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BAG4 and HSPA8
Number of citations of the paper that reports this interaction (PubMedID
29568061
)
70
Data Source:
BioGRID
(affinity chromatography technology, two hybrid, pull down, pull down, affinity chromatography technology, affinity chromatography technology)
BAG4
HSPA8
Description
BAG cochaperone 4
heat shock protein family A (Hsp70) member 8
Image
GO Annotations
Cellular Component
Nucleus
Cytoplasm
Cytosol
Plasma Membrane
Membrane
Prp19 Complex
Extracellular Region
Extracellular Space
Nucleus
Nucleoplasm
Spliceosomal Complex
Nucleolus
Cytoplasm
Lysosome
Lysosomal Membrane
Cytosol
Plasma Membrane
Focal Adhesion
Membrane
Secretory Granule Lumen
Melanosome
Lysosomal Lumen
Clathrin-sculpted Gamma-aminobutyric Acid Transport Vesicle Membrane
Extracellular Exosome
Blood Microparticle
Lumenal Side Of Lysosomal Membrane
Protein Folding Chaperone Complex
Ficolin-1-rich Granule Lumen
Ribonucleoprotein Complex
Molecular Function
Adenyl-nucleotide Exchange Factor Activity
RNA Binding
Protein Binding
Ubiquitin Protein Ligase Binding
Protein-containing Complex Binding
Protein-folding Chaperone Binding
Nucleotide Binding
G Protein-coupled Receptor Binding
RNA Binding
Protein Binding
ATP Binding
Hydrolase Activity
ATP Hydrolysis Activity
Enzyme Binding
MHC Class II Protein Complex Binding
Protein-macromolecule Adaptor Activity
Heat Shock Protein Binding
Ubiquitin Protein Ligase Binding
Protein Folding Chaperone
Cadherin Binding
Receptor Ligand Activity
Unfolded Protein Binding
Protein-folding Chaperone Binding
C3HC4-type RING Finger Domain Binding
ATP-dependent Protein Disaggregase Activity
ATP-dependent Protein Folding Chaperone
Biological Process
Protein Folding
Positive Regulation Of Fibroblast Migration
Positive Regulation Of Actin Filament Polymerization
Negative Regulation Of Apoptotic Process
Positive Regulation Of Cell Adhesion
Protein Stabilization
Positive Regulation Of Stress Fiber Assembly
Positive Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction
Cellular Response To Tumor Necrosis Factor
Cellular Response To Epidermal Growth Factor Stimulus
Protein Localization To Plasma Membrane
Negative Regulation Of MRNA Modification
Ruffle Assembly
Negative Regulation Of Protein Targeting To Mitochondrion
MRNA Splicing, Via Spliceosome
MRNA Processing
Protein Folding
Autophagy
Response To Unfolded Protein
Signal Transduction
RNA Splicing
Cellular Response To Starvation
Negative Regulation Of Signal Transduction
Protein Catabolic Process
Positive Regulation Of Cell Migration
Regulation Of Protein Stability
Cellular Response To Stress
Regulation Of Cytoplasmic Pattern Recognition Receptor Signaling Pathway
Protein Refolding
Regulation Of Protein-containing Complex Assembly
Negative Regulation Of DNA-templated Transcription
ATP Metabolic Process
Negative Regulation Of Cellular Component Organization
Membrane Organization
Regulation Of Protein Complex Stability
Chaperone-mediated Autophagy
Protein Targeting To Lysosome Involved In Chaperone-mediated Autophagy
Cellular Response To Steroid Hormone Stimulus
Clathrin Coat Disassembly
Negative Regulation Of NLRP3 Inflammasome Complex Assembly
Regulation Of Supramolecular Fiber Organization
Negative Regulation Of Supramolecular Fiber Organization
Regulation Of Protein Import
Chaperone-mediated Autophagy Translocation Complex Disassembly
Pathways
Regulation of HSF1-mediated heat shock response
Signaling by FGFR1 in disease
TNF signaling
Signaling by plasma membrane FGFR1 fusions
Regulation of HSF1-mediated heat shock response
HSP90 chaperone cycle for steroid hormone receptors (SHR) in the presence of ligand
Attenuation phase
HSF1-dependent transactivation
Lysosome Vesicle Biogenesis
Golgi Associated Vesicle Biogenesis
CHL1 interactions
AUF1 (hnRNP D0) binds and destabilizes mRNA
Interleukin-4 and Interleukin-13 signaling
Neutrophil degranulation
mRNA Splicing - Major Pathway
Clathrin-mediated endocytosis
Protein methylation
GABA synthesis, release, reuptake and degradation
Lipophagy
Chaperone Mediated Autophagy
Late endosomal microautophagy
Respiratory syncytial virus genome transcription
PKR-mediated signaling
Drugs
Dasatinib
(2R,3R,4S,5R)-2-[6-amino-8-[(3,4-dichlorophenyl)methylamino]purin-9-yl]-5-(hydroxymethyl)oxolane-3,4-diol
Copper
Artenimol
Diseases
GWAS
Autism spectrum disorder or schizophrenia (
28540026
)
Schizophrenia (
28991256
29483656
)
Mean corpuscular hemoglobin (
32888494
)
Mean corpuscular hemoglobin concentration (
29403010
32888494
)
Postoperative acute renal failure after cardiac surgery (
30678657
)
Red cell distribution width (
32888494
)
Serum metabolite levels (
33031748
)
Interacting Genes
141 interacting genes:
ABI2
ACOT7
ADAMTSL4
ALG13
ANKHD1
APOBEC1
ARID5A
ATAD2
ATOSB
ATP23
BAP1
BCAS3
BCL2
BCL6B
BEX1
BLZF1
BMS1
C3orf38
CASP2
CASZ1
CBFA2T2
CCL5
CEP55
CIMAP1C
CPSF7
DDIT4L
DIRAS3
DMRTB1
DZIP3
EFEMP1
EIF4ENIF1
EPSTI1
ERRFI1
FAM222B
FARS2
FTH1
FYN
GLCE
GPANK1
GPS2
GRAP2
GRIP1
HOXA1
HSPA1A
HSPA1B
HSPA1L
HSPA2
HSPA6
HSPA8
IL13RA2
IL24
IST1
ITIH5
KCTD6
KCTD7
KIF5B
KLK5
KLK7
KLK9
KRT31
KRTAP13-1
KRTAP13-4
KRTAP4-12
KRTAP4-2
KRTAP4-4
KRTAP4-5
KRTAP6-3
LASP1
LRATD2
LYPD3
MAGED1
MEI4
MRC2
MTA3
MYOZ1
MYOZ3
MYPOP
NAT2
ODF1
P4HA3
PDCD6
PDLIM2
PEF1
PGRMC2
PHF19
PKP2
PLAC8
PPIL6
PRDM14
PRPF6
PRRC2B
PSMB5
PYCR3
QKI
RAMAC
RASL10B
RBFOX2
RBM22
RBM42
RBM7
RBPMS
RHOBTB2
RNF20
RPL22
RUNX1
SAMD4A
SAXO1
SAXO4
SCGB3A1
SF1
SF3B4
SH3RF2
SIAH1
SNRPA
SNRPB
SNRPC
SNRPN
SNW1
SS18L1
SUOX
TBC1D3B
TBC1D3G
TBC1D7
TCL1B
TEKT5
TFAP2D
TFIP11
THRSP
TINAGL1
TLE5
TNFRSF1A
TNFRSF25
TRAPPC6A
TSG101
UNKL
USP22
VIM
VPS37C
ZBTB45
ZBTB5
ZIM2
92 interacting genes:
ABI1
AIPL1
ALDOB
APOB
ATM
BAG1
BAG2
BAG3
BAG4
BAG6
BRCA1
CCT3
CD40
CDKN2A
CITED1
CLTA
COL7A1
CXCR4
CYCS
DNAJA1
DNAJA3
DPP3
DYNLL1
EGFR
ERBB3
ERH
ESR1
FANCC
FBP1
FNDC3B
FOXP1
GAK
GCH1
GOT2
H3C1
HDAC10
HDAC3
HGS
HLTF
HSF1
HSP90AA1
HSPA1A
HSPBP1
HSPH1
HTN3
HTT
IL32
JAK2
JUN
LALBA
LINC01554
MAPK8
MAPT
NEDD8
NMI
NOA1
PHC1
PPID
PTEN
PTPRF
RAF1
RB1
REL
RGS2
RNF26
SAYSD1
SIRPA
SNCA
SP1
SRRT
ST13
STAT1
STIP1
STMN1
STUB1
SUMO2
SUMO4
TADA3
TCERG1
TGM2
TM4SF1
TNFRSF1A
TRIM38
TSSK6
TTC1
UBC
UCHL1
USP40
VHL
WEE2-AS1
YWHAG
YWHAQ
Entrez ID
9530
3312
HPRD ID
04861
07205
Ensembl ID
ENSG00000156735
ENSG00000109971
Uniprot IDs
O95429
P11142
Q53HF2
V9HW22
PDB IDs
1M62
1M7K
3AGY
3AGZ
3ESK
3FZF
3FZH
3FZK
3FZL
3FZM
3LDQ
3M3Z
4H5N
4H5R
4H5T
4H5V
4H5W
4HWI
4KBQ
5AQF
5AQG
5AQH
5AQI
5AQJ
5AQK
5AQL
5AQM
5AQN
5AQO
5AQP
5AQQ
5AQR
5AQS
5AQT
5AQU
5AQV
6B1I
6B1M
6B1N
6ZYJ
Enriched GO Terms of Interacting Partners
?
MRNA Splicing, Via Spliceosome
RNA Splicing, Via Transesterification Reactions
Spliceosomal Complex
Protein Refolding
MRNA Metabolic Process
MRNA Processing
ATP-dependent Protein Folding Chaperone
Intermediate Filament
RNA Binding
RNA Splicing
Protein Binding
Hair Cycle
C3HC4-type RING Finger Domain Binding
Transcription Corepressor Activity
ATP-dependent Protein Disaggregase Activity
Protein Folding Chaperone
Cellular Heat Acclimation
Nucleus
Heat Shock Protein Binding
U1 SnRNP
U4/U6 X U5 Tri-snRNP Complex
Regulation Of RNA Splicing
RNA Processing
RNA Metabolic Process
Negative Regulation Of Protein Ubiquitination
Regulation Of Protein Ubiquitination
Catalytic Step 2 Spliceosome
Regulation Of MRNA Metabolic Process
Identical Protein Binding
Negative Regulation Of Post-translational Protein Modification
Negative Regulation Of Inclusion Body Assembly
Keratin Filament
Negative Regulation Of Extrinsic Apoptotic Signaling Pathway In Absence Of Ligand
Regulation Of Post-translational Protein Modification
SnRNP Binding
Negative Regulation Of RNA Metabolic Process
Ubiquitin Protein Ligase Binding
MRNA Binding
Response To Temperature Stimulus
Nucleic Acid Binding
Negative Regulation Of Nucleobase-containing Compound Metabolic Process
Regulation Of MRNA Splicing, Via Spliceosome
U2-type Prespliceosome
Unfolded Protein Binding
Positive Regulation Of Antibacterial Peptide Production
Epidermal Lamellar Body
Macromolecule Metabolic Process
Regulation Of Extrinsic Apoptotic Signaling Pathway In Absence Of Ligand
Calcium-dependent Protein Binding
Blood Microparticle
Ubiquitin Protein Ligase Binding
Regulation Of Protein Stability
Regulation Of Apoptotic Process
Regulation Of Programmed Cell Death
Protein Folding
Positive Regulation Of Metabolic Process
Regulation Of Metabolic Process
Protein Stabilization
Negative Regulation Of Apoptotic Process
Enzyme Binding
Response To Stress
Negative Regulation Of Programmed Cell Death
Cytosol
Apoptotic Process
Programmed Cell Death
Positive Regulation Of Macromolecule Metabolic Process
Cell Death
Positive Regulation Of Programmed Cell Death
Adenyl-nucleotide Exchange Factor Activity
Regulation Of Macromolecule Metabolic Process
Negative Regulation Of Macromolecule Metabolic Process
Regulation Of Intracellular Signal Transduction
Regulation Of Primary Metabolic Process
Positive Regulation Of Apoptotic Process
Negative Regulation Of Metabolic Process
Regulation Of Signal Transduction
Negative Regulation Of Signal Transduction
Regulation Of Protein Modification Process
Heat Shock Protein Binding
Negative Regulation Of Signaling
Negative Regulation Of Cell Communication
Regulation Of Multicellular Organismal Process
Hsp70 Protein Binding
Cellular Response To Stress
Regulation Of Signaling
Regulation Of Macromolecule Biosynthetic Process
Regulation Of Cell Communication
Positive Regulation Of Biosynthetic Process
Positive Regulation Of Macromolecule Biosynthetic Process
Protein Folding Chaperone Complex
Negative Regulation Of Intracellular Signal Transduction
Response To Heat
Cellular Response To Oxygen-containing Compound
Negative Regulation Of Biosynthetic Process
Regulation Of Gene Expression
Positive Regulation Of Catabolic Process
Nucleus
Response To Peptide
Positive Regulation Of Protein Metabolic Process
Negative Regulation Of Macromolecule Biosynthetic Process
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Tagcloud (Intersection)
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