CD80 and IQCB1

Data Source: HiPPIP (Novel)

		CD80	IQCB1
Name		CD80 molecule	IQ motif containing B1
Structure			No pdb structure
GO Annotations	Cellular Component	Plasma Membrane External Side Of Plasma Membrane Cell Surface Membrane Protein Complex Involved In Cell Adhesion	Photoreceptor Outer Segment Cytoplasm Centrosome Centriole Cytosol Cytoskeleton Cilium Photoreceptor Connecting Cilium Extracellular Exosome
	Molecular Function	Virus Receptor Activity Protein Binding Coreceptor Activity Receptor Ligand Activity	Protein Binding Calmodulin Binding Enzyme Binding Protein-macromolecule Adaptor Activity BBSome Binding
	Biological Process	Immune System Process Regulation Of Immune System Process Negative Regulation Of T Cell Mediated Immunity Immune Response Cell Surface Receptor Signaling Pathway Positive Regulation Of Signal Transduction T Cell Costimulation Positive Regulation Of Granulocyte Macrophage Colony-stimulating Factor Production Positive Regulation Of Interleukin-2 Production Intracellular Signal Transduction Positive Regulation Of T Cell Proliferation T Cell Activation Negative Regulation Of T Cell Proliferation Positive Regulation Of T-helper 1 Cell Differentiation Positive Regulation Of DNA-templated Transcription Symbiont Entry Into Host Cell Positive Regulation Of Peptidyl-tyrosine Phosphorylation Cellular Response To Lipopolysaccharide	Cell Projection Organization Photoreceptor Cell Maintenance Maintenance Of Animal Organ Identity Cilium Assembly Cytosolic Ciliogenesis
Pathways		PIP3 activates AKT signaling Constitutive Signaling by Aberrant PI3K in Cancer Co-stimulation by CD28 CD28 dependent PI3K/Akt signaling CD28 dependent Vav1 pathway Co-inhibition by CTLA4 Interleukin-10 signaling PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling	Anchoring of the basal body to the plasma membrane
Drugs		Abatacept Galiximab Belatacept	None
Diseases		None	Senior-Loken syndrome
GWAS		Asthma ( 32296059 ) Autoimmune thyroid disease ( 32581359 ) Carotid plaque burden ( 28282560 ) Celiac disease ( 20190752 ) Juvenile idiopathic arthritis (oligoarticular or rheumatoid factor-negative polyarticular) ( 23603761 ) Lobular breast cancer (menopausal hormone therapy interaction) ( 24080446 ) Primary biliary cholangitis ( 21399635 28425483 28062665 26394269 23000144 ) Primary biliary cirrhosis ( 22961000 ) Systemic lupus erythematosus ( 25862617 23273568 ) Systemic sclerosis ( 31672989 ) Vitiligo ( 27723757 22561518 )	Hemoglobin levels ( 32327693 ) Multiple sclerosis ( 24076602 31604244 ) Multiple sclerosis and triglyceride levels (pleiotropy) ( 26920376 )
Novel Interactors		4 novel interactors: IQCB1 MRPL3 TRH UPK1B	6 novel interactors: CD80 LMOD1 NECTIN3 TBL1X TRH UPK1B
Interacting Genes		5 interacting genes: CD274 CD28 CD86 CTLA4 NGFR	12 interacting genes: CALM2 CALML3 KIF9 LDOC1 MARCHF7 MNS1 PCMT1 PDE9A SESTD1 SMARCD1 SPG21 TRIM32
Entrez ID		941	9657
HPRD ID		00202	11049
Ensembl ID		ENSG00000121594	ENSG00000173226
Uniprot IDs		A0N0P2 P33681	Q15051
PDB IDs		1DR9 1I8L 7TPS 8FXW 8FXZ 8HXA	Not available
GO Terms Enriched among Interactors		T Cell Costimulation Regulation Of T Cell Proliferation Protein Complex Involved In Cell Adhesion Coreceptor Activity Regulation Of Mononuclear Cell Proliferation Negative Regulation Of T Cell Proliferation Regulation Of Leukocyte Proliferation Regulation Of CD4-positive, Alpha-beta T Cell Activation Negative Regulation Of Lymphocyte Proliferation Negative Regulation Of Mononuclear Cell Proliferation Negative Regulation Of Leukocyte Proliferation Positive Regulation Of T Cell Proliferation External Side Of Plasma Membrane Regulation Of Leukocyte Cell-cell Adhesion Regulation Of Alpha-beta T Cell Activation Regulation Of T Cell Activation Negative Regulation Of T Cell Activation Regulation Of CD4-positive, Alpha-beta T Cell Proliferation Positive Regulation Of Lymphocyte Proliferation Positive Regulation Of Mononuclear Cell Proliferation Negative Regulation Of Leukocyte Cell-cell Adhesion Positive Regulation Of Interleukin-4 Production Regulation Of Cell-cell Adhesion Positive Regulation Of Leukocyte Proliferation Negative Regulation Of Lymphocyte Activation Regulation Of Lymphocyte Activation Regulation Of T Cell Differentiation Regulation Of Interleukin-4 Production Negative Regulation Of Leukocyte Activation Negative Regulation Of Cell-cell Adhesion Regulation Of Lymphocyte Differentiation Regulation Of Regulatory T Cell Differentiation Positive Regulation Of Interleukin-2 Production Negative Regulation Of Cell Activation Positive Regulation Of Interleukin-10 Production Regulation Of Cell Activation Positive Regulation Of Immune Response Positive Regulation Of CD4-positive, Alpha-beta T Cell Activation Positive Regulation Of T Cell Activation Positive Regulation Of Leukocyte Cell-cell Adhesion Negative Regulation Of Cell Population Proliferation Positive Regulation Of Immunoglobulin Production Adaptive Immune Response Negative Regulation Of Cell Adhesion Regulation Of Cell Adhesion Regulation Of Interleukin-2 Production Regulation Of Interleukin-10 Production Thyrotropin-releasing Hormone Activity Regulation Of Activated CD4-positive, Alpha-beta T Cell Apoptotic Process Positive Regulation Of Activated CD8-positive, Alpha-beta T Cell Apoptotic Process	Detection Of Calcium Ion Regulation Of Cilium Assembly Regulation Of Organelle Assembly Calcium Channel Complex Regulation Of Release Of Sequestered Calcium Ion Into Cytosol By Sarcoplasmic Reticulum Regulation Of Calcium Ion Transmembrane Transport Negative Regulation Of Calcium Ion Transmembrane Transport Calcineurin-mediated Signaling Myelin Sheath Negative Regulation Of Cell Population Proliferation Regulation Of Organelle Organization Thyrotropin-releasing Hormone Activity Positive Regulation Of Interleukin-17-mediated Signaling Pathway Negative Regulation Of Cilium Assembly Actin Ubiquitination Negative Regulation Of Intrinsic Apoptotic Signaling Pathway In Response To DNA Damage Positive Regulation Of Chemokine (C-C Motif) Ligand 20 Production