CD80 and CD86

Number of citations of the paper that reports this interaction (PMID 12606712)
12

Data Source:
HPRD (in vitro)

		CD80	CD86
Gene Name		CD80 molecule	CD86 molecule
Image
Gene Ontology Annotations	Cellular Component	Plasma Membrane External Side Of Plasma Membrane Cell Surface Integral Component Of Membrane	Plasma Membrane External Side Of Plasma Membrane Cell Surface Integral Component Of Membrane Intracellular Membrane-bounded Organelle Extracellular Vesicular Exosome
	Molecular Function	Protein Binding Coreceptor Activity	Receptor Activity Receptor Binding Protein Binding Coreceptor Activity
	Biological Process	Epidermal Growth Factor Receptor Signaling Pathway Cell-cell Signaling Fibroblast Growth Factor Receptor Signaling Pathway Positive Regulation Of Signal Transduction Viral Process T Cell Costimulation Intracellular Signal Transduction Fc-epsilon Receptor Signaling Pathway T Cell Activation Positive Regulation Of Interleukin-2 Biosynthetic Process Innate Immune Response Positive Regulation Of Granulocyte Macrophage Colony-stimulating Factor Biosynthetic Process Positive Regulation Of T-helper 1 Cell Differentiation Positive Regulation Of Transcription, DNA-templated Positive Regulation Of Alpha-beta T Cell Proliferation Neurotrophin TRK Receptor Signaling Pathway Phosphatidylinositol-mediated Signaling Positive Regulation Of Peptidyl-tyrosine Phosphorylation	Response To Yeast Toll-like Receptor Signaling Pathway T Cell Proliferation Involved In Immune Response Negative Regulation Of T Cell Anergy Immune Response Epidermal Growth Factor Receptor Signaling Pathway Cell-cell Signaling Aging Positive Regulation Of Cell Proliferation Fibroblast Growth Factor Receptor Signaling Pathway Viral Process T Cell Costimulation Response To Interferon-gamma Fc-epsilon Receptor Signaling Pathway Positive Regulation Of Activated T Cell Proliferation T Cell Activation B Cell Activation Response To Drug Myeloid Dendritic Cell Differentiation Positive Regulation Of Lymphotoxin A Biosynthetic Process Positive Regulation Of Interleukin-2 Biosynthetic Process Innate Immune Response Positive Regulation Of Interleukin-4 Biosynthetic Process Positive Regulation Of T-helper 2 Cell Differentiation Positive Regulation Of Transcription, DNA-templated Neurotrophin TRK Receptor Signaling Pathway Phosphatidylinositol-mediated Signaling Defense Response To Virus Cellular Response To Lipopolysaccharide Cellular Response To Metal Ion Cellular Response To Cytokine Stimulus
Pathways		Signaling by the B Cell Receptor (BCR) Costimulation by the CD28 family Signaling by FGFR in disease PIP3 activates AKT signaling Signaling by EGFRvIII in Cancer Signaling by SCF-KIT Downstream signaling events of B Cell Receptor (BCR) DAP12 signaling PI3K/AKT activation PI-3K cascade PI3K events in ERBB2 signaling Downstream signaling of activated FGFR Innate Immune System Signaling by PDGF Signalling by NGF DAP12 interactions GAB1 signalosome CD28 co-stimulation CTLA4 inhibitory signaling CD28 dependent PI3K/Akt signaling Signaling by Ligand-Responsive EGFR Variants in Cancer NGF signalling via TRKA from the plasma membrane Signaling by ERBB4 Signaling by Overexpressed Wild-Type EGFR in Cancer Role of LAT2/NTAL/LAB on calcium mobilization Constitutive PI3K/AKT Signaling in Cancer PI3K events in ERBB4 signaling CD28 dependent Vav1 pathway Signaling by FGFR Signaling by ERBB2 Signaling by EGFR Downstream signal transduction Fc epsilon receptor (FCERI) signaling Signaling by EGFR in Cancer PI3K/AKT Signaling in Cancer Adaptive Immune System	Signaling by the B Cell Receptor (BCR) Costimulation by the CD28 family Signaling by FGFR in disease PIP3 activates AKT signaling Signaling by EGFRvIII in Cancer Signaling by SCF-KIT Downstream signaling events of B Cell Receptor (BCR) DAP12 signaling PI3K/AKT activation PI-3K cascade PI3K events in ERBB2 signaling Downstream signaling of activated FGFR Innate Immune System Signaling by PDGF Signalling by NGF DAP12 interactions GAB1 signalosome CD28 co-stimulation CTLA4 inhibitory signaling CD28 dependent PI3K/Akt signaling Signaling by Ligand-Responsive EGFR Variants in Cancer NGF signalling via TRKA from the plasma membrane Signaling by ERBB4 Signaling by Overexpressed Wild-Type EGFR in Cancer Role of LAT2/NTAL/LAB on calcium mobilization Constitutive PI3K/AKT Signaling in Cancer PI3K events in ERBB4 signaling CD28 dependent Vav1 pathway Signaling by FGFR Signaling by ERBB2 Signaling by EGFR Downstream signal transduction Fc epsilon receptor (FCERI) signaling Signaling by EGFR in Cancer PI3K/AKT Signaling in Cancer Adaptive Immune System
Drugs		Abatacept Belatacept	Antithymocyte globulin Abatacept Belatacept
Diseases
GWAS		Celiac disease ( 20190752) Primary biliary cirrhosis ( 23000144 21399635) Systemic lupus erythematosus ( 23273568) Vitiligo ( 22561518)	Multiple sclerosis ( 22190364 21833088)
Protein-Protein Interactions		5 interactors: CD274 CD28 CD86 CTLA4 NGFR	6 interactors: CD28 CD80 CTLA4 ECE2 MARCH8 PARP1
Entrez ID		941	942
HPRD ID		00202	03011
Ensembl ID		ENSG00000121594	ENSG00000114013
Uniprot IDs		A0N0P2 P33681	A8K632 P42081
PDB IDs		1DR9 1I8L	1I85 1NCN
Enriched GO Terms of Interacting Partners?		T Cell Costimulation Regulation Of T Cell Proliferation Positive Regulation Of T Cell Activation Positive Regulation Of Homotypic Cell-cell Adhesion Positive Regulation Of Cell-cell Adhesion Regulation Of T Cell Activation Positive Regulation Of Cell Activation Regulation Of Cell-cell Adhesion Positive Regulation Of Cell Adhesion Regulation Of Lymphocyte Activation Positive Regulation Of T Cell Proliferation Regulation Of Cell Activation Regulation Of Cell Proliferation Positive Regulation Of Lymphocyte Proliferation Positive Regulation Of Mononuclear Cell Proliferation Regulation Of Cell Adhesion Positive Regulation Of Interleukin-2 Biosynthetic Process Neurotrophin TRK Receptor Signaling Pathway Positive Regulation Of Cell Proliferation Neurotrophin Signaling Pathway Regulation Of Interleukin-2 Biosynthetic Process Positive Regulation Of Immune System Process Positive Regulation Of Interleukin-2 Production Regulation Of Activated T Cell Proliferation Positive Regulation Of Cytokine Production Immune Response-regulating Cell Surface Receptor Signaling Pathway Negative Regulation Of Immune System Process Cell Surface Receptor Signaling Pathway Immune Response Regulation Of Immune System Process Negative Regulation Of T Cell Proliferation Immune Response-regulating Signaling Pathway Positive Regulation Of Cytokine Biosynthetic Process Negative Regulation Of Lymphocyte Proliferation Negative Regulation Of Mononuclear Cell Proliferation Negative Regulation Of Leukocyte Proliferation Regulation Of Cytokine Production Cellular Response To Growth Factor Stimulus Response To Growth Factor Negative Regulation Of T Cell Activation Negative Regulation Of Leukocyte Cell-cell Adhesion Positive Regulation Of Immune Response Negative Regulation Of Homotypic Cell-cell Adhesion Negative Regulation Of T Cell Anergy Positive Regulation Of Lymphotoxin A Biosynthetic Process Regulation Of Cytokine Biosynthetic Process Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Regulation Of T Cell Differentiation Negative Regulation Of Lymphocyte Activation Negative Regulation Of Cell-cell Adhesion	T Cell Costimulation Regulation Of T Cell Proliferation Positive Regulation Of Alpha-beta T Cell Proliferation Positive Regulation Of Interleukin-2 Biosynthetic Process Positive Regulation Of T Cell Activation Positive Regulation Of Homotypic Cell-cell Adhesion Regulation Of Interleukin-2 Biosynthetic Process Positive Regulation Of Cell-cell Adhesion Positive Regulation Of Interleukin-2 Production Immune System Process Regulation Of T Cell Activation Positive Regulation Of Cell Activation Regulation Of Cell-cell Adhesion Immune Response-regulating Cell Surface Receptor Signaling Pathway Positive Regulation Of Cell Adhesion Regulation Of Lymphocyte Activation Positive Regulation Of Cytokine Biosynthetic Process Immune Response-regulating Signaling Pathway Regulation Of Cell Activation Positive Regulation Of T Cell Proliferation Cellular Response To Growth Factor Stimulus Response To Growth Factor Regulation Of Cytokine Biosynthetic Process Regulation Of Cell Adhesion Positive Regulation Of Lymphocyte Proliferation Positive Regulation Of Mononuclear Cell Proliferation Positive Regulation Of Immune Response Regulation Of T Cell Differentiation Phosphatidylinositol-mediated Signaling Antigen Receptor-mediated Signaling Pathway Positive Regulation Of Adaptive Immune Response Regulation Of Lymphocyte Differentiation Epidermal Growth Factor Receptor Signaling Pathway ERBB Signaling Pathway Fibroblast Growth Factor Receptor Signaling Pathway Regulation Of Growth Rate Protein Poly-ADP-ribosylation Positive Regulation Of Granulocyte Macrophage Colony-stimulating Factor Biosynthetic Process Regulation Of Immune Response Cellular Response To Fibroblast Growth Factor Stimulus Regulation Of Granulocyte Macrophage Colony-stimulating Factor Biosynthetic Process Response To Fibroblast Growth Factor Enzyme Linked Receptor Protein Signaling Pathway Regulation Of Adaptive Immune Response Positive Regulation Of Immune System Process Neurotrophin TRK Receptor Signaling Pathway Negative Regulation Of Regulatory T Cell Differentiation Neurotrophin Signaling Pathway Fc-epsilon Receptor Signaling Pathway Positive Regulation Of T-helper 1 Cell Differentiation
Tagcloud ?		amixl atl bc blast burkitt cd54 cd58 cd86 cll cml costimulatory crisis dr granular hematological hla immuno lgl lymphoblastic lymphocytic lymphoma malignancies manipulating modality myeloblastic neoplastic ph1 philadelphia sharply	amixl atl bc blast burkitt cd54 cd58 cd80 cll cml costimulatory crisis dr granular hematological hla immuno lgl lymphoblastic lymphocytic lymphoma malignancies manipulating modality myeloblastic neoplastic ph1 philadelphia sharply
Tagcloud (Difference) ?
Tagcloud (Intersection) ?		amixl atl bc blast burkitt cd54 cd58 cd80 cd86 cll cml costimulatory crisis dr granular hematological hla immuno lgl lymphoblastic lymphocytic lymphoma malignancies manipulating modality myeloblastic neoplastic ph1 philadelphia sharply