PDLIM7 and PAK7

Number of citations of the paper that reports this interaction (PMID 16189514)
699

Data Source:
HPRD (two hybrid)

		PDLIM7	PAK7
Gene Name		PDZ and LIM domain 7 (enigma)	p21 protein (Cdc42/Rac)-activated kinase 7
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Gene Ontology Annotations	Cellular Component	Stress Fiber Ruffle Nucleus Cytoplasm Focal Adhesion Actin Cytoskeleton	Nucleus Cytoplasm Mitochondrion
	Molecular Function	Protein Binding Zinc Ion Binding	Receptor Signaling Protein Serine/threonine Kinase Activity ATP Binding
	Biological Process	Ossification Receptor-mediated Endocytosis Multicellular Organismal Development Actin Cytoskeleton Organization Cell Differentiation Positive Regulation Of Osteoblast Differentiation	Mitotic Cell Cycle Protein Phosphorylation Apoptotic Process Cytoskeleton Organization Signal Transduction Learning Memory Locomotory Behavior Cell Proliferation Cell Growth Cell Migration Signal Transduction By Phosphorylation Intracellular Signal Transduction Negative Regulation Of Extrinsic Apoptotic Signaling Pathway
Pathways			Axon guidance Activation of Rac Signaling by Robo receptor
Drugs
Diseases
GWAS			Obesity-related traits ( 23251661)
Protein-Protein Interactions		34 interactors: AP5B1 BSG C20orf195 CCDC185 DGCR6 ENKD1 GEM GFAP HNRNPD IQGAP1 MDM2 PAK7 PCBP1 PHF1 PRKCA PRKCB PRKCZ PRKD2 PSMF1 RET SH2B2 SH3BP2 SMURF1 SPP1 TP53 TPM2 TRAF2 TRAF3 TSG101 UBE2I UBQLN4 WWP2 ZMYND11 ZNF165	20 interactors: ARMC7 ATPAF2 BAD CARD9 CCNG1 CDC42 CRBN EMD EXOSC1 FAM212A FHL3 GCC1 LENG1 LZTS2 PDLIM7 PSMF1 RAC1 SORBS3 TUBGCP4 UXT
Entrez ID		9260	57144
HPRD ID		10436	06423
Ensembl ID		ENSG00000196923	ENSG00000101349
Uniprot IDs		Q9NR12	B0AZM9 Q9P286
PDB IDs		2Q3G	2F57
Enriched GO Terms of Interacting Partners?		Regulation Of Signaling Regulation Of Signal Transduction Positive Regulation Of Cellular Protein Metabolic Process Enzyme Linked Receptor Protein Signaling Pathway Regulation Of Sequence-specific DNA Binding Transcription Factor Activity Intracellular Signal Transduction Positive Regulation Of Protein Metabolic Process Positive Regulation Of Signal Transduction Cell Death Death Response To Organic Substance Immune System Process Regulation Of Protein Metabolic Process Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Cellular Response To Organic Substance Histone H3-T6 Phosphorylation Apoptotic Process Regulation Of Cellular Protein Metabolic Process Programmed Cell Death Regulation Of Nitrogen Compound Metabolic Process Viral Process Positive Regulation Of Sequence-specific DNA Binding Transcription Factor Activity Protein Ubiquitination Regulation Of Metabolic Process Negative Regulation Of Signal Transduction Positive Regulation Of Cell Adhesion Cellular Response To Growth Factor Stimulus Regulation Of Apoptotic Process Protein Modification By Small Protein Conjugation Vascular Endothelial Growth Factor Receptor Signaling Pathway Response To Growth Factor Protein Catabolic Process Cell Surface Receptor Signaling Pathway Negative Regulation Of Signaling Positive Regulation Of Protein Modification Process Negative Regulation Of Apoptotic Process Positive Regulation Of NF-kappaB Transcription Factor Activity Regulation Of Cell Death Blood Coagulation Cellular Protein Modification Process Negative Regulation Of Programmed Cell Death Hemostasis Regulation Of Cellular Process Regulation Of Establishment Of Protein Localization Cellular Response To Stimulus Regulation Of Transcription, DNA-templated Negative Regulation Of Insulin Receptor Signaling Pathway Mitotic Cell Cycle Process Regulation Of Nucleic Acid-templated Transcription Regulation Of RNA Biosynthetic Process	Cytoskeleton Organization Organelle Organization Actin Cytoskeleton Organization Actin Filament-based Process Cellular Protein Complex Assembly Mitotic Cell Cycle Process Positive Regulation Of Phosphatidylinositol 3-kinase Activity Positive Regulation Of Substrate Adhesion-dependent Cell Spreading Mitotic Cell Cycle Positive Regulation Of Signal Transduction Regulation Of Substrate Adhesion-dependent Cell Spreading Positive Regulation Of Intracellular Signal Transduction Regulation Of Phosphorylation Immune Response-regulating Signaling Pathway Positive Regulation Of Phosphorylation Positive Regulation Of T Cell Activation Positive Regulation Of Stress Fiber Assembly Positive Regulation Of Homotypic Cell-cell Adhesion Regulation Of Apoptotic Process Regulation Of Canonical Wnt Signaling Pathway Positive Regulation Of Actin Filament Bundle Assembly Regulation Of Phosphorus Metabolic Process Regulation Of Signal Transduction Regulation Of Phosphatidylinositol 3-kinase Activity Positive Regulation Of Intracellular Transport Positive Regulation Of Transferase Activity Cellular Response To Chromate Organelle Transport Along Microtubule Positive Regulation Of Cell-cell Adhesion Regulation Of Cell Death Protein Complex Assembly Regulation Of Lipid Kinase Activity Cell Cycle Process Fc Receptor Signaling Pathway Regulation Of Stress Fiber Assembly Wnt Signaling Pathway Positive Regulation Of DNA Replication Cellular Macromolecular Complex Assembly Regulation Of Signaling Regulation Of T Cell Activation Positive Regulation Of Cell Activation Actin Filament Organization Positive Regulation Of Neuron Death Regulation Of Wnt Signaling Pathway Positive Regulation Of Mitochondrial Membrane Potential Embryonic Olfactory Bulb Interneuron Precursor Migration Negative Regulation Of Interleukin-23 Production Positive Regulation Of Hair Follicle Cell Proliferation Suppression By Virus Of Host Apoptotic Process T Cell Costimulation
Tagcloud ?			10a 200c 30a 30c arhgap5 cd36 cdh2 cdk5r1 chips cyp27b1 figure gemcitabine gna13 gp5 hist1h2bf hlf igsf3 ikbkb il32 intriguing mirs nrp2 oxidoreductase putatively rab23 rap2a slc11a1 sod3 tp53i3
Tagcloud (Difference) ?			10a 200c 30a 30c arhgap5 cd36 cdh2 cdk5r1 chips cyp27b1 figure gemcitabine gna13 gp5 hist1h2bf hlf igsf3 ikbkb il32 intriguing mirs nrp2 oxidoreductase putatively rab23 rap2a slc11a1 sod3 tp53i3
Tagcloud (Intersection) ?