CD80 and CTLA4

Number of citations of the paper that reports this interaction (PMID 7545666)
11

Data Source:
HPRD (in vitro)

		CD80	CTLA4
Gene Name		CD80 molecule	cytotoxic T-lymphocyte-associated protein 4
Image
Gene Ontology Annotations	Cellular Component	Plasma Membrane External Side Of Plasma Membrane Cell Surface Integral Component Of Membrane	Golgi Apparatus Plasma Membrane Integral Component Of Plasma Membrane External Side Of Plasma Membrane Clathrin-coated Endocytic Vesicle Perinuclear Region Of Cytoplasm
	Molecular Function	Protein Binding Coreceptor Activity	Protein Binding
	Biological Process	Epidermal Growth Factor Receptor Signaling Pathway Cell-cell Signaling Fibroblast Growth Factor Receptor Signaling Pathway Positive Regulation Of Signal Transduction Viral Process T Cell Costimulation Intracellular Signal Transduction Fc-epsilon Receptor Signaling Pathway T Cell Activation Positive Regulation Of Interleukin-2 Biosynthetic Process Innate Immune Response Positive Regulation Of Granulocyte Macrophage Colony-stimulating Factor Biosynthetic Process Positive Regulation Of T-helper 1 Cell Differentiation Positive Regulation Of Transcription, DNA-templated Positive Regulation Of Alpha-beta T Cell Proliferation Neurotrophin TRK Receptor Signaling Pathway Phosphatidylinositol-mediated Signaling Positive Regulation Of Peptidyl-tyrosine Phosphorylation	Immune Response Cellular Response To DNA Damage Stimulus Negative Regulation Of B Cell Proliferation T Cell Costimulation Negative Regulation Of T Cell Proliferation Positive Regulation Of Apoptotic Process Negative Regulation Of Regulatory T Cell Differentiation Negative Regulation Of Immune Response B Cell Receptor Signaling Pathway
Pathways		Signaling by the B Cell Receptor (BCR) Costimulation by the CD28 family Signaling by FGFR in disease PIP3 activates AKT signaling Signaling by EGFRvIII in Cancer Signaling by SCF-KIT Downstream signaling events of B Cell Receptor (BCR) DAP12 signaling PI3K/AKT activation PI-3K cascade PI3K events in ERBB2 signaling Downstream signaling of activated FGFR Innate Immune System Signaling by PDGF Signalling by NGF DAP12 interactions GAB1 signalosome CD28 co-stimulation CTLA4 inhibitory signaling CD28 dependent PI3K/Akt signaling Signaling by Ligand-Responsive EGFR Variants in Cancer NGF signalling via TRKA from the plasma membrane Signaling by ERBB4 Signaling by Overexpressed Wild-Type EGFR in Cancer Role of LAT2/NTAL/LAB on calcium mobilization Constitutive PI3K/AKT Signaling in Cancer PI3K events in ERBB4 signaling CD28 dependent Vav1 pathway Signaling by FGFR Signaling by ERBB2 Signaling by EGFR Downstream signal transduction Fc epsilon receptor (FCERI) signaling Signaling by EGFR in Cancer PI3K/AKT Signaling in Cancer Adaptive Immune System	Costimulation by the CD28 family CTLA4 inhibitory signaling Adaptive Immune System
Drugs		Abatacept Belatacept	Alpha-D-Mannose
Diseases
GWAS		Celiac disease ( 20190752) Primary biliary cirrhosis ( 23000144 21399635) Systemic lupus erythematosus ( 23273568) Vitiligo ( 22561518)	Alopecia areata ( 20596022) Celiac disease ( 20190752) Graves' disease ( 21841780) Hypothyroidism ( 22493691) Rheumatoid arthritis ( 20453842 19503088) Type 1 diabetes ( 19430480 18978792) Type 1 diabetes autoantibodies ( 21829393)
Protein-Protein Interactions		5 interactors: CD274 CD28 CD86 CTLA4 NGFR	14 interactors: AP1M1 AP2M1 CD80 CD86 FYN JAK2 LCK LYN PIK3R1 PPP2R5A PTPN11 STAT5A STAT5B TXK
Entrez ID		941	1493
HPRD ID		00202	00474
Ensembl ID		ENSG00000121594	ENSG00000163599
Uniprot IDs		A0N0P2 P33681	P16410
PDB IDs		1DR9 1I8L	1AH1 1H6E 1I85 1I8L 2X44 3BX7 3OSK
Enriched GO Terms of Interacting Partners?		T Cell Costimulation Regulation Of T Cell Proliferation Positive Regulation Of T Cell Activation Positive Regulation Of Homotypic Cell-cell Adhesion Positive Regulation Of Cell-cell Adhesion Regulation Of T Cell Activation Positive Regulation Of Cell Activation Regulation Of Cell-cell Adhesion Positive Regulation Of Cell Adhesion Regulation Of Lymphocyte Activation Positive Regulation Of T Cell Proliferation Regulation Of Cell Activation Regulation Of Cell Proliferation Positive Regulation Of Lymphocyte Proliferation Positive Regulation Of Mononuclear Cell Proliferation Regulation Of Cell Adhesion Positive Regulation Of Interleukin-2 Biosynthetic Process Neurotrophin TRK Receptor Signaling Pathway Positive Regulation Of Cell Proliferation Neurotrophin Signaling Pathway Regulation Of Interleukin-2 Biosynthetic Process Positive Regulation Of Immune System Process Positive Regulation Of Interleukin-2 Production Regulation Of Activated T Cell Proliferation Positive Regulation Of Cytokine Production Immune Response-regulating Cell Surface Receptor Signaling Pathway Negative Regulation Of Immune System Process Cell Surface Receptor Signaling Pathway Immune Response Regulation Of Immune System Process Negative Regulation Of T Cell Proliferation Immune Response-regulating Signaling Pathway Positive Regulation Of Cytokine Biosynthetic Process Negative Regulation Of Lymphocyte Proliferation Negative Regulation Of Mononuclear Cell Proliferation Negative Regulation Of Leukocyte Proliferation Regulation Of Cytokine Production Cellular Response To Growth Factor Stimulus Response To Growth Factor Negative Regulation Of T Cell Activation Negative Regulation Of Leukocyte Cell-cell Adhesion Positive Regulation Of Immune Response Negative Regulation Of Homotypic Cell-cell Adhesion Negative Regulation Of T Cell Anergy Positive Regulation Of Lymphotoxin A Biosynthetic Process Regulation Of Cytokine Biosynthetic Process Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Regulation Of T Cell Differentiation Negative Regulation Of Lymphocyte Activation Negative Regulation Of Cell-cell Adhesion	Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Positive Regulation Of Cell Activation Positive Regulation Of T Cell Activation Regulation Of Immune System Process Positive Regulation Of Homotypic Cell-cell Adhesion Regulation Of Cell-cell Adhesion Positive Regulation Of Cell Adhesion Enzyme Linked Receptor Protein Signaling Pathway Positive Regulation Of Cell-cell Adhesion Regulation Of Cell Activation T Cell Costimulation Regulation Of T Cell Activation Regulation Of Immune Response Regulation Of Cell Adhesion Regulation Of Lymphocyte Activation Immune System Process Leukocyte Activation Growth Hormone Receptor Signaling Pathway Cellular Response To Peptide Hormone Stimulus Cellular Response To Growth Hormone Stimulus Epidermal Growth Factor Receptor Signaling Pathway ERBB Signaling Pathway Cellular Response To Peptide Positive Regulation Of Immune System Process Immune Response-regulating Cell Surface Receptor Signaling Pathway Hemopoiesis Positive Regulation Of Immune Response Neurotrophin TRK Receptor Signaling Pathway Lymphocyte Activation Peptidyl-tyrosine Autophosphorylation Cell Activation Response To Growth Hormone Neurotrophin Signaling Pathway Fc-epsilon Receptor Signaling Pathway Immune System Development Response To Peptide Hormone Positive Regulation Of Interleukin-2 Biosynthetic Process Cellular Response To Organonitrogen Compound Immune Response-regulating Signaling Pathway Response To Peptide T Cell Aggregation Fc Receptor Signaling Pathway T Cell Activation Lymphocyte Aggregation Leukocyte Aggregation Phosphatidylinositol-mediated Signaling Regulation Of Cytokine Production Leukocyte Cell-cell Adhesion Viral Process Cellular Response To Organic Substance
Tagcloud ?		amixl atl bc blast burkitt cd54 cd58 cd86 cll cml costimulatory crisis dr granular hematological hla immuno lgl lymphoblastic lymphocytic lymphoma malignancies manipulating modality myeloblastic neoplastic ph1 philadelphia sharply	airway allergic asthma b7 bal blocking bronchoalveolar cd28 challenge challenges costimulation costimulatory engagement eosinophils eu hyperresponsiveness ige igg immunosuppressive infiltration inhalation lavage lymphocyte methacholine ovalbumin parabronchial sensitized tcr
Tagcloud (Difference) ?		amixl atl bc blast burkitt cd54 cd58 cd86 cll cml crisis dr granular hematological hla immuno lgl lymphoblastic lymphocytic lymphoma malignancies manipulating modality myeloblastic neoplastic ph1 philadelphia sharply	airway allergic asthma b7 bal blocking bronchoalveolar cd28 challenge challenges costimulation engagement eosinophils eu hyperresponsiveness ige igg immunosuppressive infiltration inhalation lavage lymphocyte methacholine ovalbumin parabronchial sensitized tcr
Tagcloud (Intersection) ?		costimulatory