, abdominal aortic or thoracic aortic aneurysm (pleiotropy) ( 27418160) Metabolically unhealthy in normal weight ( 33500527) Metabolite levels ( 23823483) Myocardial infarction ( 17478679) Myocardial infarction (early onset) ( 19198609) Nasopharyngeal carcinoma ( 26545403 20512145) Non-glioblastoma glioma ( 28346443) Non-melanoma skin cancer ( 29739929) Parental longevity (both parents in top 10%) ( 29227965) Parental longevity (father's age at death) ( 29227965) Psychosis proneness (hypomanic personality scale and perceptual aberration scale) ( 28525603) Psychosis proneness (hypomanic personality scale and revised physical anhedonia scale) ( 28525603) Psychosis proneness (hypomanic personality scale and revised social anhedonia scale) ( 28525603) Psychosis proneness (hypomanic personality scale) ( 28525603) Pulse pressure ( 27841878) Spleen volume ( 34128465) Type 2 diabetes ( 30718926 17463246 17463248 17463249 18372903 19056611 19401414 20581827 21573907 27189021 30297969 22293688 22961080 23945395 24509480 26818947 29358691 26961502) Vertical cup-disc ratio ( 20548946)	Red cell distribution width ( 32888494)
Interacting Genes		63 interacting genes: AKT1 APP ARAF ARNT ARPC3 ATP6V1H BECN1 CBLC CCDC33 CCDC90B CCNC CCND2 CCNE1 CD44 CDK17 CDK4 CDK6 CDK8 CDKN2C CEP126 CNKSR3 ELP1 EPHA2 ERBB2 FGFR4 FZR1 GLIS2 GRM1 HGF HIF1A IGF1R INCA1 ISL1 KAT2A KDELR2 LATS2 MAGEA11 MAP2K3 MAP2K5 MAP2K6 MDM4 MET MYC NF2 NIF3L1 PDGFRA PICK1 PYCR3 RAF1 RASSF1 RTL8C RUSC1 SPG21 STK11 TEAD2 TERT TGFB1I1 TNFRSF1A TP53 TRAF1 TSC1 TTYH2 ZBTB17	95 interacting genes: AKT1S1 ANAPC1 ANAPC11 ANAPC2 ANAPC7 ANLN ARNT BECN1 BEX1 BLID BTRC C7orf25 CCL5 CCNA1 CCNB1 CCND2 CCNE1 CCNF CDC14A CDC27 CDC6 CDK2 CDK4 CDK5 CDK6 CDKN2B CDR2 CDT1 CLSPN CYP17A1 DCPS DKK3 DNAJA1 DNM1L DTYMK E2F3 EPHA2 EPSTI1 ERBB2 FBXO5 FGFR4 GLIS2 GMNN HECW2 HIF1A ID2 KAT2A KIF18B LATS2 MAD2L2 MAK MAP2K3 MAP2K5 MAP3K5 MAPK8 MET MOAP1 MTA3 MYC NAT2 NEDD9 NEK2 NF2 OTUD7B PAX3 PDGFRA PSMC3IP PTP4A3 PTTG1 RASSF1 RB1 RBBP8 SASS6 SENP2 SIRT1 SIRT2 SKIL SKP2 SMURF1 SOX2 SOX4 SRC STK11 TBK1 TEAD2 TERT THRSP TK1 TTF2 UBC UBE2D1 UBE2D3 UBE2K UHRF1 USP10
Entrez ID		1030	51343
HPRD ID		02696	04687
Ensembl ID		ENSG00000147883	ENSG00000105325
Uniprot IDs		K7PPU3 P42772	Q9UM11
PDB IDs			4UI9 5L9T 5L9U 8TAR 8TAU 9GAW
Enriched GO Terms of Interacting Partners?		Protein Kinase Activity Regulation Of Cell Cycle Response To Growth Factor Kinase Activity Regulation Of Cell Population Proliferation Regulation Of Intracellular Signal Transduction Regulation Of Signal Transduction Regulation Of Cell Communication Regulation Of Signaling Positive Regulation Of Signal Transduction Regulation Of Programmed Cell Death Regulation Of Apoptotic Process Positive Regulation Of Cell Communication Positive Regulation Of Signaling Negative Regulation Of Signaling Regulation Of Apoptotic Signaling Pathway Signal Transduction Negative Regulation Of Cell Communication Regulation Of MAPK Cascade Protein Tyrosine Kinase Activity Negative Regulation Of Programmed Cell Death Cellular Response To Decreased Oxygen Levels Negative Regulation Of Signal Transduction Protein Serine Kinase Activity Cellular Response To Growth Factor Stimulus Negative Regulation Of Cell Population Proliferation Regulation Of Metabolic Process Cellular Response To Oxygen Levels Intracellular Signal Transduction Negative Regulation Of Apoptotic Process Positive Regulation Of RNA Biosynthetic Process Positive Regulation Of DNA-templated Transcription Cyclin-dependent Protein Kinase Holoenzyme Complex Cell Surface Receptor Signaling Pathway Animal Organ Development Protein Serine/threonine Kinase Activity Transmembrane Receptor Protein Tyrosine Kinase Activity Cell Population Proliferation Protein Phosphorylation Positive Regulation Of RNA Metabolic Process Regulation Of Primary Metabolic Process Regulation Of Protein Metabolic Process Positive Regulation Of Nucleobase-containing Compound Metabolic Process Positive Regulation Of Intracellular Signal Transduction Cellular Response To Stress Regulation Of DNA-templated Transcription Regulation Of Phosphorus Metabolic Process Positive Regulation Of Cell Population Proliferation Regulation Of RNA Biosynthetic Process Phosphorylation	Regulation Of Cell Cycle Regulation Of Cell Cycle Process Cell Division Regulation Of Mitotic Cell Cycle Regulation Of Cell Cycle Phase Transition Regulation Of Mitotic Cell Cycle Phase Transition Mitotic Cell Cycle Phase Transition Cell Cycle Phase Transition Nucleoplasm G1/S Transition Of Mitotic Cell Cycle Cell Cycle G1/S Phase Transition Nucleus Regulation Of Primary Metabolic Process Cytoplasm Regulation Of Chromosome Segregation Cytosol Regulation Of Chromosome Organization Regulation Of Sister Chromatid Segregation Regulation Of Metabolic Process Regulation Of Protein Modification Process Positive Regulation Of Mitotic Cell Cycle Phase Transition Regulation Of Macromolecule Metabolic Process Regulation Of Nucleobase-containing Compound Metabolic Process Protein Modification Process Negative Regulation Of Cell Cycle Positive Regulation Of Macromolecule Metabolic Process Positive Regulation Of Nucleobase-containing Compound Metabolic Process Positive Regulation Of Metabolic Process Regulation Of Protein Metabolic Process Kinase Activity Positive Regulation Of Cell Cycle Phase Transition Spindle Protein Kinase Activity Regulation Of Organelle Organization Negative Regulation Of Metabolic Process Positive Regulation Of Mitotic Cell Cycle Positive Regulation Of Protein Metabolic Process Positive Regulation Of Cell Cycle Process Post-translational Protein Modification Negative Regulation Of Macromolecule Metabolic Process Modification-dependent Protein Catabolic Process Intracellular Signal Transduction Regulation Of Cellular Component Organization Positive Regulation Of Cell Population Proliferation Cellular Response To Stress Ubiquitin-dependent Protein Catabolic Process Positive Regulation Of RNA Metabolic Process Transferase Activity Positive Regulation Of Cell Cycle Negative Regulation Of Cell Cycle Process
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