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CD80 and NGFR
Number of citations of the paper that reports this interaction (PubMedID
21982860
)
0
Data Source:
BioGRID
(pull down)
CD80
NGFR
Description
CD80 molecule
nerve growth factor receptor
Image
GO Annotations
Cellular Component
Plasma Membrane
External Side Of Plasma Membrane
Cell Surface
Membrane
Protein Complex Involved In Cell Adhesion
Extracellular Region
Nucleoplasm
Cytoplasm
Endosome
Cytosol
Plasma Membrane
Cell-cell Junction
Cell Surface
Postsynaptic Density
Membrane
Growth Cone
Neuromuscular Junction
Cell Projection
Dendritic Spine
Perikaryon
Organelle
Synapse
Presynapse
Molecular Function
Virus Receptor Activity
Protein Binding
Coreceptor Activity
Receptor Ligand Activity
Amyloid-beta Binding
Transmembrane Signaling Receptor Activity
Death Receptor Activity
Protein Binding
Calmodulin Binding
Coreceptor Activity
Small GTPase Binding
Ubiquitin Protein Ligase Binding
Signaling Receptor Activity
Neurotrophin Binding
Nerve Growth Factor Binding
Biological Process
Immune System Process
Regulation Of Immune System Process
Negative Regulation Of T Cell Mediated Immunity
Immune Response
Cell Surface Receptor Signaling Pathway
Positive Regulation Of Signal Transduction
T Cell Costimulation
Positive Regulation Of Granulocyte Macrophage Colony-stimulating Factor Production
Positive Regulation Of Interleukin-2 Production
Intracellular Signal Transduction
Positive Regulation Of T Cell Proliferation
T Cell Activation
Negative Regulation Of T Cell Proliferation
Positive Regulation Of T-helper 1 Cell Differentiation
Positive Regulation Of DNA-templated Transcription
Symbiont Entry Into Host Cell
Positive Regulation Of Peptidyl-tyrosine Phosphorylation
Cellular Response To Lipopolysaccharide
Intracellular Glucose Homeostasis
Hair Follicle Development
Intracellular Protein Transport
Apoptotic Process
Signal Transduction
Rho Protein Signal Transduction
Nervous System Development
Axon Guidance
Central Nervous System Development
Circadian Rhythm
Fibroblast Growth Factor Receptor Signaling Pathway
Regulation Of Gene Expression
Detection Of Temperature Stimulus
Nerve Development
Cell Differentiation
Negative Regulation Of Cell Migration
Hair Follicle Morphogenesis
Circadian Regulation Of Gene Expression
Dorsal Aorta Development
Negative Regulation Of Fibroblast Growth Factor Receptor Signaling Pathway
Regulation Of Cell Population Proliferation
Odontogenesis Of Dentin-containing Tooth
Positive Regulation Of Odontogenesis Of Dentin-containing Tooth
Glucose Homeostasis
Positive Regulation Of Apoptotic Process
Skin Development
Fibroblast Proliferation
Positive Regulation Of Fibroblast Proliferation
Rhythmic Process
Neuron Apoptotic Process
Negative Regulation Of Hair Follicle Development
Extrinsic Apoptotic Signaling Pathway
Presynaptic Modulation Of Chemical Synaptic Transmission
Positive Regulation Of Protein Localization To Nucleus
Positive Regulation Of MiRNA Transcription
Negative Regulation Of Blood Vessel Endothelial Cell Proliferation Involved In Sprouting Angiogenesis
Cellular Response To Amyloid-beta
Positive Regulation Of Endothelial Cell Apoptotic Process
Positive Regulation Of Apoptotic Signaling Pathway
Pathways
PIP3 activates AKT signaling
Constitutive Signaling by Aberrant PI3K in Cancer
Co-stimulation by CD28
CD28 dependent PI3K/Akt signaling
CD28 dependent Vav1 pathway
Co-inhibition by CTLA4
Interleukin-10 signaling
PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling
Axonal growth inhibition (RHOA activation)
NRAGE signals death through JNK
p75NTR negatively regulates cell cycle via SC1
Ceramide signalling
Regulated proteolysis of p75NTR
NFG and proNGF binds to p75NTR
NADE modulates death signalling
NRIF signals cell death from the nucleus
NRIF signals cell death from the nucleus
p75NTR recruits signalling complexes
p75NTR recruits signalling complexes
NF-kB is activated and signals survival
Axonal growth stimulation
Drugs
Abatacept
Galiximab
Belatacept
Diseases
GWAS
Asthma (
32296059
)
Autoimmune thyroid disease (
32581359
)
Carotid plaque burden (
28282560
)
Celiac disease (
20190752
)
Juvenile idiopathic arthritis (oligoarticular or rheumatoid factor-negative polyarticular) (
23603761
)
Lobular breast cancer (menopausal hormone therapy interaction) (
24080446
)
Primary biliary cholangitis (
21399635
28425483
28062665
26394269
23000144
)
Primary biliary cirrhosis (
22961000
)
Systemic lupus erythematosus (
25862617
23273568
)
Systemic sclerosis (
31672989
)
Vitiligo (
27723757
22561518
)
Immune reponse to smallpox (secreted IL-2) (
22610502
)
Lower body strength (
27325353
)
Mean spheric corpuscular volume (
32888494
)
Prostate cancer (
23535732
)
Interacting Genes
5 interacting genes:
CD274
CD28
CD86
CTLA4
NGFR
50 interacting genes:
ANXA7
APP
BEX1
BEX3
BNIP3L
CAV1
CD80
CDKN1A
EGR1
FSCN1
GRB2
H2AX
IL2
KIDINS220
LINGO1
MAG
MAGED1
MAGEH1
MAPK1
MAPK3
MDM2
NDN
NFKBIB
NGF
NSMCE3
NTF4
NTRK1
NTRK2
NTRK3
PRKACB
PTPN13
RCC1
RIPK2
RPN2
RTN4R
SHC1
SMN1
SORT1
STMN2
TK1
TP53
TRA2B
TRADD
TRAF2
TRAF4
TRAF6
TRIM37
TTR
UFD1
ZNF274
Entrez ID
941
4804
HPRD ID
00202
01197
Ensembl ID
ENSG00000121594
ENSG00000064300
Uniprot IDs
A0N0P2
P33681
P08138
PDB IDs
1DR9
1I8L
7TPS
8FXW
8FXZ
8HXA
2N80
2N83
2N97
3EWV
5ZGG
7CSQ
8X8T
Enriched GO Terms of Interacting Partners
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T Cell Costimulation
Regulation Of T Cell Proliferation
Protein Complex Involved In Cell Adhesion
Coreceptor Activity
Regulation Of Mononuclear Cell Proliferation
Negative Regulation Of T Cell Proliferation
Regulation Of Leukocyte Proliferation
Regulation Of CD4-positive, Alpha-beta T Cell Activation
Negative Regulation Of Lymphocyte Proliferation
Negative Regulation Of Mononuclear Cell Proliferation
Negative Regulation Of Leukocyte Proliferation
Positive Regulation Of T Cell Proliferation
External Side Of Plasma Membrane
Regulation Of Leukocyte Cell-cell Adhesion
Regulation Of Alpha-beta T Cell Activation
Regulation Of T Cell Activation
Negative Regulation Of T Cell Activation
Regulation Of CD4-positive, Alpha-beta T Cell Proliferation
Positive Regulation Of Lymphocyte Proliferation
Positive Regulation Of Mononuclear Cell Proliferation
Negative Regulation Of Leukocyte Cell-cell Adhesion
Positive Regulation Of Interleukin-4 Production
Regulation Of Cell-cell Adhesion
Positive Regulation Of Leukocyte Proliferation
Negative Regulation Of Lymphocyte Activation
Regulation Of Lymphocyte Activation
Regulation Of T Cell Differentiation
Regulation Of Interleukin-4 Production
Negative Regulation Of Leukocyte Activation
Negative Regulation Of Cell-cell Adhesion
Regulation Of Lymphocyte Differentiation
Regulation Of Regulatory T Cell Differentiation
Positive Regulation Of Interleukin-2 Production
Negative Regulation Of Cell Activation
Positive Regulation Of Interleukin-10 Production
Regulation Of Cell Activation
Positive Regulation Of Immune Response
Positive Regulation Of CD4-positive, Alpha-beta T Cell Activation
Positive Regulation Of T Cell Activation
Positive Regulation Of Leukocyte Cell-cell Adhesion
Negative Regulation Of Cell Population Proliferation
Positive Regulation Of Immunoglobulin Production
Adaptive Immune Response
Negative Regulation Of Cell Adhesion
Regulation Of Cell Adhesion
Regulation Of Interleukin-2 Production
Regulation Of Interleukin-10 Production
Thyrotropin-releasing Hormone Activity
Regulation Of Activated CD4-positive, Alpha-beta T Cell Apoptotic Process
Positive Regulation Of Activated CD8-positive, Alpha-beta T Cell Apoptotic Process
Neurotrophin Signaling Pathway
Cell Surface Receptor Signaling Pathway
Regulation Of Programmed Cell Death
Nerve Growth Factor Signaling Pathway
Regulation Of Apoptotic Process
Response To Growth Factor
Signal Transduction
Response To Nerve Growth Factor
Regulation Of Protein Metabolic Process
Protein-containing Complex
Cellular Response To Nerve Growth Factor Stimulus
Regulation Of Protein Modification Process
Enzyme-linked Receptor Protein Signaling Pathway
Regulation Of MAPK Cascade
Cell Surface Receptor Protein Tyrosine Kinase Signaling Pathway
Positive Regulation Of Protein Modification Process
Regulation Of Intracellular Signal Transduction
Enzyme Binding
Apoptotic Process
Regulation Of Multicellular Organismal Process
Regulation Of Metabolic Process
Positive Regulation Of Metabolic Process
Programmed Cell Death
Cell Death
Identical Protein Binding
Regulation Of Macromolecule Metabolic Process
Positive Regulation Of MAPK Cascade
Neurotrophin TRK Receptor Signaling Pathway
Neurotrophin Receptor Activity
Neurotrophin Binding
Positive Regulation Of Macromolecule Metabolic Process
Cellular Response To Growth Factor Stimulus
Signaling Adaptor Activity
Regulation Of Gene Expression
Regulation Of Cellular Component Organization
Circadian Rhythm
Regulation Of Macromolecule Biosynthetic Process
Caveolin-mediated Endocytosis
Nerve Growth Factor Receptor Binding
Negative Regulation Of Macromolecule Metabolic Process
Regulation Of Signal Transduction
Cytokine-mediated Signaling Pathway
Regulation Of Plasma Membrane Bounded Cell Projection Organization
Myelination
Apoptotic Signaling Pathway
Axon Ensheathment
Regulation Of Cell Projection Organization
Positive Regulation Of Protein Metabolic Process
Positive Regulation Of Programmed Cell Death
Response To Radiation
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