PAK5 and BAD

Number of citations of the paper that reports this interaction (PubMedID 12897128)
42

Data Source:
HPRD (in vivo, in vitro)

		PAK5	BAD
Description		p21 (RAC1) activated kinase 5	BCL2 associated agonist of cell death
Image
GO Annotations	Cellular Component	Nucleus Nucleoplasm Cytoplasm Mitochondrion Cytosol Plasma Membrane Nuclear Membrane Synapse	Cytoplasm Mitochondrion Mitochondrial Outer Membrane Cytosol Membrane BAD-BCL-2 Complex
	Molecular Function	Nucleotide Binding Protein Kinase Activity Protein Serine/threonine Kinase Activity Protein Binding ATP Binding Kinase Activity Transferase Activity Protein Serine Kinase Activity	Protein Binding Phospholipid Binding Lipid Binding Protein Kinase Binding Protein Phosphatase Binding Cysteine-type Endopeptidase Activator Activity
	Biological Process	Regulation Of Cell Growth Apoptotic Process Cytoskeleton Organization Signal Transduction Learning Memory Locomotory Behavior Cell Population Proliferation Cellular Response To Starvation Cell Migration Intracellular Signal Transduction Regulation Of MAPK Cascade Negative Regulation Of Extrinsic Apoptotic Signaling Pathway	Release Of Cytochrome C From Mitochondria Glucose Catabolic Process Apoptotic Process Extrinsic Apoptotic Signaling Pathway Via Death Domain Receptors Intrinsic Apoptotic Signaling Pathway In Response To DNA Damage Positive Regulation Of Autophagy Positive Regulation Of Mitochondrial Membrane Potential Cytokine-mediated Signaling Pathway Positive Regulation Of Insulin Secretion Positive Regulation Of Insulin Secretion Involved In Cellular Response To Glucose Stimulus Glucose Homeostasis Regulation Of Apoptotic Process Positive Regulation Of Apoptotic Process Negative Regulation Of Apoptotic Process Type B Pancreatic Cell Proliferation Positive Regulation Of B Cell Differentiation Positive Regulation Of T Cell Differentiation Positive Regulation Of Proteolysis ADP Metabolic Process ATP Metabolic Process Regulation Of Mitochondrial Membrane Permeability Pore Complex Assembly Epithelial Cell Proliferation Positive Regulation Of Epithelial Cell Proliferation Cellular Response To Mechanical Stimulus Cellular Response To Nicotine Cellular Response To Lipid Cellular Response To Hypoxia Positive Regulation Of Release Of Cytochrome C From Mitochondria Apoptotic Signaling Pathway Extrinsic Apoptotic Signaling Pathway Extrinsic Apoptotic Signaling Pathway In Absence Of Ligand Intrinsic Apoptotic Signaling Pathway Positive Regulation Of Intrinsic Apoptotic Signaling Pathway In Response To Osmotic Stress Positive Regulation Of Type B Pancreatic Cell Development
Pathways		Activation of RAC1 CDC42 GTPase cycle RAC1 GTPase cycle RHOD GTPase cycle RHOH GTPase cycle	Activation of BAD and translocation to mitochondria Activation of BAD and translocation to mitochondria BH3-only proteins associate with and inactivate anti-apoptotic BCL-2 members NRAGE signals death through JNK AKT phosphorylates targets in the cytosol Constitutive Signaling by AKT1 E17K in Cancer
Drugs		Fostamatinib	Navitoclax
Diseases
GWAS		Atopy ( 28927820) Plasma factor V levels in venous thrombosis (conditioned on rs6027) ( 31271701) Schizophrenia, bipolar disorder or recurrent major depressive disorder x sex interaction ( 34099189)	Crohn's disease ( 28067908) Heel bone mineral density ( 30598549) Platelet count ( 22423221) Sarcoidosis ( 22837380) Vitiligo ( 27723757) Waist-hip index ( 34021172) Waist-to-hip ratio adjusted for BMI ( 34021172)
Interacting Genes		36 interacting genes: ARHGEF19 ARMC7 ATPAF2 BAD CARD9 CATSPER1 CCDC57 CCNG1 CDC42 CRBN CSNK1D DDX6 DNPEP EMD ENKD1 EXOSC1 FHL3 GCC1 INKA1 LENG1 LNX1 LZTS2 MARK2 MYO15B NTAQ1 PDLIM7 PRPF31 PSMF1 PTPN21 RAC1 RHOJ SORBS3 SRSF11 TSGA10 TUBGCP4 UXT	46 interacting genes: ACTN2 AKT1 ARAF BCL2 BCL2A1 BCL2L1 BCL2L10 BCL2L2 BRAF CDKN1A CHEK1 CREB3L3 EWSR1 HRK KEAP1 KRT31 MAP2K5 MAPK8 MCL1 PAK1 PAK5 PIM1 PIM2 PIM3 PPP1CA PPP3CA PRDX2 PRKACA PRKCI RAF1 RPS6KA1 RPS6KA2 RPS6KA3 RPS6KA5 S100A10 SFN SNCA STEAP3 SUMO2 WASF1 YWHAB YWHAE YWHAG YWHAH YWHAQ YWHAZ
Entrez ID		57144	572
HPRD ID		06423	04409
Ensembl ID		ENSG00000101349	ENSG00000002330
Uniprot IDs		B0AZM9 Q9P286	Q92934
PDB IDs		2F57 8C12	1G5J 7Q16
Enriched GO Terms of Interacting Partners?		Cytoskeleton Organization Cytoskeleton Cytoplasm Wnt Signaling Pathway Microtubule-based Process Microtubule Nucleation Microtubule Cytoskeleton Organization Wnt Signaling Pathway, Planar Cell Polarity Pathway Organelle Organization G Protein-coupled Receptor Signaling Pathway Involved In Heart Process Cell Projection Assembly Spindle Non-canonical Wnt Signaling Pathway Thioesterase Binding Positive Regulation Of Stress Fiber Assembly Positive Regulation Of Actin Filament Bundle Assembly Centrosome Establishment Or Maintenance Of Cell Polarity Midbrain Dopaminergic Neuron Differentiation Cellular Component Assembly GTP-dependent Protein Binding Cytoplasmic Ribonucleoprotein Granule Actin Cytoskeleton Organization Plasma Membrane Bounded Cell Projection Assembly Tau-protein Kinase Activity Establishment Of Cell Polarity Regulation Of Stress Fiber Assembly	Intracellular Signal Transduction Protein Serine Kinase Activity Protein Serine/threonine Kinase Activity Regulation Of Programmed Cell Death Negative Regulation Of Apoptotic Process Cellular Response To Stress Regulation Of Apoptotic Process Negative Regulation Of Programmed Cell Death Protein Kinase Activity Kinase Activity Apoptotic Mitochondrial Changes Release Of Cytochrome C From Mitochondria Cytosol Apoptotic Process Programmed Cell Death Cell Death Protein Phosphorylation Response To Stress TORC1 Signaling Regulation Of Cellular Component Organization Signal Transduction Phosphorylation Protein Sequestering Activity Regulation Of Extrinsic Apoptotic Signaling Pathway In Absence Of Ligand Intrinsic Apoptotic Signaling Pathway In Response To DNA Damage Cytoplasm Cellular Response To Starvation TOR Signaling Cellular Response To Nutrient Levels Mitochondrion Organization Negative Regulation Of Extrinsic Apoptotic Signaling Pathway Protein Modification Process Response To Starvation Protein Domain Specific Binding Negative Regulation Of Extrinsic Apoptotic Signaling Pathway In Absence Of Ligand Regulation Of Extrinsic Apoptotic Signaling Pathway Extrinsic Apoptotic Signaling Pathway In Absence Of Ligand Regulation Of Protein Metabolic Process Phosphoserine Residue Binding Extrinsic Apoptotic Signaling Pathway Channel Activity Positive Regulation Of Programmed Cell Death Mitochondrial Outer Membrane Intracellular Signaling Cassette Bcl-2 Family Protein Complex Regulation Of Protein Localization Identical Protein Binding ATP Binding Intracellular Protein Localization Apoptotic Signaling Pathway
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