BAG4 and TNFRSF1A

Number of citations of the paper that reports this interaction (PMID 9915703)
58

Data Source:
HPRD (in vivo, in vitro, two hybrid)

		BAG4	TNFRSF1A
Gene Name		BCL2-associated athanogene 4	tumor necrosis factor receptor superfamily, member 1A
Image
Gene Ontology Annotations	Cellular Component	Nucleus Cytosol Plasma Membrane	Golgi Membrane Extracellular Region Extracellular Space Nucleus Mitochondrion Cytosol Plasma Membrane Integral Component Of Plasma Membrane Cell Surface Axon Receptor Complex Membrane Raft Synapse
	Molecular Function	Receptor Signaling Protein Activity Protein Binding Poly(A) RNA Binding Chaperone Binding	Protease Binding Tumor Necrosis Factor-activated Receptor Activity Protein Binding Protein Complex Binding Tumor Necrosis Factor Binding
	Biological Process	Protein Folding Positive Regulation Of Fibroblast Migration Positive Regulation Of Actin Filament Polymerization Positive Regulation Of Peptidyl-serine Phosphorylation Intracellular Signal Transduction Negative Regulation Of Apoptotic Process Positive Regulation Of Cell Adhesion Protein Heterooligomerization Positive Regulation Of Stress Fiber Assembly Positive Regulation Of Protein Kinase B Signaling Cellular Response To Tumor Necrosis Factor Cellular Response To Epidermal Growth Factor Stimulus Protein Localization To Plasma Membrane Negative Regulation Of MRNA Modification Ruffle Assembly Negative Regulation Of Phosphatidylinositol-3,4,5-trisphosphate 5-phosphatase Activity	Response To Hypoxia Prostaglandin Metabolic Process Inflammatory Response Extrinsic Apoptotic Signaling Pathway Via Death Domain Receptors Intrinsic Apoptotic Signaling Pathway In Response To DNA Damage Response To Wounding Negative Regulation Of Gene Expression Viral Process Cytokine-mediated Signaling Pathway Response To Lipopolysaccharide Negative Regulation Of Interleukin-6 Production Positive Regulation Of Tumor Necrosis Factor Production Tetrapyrrole Metabolic Process Positive Regulation Of Protein Import Into Nucleus, Translocation Tumor Necrosis Factor-mediated Signaling Pathway Positive Regulation Of Tyrosine Phosphorylation Of Stat1 Protein Defense Response To Bacterium Negative Regulation Of Apoptotic Process Positive Regulation Of I-kappaB Kinase/NF-kappaB Signaling Response To Amino Acid Response To Alkaloid Positive Regulation Of Neuron Apoptotic Process Response To Ethanol Positive Regulation Of Angiogenesis Positive Regulation Of Transcription From RNA Polymerase II Promoter Negative Regulation Of Inflammatory Response Positive Regulation Of Inflammatory Response Protein Heterooligomerization Cellular Response To Mechanical Stimulus Cellular Response To Estradiol Stimulus Apoptotic Signaling Pathway
Pathways			TNF signaling Death Receptor Signalling Programmed Cell Death Extrinsic Pathway
Drugs			6-[3-(4-Morpholinyl)Propyl]-2-(3-Nitrophenyl)-5-Thioxo-5,6,-Dihydro-7h-Thienol[2\',3\':4,5]Pyrrolo[1,2-C]Imidazol-7-One
Diseases
GWAS			Adverse response to chemotherapy (neutropenia/leucopenia) (all anthracycline-based drugs) ( 23648065) Adverse response to chemotherapy (neutropenia/leucopenia) (epirubicin) ( 23648065) Multiple sclerosis ( 19525953 21833088) Primary biliary cirrhosis ( 21399635)
Protein-Protein Interactions		6 interactors: APOBEC1 BCL2 HSPA1A HSPA8 TNFRSF1A TNFRSF25	60 interactors: ADAM17 ATF6 BAG4 BCL10 CASP10 CASP7 CHUK CLIP3 DAPK1 DAXX ERAP1 ERN1 FANCD2 GNB2L1 GRB2 GYS2 HRG HSP90AA1 HSPA8 IKBKB IKBKG JAK1 JAK2 LTA LTB MADD MAGEH1 MAPK1 MOAP1 MYOC NSMAF PIP4K2B PRDX3 PRKCD PSMD2 PTK2 PTPN11 PTPN6 RASSF1 RIPK1 RIPK2 RIPK3 SGTA SRC STAMBP STAT1 SUMO1 SYK TNF TNFRSF25 TNFSF13 TRADD TRAF1 TRAF2 TRAF3 TRAP1 TRPC4AP UBE2I UBQLN1 UCHL1
Entrez ID		9530	7132
HPRD ID		04861	01861
Ensembl ID		ENSG00000156735	ENSG00000067182
Uniprot IDs		O95429	J9PH39 P19438
PDB IDs		1M62 1M7K	1EXT 1FT4 1ICH 1NCF 1TNR
Enriched GO Terms of Interacting Partners?		Response To Abiotic Stimulus Response To Organic Substance Protein Refolding Response To Other Organism Response To Biotic Stimulus Response To External Stimulus Regulation Of Cellular Response To Heat Response To Virus Tumor Necrosis Factor-mediated Signaling Pathway Extrinsic Apoptotic Signaling Pathway Via Death Domain Receptors Apoptotic Signaling Pathway Response To Gamma Radiation Negative Regulation Of Extrinsic Apoptotic Signaling Pathway In Absence Of Ligand Cellular Response To Heat Posttranscriptional Regulation Of Gene Expression Regulation Of Extrinsic Apoptotic Signaling Pathway In Absence Of Ligand Regulation Of Apoptotic Process MRNA Metabolic Process Cellular Response To Stress Viral Process Intrinsic Apoptotic Signaling Pathway In Response To DNA Damage Regulation Of Cell Death Negative Regulation Of Cellular PH Reduction Negative Regulation Of Fibril Organization CD8-positive, Alpha-beta T Cell Lineage Commitment Negative Regulation Of Retinal Cell Programmed Cell Death Cellular Response To Tumor Necrosis Factor Extrinsic Apoptotic Signaling Pathway Response To Heat Response To Stress Response To Tumor Necrosis Factor Negative Regulation Of Extrinsic Apoptotic Signaling Pathway Response To Unfolded Protein Cellular Response To Stimulus Response To Cytokine Cellular Heat Acclimation Cytidine To Uridine Editing Regulation Of Protein Stability Cellular Response To Organic Substance Response To Ethanol Response To Ionizing Radiation Response To Alkaloid Regulation Of Cellular Component Organization Negative Regulation Of Cell Growth Defense Response To Virus Regulation Of Fibril Organization Negative Regulation Of Methylation-dependent Chromatin Silencing Regulation Of Retinal Cell Programmed Cell Death Positive Regulation Of Neuron Maturation Response To Organonitrogen Compound	Apoptotic Process Regulation Of Apoptotic Process Programmed Cell Death Regulation Of Cell Death Cell Death Death Regulation Of Signal Transduction Regulation Of Immune Response Positive Regulation Of Signal Transduction Positive Regulation Of Protein Metabolic Process Regulation Of Signaling Positive Regulation Of Cellular Protein Metabolic Process Regulation Of Protein Metabolic Process Immune Response Regulation Of Cellular Protein Metabolic Process Positive Regulation Of Cellular Metabolic Process Regulation Of Innate Immune Response Innate Immune Response Response To Stress Regulation Of Immune System Process Regulation Of Phosphorylation Regulation Of Sequence-specific DNA Binding Transcription Factor Activity Response To Stimulus Cellular Response To Stimulus Positive Regulation Of Protein Modification Process Positive Regulation Of Intracellular Signal Transduction Regulation Of Intracellular Signal Transduction Cell Communication Regulation Of Phosphorus Metabolic Process Defense Response Positive Regulation Of Immune Response Immune System Process Signal Transduction Positive Regulation Of Metabolic Process Intracellular Signal Transduction Signaling Regulation Of Kinase Activity Positive Regulation Of Immune System Process Regulation Of Protein Phosphorylation Response To Organic Substance Regulation Of Protein Kinase Activity Regulation Of Catalytic Activity Immune Response-regulating Signaling Pathway Positive Regulation Of Transferase Activity Positive Regulation Of Sequence-specific DNA Binding Transcription Factor Activity Positive Regulation Of Apoptotic Process Positive Regulation Of Programmed Cell Death Response To Cytokine Positive Regulation Of NF-kappaB Transcription Factor Activity Positive Regulation Of Protein Phosphorylation
Tagcloud ?		adenocarcinoma aid alk braf clinicopathologic define differentiated druggable fgfr fgfr1 fgfr2 fgfr3 fibroblast fourteen fusion fusions harbored kras needs nsclc relapse ret ros1 screened smokers subset tacc3 tendency verified	casp3 cl coincided corpora cyclic disaggregation estrous extrinsic fas fasl faslg fos ifng ifngamma jun lutea luteal luteolysis luteolytic p4 pgf2alpha postmortem pregnancy proportions tnfa tnfr2 viable
Tagcloud (Difference) ?		adenocarcinoma aid alk braf clinicopathologic define differentiated druggable fgfr fgfr1 fgfr2 fgfr3 fibroblast fourteen fusion fusions harbored kras needs nsclc relapse ret ros1 screened smokers subset tacc3 tendency verified	casp3 cl coincided corpora cyclic disaggregation estrous extrinsic fas fasl faslg fos ifng ifngamma jun lutea luteal luteolysis luteolytic p4 pgf2alpha postmortem pregnancy proportions tnfa tnfr2 viable
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