CDKN2B and RUSC1

Number of citations of the paper that reports this interaction (PubMedID 32296183)
50

Data Source:
BioGRID (two hybrid)

		CDKN2B	RUSC1
Description		cyclin dependent kinase inhibitor 2B	RUN and SH3 domain containing 1
Image		No pdb structure
GO Annotations	Cellular Component	Nucleus Cytoplasm Cytosol	Nucleus Cytoplasm Endosome Early Endosome Golgi Apparatus Cytosol Cytoskeleton Microtubule Postsynaptic Density Microtubule Cytoskeleton Cytoplasmic Vesicle Synapse
	Molecular Function	Cyclin-dependent Protein Serine/threonine Kinase Inhibitor Activity Protein Binding Protein Kinase Binding	Actin Binding Protein Binding
	Biological Process	Transforming Growth Factor Beta Receptor Signaling Pathway Negative Regulation Of Cell Population Proliferation Megakaryocyte Differentiation Positive Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway Cellular Response To Nutrient Spleen Development Negative Regulation Of Epithelial Cell Proliferation Regulation Of G0 To G1 Transition Cellular Response To Cell-matrix Adhesion Cellular Senescence Regulation Of G1/S Transition Of Mitotic Cell Cycle Negative Regulation Of G1/S Transition Of Mitotic Cell Cycle	Protein Polyubiquitination
Pathways		SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription Oxidative Stress Induced Senescence Senescence-Associated Secretory Phenotype (SASP) Oncogene Induced Senescence Cyclin D associated events in G1
Drugs
Diseases		Type II diabetes mellitus Osteosarcoma Malignant pleural mesothelioma
GWAS		Ankle-brachial index ( 22199011) Basal cell carcinoma ( 27539887 25855136 24403052) Breast cancer ( 29059683 23535729 20453838) Cancer ( 27197191) Cancer (pleiotropy) ( 27197191) Carotid plaque burden ( 28282560) Cataracts ( 34127677) Chronic lymphocytic leukemia ( 23770605) Coronary artery calcification ( 23561647 22144573) Coronary artery disease ( 26708285 21239051 29212778 29263402) Coronary heart disease ( 21378990 29615537 21971053 17554300) Coronary heart disease (SNP X SNP interaction) ( 21626137) Coronary heart disease x type 2 diabetes interaction ( 32541925) Cutaneous malignant melanoma ( 32341527) Endometrial cancer ( 30093612) Endometrial cancer (endometrioid histology) ( 30093612) Endometriosis ( 23104006) Esophageal squamous cell carcinoma ( 25129146) Facial pigmentation measurement (polar light) ( 32835660) Facial pigmentation measurement (UV light) ( 32835660) Fasting blood glucose ( 33842983 22581228 25631608) Fasting blood glucose (BMI interaction) ( 22581228) Fasting plasma glucose ( 25187374) Glaucoma ( 22792221) Glaucoma (primary open-angle) ( 22419738) Glioblastoma ( 28346443) Glioblastoma (age-stratified) ( 30152087) Glioma ( 28346443 21531791 19578367) Haemorrhoidal disease ( 33888516) Inflammatory bowel disease ( 27569725) Intracranial aneurysm ( 18997786 20364137) Intracranial, abdominal aortic or thoracic aortic aneurysm (pleiotropy) ( 27418160) Metabolically unhealthy in normal weight ( 33500527) Metabolite levels ( 23823483) Myocardial infarction ( 17478679) Myocardial infarction (early onset) ( 19198609) Nasopharyngeal carcinoma ( 26545403 20512145) Non-glioblastoma glioma ( 28346443) Non-melanoma skin cancer ( 29739929) Parental longevity (both parents in top 10%) ( 29227965) Parental longevity (father's age at death) ( 29227965) Psychosis proneness (hypomanic personality scale and perceptual aberration scale) ( 28525603) Psychosis proneness (hypomanic personality scale and revised physical anhedonia scale) ( 28525603) Psychosis proneness (hypomanic personality scale and revised social anhedonia scale) ( 28525603) Psychosis proneness (hypomanic personality scale) ( 28525603) Pulse pressure ( 27841878) Spleen volume ( 34128465) Type 2 diabetes ( 30718926 17463246 17463248 17463249 18372903 19056611 19401414 20581827 21573907 27189021 30297969 22293688 22961080 23945395 24509480 26818947 29358691 26961502) Vertical cup-disc ratio ( 20548946)	Body fat distribution (leg fat ratio) ( 30664634) Body fat distribution (trunk fat ratio) ( 30664634) Brain morphology (min-P) ( 32665545) Brain morphology (MOSTest) ( 32665545) Cortical surface area (min-P) ( 32665545) Cortical surface area (MOSTest) ( 32665545) Cortical thickness (min-P) ( 32665545) Cortical thickness (MOSTest) ( 32665545) Crohn's disease ( 28067908) Inflammatory bowel disease ( 28067908) Subcortical volume (min-P) ( 32665545) Subcortical volume (MOSTest) ( 32665545)
Interacting Genes		63 interacting genes: AKT1 APP ARAF ARNT ARPC3 ATP6V1H BECN1 CBLC CCDC33 CCDC90B CCNC CCND2 CCNE1 CD44 CDK17 CDK4 CDK6 CDK8 CDKN2C CEP126 CNKSR3 ELP1 EPHA2 ERBB2 FGFR4 FZR1 GLIS2 GRM1 HGF HIF1A IGF1R INCA1 ISL1 KAT2A KDELR2 LATS2 MAGEA11 MAP2K3 MAP2K5 MAP2K6 MDM4 MET MYC NF2 NIF3L1 PDGFRA PICK1 PYCR3 RAF1 RASSF1 RTL8C RUSC1 SPG21 STK11 TEAD2 TERT TGFB1I1 TNFRSF1A TP53 TRAF1 TSC1 TTYH2 ZBTB17	92 interacting genes: ABHD11 ABHD5 ABI2 AIRIM AKAP8L ANKS1A APP ATP6V0D2 BPIFA1 CCDC120 CCDC57 CCHCR1 CCNC CDKN2B CMTM6 CREM CRYBA2 CTAG1A CTAG1B DMRT3 DOK6 DTX2 DVL2 EXOC8 EXOSC8 FAM9B FNDC3B GCM2 HMG20A HNRNPF INSC KCTD9 KRTAP19-1 KRTAP19-5 KRTAP6-2 KRTAP8-1 LIMS3 LIMS4 LMO2 MAGEA3 MAGEA6 MAGED1 MED25 MEIS2 MISP MOAP1 MORN3 MYOZ3 N4BP3 NICN1 NTAQ1 NTRK1 NUDT22 OIP5 P4HA3 PFDN5 PIK3R3 PLA2G6 PM20D2 PNMA1 POLR1C PRDM14 PRR35 RBPMS SMARCB1 SMYD1 SOHLH1 SPAG8 STUB1 SUOX TBC1D25 TCHP TEKT4 TENT5B TLE5 TRAPPC6A TRIM55 TRIM63 TRIM73 TSSK3 TTC19 TTC7B UFSP1 VGLL3 WWOX WWP2 ZIC1 ZMYND12 ZNF34 ZNF620 ZNF765 ZNF77
Entrez ID		1030	23623
HPRD ID		02696	10206
Ensembl ID		ENSG00000147883	ENSG00000160753
Uniprot IDs		K7PPU3 P42772	A0A8Q3SIT1 B4DQB8 Q9BVN2
PDB IDs			4GIW
Enriched GO Terms of Interacting Partners?		Protein Kinase Activity Regulation Of Cell Cycle Response To Growth Factor Kinase Activity Regulation Of Cell Population Proliferation Regulation Of Intracellular Signal Transduction Regulation Of Signal Transduction Regulation Of Cell Communication Regulation Of Signaling Positive Regulation Of Signal Transduction Regulation Of Programmed Cell Death Regulation Of Apoptotic Process Positive Regulation Of Cell Communication Positive Regulation Of Signaling Negative Regulation Of Signaling Regulation Of Apoptotic Signaling Pathway Signal Transduction Negative Regulation Of Cell Communication Regulation Of MAPK Cascade Protein Tyrosine Kinase Activity Negative Regulation Of Programmed Cell Death Cellular Response To Decreased Oxygen Levels Negative Regulation Of Signal Transduction Protein Serine Kinase Activity Cellular Response To Growth Factor Stimulus Negative Regulation Of Cell Population Proliferation Regulation Of Metabolic Process Cellular Response To Oxygen Levels Intracellular Signal Transduction Negative Regulation Of Apoptotic Process Positive Regulation Of RNA Biosynthetic Process Positive Regulation Of DNA-templated Transcription Cyclin-dependent Protein Kinase Holoenzyme Complex Cell Surface Receptor Signaling Pathway Animal Organ Development Protein Serine/threonine Kinase Activity Transmembrane Receptor Protein Tyrosine Kinase Activity Cell Population Proliferation Protein Phosphorylation Positive Regulation Of RNA Metabolic Process Regulation Of Primary Metabolic Process Regulation Of Protein Metabolic Process Positive Regulation Of Nucleobase-containing Compound Metabolic Process Positive Regulation Of Intracellular Signal Transduction Cellular Response To Stress Regulation Of DNA-templated Transcription Regulation Of Phosphorus Metabolic Process Positive Regulation Of Cell Population Proliferation Regulation Of RNA Biosynthetic Process Phosphorylation	Protein Binding
Tagcloud ?
Tagcloud (Difference) ?
Tagcloud (Intersection) ?